Amino acid dipepetide frequency for Corticimicrobacter populi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.402AlaAla: 15.402 ± 0.174	1.312AlaCys: 1.312 ± 0.04	6.447AlaAsp: 6.447 ± 0.094	6.304AlaGlu: 6.304 ± 0.093	3.678AlaPhe: 3.678 ± 0.064	10.521AlaGly: 10.521 ± 0.162	2.657AlaHis: 2.657 ± 0.048	5.455AlaIle: 5.455 ± 0.076	2.302AlaLys: 2.302 ± 0.06	14.689AlaLeu: 14.689 ± 0.144	3.076AlaMet: 3.076 ± 0.061	2.494AlaAsn: 2.494 ± 0.051	5.03AlaPro: 5.03 ± 0.073	6.058AlaGln: 6.058 ± 0.092	9.097AlaArg: 9.097 ± 0.106	6.541AlaSer: 6.541 ± 0.087	5.768AlaThr: 5.768 ± 0.071	8.061AlaVal: 8.061 ± 0.106	1.998AlaTrp: 1.998 ± 0.043	2.548AlaTyr: 2.548 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.032	0.144CysCys: 0.144 ± 0.012	0.471CysAsp: 0.471 ± 0.02	0.433CysGlu: 0.433 ± 0.019	0.31CysPhe: 0.31 ± 0.016	0.917CysGly: 0.917 ± 0.031	0.279CysHis: 0.279 ± 0.02	0.423CysIle: 0.423 ± 0.018	0.199CysLys: 0.199 ± 0.013	0.99CysLeu: 0.99 ± 0.032	0.251CysMet: 0.251 ± 0.014	0.268CysAsn: 0.268 ± 0.018	0.464CysPro: 0.464 ± 0.026	0.335CysGln: 0.335 ± 0.019	0.661CysArg: 0.661 ± 0.024	0.5CysSer: 0.5 ± 0.023	0.466CysThr: 0.466 ± 0.023	0.682CysVal: 0.682 ± 0.025	0.131CysTrp: 0.131 ± 0.013	0.21CysTyr: 0.21 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.806AspAla: 6.806 ± 0.099	0.487AspCys: 0.487 ± 0.021	2.904AspAsp: 2.904 ± 0.058	3.152AspGlu: 3.152 ± 0.049	2.107AspPhe: 2.107 ± 0.045	4.519AspGly: 4.519 ± 0.086	1.213AspHis: 1.213 ± 0.035	3.229AspIle: 3.229 ± 0.05	1.425AspLys: 1.425 ± 0.039	5.743AspLeu: 5.743 ± 0.074	1.492AspMet: 1.492 ± 0.037	1.417AspAsn: 1.417 ± 0.047	3.01AspPro: 3.01 ± 0.059	1.925AspGln: 1.925 ± 0.05	3.476AspArg: 3.476 ± 0.062	2.611AspSer: 2.611 ± 0.044	3.212AspThr: 3.212 ± 0.057	3.889AspVal: 3.889 ± 0.062	1.119AspTrp: 1.119 ± 0.035	1.506AspTyr: 1.506 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.58GluAla: 6.58 ± 0.097	0.373GluCys: 0.373 ± 0.022	2.397GluAsp: 2.397 ± 0.056	2.474GluGlu: 2.474 ± 0.051	1.646GluPhe: 1.646 ± 0.044	3.573GluGly: 3.573 ± 0.069	1.498GluHis: 1.498 ± 0.039	2.99GluIle: 2.99 ± 0.057	1.652GluLys: 1.652 ± 0.044	5.447GluLeu: 5.447 ± 0.082	1.224GluMet: 1.224 ± 0.03	1.497GluAsn: 1.497 ± 0.034	2.441GluPro: 2.441 ± 0.052	3.324GluGln: 3.324 ± 0.054	4.411GluArg: 4.411 ± 0.08	2.676GluSer: 2.676 ± 0.053	2.894GluThr: 2.894 ± 0.06	3.6GluVal: 3.6 ± 0.065	0.707GluTrp: 0.707 ± 0.03	1.271GluTyr: 1.271 