Amino acid dipepetide frequency for Streptococcus phage Javan509

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.044AlaAla: 5.044 ± 0.891
0.194AlaCys: 0.194 ± 0.142
4.171AlaAsp: 4.171 ± 0.695
6.693AlaGlu: 6.693 ± 0.567
2.522AlaPhe: 2.522 ± 0.567
4.074AlaGly: 4.074 ± 0.833
1.455AlaHis: 1.455 ± 0.391
6.984AlaIle: 6.984 ± 1.021
8.05AlaLys: 8.05 ± 0.873
5.432AlaLeu: 5.432 ± 0.846
1.94AlaMet: 1.94 ± 0.469
4.947AlaAsn: 4.947 ± 0.901
0.97AlaPro: 0.97 ± 0.264
2.522AlaGln: 2.522 ± 0.559
2.425AlaArg: 2.425 ± 0.514
4.656AlaSer: 4.656 ± 0.723
4.171AlaThr: 4.171 ± 0.546
4.753AlaVal: 4.753 ± 0.691
1.164AlaTrp: 1.164 ± 0.32
2.231AlaTyr: 2.231 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.291CysAla: 0.291 ± 0.181
0.194CysCys: 0.194 ± 0.128
0.388CysAsp: 0.388 ± 0.236
0.582CysGlu: 0.582 ± 0.242
0.388CysPhe: 0.388 ± 0.174
0.679CysGly: 0.679 ± 0.222
0.097CysHis: 0.097 ± 0.098
0.194CysIle: 0.194 ± 0.141
0.388CysLys: 0.388 ± 0.191
0.679CysLeu: 0.679 ± 0.231
0.097CysMet: 0.097 ± 0.096
0.291CysAsn: 0.291 ± 0.158
0.0CysPro: 0.0 ± 0.0
0.097CysGln: 0.097 ± 0.083
0.582CysArg: 0.582 ± 0.223
0.582CysSer: 0.582 ± 0.267
0.097CysThr: 0.097 ± 0.09
0.291CysVal: 0.291 ± 0.227
0.097CysTrp: 0.097 ± 0.091
0.388CysTyr: 0.388 ± 0.241
0.0CysXaa: 0.0 ± 0.0
Asp
4.462AspAla: 4.462 ± 0.639
0.679AspCys: 0.679 ± 0.275
5.529AspAsp: 5.529 ± 0.724
4.85AspGlu: 4.85 ± 0.703
2.425AspPhe: 2.425 ± 0.354
4.365AspGly: 4.365 ± 0.68
0.291AspHis: 0.291 ± 0.174
5.238AspIle: 5.238 ± 0.606
5.335AspLys: 5.335 ± 0.825
6.305AspLeu: 6.305 ± 0.804
1.067AspMet: 1.067 ± 0.262
3.88AspAsn: 3.88 ± 0.55
1.746AspPro: 1.746 ± 0.446
1.455AspGln: 1.455 ± 0.29
1.746AspArg: 1.746 ± 0.378
3.589AspSer: 3.589 ± 0.588
4.462AspThr: 4.462 ± 0.885
4.268AspVal: 4.268 ± 0.59
1.164AspTrp: 1.164 ± 0.356
3.201AspTyr: 3.201 ± 0.623
0.0AspXaa: 0.0 ± 0.0
Glu
5.917GluAla: 5.917 ± 0.794
0.291GluCys: 0.291 ± 0.147
3.977GluAsp: 3.977 ± 0.678
5.044GluGlu: 5.044 ± 1.046
3.007GluPhe: 3.007 ± 0.523
3.589GluGly: 3.589 ± 0.526
0.873GluHis: 0.873 ± 0.262
5.82GluIle: 5.82 ± 0.734
6.693GluLys: 6.693 ± 0.747
7.081GluLeu: 7.081 ± 1.038
2.037GluMet: 2.037 ± 0.455
3.783GluAsn: 3.783 ± 0.655
2.037GluPro: 2.037 ± 0.419
3.686GluGln: 3.686 ± 0.838
2.328GluArg: 2.328 ± 0.473
3.492GluSer: 3.492 ± 0.613
4.074GluThr: 4.074 ± 0.625
3.977GluVal: 3.977 ± 0.827
0.873GluTrp: 0.873 ± 0.283
2.231GluTyr: 2.231 ± 0.496
0.0GluXaa: 0.0 ± 0.0
Phe
3.104PheAla: 3.104 ± 0.595
0.194PheCys: 0.194 ± 0.13
3.589PheAsp: 3.589 ± 0.475
3.88PheGlu: 3.88 ± 0.786
1.746PhePhe: 1.746 ± 0.374
2.716PheGly: 2.716 ± 0.516
0.291PheHis: 0.291 ± 0.138
2.037PheIle: 2.037 ± 0.438
3.395PheLys: 3.395 ± 0.437
2.328PheLeu: 2.328 ± 0.464
0.97PheMet: 0.97 ± 0.356
2.425PheAsn: 2.425 ± 0.533
0.873PhePro: 0.873 ± 0.368
1.164PheGln: 1.164 ± 0.319
1.552PheArg: 1.552 ± 0.352
2.328PheSer: 2.328 ± 0.505
2.134PheThr: 2.134 ± 0.547
2.813PheVal: 2.813 ± 0.581
0.485PheTrp: 0.485 ± 0.222
1.552PheTyr: 1.552 ± 0.371
0.0PheXaa: 0.0 ± 0.0
Gly
4.462GlyAla: 4.462 ± 0.897
0.291GlyCys: 0.291 ± 0.185
4.074GlyAsp: 4.074 ± 0.526
4.85GlyGlu: 4.85 ± 0.684
2.91GlyPhe: 2.91 ± 0.703
4.171GlyGly: 4.171 ± 0.718
0.97GlyHis: 0.97 ± 0.252
6.402GlyIle: 6.402 ± 0.906
5.335GlyLys: 5.335 ± 0.783
5.917GlyLeu: 5.917 ± 0.902
1.843GlyMet: 1.843 ± 0.452
3.686GlyAsn: 3.686 ± 0.522
1.552GlyPro: 1.552 ± 0.638
2.716GlyGln: 2.716 ± 0.501
2.231GlyArg: 2.231 ± 0.388
3.104GlySer: 3.104 ± 0.458
3.88GlyThr: 3.88 ± 0.626
2.91GlyVal: 2.91 ± 0.506
0.776GlyTrp: 0.776 ± 0.312
3.977GlyTyr: 3.977 ± 0.596
0.0GlyXaa: 0.0 ± 0.0
His
0.873HisAla: 0.873 ± 0.277
0.291HisCys: 0.291 ± 0.146
0.97HisAsp: 0.97 ± 0.265
1.164HisGlu: 1.164 ± 0.311
0.679HisPhe: 0.679 ± 0.23
0.873HisGly: 0.873 ± 0.326
0.291HisHis: 0.291 ± 0.203
0.97HisIle: 0.97 ± 0.339
0.485HisLys: 0.485 ± 0.173
1.261HisLeu: 1.261 ± 0.402
0.291HisMet: 0.291 ± 0.16
0.776HisAsn: 0.776 ± 0.295
0.388HisPro: 0.388 ± 0.231
0.582HisGln: 0.582 ± 0.2
0.582HisArg: 0.582 ± 0.223
0.679HisSer: 0.679 ± 0.237
0.582HisThr: 0.582 ± 0.282
0.776HisVal: 0.776 ± 0.283
0.097HisTrp: 0.097 ± 0.098
0.485HisTyr: 0.485 ± 0.205
0.0HisXaa: 0.0 ± 0.0
Ile
4.559IleAla: 4.559 ± 0.534
0.388IleCys: 0.388 ± 0.227
6.887IleAsp: 6.887 ± 0.926
5.529IleGlu: 5.529 ± 1.066
2.619IlePhe: 2.619 ± 0.544
3.492IleGly: 3.492 ± 0.892
1.067IleHis: 1.067 ± 0.344
4.171IleIle: 4.171 ± 0.708
7.565IleLys: 7.565 ± 0.918
5.238IleLeu: 5.238 ± 0.546
1.94IleMet: 1.94 ± 0.567
3.783IleAsn: 3.783 ± 0.681
2.231IlePro: 2.231 ± 0.487
2.328IleGln: 2.328 ± 0.584
2.716IleArg: 2.716 ± 0.609
5.529IleSer: 5.529 ± 0.972
4.85IleThr: 4.85 ± 0.688
4.656IleVal: 4.656 ± 0.678
0.388IleTrp: 0.388 ± 0.154
2.037IleTyr: 2.037 ± 0.476
0.0IleXaa: 0.0 ± 0.0
Lys
6.887LysAla: 6.887 ± 0.787
0.291LysCys: 0.291 ± 0.17
6.111LysAsp: 6.111 ± 0.898
5.626LysGlu: 5.626 ± 0.819
2.91LysPhe: 2.91 ± 0.504
5.432LysGly: 5.432 ± 0.726
1.552LysHis: 1.552 ± 0.353
5.723LysIle: 5.723 ± 0.908
9.311LysLys: 9.311 ± 1.15
6.499LysLeu: 6.499 ± 0.832
2.231LysMet: 2.231 ± 0.564
4.559LysAsn: 4.559 ± 0.716
3.88LysPro: 3.88 ± 0.692
3.977LysGln: 3.977 ± 0.685
4.268LysArg: 4.268 ± 0.701
6.499LysSer: 6.499 ± 0.635
6.402LysThr: 6.402 ± 0.76
7.371LysVal: 7.371 ± 0.887
1.164LysTrp: 1.164 ± 0.337
3.298LysTyr: 3.298 ± 0.472
0.0LysXaa: 0.0 ± 0.0
Leu
7.856LeuAla: 7.856 ± 0.955
0.485LeuCys: 0.485 ± 0.209
5.723LeuAsp: 5.723 ± 0.663
5.432LeuGlu: 5.432 ± 1.005
3.589LeuPhe: 3.589 ± 0.504
5.82LeuGly: 5.82 ± 1.137
1.164LeuHis: 1.164 ± 0.368
4.365LeuIle: 4.365 ± 0.73
8.729LeuLys: 8.729 ± 0.929
5.335LeuLeu: 5.335 ± 0.715
1.261LeuMet: 1.261 ± 0.342
3.88LeuAsn: 3.88 ± 0.55
2.522LeuPro: 2.522 ± 0.438
3.298LeuGln: 3.298 ± 0.725
3.298LeuArg: 3.298 ± 0.63
6.402LeuSer: 6.402 ± 1.009
4.462LeuThr: 4.462 ± 0.786
5.238LeuVal: 5.238 ± 0.75
0.582LeuTrp: 0.582 ± 0.237
1.552LeuTyr: 1.552 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
2.037MetAla: 2.037 ± 0.497
0.097MetCys: 0.097 ± 0.098
1.649MetAsp: 1.649 ± 0.473
1.649MetGlu: 1.649 ± 0.482
0.485MetPhe: 0.485 ± 0.204
1.746MetGly: 1.746 ± 0.43
0.388MetHis: 0.388 ± 0.208
2.037MetIle: 2.037 ± 0.49
1.552MetLys: 1.552 ± 0.39
1.552MetLeu: 1.552 ± 0.295
0.291MetMet: 0.291 ± 0.159
1.164MetAsn: 1.164 ± 0.353
0.97MetPro: 0.97 ± 0.281
1.067MetGln: 1.067 ± 0.29
0.582MetArg: 0.582 ± 0.226
1.649MetSer: 1.649 ± 0.393
1.649MetThr: 1.649 ± 0.297
1.649MetVal: 1.649 ± 0.407
0.291MetTrp: 0.291 ± 0.153
1.067MetTyr: 1.067 ± 0.346
0.0MetXaa: 0.0 ± 0.0
Asn
4.171AsnAla: 4.171 ± 0.958
0.485AsnCys: 0.485 ± 0.216
1.843AsnAsp: 1.843 ± 0.418
3.395AsnGlu: 3.395 ± 0.527
2.522AsnPhe: 2.522 ± 0.578
4.753AsnGly: 4.753 ± 0.737
0.679AsnHis: 0.679 ± 0.293
2.813AsnIle: 2.813 ± 0.426
5.529AsnLys: 5.529 ± 0.873
4.268AsnLeu: 4.268 ± 0.635
1.552AsnMet: 1.552 ± 0.362
2.231AsnAsn: 2.231 ± 0.519
2.037AsnPro: 2.037 ± 0.529
2.813AsnGln: 2.813 ± 0.472
1.94AsnArg: 1.94 ± 0.559
3.007AsnSer: 3.007 ± 0.507
2.425AsnThr: 2.425 ± 0.439
2.91AsnVal: 2.91 ± 0.539
0.776AsnTrp: 0.776 ± 0.283
2.813AsnTyr: 2.813 ± 0.553
0.0AsnXaa: 0.0 ± 0.0
Pro
1.94ProAla: 1.94 ± 0.571
0.291ProCys: 0.291 ± 0.176
2.425ProAsp: 2.425 ± 0.559
1.746ProGlu: 1.746 ± 0.463
1.164ProPhe: 1.164 ± 0.305
1.164ProGly: 1.164 ± 0.35
0.194ProHis: 0.194 ± 0.138
2.619ProIle: 2.619 ± 0.415
4.268ProLys: 4.268 ± 0.624
1.746ProLeu: 1.746 ± 0.388
0.776ProMet: 0.776 ± 0.237
1.649ProAsn: 1.649 ± 0.519
0.582ProPro: 0.582 ± 0.2
1.067ProGln: 1.067 ± 0.351
0.873ProArg: 0.873 ± 0.293
2.231ProSer: 2.231 ± 0.479
1.552ProThr: 1.552 ± 0.462
0.873ProVal: 0.873 ± 0.282
0.194ProTrp: 0.194 ± 0.131
1.067ProTyr: 1.067 ± 0.312
0.0ProXaa: 0.0 ± 0.0
Gln
2.522GlnAla: 2.522 ± 0.46
0.097GlnCys: 0.097 ± 0.102
1.94GlnAsp: 1.94 ± 0.413
2.522GlnGlu: 2.522 ± 0.632
1.746GlnPhe: 1.746 ± 0.5
2.716GlnGly: 2.716 ± 0.508
0.388GlnHis: 0.388 ± 0.198
2.619GlnIle: 2.619 ± 0.589
3.298GlnLys: 3.298 ± 0.618
3.298GlnLeu: 3.298 ± 0.564
0.679GlnMet: 0.679 ± 0.245
2.425GlnAsn: 2.425 ± 0.494
1.164GlnPro: 1.164 ± 0.371
1.067GlnGln: 1.067 ± 0.298
2.037GlnArg: 2.037 ± 0.472
3.007GlnSer: 3.007 ± 0.53
2.328GlnThr: 2.328 ± 0.64
2.328GlnVal: 2.328 ± 0.427
0.873GlnTrp: 0.873 ± 0.355
0.97GlnTyr: 0.97 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
3.007ArgAla: 3.007 ± 0.617
0.388ArgCys: 0.388 ± 0.221
1.94ArgAsp: 1.94 ± 0.464
3.007ArgGlu: 3.007 ± 0.626
1.358ArgPhe: 1.358 ± 0.381
2.134ArgGly: 2.134 ± 0.385
0.485ArgHis: 0.485 ± 0.239
2.522ArgIle: 2.522 ± 0.406
3.298ArgLys: 3.298 ± 0.533
4.268ArgLeu: 4.268 ± 0.678
0.776ArgMet: 0.776 ± 0.289
1.843ArgAsn: 1.843 ± 0.379
1.067ArgPro: 1.067 ± 0.268
1.067ArgGln: 1.067 ± 0.377
0.97ArgArg: 0.97 ± 0.369
1.94ArgSer: 1.94 ± 0.543
2.134ArgThr: 2.134 ± 0.466
2.425ArgVal: 2.425 ± 0.406
0.388ArgTrp: 0.388 ± 0.197
2.037ArgTyr: 2.037 ± 0.51
0.0ArgXaa: 0.0 ± 0.0
Ser
5.044SerAla: 5.044 ± 1.345
0.485SerCys: 0.485 ± 0.238
4.171SerAsp: 4.171 ± 0.7
3.492SerGlu: 3.492 ± 0.563
3.201SerPhe: 3.201 ± 0.632
5.82SerGly: 5.82 ± 0.914
0.776SerHis: 0.776 ± 0.243
4.462SerIle: 4.462 ± 0.525
5.529SerLys: 5.529 ± 0.682
5.723SerLeu: 5.723 ± 0.907
1.843SerMet: 1.843 ± 0.369
3.395SerAsn: 3.395 ± 0.591
1.358SerPro: 1.358 ± 0.314
2.716SerGln: 2.716 ± 0.619
2.037SerArg: 2.037 ± 0.714
4.656SerSer: 4.656 ± 0.879
3.395SerThr: 3.395 ± 0.571
3.686SerVal: 3.686 ± 0.486
0.679SerTrp: 0.679 ± 0.284
2.716SerTyr: 2.716 ± 0.506
0.0SerXaa: 0.0 ± 0.0
Thr
4.85ThrAla: 4.85 ± 0.798
0.194ThrCys: 0.194 ± 0.145
3.395ThrAsp: 3.395 ± 0.528
3.589ThrGlu: 3.589 ± 0.631
2.425ThrPhe: 2.425 ± 0.415
5.044ThrGly: 5.044 ± 0.965
0.776ThrHis: 0.776 ± 0.233
5.432ThrIle: 5.432 ± 0.689
4.947ThrLys: 4.947 ± 0.698
5.432ThrLeu: 5.432 ± 1.059
1.067ThrMet: 1.067 ± 0.241
2.425ThrAsn: 2.425 ± 0.422
1.455ThrPro: 1.455 ± 0.33
2.328ThrGln: 2.328 ± 0.406
1.164ThrArg: 1.164 ± 0.331
4.171ThrSer: 4.171 ± 0.521
3.007ThrThr: 3.007 ± 0.538
4.947ThrVal: 4.947 ± 0.599
0.776ThrTrp: 0.776 ± 0.265
2.231ThrTyr: 2.231 ± 0.386
0.0ThrXaa: 0.0 ± 0.0
Val
3.492ValAla: 3.492 ± 0.575
0.291ValCys: 0.291 ± 0.167
4.268ValAsp: 4.268 ± 0.576
4.753ValGlu: 4.753 ± 0.635
2.037ValPhe: 2.037 ± 0.447
4.171ValGly: 4.171 ± 0.583
0.582ValHis: 0.582 ± 0.22
4.559ValIle: 4.559 ± 0.745
5.141ValLys: 5.141 ± 0.574
4.462ValLeu: 4.462 ± 0.673
1.843ValMet: 1.843 ± 0.425
3.589ValAsn: 3.589 ± 0.5
2.134ValPro: 2.134 ± 0.42
2.522ValGln: 2.522 ± 0.441
2.716ValArg: 2.716 ± 0.541
4.268ValSer: 4.268 ± 0.654
5.238ValThr: 5.238 ± 0.678
4.171ValVal: 4.171 ± 0.718
0.291ValTrp: 0.291 ± 0.168
2.037ValTyr: 2.037 ± 0.492
0.0ValXaa: 0.0 ± 0.0
Trp
0.873TrpAla: 0.873 ± 0.357
0.194TrpCys: 0.194 ± 0.125
0.291TrpAsp: 0.291 ± 0.136
0.97TrpGlu: 0.97 ± 0.324
0.291TrpPhe: 0.291 ± 0.139
1.358TrpGly: 1.358 ± 0.439
0.291TrpHis: 0.291 ± 0.227
0.679TrpIle: 0.679 ± 0.283
1.067TrpLys: 1.067 ± 0.322
1.164TrpLeu: 1.164 ± 0.381
0.194TrpMet: 0.194 ± 0.166
0.388TrpAsn: 0.388 ± 0.182
0.097TrpPro: 0.097 ± 0.098
0.291TrpGln: 0.291 ± 0.169
0.776TrpArg: 0.776 ± 0.32
1.164TrpSer: 1.164 ± 0.298
0.582TrpThr: 0.582 ± 0.205
0.388TrpVal: 0.388 ± 0.183
0.097TrpTrp: 0.097 ± 0.099
0.485TrpTyr: 0.485 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.007TyrAla: 3.007 ± 0.58
0.582TyrCys: 0.582 ± 0.238
2.716TyrAsp: 2.716 ± 0.671
2.037TyrGlu: 2.037 ± 0.468
1.649TyrPhe: 1.649 ± 0.364
1.94TyrGly: 1.94 ± 0.344
0.485TyrHis: 0.485 ± 0.226
2.328TyrIle: 2.328 ± 0.467
4.074TyrLys: 4.074 ± 0.733
3.007TyrLeu: 3.007 ± 0.618
0.776TyrMet: 0.776 ± 0.255
1.843TyrAsn: 1.843 ± 0.471
1.358TyrPro: 1.358 ± 0.292
1.261TyrGln: 1.261 ± 0.373
2.231TyrArg: 2.231 ± 0.62
2.231TyrSer: 2.231 ± 0.512
2.231TyrThr: 2.231 ± 0.431
2.134TyrVal: 2.134 ± 0.431
0.485TyrTrp: 0.485 ± 0.204
1.261TyrTyr: 1.261 ± 0.376
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski