Amino acid dipepetide frequency for Streptomyces cacaoi subsp. cacaoi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.003AlaAla: 23.003 ± 0.171	1.177AlaCys: 1.177 ± 0.022	8.438AlaAsp: 8.438 ± 0.057	9.415AlaGlu: 9.415 ± 0.083	3.32AlaPhe: 3.32 ± 0.042	15.47AlaGly: 15.47 ± 0.127	3.429AlaHis: 3.429 ± 0.042	2.468AlaIle: 2.468 ± 0.037	2.252AlaLys: 2.252 ± 0.045	15.183AlaLeu: 15.183 ± 0.109	2.257AlaMet: 2.257 ± 0.038	1.542AlaAsn: 1.542 ± 0.029	8.646AlaPro: 8.646 ± 0.084	3.815AlaGln: 3.815 ± 0.05	12.172AlaArg: 12.172 ± 0.083	5.556AlaSer: 5.556 ± 0.055	6.444AlaThr: 6.444 ± 0.058	12.436AlaVal: 12.436 ± 0.079	1.783AlaTrp: 1.783 ± 0.028	2.495AlaTyr: 2.495 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.302CysAla: 1.302 ± 0.026	0.109CysCys: 0.109 ± 0.008	0.454CysAsp: 0.454 ± 0.014	0.44CysGlu: 0.44 ± 0.015	0.241CysPhe: 0.241 ± 0.01	1.033CysGly: 1.033 ± 0.021	0.18CysHis: 0.18 ± 0.009	0.154CysIle: 0.154 ± 0.009	0.091CysLys: 0.091 ± 0.007	0.761CysLeu: 0.761 ± 0.021	0.121CysMet: 0.121 ± 0.008	0.12CysAsn: 0.12 ± 0.007	0.539CysPro: 0.539 ± 0.017	0.148CysGln: 0.148 ± 0.008	0.669CysArg: 0.669 ± 0.018	0.408CysSer: 0.408 ± 0.015	0.545CysThr: 0.545 ± 0.015	0.73CysVal: 0.73 ± 0.017	0.123CysTrp: 0.123 ± 0.007	0.157CysTyr: 0.157 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.068AspAla: 8.068 ± 0.067	0.394AspCys: 0.394 ± 0.016	3.496AspAsp: 3.496 ± 0.045	4.224AspGlu: 4.224 ± 0.049	1.512AspPhe: 1.512 ± 0.026	7.376AspGly: 7.376 ± 0.07	1.323AspHis: 1.323 ± 0.026	1.602AspIle: 1.602 ± 0.027	1.03AspLys: 1.03 ± 0.028	5.305AspLeu: 5.305 ± 0.06	0.803AspMet: 0.803 ± 0.02	0.812AspAsn: 0.812 ± 0.021	4.546AspPro: 4.546 ± 0.046	1.2AspGln: 1.2 ± 0.023	4.799AspArg: 4.799 ± 0.049	2.464AspSer: 2.464 ± 0.036	3.12AspThr: 3.12 ± 0.038	4.316AspVal: 4.316 ± 0.05	0.934AspTrp: 0.934 ± 0.022	0.929AspTyr: 0.929 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.821GluAla: 7.821 ± 0.067	0.383GluCys: 0.383 ± 0.013	3.009GluAsp: 3.009 ± 0.042	4.044GluGlu: 4.044 ± 0.055	1.38GluPhe: 1.38 ± 0.03	4.857GluGly: 4.857 ± 0.053	1.732GluHis: 1.732 ± 0.027	1.921GluIle: 1.921 ± 0.03	1.439GluLys: 1.439 ± 0.032	6.88GluLeu: 6.88 ± 0.069	0.899GluMet: 0.899 ± 0.019	0.952GluAsn: 0.952 ± 0.021	4.083GluPro: 4.083 ± 0.049	2.474GluGln: 2.474 ± 0.036	6.307GluArg: 6.307 ± 0.07	2.544GluSer: 2.544 ± 0.035	2.971GluThr: 2.971 ± 0.038	4.356GluVal: 4.356 ± 0.048	0.743GluTrp: 0.743 ± 