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.53PheAla: 3.53 ± 0.062	0.372PheCys: 0.372 ± 0.019	2.431PheAsp: 2.431 ± 0.052	2.039PheGlu: 2.039 ± 0.044	1.343PhePhe: 1.343 ± 0.043	3.073PheGly: 3.073 ± 0.055	0.657PheHis: 0.657 ± 0.023	1.601PheIle: 1.601 ± 0.045	0.954PheLys: 0.954 ± 0.029	3.235PheLeu: 3.235 ± 0.063	0.897PheMet: 0.897 ± 0.03	1.146PheAsn: 1.146 ± 0.036	1.46PhePro: 1.46 ± 0.042	1.113PheGln: 1.113 ± 0.036	1.973PheArg: 1.973 ± 0.047	2.336PheSer: 2.336 ± 0.053	1.655PheThr: 1.655 ± 0.045	2.487PheVal: 2.487 ± 0.057	0.576PheTrp: 0.576 ± 0.028	0.922PheTyr: 0.922 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.836GlyAla: 7.836 ± 0.106	0.854GlyCys: 0.854 ± 0.028	3.82GlyAsp: 3.82 ± 0.068	4.128GlyGlu: 4.128 ± 0.065	3.033GlyPhe: 3.033 ± 0.058	6.218GlyGly: 6.218 ± 0.098	1.998GlyHis: 1.998 ± 0.047	4.527GlyIle: 4.527 ± 0.072	2.953GlyLys: 2.953 ± 0.067	9.214GlyLeu: 9.214 ± 0.099	2.529GlyMet: 2.529 ± 0.048	2.308GlyAsn: 2.308 ± 0.052	2.746GlyPro: 2.746 ± 0.054	3.923GlyGln: 3.923 ± 0.075	5.642GlyArg: 5.642 ± 0.081	4.605GlySer: 4.605 ± 0.073	4.365GlyThr: 4.365 ± 0.072	6.131GlyVal: 6.131 ± 0.075	1.578GlyTrp: 1.578 ± 0.044	2.319GlyTyr: 2.319 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.034HisAla: 3.034 ± 0.066	0.301HisCys: 0.301 ± 0.017	1.555HisAsp: 1.555 ± 0.041	1.26HisGlu: 1.26 ± 0.033	0.823HisPhe: 0.823 ± 0.028	2.081HisGly: 2.081 ± 0.042	0.696HisHis: 0.696 ± 0.026	1.194HisIle: 1.194 ± 0.037	0.472HisLys: 0.472 ± 0.021	2.232HisLeu: 2.232 ± 0.052	0.526HisMet: 0.526 ± 0.02	0.516HisAsn: 0.516 ± 0.021	1.605HisPro: 1.605 ± 0.041	0.954HisGln: 0.954 ± 0.031	1.441HisArg: 1.441 ± 0.038	1.066HisSer: 1.066 ± 0.033	1.188HisThr: 1.188 ± 0.035	1.509HisVal: 1.509 ± 0.042	0.42HisTrp: 0.42 ± 0.023	0.671HisTyr: 0.671 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.006IleAla: 6.006 ± 0.083	0.456IleCys: 0.456 ± 0.022	3.411IleAsp: 3.411 ± 0.066	3.448IleGlu: 3.448 ± 0.063	1.51IlePhe: 1.51 ± 0.048	4.428IleGly: 4.428 ± 0.07	1.01IleHis: 1.01 ± 0.03	2.095IleIle: 2.095 ± 0.052	1.396IleLys: 1.396 ± 0.036	4.79IleLeu: 4.79 ± 0.081	1.073IleMet: 1.073 ± 0.034	1.564IleAsn: 1.564 ± 0.038	2.291IlePro: 2.291 ± 0.05	1.687IleGln: 1.687 ± 0.038	3.376IleArg: 3.376 ± 0.059	2.971IleSer: 2.971 ± 0.051	2.417IleThr: 2.417 ± 0.064	3.795IleVal: 3.795 ± 0.064	0.597IleTrp: 0.597 ± 0.029	1.105IleTyr: 1.105 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.854LysAla: 