Amino acid dipepetide frequency for Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / LMG 13176 / NBRC 15968 / NCIMB 11800 / UQM 2034)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.513AlaAla: 8.513 ± 0.093
0.761AlaCys: 0.761 ± 0.022
4.74AlaAsp: 4.74 ± 0.055
4.159AlaGlu: 4.159 ± 0.046
3.686AlaPhe: 3.686 ± 0.04
6.701AlaGly: 6.701 ± 0.073
1.491AlaHis: 1.491 ± 0.025
5.308AlaIle: 5.308 ± 0.057
3.926AlaLys: 3.926 ± 0.05
7.495AlaLeu: 7.495 ± 0.07
1.874AlaMet: 1.874 ± 0.035
3.689AlaAsn: 3.689 ± 0.062
3.127AlaPro: 3.127 ± 0.055
3.099AlaGln: 3.099 ± 0.039
3.116AlaArg: 3.116 ± 0.041
4.668AlaSer: 4.668 ± 0.054
4.992AlaThr: 4.992 ± 0.082
5.59AlaVal: 5.59 ± 0.062
0.94AlaTrp: 0.94 ± 0.022
3.21AlaTyr: 3.21 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.017
0.158CysCys: 0.158 ± 0.009
0.44CysAsp: 0.44 ± 0.048
0.386CysGlu: 0.386 ± 0.013
0.427CysPhe: 0.427 ± 0.014
0.629CysGly: 0.629 ± 0.019
0.203CysHis: 0.203 ± 0.009
0.605CysIle: 0.605 ± 0.017
0.442CysLys: 0.442 ± 0.013
0.799CysLeu: 0.799 ± 0.017
0.216CysMet: 0.216 ± 0.009
0.385CysAsn: 0.385 ± 0.017
0.324CysPro: 0.324 ± 0.011
0.274CysGln: 0.274 ± 0.01
0.403CysArg: 0.403 ± 0.013
0.551CysSer: 0.551 ± 0.016
0.535CysThr: 0.535 ± 0.019
0.493CysVal: 0.493 ± 0.015
0.125CysTrp: 0.125 ± 0.008
0.387CysTyr: 0.387 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.405AspAla: 4.405 ± 0.065
0.373AspCys: 0.373 ± 0.011
2.551AspAsp: 2.551 ± 0.045
2.933AspGlu: 2.933 ± 0.036
2.619AspPhe: 2.619 ± 0.033
4.003AspGly: 4.003 ± 0.062
1.019AspHis: 1.019 ± 0.021
4.001AspIle: 4.001 ± 0.042
3.598AspLys: 3.598 ± 0.041
4.676AspLeu: 4.676 ± 0.047
1.299AspMet: 1.299 ± 0.025
2.861AspAsn: 2.861 ± 0.045
2.297AspPro: 2.297 ± 0.04
1.822AspGln: 1.822 ± 0.032
2.3AspArg: 2.3 ± 0.035
2.964AspSer: 2.964 ± 0.048
3.094AspThr: 3.094 ± 0.06
3.501AspVal: 3.501 ± 0.044
0.796AspTrp: 0.796 ± 0.017
2.524AspTyr: 2.524 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
4.343GluAla: 4.343 ± 0.055
0.338GluCys: 0.338 ± 0.013
2.835GluAsp: 2.835 ± 0.048
3.854GluGlu: 3.854 ± 0.06
1.962GluPhe: 1.962 ± 0.032
3.485GluGly: 3.485 ± 0.037
1.214GluHis: 1.214 ± 0.021
3.725GluIle: 3.725 ± 0.041
4.462GluLys: 4.462 ± 0.061
5.439GluLeu: 5.439 ± 0.063
1.516GluMet: 1.516 ± 0.029
2.804GluAsn: 2.804 ± 0.037
1.543GluPro: 1.543 ± 0.028
2.727GluGln: 2.727 ± 0.041
2.703GluArg: 2.703 ± 0.041
2.61GluSer: 2.61 ± 0.036
2.85GluThr: 2.85 ± 0.034