0.019	0.988GluTyr: 0.988 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.652PheAla: 3.652 ± 0.043	0.27PheCys: 0.27 ± 0.01	1.802PheAsp: 1.802 ± 0.033	1.31PheGlu: 1.31 ± 0.028	0.867PhePhe: 0.867 ± 0.025	2.884PheGly: 2.884 ± 0.039	0.643PheHis: 0.643 ± 0.018	0.596PheIle: 0.596 ± 0.019	0.379PheLys: 0.379 ± 0.013	2.6PheLeu: 2.6 ± 0.041	0.345PheMet: 0.345 ± 0.012	0.436PheAsn: 0.436 ± 0.016	1.357PhePro: 1.357 ± 0.024	0.57PheGln: 0.57 ± 0.017	1.866PheArg: 1.866 ± 0.031	1.354PheSer: 1.354 ± 0.023	1.873PheThr: 1.873 ± 0.031	2.1PheVal: 2.1 ± 0.031	0.38PheTrp: 0.38 ± 0.014	0.48PheTyr: 0.48 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	13.206GlyAla: 13.206 ± 0.115	0.907GlyCys: 0.907 ± 0.023	5.318GlyAsp: 5.318 ± 0.055	5.853GlyGlu: 5.853 ± 0.054	2.807GlyPhe: 2.807 ± 0.039	10.366GlyGly: 10.366 ± 0.11	2.52GlyHis: 2.52 ± 0.032	3.072GlyIle: 3.072 ± 0.044	2.303GlyLys: 2.303 ± 0.045	9.578GlyLeu: 9.578 ± 0.072	2.077GlyMet: 2.077 ± 0.03	1.631GlyAsn: 1.631 ± 0.029	6.933GlyPro: 6.933 ± 0.094	2.69GlyGln: 2.69 ± 0.039	9.026GlyArg: 9.026 ± 0.071	5.92GlySer: 5.92 ± 0.069	7.128GlyThr: 7.128 ± 0.062	7.496GlyVal: 7.496 ± 0.067	1.639GlyTrp: 1.639 ± 0.025	2.167GlyTyr: 2.167 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.939HisAla: 2.939 ± 0.046	0.232HisCys: 0.232 ± 0.009	1.334HisAsp: 1.334 ± 0.026	1.337HisGlu: 1.337 ± 0.024	0.668HisPhe: 0.668 ± 0.018	2.849HisGly: 2.849 ± 0.04	0.739HisHis: 0.739 ± 0.019	0.639HisIle: 0.639 ± 0.021	0.341HisLys: 0.341 ± 0.014	2.494HisLeu: 2.494 ± 0.031	0.354HisMet: 0.354 ± 0.011	0.332HisAsn: 0.332 ± 0.013	1.988HisPro: 1.988 ± 0.031	0.587HisGln: 0.587 ± 0.016	2.487HisArg: 2.487 ± 0.035	1.07HisSer: 1.07 ± 0.023	1.611HisThr: 1.611 ± 0.026	1.65HisVal: 1.65 ± 0.028	0.369HisTrp: 0.369 ± 0.013	0.444HisTyr: 0.444 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.894IleAla: 3.894 ± 0.04	0.253IleCys: 0.253 ± 0.01	1.764IleAsp: 1.764 ± 0.029	1.721IleGlu: 1.721 ± 0.032	0.556IlePhe: 0.556 ± 0.015	3.029IleGly: 3.029 ± 0.041	0.51IleHis: 0.51 ± 0.015	0.616IleIle: 0.616 ± 0.017	0.556IleLys: 0.556 ± 0.018	1.872IleLeu: 1.872 ± 0.032	0.335IleMet: 0.335 ± 0.013	0.515IleAsn: 0.515 ± 0.016	1.483IlePro: 1.483 ± 0.027	0.566IleGln: 0.566 ± 0.016	1.926IleArg: 1.926 ± 0.031	1.343IleSer: 1.343 ± 0.027	1.697IleThr: 1.697 ± 0.028	2.274IleVal: 2.274 ± 0.039	0.301IleTrp: 0.301 ± 0.01	0.41IleTyr: 0.41 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.36LysAla: 2.36 ± 0.047	0.103LysCys: 0.103 ± 0.007	1.128LysAsp: 1.128 ± 0.026	1.114LysGlu: 1.114 ± 0.027	0.372LysPhe: 0.372 ± 0.014	1.7LysGly: 1.7 ± 0.038	0.387LysHis: 0.387 ± 0.013	0.655LysIle: 0.655 ± 0.02	0.85LysLys: 0.85 ± 0.034	1.721LysLeu: 1.721 ± 0.035	0.338LysMet: 0.338 ± 0.014	0.449LysAsn: 0.449 ± 0.017	1.124LysPro: 1.124 ± 0.024	0.634LysGln: 0.634 ± 0.019	1.302LysArg: 1.302 ± 0.025	1.015LysSer: 1.015 ± 0.029	1.032LysThr: 1.032 ± 0.025	1.501LysVal: 1.501 ± 0.033	0.207LysTrp: 0.207 ± 0.009	0.357LysTyr: 0.357 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.184LeuAla: 15.184 ± 0.112	0.96LeuCys: 0.96 ± 0.021	6.565LeuAsp: 6.565 ± 0.059	4.799LeuGlu: 4.799 ± 0.059	2.562LeuPhe: 2.562 ± 0.037	9.31LeuGly: 9.31 ± 0.085	2.481LeuHis: 2.481 ± 0.032	2.693LeuIle: 2.693 ± 0.038	1.657LeuLys: 1.657 ± 0.031	11.604LeuLeu: 11.604 ± 0.11	1.515LeuMet: 1.515 ± 0.029	1.418LeuAsn: 1.418 ± 0.03	6.882LeuPro: 6.882 ± 0.064	1.886LeuGln: 1.886 ± 0.03	9.308LeuArg: 9.308 ± 0.071	5.16LeuSer: 5.16 ± 0.052	6.666LeuThr: 6.666 ± 0.053	8.715LeuVal: 8.715 ± 0.074	1.258LeuTrp: 1.258 ± 0.024	1.705LeuTyr: 1.705 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.195MetAla: 2.195 ± 0.033	0.14MetCys: 0.14 ± 0.007	0.833MetAsp: 0.833 ± 0.019	0.705MetGlu: 0.705 ± 0.02	0.396MetPhe: 0.396 ± 0.013	1.227MetGly: 1.227 ± 0.023	0.359MetHis: 0.359 ± 0.013	0.529MetIle: 0.529 ± 0.015	0.359MetLys: 0.359 ± 0.015	1.637MetLeu: 1.637 ± 0.028	0.267MetMet: 0.267 ± 0.01	0.378MetAsn: 0.378 ± 0.012	1.135MetPro: 1.135 ± 0.024	0.411MetGln: 0.411 ± 0.014	1.435MetArg: 1.435 ± 0.027	1.252MetSer: 1.252 ± 0.02	1.431MetThr: 1.431 ± 0.026	1.154MetVal: 1.154 ± 0.022	0.191MetTrp: 0.191 ± 0.009	0.308MetTyr: 0.308 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.944AsnAla: 1.944 ± 0.031	0.149AsnCys: 0.149 ± 0.008	0.756AsnAsp: 0.756 ± 0.019	0.712AsnGlu: 0.712 ± 0.018	0.404AsnPhe: 0.404 ± 0.014	1.615AsnGly: 1.615 ± 0.028	0.35AsnHis: 0.35 ± 0.012	0.551AsnIle: 0.551 ± 0.016	0.347AsnLys: 0.347 ± 0.014	1.386AsnLeu: 1.386 ± 0.025	0.282AsnMet: 0.282 ± 0.012	0.33AsnAsn: 0.33 ± 0.013	1.152AsnPro: 1.152 ± 0.024	0.399AsnGln: 0.399 ± 0.014	1.104AsnArg: 1.104 ± 0.024	0.815AsnSer: 0.815 ± 0.019	0.929AsnThr: 0.929 ± 0.02	1.121AsnVal: 1.121 ± 0.025	0.226AsnTrp: 0.226 ± 0.012	0.335AsnTyr: 0.335 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.136ProAla: 10.136 ± 0.104	0.386ProCys: 0.386 ± 0.013	4.956ProAsp: 4.956 ± 0.047	4.996ProGlu: 4.996 ± 0.063	1.519ProPhe: 1.519 ± 0.025	8.818ProGly: 8.818 ± 0.104	1.719ProHis: 1.719 ± 0.028	0.879ProIle: 0.879 ± 0.023	0.973ProLys: 0.973 ± 0.024	5.612ProLeu: 5.612 ± 0.057	0.941ProMet: 0.941 ± 0.022	0.715ProAsn: 0.715 ± 0.018	4.426ProPro: 4.426 ± 0.072	1.893ProGln: 1.893 ± 0.035	4.814ProArg: 4.814 ± 0.048	3.368ProSer: 3.368 ± 0.048	2.897ProThr: 2.897 ± 0.037	5.684ProVal: 5.684 ± 0.045	0.921ProTrp: 0.921 ± 0.023	1.368ProTyr: 1.368 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.358GlnAla: 3.358 ± 0.037	0.166GlnCys: 0.166 ± 0.007	1.36GlnAsp: 1.36 ± 0.028	1.585GlnGlu: 1.585 ± 0.029	0.598GlnPhe: 0.598 ± 0.016	2.289GlnGly: 2.289 ± 0.037	0.7GlnHis: 0.7 ± 0.019	0.874GlnIle: 0.874 ± 0.021	0.507GlnLys: 0.507 ± 0.017	3.063GlnLeu: 3.063 ± 0.041	0.457GlnMet: 0.457 ± 0.014	0.397GlnAsn: 0.397 ± 0.013	1.788GlnPro: 1.788 ± 0.043	1.332GlnGln: 1.332 ± 0.034	2.476GlnArg: 2.476 ± 0.04	1.108GlnSer: 1.108 ± 0.025	1.164GlnThr: 1.164 ± 0.023	2.043GlnVal: 2.043 ± 0.036	0.378GlnTrp: 0.378 ± 0.013	0.475GlnTyr: 0.475 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.538ArgAla: 11.538 ± 0.098	0.701ArgCys: 0.701 ± 0.02	4.516ArgAsp: 4.516 ± 0.043	5.441ArgGlu: 5.441 ± 0.054	2.33ArgPhe: 2.33 ± 0.029	6.614ArgGly: 6.614 ± 0.063	2.313ArgHis: 2.313 ± 0.032	3.001ArgIle: 3.001 ± 0.039	1.595ArgLys: 1.595 ± 0.027	9.338ArgLeu: 9.338 ± 0.074	1.825ArgMet: 1.825 ± 0.027	1.338ArgAsn: 1.338 ± 0.025	5.914ArgPro: 5.914 ± 0.059	2.393ArgGln: 2.393 ± 0.033	8.678ArgArg: 8.678 ± 0.078	4.28ArgSer: 4.28 ± 0.044	6.045ArgThr: 6.045 ± 0.054	5.943ArgVal: 5.943 ± 0.051	1.425ArgTrp: 1.425 ± 0.024	1.853ArgTyr: 1.853 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.985SerAla: 6.985 ± 0.06	0.415SerCys: 0.415 ± 0.016	2.484SerAsp: 2.484 ± 0.039	2.347SerGlu: 2.347 ± 0.033	1.428SerPhe: 1.428 ± 0.026	6.553SerGly: 6.553 ± 0.065	0.947SerHis: 0.947 ± 0.022	1.046SerIle: 1.046 ± 0.022	0.84SerLys: 0.84 ± 0.024	4.455SerLeu: 4.455 ± 0.048	0.948SerMet: 0.948 ± 0.019	0.685SerAsn: 0.685 ± 0.016	3.356SerPro: 3.356 ± 0.045	1.073SerGln: 1.073 ± 0.023	3.899SerArg: 3.899 ± 0.039	2.776SerSer: 2.776 ± 0.044	2.822SerThr: 2.822 ± 0.037	3.944SerVal: 3.944 ± 0.039	0.825SerTrp: 0.825 ± 0.021	1.045SerTyr: 1.045 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.223ThrAla: 9.223 ± 0.075	0.4ThrCys: 0.4 ± 0.015	3.453ThrAsp: 3.453 ± 0.041	3.316ThrGlu: 3.316 ± 0.039	1.455ThrPhe: 1.455 ± 0.025	7.236ThrGly: 7.236 ± 0.074	1.215ThrHis: 1.215 ± 0.024	1.24ThrIle: 1.24 ± 0.025	0.884ThrLys: 0.884 ± 0.024	5.525ThrLeu: 5.525 ± 0.045	0.859ThrMet: 0.859 ± 0.02	0.786ThrAsn: 0.786 ± 0.016	4.098ThrPro: 4.098 ± 0.048	1.119ThrGln: 1.119 ± 0.022	4.015ThrArg: 4.015 ± 0.049	2.826ThrSer: 2.826 ± 0.038	3.322ThrThr: 3.322 ± 0.047	5.95ThrVal: 5.95 ± 0.049	0.801ThrTrp: 0.801 ± 0.021	1.077ThrTyr: 1.077 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.307ValAla: 10.307 ± 0.078	0.87ValCys: 0.87 ± 0.019	4.585ValAsp: 4.585 ± 0.054	4.546ValGlu: 4.546 ± 0.053	2.301ValPhe: 2.301 ± 0.033	6.268ValGly: 6.268 ± 0.06	2.167ValHis: 2.167 ± 0.03	2.183ValIle: 2.183 ± 0.035	1.337ValLys: 1.337 ± 0.031	9.679ValLeu: 9.679 ± 0.075	1.207ValMet: 1.207 ± 0.024	1.419ValAsn: 1.419 ± 0.026	5.81ValPro: 5.81 ± 0.058	1.88ValGln: 1.88 ± 0.029	7.66ValArg: 7.66 ± 0.071	3.955ValSer: 3.955 ± 0.039	5.144ValThr: 5.144 ± 0.05	7.509ValVal: 7.509 ± 0.071	1.061ValTrp: 1.061 ± 0.025	1.338ValTyr: 1.338 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.606TrpAla: 1.606 ± 0.029	0.165TrpCys: 0.165 ± 0.007	0.755TrpAsp: 0.755 ± 0.021	0.732TrpGlu: 0.732 ± 0.018	0.49TrpPhe: 0.49 ± 0.015	1.005TrpGly: 1.005 ± 0.021	0.361TrpHis: 0.361 ± 0.013	0.487TrpIle: 0.487 ± 0.014	0.311TrpLys: 0.311 ± 0.012	1.72TrpLeu: 1.72 ± 0.03	0.279TrpMet: 0.279 ± 0.012	0.352TrpAsn: 0.352 ± 0.014	0.762TrpPro: 0.762 ± 0.019	0.575TrpGln: 0.575 ± 0.017	1.357TrpArg: 1.357 ± 0.024	0.832TrpSer: 0.832 ± 0.019	0.897TrpThr: 0.897 ± 0.019	0.878TrpVal: 0.878 ± 0.019	0.313TrpTrp: 0.313 ± 0.012	0.312TrpTyr: 0.312 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.036	0.146TyrCys: 0.146 ± 0.008	1.249TyrAsp: 1.249 ± 0.027	1.145TyrGlu: 1.145 ± 0.024	0.561TyrPhe: 0.561 ± 0.017	2.138TyrGly: 2.138 ± 0.038	0.389TyrHis: 0.389 ± 0.013	0.416TyrIle: 0.416 ± 0.014	0.298TyrLys: 0.298 ± 0.015	1.914TyrLeu: 1.914 ± 0.032	0.232TyrMet: 0.232 ± 0.01	0.3TyrAsn: 0.3 ± 0.012	0.999TyrPro: 0.999 ± 0.02	0.47TyrGln: 0.47 ± 0.016	1.782TyrArg: 1.782 ± 0.03	0.828TyrSer: 0.828 ± 0.019	1.06TyrThr: 1.06 ± 0.025	1.423TyrVal: 1.423 ± 0.028	0.313TyrTrp: 0.313 ± 0.012	0.364TyrTyr: 0.364 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6946 proteins (2355190 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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