2.854 ± 0.066	0.122LysCys: 0.122 ± 0.01	1.283LysAsp: 1.283 ± 0.042	1.26LysGlu: 1.26 ± 0.041	0.716LysPhe: 0.716 ± 0.029	1.974LysGly: 1.974 ± 0.044	0.56LysHis: 0.56 ± 0.027	1.324LysIle: 1.324 ± 0.044	0.897LysLys: 0.897 ± 0.034	2.811LysLeu: 2.811 ± 0.058	0.616LysMet: 0.616 ± 0.028	0.73LysAsn: 0.73 ± 0.027	1.474LysPro: 1.474 ± 0.045	1.148LysGln: 1.148 ± 0.037	1.879LysArg: 1.879 ± 0.049	1.464LysSer: 1.464 ± 0.04	1.534LysThr: 1.534 ± 0.048	2.04LysVal: 2.04 ± 0.055	0.33LysTrp: 0.33 ± 0.018	0.614LysTyr: 0.614 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.811LeuAla: 14.811 ± 0.162	1.084LeuCys: 1.084 ± 0.035	6.854LeuAsp: 6.854 ± 0.101	5.627LeuGlu: 5.627 ± 0.092	3.74LeuPhe: 3.74 ± 0.069	8.759LeuGly: 8.759 ± 0.107	2.427LeuHis: 2.427 ± 0.053	5.041LeuIle: 5.041 ± 0.079	2.932LeuLys: 2.932 ± 0.062	12.318LeuLeu: 12.318 ± 0.188	2.439LeuMet: 2.439 ± 0.051	2.939LeuAsn: 2.939 ± 0.056	6.553LeuPro: 6.553 ± 0.076	4.836LeuGln: 4.836 ± 0.077	7.917LeuArg: 7.917 ± 0.095	6.985LeuSer: 6.985 ± 0.093	5.812LeuThr: 5.812 ± 0.079	7.458LeuVal: 7.458 ± 0.107	1.351LeuTrp: 1.351 ± 0.042	2.43LeuTyr: 2.43 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.926MetAla: 2.926 ± 0.053	0.15MetCys: 0.15 ± 0.011	1.148MetAsp: 1.148 ± 0.038	1.043MetGlu: 1.043 ± 0.031	0.673MetPhe: 0.673 ± 0.028	1.751MetGly: 1.751 ± 0.041	0.589MetHis: 0.589 ± 0.03	1.126MetIle: 1.126 ± 0.034	0.783MetLys: 0.783 ± 0.028	2.993MetLeu: 2.993 ± 0.052	0.649MetMet: 0.649 ± 0.029	0.731MetAsn: 0.731 ± 0.026	1.505MetPro: 1.505 ± 0.035	1.227MetGln: 1.227 ± 0.033	1.765MetArg: 1.765 ± 0.048	1.77MetSer: 1.77 ± 0.041	1.689MetThr: 1.689 ± 0.035	1.665MetVal: 1.665 ± 0.042	0.194MetTrp: 0.194 ± 0.013	0.359MetTyr: 0.359 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.052AsnAla: 3.052 ± 0.058	0.225AsnCys: 0.225 ± 0.016	1.357AsnAsp: 1.357 ± 0.042	1.215AsnGlu: 1.215 ± 0.033	0.843AsnPhe: 0.843 ± 0.028	2.238AsnGly: 2.238 ± 0.051	0.527AsnHis: 0.527 ± 0.021	1.437AsnIle: 1.437 ± 0.038	0.676AsnLys: 0.676 ± 0.026	2.895AsnLeu: 2.895 ± 0.052	0.683AsnMet: 0.683 ± 0.024	0.768AsnAsn: 0.768 ± 0.032	1.72AsnPro: 1.72 ± 0.044	1.021AsnGln: 1.021 ± 0.032	1.813AsnArg: 1.813 ± 0.048	1.241AsnSer: 1.241 ± 0.038	1.608AsnThr: 1.608 ± 0.038	1.863AsnVal: 1.863 ± 0.052	0.421AsnTrp: 0.421 ± 0.023	0.753AsnTyr: 0.753 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.709ProAla: 6.709 ± 0.103	0.392ProCys: 0.392 ± 0.021	3.759ProAsp: 3.759 ± 0.064	3.587ProGlu: 3.587 ± 0.069	1.767ProPhe: 1.767 ± 0.039	4.391ProGly: 4.391 ± 0.068	1.14ProHis: 1.14 ± 0.038	1.943ProIle: 1.943 ± 0.044	1.048ProLys: 1.048 ± 0.034	5.145ProLeu: 5.145 ± 0.079	1.129ProMet: 1.129 ± 0.032	1.162ProAsn: 1.162 ± 0.039	2.148ProPro: 2.148 ± 0.049	2.011ProGln: 2.011 ± 0.041	2.783ProArg: 2.783 ± 0.061	2.59ProSer: 2.59 ± 0.051	2.239ProThr: 2.239 ± 0.048	4.303ProVal: 4.303 ± 0.074	0.807ProTrp: 0.807 ± 0.03	1.202ProTyr: 1.202 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	7.231GlnAla: 7.231 ± 0.116	0.312GlnCys: 0.312 ± 0.017	2.331GlnAsp: 2.331 ± 0.046	2.077GlnGlu: 2.077 ± 0.043	1.241GlnPhe: 1.241 ± 0.035	3.789GlnGly: 3.789 ± 0.067	1.19GlnHis: 1.19 ± 0.038	2.222GlnIle: 2.222 ± 0.048	1.039GlnLys: 1.039 ± 0.032	4.078GlnLeu: 4.078 ± 0.073	1.008GlnMet: 1.008 ± 0.03	1.047GlnAsn: 1.047 ± 0.037	2.613GlnPro: 2.613 ± 0.056	2.666GlnGln: 2.666 ± 0.062	3.623GlnArg: 3.623 ± 0.059	2.298GlnSer: 2.298 ± 0.045	2.334GlnThr: 2.334 ± 0.048	3.343GlnVal: 3.343 ± 0.062	0.724GlnTrp: 0.724 ± 0.027	0.946GlnTyr: 0.946 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	7.165ArgAla: 7.165 ± 0.1	0.557ArgCys: 0.557 ± 0.022	3.682ArgAsp: 3.682 ± 0.067	3.871ArgGlu: 3.871 ± 0.065	2.656ArgPhe: 2.656 ± 0.051	4.133ArgGly: 4.133 ± 0.07	2.14ArgHis: 2.14 ± 0.053	4.364ArgIle: 4.364 ± 0.066	2.052ArgLys: 2.052 ± 0.049	8.535ArgLeu: 8.535 ± 0.106	1.903ArgMet: 1.903 ± 0.039	2.149ArgAsn: 2.149 ± 0.045	3.283ArgPro: 3.283 ± 0.06	4.214ArgGln: 4.214 ± 0.081	5.284ArgArg: 5.284 ± 0.079	3.58ArgSer: 3.58 ± 0.056	3.775ArgThr: 3.775 ± 0.054	4.616ArgVal: 4.616 ± 0.075	1.166ArgTrp: 1.166 ± 0.036	2.163ArgTyr: 2.163 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.035SerAla: 6.035 ± 0.082	0.472SerCys: 0.472 ± 0.023	2.756SerAsp: 2.756 ± 0.053	2.575SerGlu: 2.575 ± 0.053	1.984SerPhe: 1.984 ± 0.048	5.495SerGly: 5.495 ± 0.089	1.299SerHis: 1.299 ± 0.035	2.813SerIle: 2.813 ± 0.057	1.317SerLys: 1.317 ± 0.039	6.385SerLeu: 6.385 ± 0.085	1.509SerMet: 1.509 ± 0.033	1.482SerAsn: 1.482 ± 0.045	2.743SerPro: 2.743 ± 0.05	2.334SerGln: 2.334 ± 0.047	4.008SerArg: 4.008 ± 0.069	3.316SerSer: 3.316 ± 0.071	2.898SerThr: 2.898 ± 0.054	4.197SerVal: 4.197 ± 0.067	0.79SerTrp: 0.79 ± 0.028	1.379SerTyr: 1.379 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.781ThrAla: 5.781 ± 0.073	0.461ThrCys: 0.461 ± 0.025	2.793ThrAsp: 2.793 ± 0.06	2.431ThrGlu: 2.431 ± 0.044	1.617ThrPhe: 1.617 ± 0.04	4.705ThrGly: 4.705 ± 0.074	1.325ThrHis: 1.325 ± 0.035	2.31ThrIle: 2.31 ± 0.052	0.868ThrLys: 0.868 ± 0.03	7.304ThrLeu: 7.304 ± 0.086	0.987ThrMet: 0.987 ± 0.027	1.168ThrAsn: 1.168 ± 0.036	3.4ThrPro: 3.4 ± 0.067	2.239ThrGln: 2.239 ± 0.046	3.547ThrArg: 3.547 ± 0.061	2.591ThrSer: 2.591 ± 0.048	2.644ThrThr: 2.644 ± 0.058	4.105ThrVal: 4.105 ± 0.062	0.736ThrTrp: 0.736 ± 0.027	1.154ThrTyr: 1.154 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.461ValAla: 8.461 ± 0.101	0.716ValCys: 0.716 ± 0.026	3.74ValAsp: 3.74 ± 0.065	4.002ValGlu: 4.002 ± 0.074	2.63ValPhe: 2.63 ± 0.049	5.093ValGly: 5.093 ± 0.079	1.397ValHis: 1.397 ± 0.033	3.592ValIle: 3.592 ± 0.069	1.73ValLys: 1.73 ± 0.05	8.416ValLeu: 8.416 ± 0.101	1.816ValMet: 1.816 ± 0.042	1.914ValAsn: 1.914 ± 0.049	3.811ValPro: 3.811 ± 0.062	3.023ValGln: 3.023 ± 0.061	5.214ValArg: 5.214 ± 0.08	4.52ValSer: 4.52 ± 0.074	3.768ValThr: 3.768 ± 0.065	5.527ValVal: 5.527 ± 0.096	0.908ValTrp: 0.908 ± 0.028	1.619ValTyr: 1.619 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.285TrpAla: 1.285 ± 0.04	0.169TrpCys: 0.169 ± 0.013	0.585TrpAsp: 0.585 ± 0.025	0.524TrpGlu: 0.524 ± 0.021	0.545TrpPhe: 0.545 ± 0.023	0.894TrpGly: 0.894 ± 0.03	0.466TrpHis: 0.466 ± 0.025	0.724TrpIle: 0.724 ± 0.029	0.409TrpLys: 0.409 ± 0.021	2.487TrpLeu: 2.487 ± 0.059	0.422TrpMet: 0.422 ± 0.017	0.463TrpAsn: 0.463 ± 0.022	0.751TrpPro: 0.751 ± 0.03	1.088TrpGln: 1.088 ± 0.035	1.366TrpArg: 1.366 ± 0.045	0.846TrpSer: 0.846 ± 0.032	0.655TrpThr: 0.655 ± 0.028	0.942TrpVal: 0.942 ± 0.03	0.27TrpTrp: 0.27 ± 0.019	0.323TrpTyr: 0.323 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.839TyrAla: 2.839 ± 0.062	0.27TyrCys: 0.27 ± 0.015	1.515TyrAsp: 1.515 ± 0.044	1.227TyrGlu: 1.227 ± 0.031	0.937TyrPhe: 0.937 ± 0.033	2.176TyrGly: 2.176 ± 0.045	0.477TyrHis: 0.477 ± 0.02	1.018TyrIle: 1.018 ± 0.031	0.525TyrLys: 0.525 ± 0.022	2.608TyrLeu: 2.608 ± 0.052	0.507TyrMet: 0.507 ± 0.023	0.591TyrAsn: 0.591 ± 0.026	1.205TyrPro: 1.205 ± 0.035	0.986TyrGln: 0.986 ± 0.034	2.013TyrArg: 2.013 ± 0.048	1.278TyrSer: 1.278 ± 0.034	1.245TyrThr: 1.245 ± 0.039	1.685TyrVal: 1.685 ± 0.039	0.393TyrTrp: 0.393 ± 0.02	0.664TyrTyr: 0.664 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3237 proteins (1076608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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