3.557GluVal: 3.557 ± 0.043
0.739GluTrp: 0.739 ± 0.015
2.065GluTyr: 2.065 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.139PheAla: 3.139 ± 0.037
0.43PheCys: 0.43 ± 0.012
2.654PheAsp: 2.654 ± 0.032
2.362PheGlu: 2.362 ± 0.033
2.241PhePhe: 2.241 ± 0.038
2.978PheGly: 2.978 ± 0.038
0.889PheHis: 0.889 ± 0.017
2.969PheIle: 2.969 ± 0.043
2.445PheLys: 2.445 ± 0.035
4.037PheLeu: 4.037 ± 0.055
1.121PheMet: 1.121 ± 0.025
2.651PheAsn: 2.651 ± 0.035
1.764PhePro: 1.764 ± 0.032
1.372PheGln: 1.372 ± 0.024
2.301PheArg: 2.301 ± 0.03
3.53PheSer: 3.53 ± 0.041
3.177PheThr: 3.177 ± 0.051
2.687PheVal: 2.687 ± 0.033
0.52PheTrp: 0.52 ± 0.017
1.969PheTyr: 1.969 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.16GlyAla: 5.16 ± 0.068
0.653GlyCys: 0.653 ± 0.022
3.489GlyAsp: 3.489 ± 0.039
3.381GlyGlu: 3.381 ± 0.045
3.301GlyPhe: 3.301 ± 0.043
5.085GlyGly: 5.085 ± 0.058
1.375GlyHis: 1.375 ± 0.026
5.173GlyIle: 5.173 ± 0.045
4.892GlyLys: 4.892 ± 0.061
6.073GlyLeu: 6.073 ± 0.051
1.84GlyMet: 1.84 ± 0.029
3.898GlyAsn: 3.898 ± 0.062
1.798GlyPro: 1.798 ± 0.033
2.571GlyGln: 2.571 ± 0.038
3.023GlyArg: 3.023 ± 0.038
4.315GlySer: 4.315 ± 0.057
4.694GlyThr: 4.694 ± 0.112
4.68GlyVal: 4.68 ± 0.056
1.057GlyTrp: 1.057 ± 0.021
3.207GlyTyr: 3.207 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
1.418HisAla: 1.418 ± 0.024
0.221HisCys: 0.221 ± 0.01
0.923HisAsp: 0.923 ± 0.021
1.059HisGlu: 1.059 ± 0.025
1.222HisPhe: 1.222 ± 0.021
1.209HisGly: 1.209 ± 0.024
0.623HisHis: 0.623 ± 0.021
1.494HisIle: 1.494 ± 0.023
0.964HisLys: 0.964 ± 0.02
2.061HisLeu: 2.061 ± 0.029
0.491HisMet: 0.491 ± 0.013
0.918HisAsn: 0.918 ± 0.018
1.178HisPro: 1.178 ± 0.021
0.872HisGln: 0.872 ± 0.02
0.892HisArg: 0.892 ± 0.018
1.115HisSer: 1.115 ± 0.021
1.273HisThr: 1.273 ± 0.021
1.141HisVal: 1.141 ± 0.023
0.293HisTrp: 0.293 ± 0.011
1.019HisTyr: 1.019 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.699IleAla: 5.699 ± 0.054
0.679IleCys: 0.679 ± 0.02
3.706IleAsp: 3.706 ± 0.039
3.38IleGlu: 3.38 ± 0.04
2.675IlePhe: 2.675 ± 0.038
4.385IleGly: 4.385 ± 0.05
1.369IleHis: 1.369 ± 0.024
4.249IleIle: 4.249 ± 0.052
3.561IleLys: 3.561 ± 0.046
5.692IleLeu: 5.692 ± 0.068
1.342IleMet: 1.342 ± 0.025
3.525IleAsn: 3.525 ± 0.037
3.198IlePro: 3.198 ± 0.035
2.313IleGln: 2.313 ± 0.032
3.471IleArg: 3.471 ± 0.041
4.87IleSer: 4.87 ± 0.052
4.609IleThr: 4.609 ± 0.048
4.078IleVal: 4.078 ± 0.05
0.741IleTrp: 0.741 ± 0.018
2.573IleTyr: 2.573 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.852LysAla: 4.852 ± 0.05
0.297LysCys: 0.297 ± 0.01
3.766LysAsp: 3.766 ± 0.049
4.391LysGlu: 4.391 ± 0.056
1.888LysPhe: 1.888 ± 0.029
4.366LysGly: 4.366 ± 0.051
1.17LysHis: 1.17 ± 0.025
3.697LysIle: 3.697 ± 0.044
4.198LysLys: 4.198 ± 0.055
5.061LysLeu: 5.061 ± 0.046
1.637LysMet: 1.637 ± 0.028
2.858LysAsn: 2.858 ± 0.038
2.319LysPro: 2.319 ± 0.033
2.688LysGln: 2.688 ± 0.036
2.623LysArg: 2.623 ± 0.035
3.083LysSer: 3.083 ± 0.044
3.529LysThr: 3.529 ± 0.045
3.993LysVal: 3.993 ± 0.046
0.769LysTrp: 0.769 ± 0.018
2.328LysTyr: 2.328 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
6.929LeuAla: 6.929 ± 0.064
0.932LeuCys: 0.932 ± 0.027
4.734LeuAsp: 4.734 ± 0.049
5.054LeuGlu: 5.054 ± 0.058
4.427LeuPhe: 4.427 ± 0.052
5.61LeuGly: 5.61 ± 0.047
2.096LeuHis: 2.096 ± 0.032
5.717LeuIle: 5.717 ± 0.069
5.986LeuLys: 5.986 ± 0.067
10.519LeuLeu: 10.519 ± 0.106
2.114LeuMet: 2.114 ± 0.033
4.726LeuAsn: 4.726 ± 0.047
4.554LeuPro: 4.554 ± 0.044
4.722LeuGln: 4.722 ± 0.063
4.399LeuArg: 4.399 ± 0.041
7.039LeuSer: 7.039 ± 0.07
5.67LeuThr: 5.67 ± 0.062
5.469LeuVal: 5.469 ± 0.058
0.955LeuTrp: 0.955 ± 0.02
3.526LeuTyr: 3.526 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
1.894MetAla: 1.894 ± 0.032
0.145MetCys: 0.145 ± 0.008
1.271MetAsp: 1.271 ± 0.025
1.481MetGlu: 1.481 ± 0.025
0.744MetPhe: 0.744 ± 0.017
1.467MetGly: 1.467 ± 0.027
0.538MetHis: 0.538 ± 0.014
1.463MetIle: 1.463 ± 0.025
1.838MetLys: 1.838 ± 0.029
2.368MetLeu: 2.368 ± 0.033
0.621MetMet: 0.621 ± 0.018
1.235MetAsn: 1.235 ± 0.023
1.169MetPro: 1.169 ± 0.023
1.186MetGln: 1.186 ± 0.024
1.146MetArg: 1.146 ± 0.022
1.436MetSer: 1.436 ± 0.024
1.328MetThr: 1.328 ± 0.024
1.405MetVal: 1.405 ± 0.027
0.212MetTrp: 0.212 ± 0.009
0.773MetTyr: 0.773 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.079AsnAla: 4.079 ± 0.056
0.392AsnCys: 0.392 ± 0.014
2.672AsnAsp: 2.672 ± 0.06
2.595AsnGlu: 2.595 ± 0.029
2.125AsnPhe: 2.125 ± 0.032
4.26AsnGly: 4.26 ± 0.091
0.861AsnHis: 0.861 ± 0.017
3.803AsnIle: 3.803 ± 0.042
2.973AsnLys: 2.973 ± 0.033
4.056AsnLeu: 4.056 ± 0.043
1.223AsnMet: 1.223 ± 0.022
3.084AsnAsn: 3.084 ± 0.052
2.399AsnPro: 2.399 ± 0.036
1.667AsnGln: 1.667 ± 0.028
2.31AsnArg: 2.31 ± 0.032
2.943AsnSer: 2.943 ± 0.042
3.445AsnThr: 3.445 ± 0.056
3.21AsnVal: 3.21 ± 0.043
0.721AsnTrp: 0.721 ± 0.018
2.31AsnTyr: 2.31 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.43ProAla: 4.43 ± 0.061
0.244ProCys: 0.244 ± 0.01
2.893ProAsp: 2.893 ± 0.035
2.925ProGlu: 2.925 ± 0.037
2.005ProPhe: 2.005 ± 0.028
3.283ProGly: 3.283 ± 0.04
0.727ProHis: 0.727 ± 0.02
2.014ProIle: 2.014 ± 0.031
1.759ProLys: 1.759 ± 0.031
3.744ProLeu: 3.744 ± 0.039
0.786ProMet: 0.786 ± 0.019
1.681ProAsn: 1.681 ± 0.041
1.358ProPro: 1.358 ± 0.028
1.504ProGln: 1.504 ± 0.026
1.296ProArg: 1.296 ± 0.023
2.392ProSer: 2.392 ± 0.041
2.023ProThr: 2.023 ± 0.041
4.01ProVal: 4.01 ± 0.055
0.483ProTrp: 0.483 ± 0.014
1.652ProTyr: 1.652 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.003GlnAla: 3.003 ± 0.043
0.25GlnCys: 0.25 ± 0.011
1.875GlnAsp: 1.875 ± 0.027
2.485GlnGlu: 2.485 ± 0.037
1.785GlnPhe: 1.785 ± 0.025
2.209GlnGly: 2.209 ± 0.029
1.132GlnHis: 1.132 ± 0.021
2.303GlnIle: 2.303 ± 0.031
2.095GlnLys: 2.095 ± 0.031
4.879GlnLeu: 4.879 ± 0.06
0.936GlnMet: 0.936 ± 0.02
1.566GlnAsn: 1.566 ± 0.028
1.838GlnPro: 1.838 ± 0.03
3.098GlnGln: 3.098 ± 0.055
1.899GlnArg: 1.899 ± 0.033
2.283GlnSer: 2.283 ± 0.034
2.28GlnThr: 2.28 ± 0.031
2.616GlnVal: 2.616 ± 0.036
0.562GlnTrp: 0.562 ± 0.015
1.818GlnTyr: 1.818 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.72ArgAla: 2.72 ± 0.036
0.291ArgCys: 0.291 ± 0.01
2.145ArgAsp: 2.145 ± 0.033
2.71ArgGlu: 2.71 ± 0.035
2.335ArgPhe: 2.335 ± 0.035
2.299ArgGly: 2.299 ± 0.031
0.958ArgHis: 0.958 ± 0.025
3.367ArgIle: 3.367 ± 0.04
3.113ArgLys: 3.113 ± 0.043
4.509ArgLeu: 4.509 ± 0.053
1.258ArgMet: 1.258 ± 0.023
2.536ArgAsn: 2.536 ± 0.033
1.639ArgPro: 1.639 ± 0.026
2.139ArgGln: 2.139 ± 0.03
2.086ArgArg: 2.086 ± 0.033
2.594ArgSer: 2.594 ± 0.037
2.459ArgThr: 2.459 ± 0.035
2.65ArgVal: 2.65 ± 0.035
0.712ArgTrp: 0.712 ± 0.018
2.228ArgTyr: 2.228 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.035SerAla: 5.035 ± 0.053
0.602SerCys: 0.602 ± 0.018
3.052SerAsp: 3.052 ± 0.037
2.78SerGlu: 2.78 ± 0.037
3.45SerPhe: 3.45 ± 0.046
5.073SerGly: 5.073 ± 0.064
1.128SerHis: 1.128 ± 0.021
4.169SerIle: 4.169 ± 0.048
3.079SerLys: 3.079 ± 0.037
6.325SerLeu: 6.325 ± 0.074
1.421SerMet: 1.421 ± 0.019
2.969SerAsn: 2.969 ± 0.042
2.464SerPro: 2.464 ± 0.034
2.027SerGln: 2.027 ± 0.028
2.828SerArg: 2.828 ± 0.034
4.012SerSer: 4.012 ± 0.055
3.69SerThr: 3.69 ± 0.049
4.196SerVal: 4.196 ± 0.047
0.89SerTrp: 0.89 ± 0.022
2.816SerTyr: 2.816 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.794ThrAla: 5.794 ± 0.101
0.434ThrCys: 0.434 ± 0.014
3.541ThrAsp: 3.541 ± 0.047
2.872ThrGlu: 2.872 ± 0.033
2.782ThrPhe: 2.782 ± 0.042
5.447ThrGly: 5.447 ± 0.072
1.091ThrHis: 1.091 ± 0.019
4.232ThrIle: 4.232 ± 0.051
2.709ThrLys: 2.709 ± 0.035
5.85ThrLeu: 5.85 ± 0.056
1.166ThrMet: 1.166 ± 0.022
2.782ThrAsn: 2.782 ± 0.053
3.222ThrPro: 3.222 ± 0.08
2.001ThrGln: 2.001 ± 0.034
2.436ThrArg: 2.436 ± 0.027
3.602ThrSer: 3.602 ± 0.046
4.064ThrThr: 4.064 ± 0.074
4.551ThrVal: 4.551 ± 0.112
0.724ThrTrp: 0.724 ± 0.018
2.585ThrTyr: 2.585 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
5.103ValAla: 5.103 ± 0.052
0.634ValCys: 0.634 ± 0.023
3.201ValAsp: 3.201 ± 0.04
3.148ValGlu: 3.148 ± 0.036
2.899ValPhe: 2.899 ± 0.038
3.538ValGly: 3.538 ± 0.043
1.262ValHis: 1.262 ± 0.023
4.605ValIle: 4.605 ± 0.05
4.203ValLys: 4.203 ± 0.039
6.319ValLeu: 6.319 ± 0.078
1.586ValMet: 1.586 ± 0.027
3.761ValAsn: 3.761 ± 0.071
2.84ValPro: 2.84 ± 0.048
2.392ValGln: 2.392 ± 0.034
2.838ValArg: 2.838 ± 0.035
4.585ValSer: 4.585 ± 0.058
4.565ValThr: 4.565 ± 0.099
4.417ValVal: 4.417 ± 0.058
0.763ValTrp: 0.763 ± 0.017
2.675ValTyr: 2.675 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.802TrpAla: 0.802 ± 0.019
0.127TrpCys: 0.127 ± 0.006
0.71TrpAsp: 0.71 ± 0.02
0.731TrpGlu: 0.731 ± 0.019
0.568TrpPhe: 0.568 ± 0.016
0.869TrpGly: 0.869 ± 0.02
0.309TrpHis: 0.309 ± 0.012
0.76TrpIle: 0.76 ± 0.019
0.84TrpLys: 0.84 ± 0.023
1.32TrpLeu: 1.32 ± 0.023
0.374TrpMet: 0.374 ± 0.012
0.711TrpAsn: 0.711 ± 0.019
0.383TrpPro: 0.383 ± 0.013
0.731TrpGln: 0.731 ± 0.019
0.567TrpArg: 0.567 ± 0.015
0.782TrpSer: 0.782 ± 0.02
0.761TrpThr: 0.761 ± 0.021
0.696TrpVal: 0.696 ± 0.015
0.247TrpTrp: 0.247 ± 0.011
0.537TrpTyr: 0.537 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.187TyrAla: 3.187 ± 0.037
0.404TyrCys: 0.404 ± 0.013
2.439TyrAsp: 2.439 ± 0.039
2.084TyrGlu: 2.084 ± 0.029
2.098TyrPhe: 2.098 ± 0.035
2.768TyrGly: 2.768 ± 0.035
0.932TyrHis: 0.932 ± 0.02
2.46TyrIle: 2.46 ± 0.035
2.429TyrLys: 2.429 ± 0.037
3.956TyrLeu: 3.956 ± 0.046
0.9TyrMet: 0.9 ± 0.019
2.488TyrAsn: 2.488 ± 0.041
1.796TyrPro: 1.796 ± 0.026
1.709TyrGln: 1.709 ± 0.03
2.111TyrArg: 2.111 ± 0.032
2.628TyrSer: 2.628 ± 0.041
2.844TyrThr: 2.844 ± 0.05
2.395TyrVal: 2.395 ± 0.041
0.574TyrTrp: 0.574 ± 0.016
2.084TyrTyr: 2.084 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7179 proteins (2679255 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski