Amino acid dipepetide frequency for Candidatus Nanopelagicus abundans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.641AlaAla: 10.641 ± 0.215
0.679AlaCys: 0.679 ± 0.046
5.229AlaAsp: 5.229 ± 0.122
5.014AlaGlu: 5.014 ± 0.12
3.447AlaPhe: 3.447 ± 0.114
8.219AlaGly: 8.219 ± 0.189
1.479AlaHis: 1.479 ± 0.079
7.271AlaIle: 7.271 ± 0.158
6.54AlaLys: 6.54 ± 0.149
10.138AlaLeu: 10.138 ± 0.189
2.361AlaMet: 2.361 ± 0.103
3.744AlaAsn: 3.744 ± 0.11
3.51AlaPro: 3.51 ± 0.095
3.486AlaGln: 3.486 ± 0.11
4.464AlaArg: 4.464 ± 0.108
6.051AlaSer: 6.051 ± 0.142
5.448AlaThr: 5.448 ± 0.125
7.07AlaVal: 7.07 ± 0.153
0.926AlaTrp: 0.926 ± 0.051
2.229AlaTyr: 2.229 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.748CysAla: 0.748 ± 0.041
0.066CysCys: 0.066 ± 0.013
0.544CysAsp: 0.544 ± 0.044
0.487CysGlu: 0.487 ± 0.035
0.239CysPhe: 0.239 ± 0.026
0.855CysGly: 0.855 ± 0.058
0.176CysHis: 0.176 ± 0.024
0.385CysIle: 0.385 ± 0.036
0.324CysLys: 0.324 ± 0.029
0.61CysLeu: 0.61 ± 0.038
0.102CysMet: 0.102 ± 0.016
0.242CysAsn: 0.242 ± 0.025
0.374CysPro: 0.374 ± 0.03
0.187CysGln: 0.187 ± 0.025
0.322CysArg: 0.322 ± 0.027
0.525CysSer: 0.525 ± 0.042
0.421CysThr: 0.421 ± 0.038
0.536CysVal: 0.536 ± 0.041
0.08CysTrp: 0.08 ± 0.013
0.162CysTyr: 0.162 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.734AspAla: 4.734 ± 0.13
0.412AspCys: 0.412 ± 0.033
2.386AspAsp: 2.386 ± 0.082
3.846AspGlu: 3.846 ± 0.111
2.232AspPhe: 2.232 ± 0.079
3.97AspGly: 3.97 ± 0.116
1.001AspHis: 1.001 ± 0.062
3.381AspIle: 3.381 ± 0.086
2.928AspLys: 2.928 ± 0.092
6.892AspLeu: 6.892 ± 0.149
0.764AspMet: 0.764 ± 0.044
1.707AspAsn: 1.707 ± 0.075
2.606AspPro: 2.606 ± 0.091
2.199AspGln: 2.199 ± 0.077
2.922AspArg: 2.922 ± 0.09
3.343AspSer: 3.343 ± 0.104
2.144AspThr: 2.144 ± 0.08
3.975AspVal: 3.975 ± 0.106
0.652AspTrp: 0.652 ± 0.046
1.449AspTyr: 1.449 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.896GluAla: 4.896 ± 0.117
0.366GluCys: 0.366 ± 0.036
2.535GluAsp: 2.535 ± 0.091
3.09GluGlu: 3.09 ± 0.117
2.32GluPhe: 2.32 ± 0.091
3.315GluGly: 3.315 ± 0.102
1.064GluHis: 1.064 ± 0.053
5.322GluIle: 5.322 ± 0.105
4.107GluLys: 4.107 ± 0.125
6.452GluLeu: 6.452 ± 0.135
1.281GluMet: 1.281 ± 0.067
2.628GluAsn: 2.628 ± 0.088
1.806GluPro: 1.806 ± 0.071
2.089GluGln: 2.089 ± 0.085
3.2GluArg: 3.2 ± 0.107
3.772GluSer: 3.772 ± 0.095
2.339GluThr: 2.339 ± 0.075
5.055GluVal: 5.055 ± 0.135
0.564GluTrp: 0.564 ± 0.039
1.416GluTyr: 1.416 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.681PheAla: 3.681 ± 0.111
0.327PheCys: 0.327 ± 0.031
2.419PheAsp: 2.419 ± 0.074
2.26PheGlu: 2.26 ± 0.079
1.471PhePhe: 1.471 ± 0.081
3.505PheGly: 3.505 ± 0.118
0.605PheHis: 0.605 ± 0.037
2.95PheIle: 2.95 ± 0.104
2.139PheLys: 2.139 ± 0.08
3.552PheLeu: 3.552 ± 0.116
0.772PheMet: 0.772 ± 0.047
1.597PheAsn: 1.597 ± 0.078
1.473PhePro: 1.473 ± 0.058
0.772PheGln: 0.772 ± 0.049
1.339PheArg: 1.339 ± 0.065
2.656PheSer: 2.656 ± 0.101
2.653PheThr: 2.653 ± 0.09
2.383PheVal: 2.383 ± 0.081
0.487PheTrp: 0.487 ± 0.038
0.984PheTyr: 0.984 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
7.271GlyAla: 7.271 ± 0.181
0.687GlyCys: 0.687 ± 0.044
3.923GlyAsp: 3.923 ± 0.112
4.514GlyGlu: 4.514 ± 0.105
3.472GlyPhe: 3.472 ± 0.104
6.213GlyGly: 6.213 ± 0.152
1.306GlyHis: 1.306 ± 0.06
5.602GlyIle: 5.602 ± 0.127
5.237GlyLys: 5.237 ± 0.112
7.425GlyLeu: 7.425 ± 0.154
1.801GlyMet: 1.801 ± 0.079
2.449GlyAsn: 2.449 ± 0.085
2.521GlyPro: 2.521 ± 0.078
2.455GlyGln: 2.455 ± 0.103
3.75GlyArg: 3.75 ± 0.095
5.281GlySer: 5.281 ± 0.127
3.835GlyThr: 3.835 ± 0.133
6.482GlyVal: 6.482 ± 0.146
1.039GlyTrp: 1.039 ± 0.06
2.257GlyTyr: 2.257 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.325HisAla: 1.325 ± 0.065
0.148HisCys: 0.148 ± 0.022
0.8HisAsp: 0.8 ± 0.05
0.998HisGlu: 0.998 ± 0.053
0.66HisPhe: 0.66 ± 0.045
1.388HisGly: 1.388 ± 0.059
0.401HisHis: 0.401 ± 0.037
1.042HisIle: 1.042 ± 0.053
0.822HisLys: 0.822 ± 0.046
1.773HisLeu: 1.773 ± 0.074
0.305HisMet: 0.305 ± 0.032
0.597HisAsn: 0.597 ± 0.04
1.039HisPro: 1.039 ± 0.056
0.525HisGln: 0.525 ± 0.037
0.836HisArg: 0.836 ± 0.047
1.047HisSer: 1.047 ± 0.053
0.803HisThr: 0.803 ± 0.051
1.014HisVal: 1.014 ± 0.049
0.176HisTrp: 0.176 ± 0.019
0.404HisTyr: 0.404 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
8.25IleAla: 8.25 ± 0.203
0.643IleCys: 0.643 ± 0.04
4.409IleAsp: 4.409 ± 0.116
4.363IleGlu: 4.363 ± 0.126
2.68IlePhe: 2.68 ± 0.094
5.897IleGly: 5.897 ± 0.152
1.028IleHis: 1.028 ± 0.053
4.324IleIle: 4.324 ± 0.109
4.668IleLys: 4.668 ± 0.124
5.729IleLeu: 5.729 ± 0.124
1.13IleMet: 1.13 ± 0.053
3.2IleAsn: 3.2 ± 0.099
3.095IlePro: 3.095 ± 0.098
1.757IleGln: 1.757 ± 0.066
3.104IleArg: 3.104 ± 0.099
6.158IleSer: 6.158 ± 0.13
5.066IleThr: 5.066 ± 0.112
4.382IleVal: 4.382 ± 0.118
0.781IleTrp: 0.781 ± 0.047
1.79IleTyr: 1.79 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
5.476LysAla: 5.476 ± 0.142
0.379LysCys: 0.379 ± 0.03
3.417LysAsp: 3.417 ± 0.093
3.684LysGlu: 3.684 ± 0.096
2.012LysPhe: 2.012 ± 0.079
3.835LysGly: 3.835 ± 0.104
0.803LysHis: 0.803 ± 0.05
4.368LysIle: 4.368 ± 0.101
4.247LysLys: 4.247 ± 0.138
5.864LysLeu: 5.864 ± 0.148
1.57LysMet: 1.57 ± 0.055
2.752LysAsn: 2.752 ± 0.09
2.84LysPro: 2.84 ± 0.094
1.952LysGln: 1.952 ± 0.071
2.939LysArg: 2.939 ± 0.104
5.05LysSer: 5.05 ± 0.131
3.117LysThr: 3.117 ± 0.103
4.978LysVal: 4.978 ± 0.131
0.665LysTrp: 0.665 ± 0.046
1.795LysTyr: 1.795 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
10.504LeuAla: 10.504 ± 0.189
0.624LeuCys: 0.624 ± 0.039
5.644LeuAsp: 5.644 ± 0.139
5.435LeuGlu: 5.435 ± 0.112
3.604LeuPhe: 3.604 ± 0.117
7.716LeuGly: 7.716 ± 0.167
1.465LeuHis: 1.465 ± 0.07
7.653LeuIle: 7.653 ± 0.179
5.459LeuLys: 5.459 ± 0.112
9.929LeuLeu: 9.929 ± 0.24
1.988LeuMet: 1.988 ± 0.074
3.945LeuAsn: 3.945 ± 0.118
4.621LeuPro: 4.621 ± 0.123
2.471LeuGln: 2.471 ± 0.088
4.651LeuArg: 4.651 ± 0.13
7.441LeuSer: 7.441 ± 0.167
6.306LeuThr: 6.306 ± 0.131
8.063LeuVal: 8.063 ± 0.145
0.913LeuTrp: 0.913 ± 0.059
1.853LeuTyr: 1.853 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.488MetAla: 2.488 ± 0.086
0.129MetCys: 0.129 ± 0.021
0.998MetAsp: 0.998 ± 0.057
0.86MetGlu: 0.86 ± 0.043
0.572MetPhe: 0.572 ± 0.045
1.567MetGly: 1.567 ± 0.083
0.338MetHis: 0.338 ± 0.028
1.358MetIle: 1.358 ± 0.07
1.38MetLys: 1.38 ± 0.066
1.79MetLeu: 1.79 ± 0.079
0.465MetMet: 0.465 ± 0.044
0.882MetAsn: 0.882 ± 0.046
1.069MetPro: 1.069 ± 0.058
0.775MetGln: 0.775 ± 0.049
1.284MetArg: 1.284 ± 0.058
1.93MetSer: 1.93 ± 0.072
1.108MetThr: 1.108 ± 0.054
1.482MetVal: 1.482 ± 0.062
0.181MetTrp: 0.181 ± 0.02
0.418MetTyr: 0.418 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.378AsnAla: 3.378 ± 0.104
0.338AsnCys: 0.338 ± 0.031
1.787AsnAsp: 1.787 ± 0.067
2.394AsnGlu: 2.394 ± 0.077
1.603AsnPhe: 1.603 ± 0.067
2.716AsnGly: 2.716 ± 0.093
0.605AsnHis: 0.605 ± 0.042
2.397AsnIle: 2.397 ± 0.092
2.375AsnLys: 2.375 ± 0.081
4.288AsnLeu: 4.288 ± 0.109
0.874AsnMet: 0.874 ± 0.045
1.663AsnAsn: 1.663 ± 0.066
2.213AsnPro: 2.213 ± 0.083
1.589AsnGln: 1.589 ± 0.071
1.891AsnArg: 1.891 ± 0.083
2.823AsnSer: 2.823 ± 0.111
2.015AsnThr: 2.015 ± 0.082
2.205AsnVal: 2.205 ± 0.083
0.624AsnTrp: 0.624 ± 0.037
1.105AsnTyr: 1.105 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
3.989ProAla: 3.989 ± 0.116
0.267ProCys: 0.267 ± 0.03
2.284ProAsp: 2.284 ± 0.087
2.634ProGlu: 2.634 ± 0.082
1.57ProPhe: 1.57 ± 0.069
3.241ProGly: 3.241 ± 0.102
0.764ProHis: 0.764 ± 0.049
3.082ProIle: 3.082 ± 0.099
2.658ProLys: 2.658 ± 0.104
3.576ProLeu: 3.576 ± 0.093
0.874ProMet: 0.874 ± 0.052
1.759ProAsn: 1.759 ± 0.077
1.3ProPro: 1.3 ± 0.088
1.146ProGln: 1.146 ± 0.058
1.671ProArg: 1.671 ± 0.077
2.669ProSer: 2.669 ± 0.097
2.79ProThr: 2.79 ± 0.101
3.389ProVal: 3.389 ± 0.102
0.522ProTrp: 0.522 ± 0.038
1.091ProTyr: 1.091 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.724GlnAla: 2.724 ± 0.092
0.173GlnCys: 0.173 ± 0.021
1.289GlnAsp: 1.289 ± 0.058
1.619GlnGlu: 1.619 ± 0.067
1.036GlnPhe: 1.036 ± 0.046
2.004GlnGly: 2.004 ± 0.076
0.426GlnHis: 0.426 ± 0.038
3.126GlnIle: 3.126 ± 0.097
1.757GlnLys: 1.757 ± 0.074
3.596GlnLeu: 3.596 ± 0.108
0.91GlnMet: 0.91 ± 0.064
0.899GlnAsn: 0.899 ± 0.047
1.141GlnPro: 1.141 ± 0.074
1.001GlnGln: 1.001 ± 0.065
1.608GlnArg: 1.608 ± 0.076
2.221GlnSer: 2.221 ± 0.08
1.581GlnThr: 1.581 ± 0.066
2.886GlnVal: 2.886 ± 0.086
0.382GlnTrp: 0.382 ± 0.036
0.742GlnTyr: 0.742 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
4.222ArgAla: 4.222 ± 0.109
0.418ArgCys: 0.418 ± 0.035
2.741ArgAsp: 2.741 ± 0.103
2.82ArgGlu: 2.82 ± 0.101
1.938ArgPhe: 1.938 ± 0.074
3.219ArgGly: 3.219 ± 0.095
0.781ArgHis: 0.781 ± 0.046
3.197ArgIle: 3.197 ± 0.087
2.906ArgLys: 2.906 ± 0.105
4.791ArgLeu: 4.791 ± 0.133
1.289ArgMet: 1.289 ± 0.064
1.922ArgAsn: 1.922 ± 0.073
1.737ArgPro: 1.737 ± 0.079
1.495ArgGln: 1.495 ± 0.068
2.851ArgArg: 2.851 ± 0.119
3.26ArgSer: 3.26 ± 0.1
2.603ArgThr: 2.603 ± 0.096
3.697ArgVal: 3.697 ± 0.105
0.577ArgTrp: 0.577 ± 0.038
1.259ArgTyr: 1.259 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.944SerAla: 6.944 ± 0.149
0.495SerCys: 0.495 ± 0.045
4.231SerAsp: 4.231 ± 0.112
4.277SerGlu: 4.277 ± 0.109
2.804SerPhe: 2.804 ± 0.106
6.078SerGly: 6.078 ± 0.136
1.155SerHis: 1.155 ± 0.058
4.712SerIle: 4.712 ± 0.113
4.475SerLys: 4.475 ± 0.104
6.669SerLeu: 6.669 ± 0.148
1.424SerMet: 1.424 ± 0.06
2.771SerAsn: 2.771 ± 0.082
2.579SerPro: 2.579 ± 0.089
2.194SerGln: 2.194 ± 0.063
3.189SerArg: 3.189 ± 0.089
4.651SerSer: 4.651 ± 0.13
3.774SerThr: 3.774 ± 0.092
4.989SerVal: 4.989 ± 0.108
0.968SerTrp: 0.968 ± 0.052
1.842SerTyr: 1.842 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
5.539ThrAla: 5.539 ± 0.118
0.382ThrCys: 0.382 ± 0.034
2.906ThrAsp: 2.906 ± 0.088
2.743ThrGlu: 2.743 ± 0.08
2.21ThrPhe: 2.21 ± 0.077
4.954ThrGly: 4.954 ± 0.124
0.97ThrHis: 0.97 ± 0.05
3.387ThrIle: 3.387 ± 0.09
3.318ThrLys: 3.318 ± 0.089
5.487ThrLeu: 5.487 ± 0.135
0.984ThrMet: 0.984 ± 0.056
2.097ThrAsn: 2.097 ± 0.073
3.109ThrPro: 3.109 ± 0.089
1.757ThrGln: 1.757 ± 0.069
2.224ThrArg: 2.224 ± 0.08
3.601ThrSer: 3.601 ± 0.108
3.4ThrThr: 3.4 ± 0.113
4.145ThrVal: 4.145 ± 0.127
0.679ThrTrp: 0.679 ± 0.047
1.446ThrTyr: 1.446 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
7.815ValAla: 7.815 ± 0.159
0.547ValCys: 0.547 ± 0.036
4.272ValAsp: 4.272 ± 0.104
4.517ValGlu: 4.517 ± 0.13
2.628ValPhe: 2.628 ± 0.091
5.921ValGly: 5.921 ± 0.152
1.141ValHis: 1.141 ± 0.053
6.691ValIle: 6.691 ± 0.143
4.47ValLys: 4.47 ± 0.119
7.455ValLeu: 7.455 ± 0.14
1.583ValMet: 1.583 ± 0.062
2.87ValAsn: 2.87 ± 0.087
2.614ValPro: 2.614 ± 0.088
1.592ValGln: 1.592 ± 0.064
3.4ValArg: 3.4 ± 0.108
5.242ValSer: 5.242 ± 0.109
4.319ValThr: 4.319 ± 0.116
6.43ValVal: 6.43 ± 0.141
0.706ValTrp: 0.706 ± 0.048
1.446ValTyr: 1.446 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.049
0.099TrpCys: 0.099 ± 0.017
0.58TrpAsp: 0.58 ± 0.043
0.429TrpGlu: 0.429 ± 0.033
0.522TrpPhe: 0.522 ± 0.041
0.748TrpGly: 0.748 ± 0.051
0.272TrpHis: 0.272 ± 0.032
0.792TrpIle: 0.792 ± 0.046
0.542TrpLys: 0.542 ± 0.044
1.265TrpLeu: 1.265 ± 0.06
0.253TrpMet: 0.253 ± 0.026
0.517TrpAsn: 0.517 ± 0.037
0.478TrpPro: 0.478 ± 0.039
0.69TrpGln: 0.69 ± 0.056
0.726TrpArg: 0.726 ± 0.045
0.833TrpSer: 0.833 ± 0.053
0.412TrpThr: 0.412 ± 0.033
0.764TrpVal: 0.764 ± 0.042
0.22TrpTrp: 0.22 ± 0.028
0.322TrpTyr: 0.322 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.342TyrAla: 2.342 ± 0.092
0.203TyrCys: 0.203 ± 0.02
1.149TyrAsp: 1.149 ± 0.044
1.633TyrGlu: 1.633 ± 0.071
1.003TyrPhe: 1.003 ± 0.056
2.158TyrGly: 2.158 ± 0.082
0.324TyrHis: 0.324 ± 0.029
1.413TyrIle: 1.413 ± 0.061
1.391TyrLys: 1.391 ± 0.067
3.005TyrLeu: 3.005 ± 0.099
0.341TyrMet: 0.341 ± 0.034
0.643TyrAsn: 0.643 ± 0.043
1.152TyrPro: 1.152 ± 0.053
0.99TyrGln: 0.99 ± 0.047
1.355TyrArg: 1.355 ± 0.066
1.666TyrSer: 1.666 ± 0.068
1.207TyrThr: 1.207 ± 0.059
1.732TyrVal: 1.732 ± 0.067
0.302TyrTrp: 0.302 ± 0.026
0.627TyrTyr: 0.627 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1145 proteins (363772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski