Amino acid dipepetide frequency for Bradyrhizobium elkanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.852AlaAla: 17.852 ± 0.141	1.138AlaCys: 1.138 ± 0.027	6.805AlaAsp: 6.805 ± 0.056	6.789AlaGlu: 6.789 ± 0.066	4.556AlaPhe: 4.556 ± 0.046	10.44AlaGly: 10.44 ± 0.083	2.18AlaHis: 2.18 ± 0.037	6.81AlaIle: 6.81 ± 0.062	4.667AlaLys: 4.667 ± 0.061	13.042AlaLeu: 13.042 ± 0.097	3.511AlaMet: 3.511 ± 0.043	3.161AlaAsn: 3.161 ± 0.042	5.771AlaPro: 5.771 ± 0.058	4.13AlaGln: 4.13 ± 0.048	8.641AlaArg: 8.641 ± 0.079	6.855AlaSer: 6.855 ± 0.053	6.59AlaThr: 6.59 ± 0.057	8.966AlaVal: 8.966 ± 0.067	1.491AlaTrp: 1.491 ± 0.024	2.646AlaTyr: 2.646 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.024	0.123CysCys: 0.123 ± 0.007	0.529CysAsp: 0.529 ± 0.018	0.394CysGlu: 0.394 ± 0.013	0.332CysPhe: 0.332 ± 0.013	0.937CysGly: 0.937 ± 0.022	0.221CysHis: 0.221 ± 0.011	0.414CysIle: 0.414 ± 0.013	0.217CysLys: 0.217 ± 0.011	0.776CysLeu: 0.776 ± 0.018	0.178CysMet: 0.178 ± 0.008	0.233CysAsn: 0.233 ± 0.011	0.419CysPro: 0.419 ± 0.015	0.238CysGln: 0.238 ± 0.009	0.614CysArg: 0.614 ± 0.018	0.474CysSer: 0.474 ± 0.017	0.425CysThr: 0.425 ± 0.016	0.628CysVal: 0.628 ± 0.016	0.114CysTrp: 0.114 ± 0.007	0.218CysTyr: 0.218 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.917AspAla: 6.917 ± 0.06	0.453AspCys: 0.453 ± 0.016	3.222AspAsp: 3.222 ± 0.045	3.06AspGlu: 3.06 ± 0.044	2.106AspPhe: 2.106 ± 0.032	5.04AspGly: 5.04 ± 0.051	1.298AspHis: 1.298 ± 0.03	3.045AspIle: 3.045 ± 0.04	1.976AspLys: 1.976 ± 0.033	5.563AspLeu: 5.563 ± 0.051	1.224AspMet: 1.224 ± 0.022	1.442AspAsn: 1.442 ± 0.029	3.364AspPro: 3.364 ± 0.04	1.783AspGln: 1.783 ± 0.033	4.108AspArg: 4.108 ± 0.055	2.142AspSer: 2.142 ± 0.034	2.51AspThr: 2.51 ± 0.038	4.288AspVal: 4.288 ± 0.046	0.905AspTrp: 0.905 ± 0.023	1.502AspTyr: 1.502 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.574GluAla: 6.574 ± 0.07	0.329GluCys: 0.329 ± 0.012	2.233GluAsp: 2.233 ± 0.032	2.344GluGlu: 2.344 ± 0.038	1.8GluPhe: 1.8 ± 0.029	3.553GluGly: 3.553 ± 0.047	1.143GluHis: 1.143 ± 0.025	3.237GluIle: 3.237 ± 0.044	2.058GluLys: 2.058 ± 0.034	5.252GluLeu: 5.252 ± 0.056	1.365GluMet: 1.365 ± 0.027	1.341GluAsn: 1.341 ± 0.029	2.496GluPro: 2.496 ± 0.034	2.166GluGln: 2.166 ± 0.037	4.53GluArg: 4.53 ± 0.057	2.163GluSer: 2.163 ± 0.035	3.113GluThr: 3.113 ± 0.043	3.594GluVal: 3.594 ± 0.044	0.665GluTrp: 0.665 ± 0.018	0.896GluTyr: 0.896 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	5.046PheAla: 5.046 ± 0.06	0.412PheCys: 0.412 ± 0.013	2.582PheAsp: 2.582 ± 0.035	1.987PheGlu: 1.987 ± 0.035	1.435PhePhe: 1.435 ± 0.031	3.888PheGly: 3.888 ± 0.049	0.742PheHis: 0.742 ± 0.022	1.757PheIle: 1.757 ± 0.031	1.154PheLys: 1.154 ± 0.022	3.248PheLeu: 3.248 ± 0.044	0.804PheMet: 0.804 ± 0.019	1.167PheAsn: 1.167 ± 0.027	1.623PhePro: 1.623 ± 0.031	0.994PheGln: 0.994 ± 0.025	2.265PheArg: 2.265 ± 0.031	2.231PheSer: 2.231 ± 0.038	2.06PheThr: 2.06 ± 0.032	3.08PheVal: 3.08 ± 0.042	0.54PheTrp: 0.54 ± 0.017	0.937PheTyr: 0.937 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.228GlyAla: 9.228 ± 0.083	0.838GlyCys: 0.838 ± 0.022	4.277GlyAsp: 4.277 ± 0.048	4.295GlyGlu: 4.295 ± 0.05	3.766GlyPhe: 3.766 ± 0.052	7.309GlyGly: 7.309 ± 0.096	1.868GlyHis: 1.868 ± 0.028	4.731GlyIle: 4.731 ± 0.05	3.499GlyLys: 3.499 ± 0.048	8.611GlyLeu: 8.611 ± 0.066	2.203GlyMet: 2.203 ± 0.037	2.39GlyAsn: 2.39 ± 0.046	3.512GlyPro: 3.512 ± 0.043	2.786GlyGln: 2.786 ± 0.041	5.705GlyArg: 5.705 ± 0.047	4.732GlySer: 4.732 ± 0.073	4.692GlyThr: 4.692 ± 0.064	6.255GlyVal: 6.255 ± 0.056	1.39GlyTrp: 1.39 ± 0.027	2.414GlyTyr: 2.414 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.387HisAla: 2.387 ± 0.037	0.232HisCys: 0.232 ± 0.009	1.27HisAsp: 1.27 ± 0.027	0.928HisGlu: 0.928 ± 0.02	0.833HisPhe: 0.833 ± 0.019	1.972HisGly: 1.972 ± 0.035	0.579HisHis: 0.579 ± 0.022	0.912HisIle: 0.912 ± 0.021	0.517HisLys: 0.517 ± 0.017	1.921HisLeu: 1.921 ± 0.032	0.464HisMet: 0.464 ± 0.014	0.489HisAsn: 0.489 ± 0.016	1.324HisPro: 1.324 ± 0.025	0.595HisGln: 0.595 ± 0.018	1.432HisArg: 1.432 ± 0.029	0.95HisSer: 0.95 ± 0.022	0.818HisThr: 0.818 ± 0.02	1.515HisVal: 1.515 ± 0.032	0.341HisTrp: 0.341 ± 0.013	0.529HisTyr: 0.529 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.905IleAla: 7.905 ± 0.071	0.551IleCys: 0.551 ± 0.016	3.612IleAsp: 3.612 ± 0.041	3.454IleGlu: 3.454 ± 0.043	1.74IlePhe: 1.74 ± 0.031	5.329IleGly: 5.329 ± 0.058	0.853IleHis: 0.853 ± 0.02	2.356IleIle: 2.356 ± 0.041	1.837IleLys: 1.837 ± 0.029	4.27IleLeu: 4.27 ± 0.052	1.019IleMet: 1.019 ± 0.023	1.554IleAsn: 1.554 ± 0.026	2.351IlePro: 2.351 ± 0.034	1.216IleGln: 1.216 ± 0.023	3.195IleArg: 3.195 ± 0.036	3.044IleSer: 3.044 ± 0.046	2.843IleThr: 2.843 ± 0.039	4.638IleVal: 4.638 ± 0.051	0.63IleTrp: 0.63 ± 0.017	1.213IleTyr: 1.213 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.373LysAla: 4.373 ± 0.056	0.191LysCys: 0.191 ± 0.009	1.93LysAsp: 1.93 ± 0.032	1.611LysGlu: 1.611 ± 0.027	1.099LysPhe: 1.099 ± 0.022	2.672LysGly: 2.672 ± 0.04	0.66LysHis: 0.66 ± 0.016	1.917LysIle: 1.917 ± 0.027	1.463LysLys: 1.463 ± 0.035	3.7LysLeu: 3.7 ± 0.047	0.877LysMet: 0.877 ± 0.02	0.963LysAsn: 0.963 ± 0.019	2.38LysPro: 2.38 ± 0.039	1.274LysGln: 1.274 ± 0.025	2.547LysArg: 2.547 ± 0.034	2.048LysSer: 2.048 ± 0.038	2.104LysThr: 2.104 ± 0.033	2.698LysVal: 2.698 ± 0.046	0.412LysTrp: 0.412 ± 0.014	0.752LysTyr: 0.752 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.348LeuAla: 13.348 ± 0.093	0.864LeuCys: 0.864 ± 0.022	5.688LeuAsp: 5.688 ± 0.053	4.489LeuGlu: 4.489 ± 0.049	3.643LeuPhe: 3.643 ± 0.049	8.222LeuGly: 8.222 ± 0.079	1.837LeuHis: 1.837 ± 0.03	5.159LeuIle: 5.159 ± 0.057	3.741LeuLys: 3.741 ± 0.044	9.452LeuLeu: 9.452 ± 0.095	2.321LeuMet: 2.321 ± 0.036	2.739LeuAsn: 2.739 ± 0.038	5.433LeuPro: 5.433 ± 0.054	2.745LeuGln: 2.745 ± 0.033	6.788LeuArg: 6.788 ± 0.063	6.203LeuSer: 6.203 ± 0.059	5.674LeuThr: 5.674 ± 0.054	7.569LeuVal: 7.569 ± 0.06	1.149LeuTrp: 1.149 ± 0.025	2.031LeuTyr: 2.031 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.922MetAla: 2.922 ± 0.038	0.156MetCys: 0.156 ± 0.009	1.027MetAsp: 1.027 ± 0.021	0.938MetGlu: 0.938 ± 0.024	0.837MetPhe: 0.837 ± 0.02	1.615MetGly: 1.615 ± 0.029	0.435MetHis: 0.435 ± 0.012	1.456MetIle: 1.456 ± 0.027	1.024MetLys: 1.024 ± 0.021	2.58MetLeu: 2.58 ± 0.034	0.702MetMet: 0.702 ± 0.019	0.748MetAsn: 0.748 ± 0.02	1.544MetPro: 1.544 ± 0.026	0.903MetGln: 0.903 ± 0.019	1.778MetArg: 1.778 ± 0.03	1.673MetSer: 1.673 ± 0.029	1.878MetThr: 1.878 ± 0.025	1.686MetVal: 1.686 ± 0.03	0.23MetTrp: 0.23 ± 0.01	0.368MetTyr: 0.368 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.423AsnAla: 3.423 ± 0.045	0.247AsnCys: 0.247 ± 0.012	1.518AsnAsp: 1.518 ± 0.03	1.309AsnGlu: 1.309 ± 0.025	1.106AsnPhe: 1.106 ± 0.025	2.526AsnGly: 2.526 ± 0.046	0.525AsnHis: 0.525 ± 0.015	1.462AsnIle: 1.462 ± 0.028	0.867AsnLys: 0.867 ± 0.023	2.719AsnLeu: 2.719 ± 0.037	0.608AsnMet: 0.608 ± 0.016	0.863AsnAsn: 0.863 ± 0.023	1.881AsnPro: 1.881 ± 0.033	0.803AsnGln: 0.803 ± 0.021	1.77AsnArg: 1.77 ± 0.029	1.418AsnSer: 1.418 ± 0.025	1.339AsnThr: 1.339 ± 0.026	2.191AsnVal: 2.191 ± 0.039	0.46AsnTrp: 0.46 ± 0.015	0.789AsnTyr: 0.789 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.477ProAla: 6.477 ± 0.071	0.307ProCys: 0.307 ± 0.012	3.608ProAsp: 3.608 ± 0.047	3.151ProGlu: 3.151 ± 0.043	2.019ProPhe: 2.019 ± 0.033	4.413ProGly: 4.413 ± 0.051	1.054ProHis: 1.054 ± 0.025	2.486ProIle: 2.486 ± 0.033	1.951ProLys: 1.951 ± 0.028	4.619ProLeu: 4.619 ± 0.046	1.199ProMet: 1.199 ± 0.024	1.585ProAsn: 1.585 ± 0.029	2.889ProPro: 2.889 ± 0.059	1.801ProGln: 1.801 ± 0.034	3.119ProArg: 3.119 ± 0.05	2.975ProSer: 2.975 ± 0.041	2.628ProThr: 2.628 ± 0.037	4.123ProVal: 4.123 ± 0.042	0.718ProTrp: 0.718 ± 0.023	1.243ProTyr: 1.243 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.045GlnAla: 4.045 ± 0.046	0.243GlnCys: 0.243 ± 0.012	1.417GlnAsp: 1.417 ± 0.026	1.268GlnGlu: 1.268 ± 0.024	1.193GlnPhe: 1.193 ± 0.025	2.371GlnGly: 2.371 ± 0.038	0.666GlnHis: 0.666 ± 0.014	1.882GlnIle: 1.882 ± 0.03	1.095GlnLys: 1.095 ± 0.024	3.214GlnLeu: 3.214 ± 0.038	0.872GlnMet: 0.872 ± 0.018	0.952GlnAsn: 0.952 ± 0.025	1.877GlnPro: 1.877 ± 0.034	1.415GlnGln: 1.415 ± 0.03	2.508GlnArg: 2.508 ± 0.038	1.863GlnSer: 1.863 ± 0.033	1.736GlnThr: 1.736 ± 0.031	2.301GlnVal: 2.301 ± 0.035	0.46GlnTrp: 0.46 ± 0.014	0.685GlnTyr: 0.685 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.982ArgAla: 7.982 ± 0.072	0.512ArgCys: 0.512 ± 0.015	4.113ArgAsp: 4.113 ± 0.051	3.917ArgGlu: 3.917 ± 0.047	2.805ArgPhe: 2.805 ± 0.039	4.88ArgGly: 4.88 ± 0.052	1.617ArgHis: 1.617 ± 0.027	3.961ArgIle: 3.961 ± 0.044	2.501ArgLys: 2.501 ± 0.038	7.436ArgLeu: 7.436 ± 0.072	1.776ArgMet: 1.776 ± 0.03	1.972ArgAsn: 1.972 ± 0.032	3.497ArgPro: 3.497 ± 0.045	2.46ArgGln: 2.46 ± 0.039	5.426ArgArg: 5.426 ± 0.061	3.753ArgSer: 3.753 ± 0.043	3.321ArgThr: 3.321 ± 0.036	4.6ArgVal: 4.6 ± 0.056	0.985ArgTrp: 0.985 ± 0.023	1.7ArgTyr: 1.7 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.512SerAla: 6.512 ± 0.069	0.459SerCys: 0.459 ± 0.017	3.137SerAsp: 3.137 ± 0.036	2.706SerGlu: 2.706 ± 0.038	2.368SerPhe: 2.368 ± 0.031	5.504SerGly: 5.504 ± 0.063	1.09SerHis: 1.09 ± 0.021	3.027SerIle: 3.027 ± 0.038	1.748SerLys: 1.748 ± 0.032	5.376SerLeu: 5.376 ± 0.05	1.348SerMet: 1.348 ± 0.024	1.542SerAsn: 1.542 ± 0.033	2.861SerPro: 2.861 ± 0.041	1.659SerGln: 1.659 ± 0.03	3.622SerArg: 3.622 ± 0.052	3.293SerSer: 3.293 ± 0.057	2.937SerThr: 2.937 ± 0.047	4.101SerVal: 4.101 ± 0.05	0.793SerTrp: 0.793 ± 0.02	1.424SerTyr: 1.424 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.569ThrAla: 6.569 ± 0.062	0.423ThrCys: 0.423 ± 0.016	2.785ThrAsp: 2.785 ± 0.04	2.532ThrGlu: 2.532 ± 0.038	2.059ThrPhe: 2.059 ± 0.033	4.962ThrGly: 4.962 ± 0.064	1.02ThrHis: 1.02 ± 0.023	3.13ThrIle: 3.13 ± 0.044	1.636ThrLys: 1.636 ± 0.028	5.764ThrLeu: 5.764 ± 0.06	1.298ThrMet: 1.298 ± 0.027	1.448ThrAsn: 1.448 ± 0.028	3.297ThrPro: 3.297 ± 0.046	1.563ThrGln: 1.563 ± 0.029	3.416ThrArg: 3.416 ± 0.04	3.236ThrSer: 3.236 ± 0.051	3.156ThrThr: 3.156 ± 0.05	4.3ThrVal: 4.3 ± 0.048	0.675ThrTrp: 0.675 ± 0.018	1.219ThrTyr: 1.219 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	9.684ValAla: 9.684 ± 0.072	0.655ValCys: 0.655 ± 0.02	4.128ValAsp: 4.128 ± 0.049	4.098ValGlu: 4.098 ± 0.052	2.713ValPhe: 2.713 ± 0.04	5.736ValGly: 5.736 ± 0.06	1.4ValHis: 1.4 ± 0.031	4.188ValIle: 4.188 ± 0.05	2.53ValLys: 2.53 ± 0.043	7.506ValLeu: 7.506 ± 0.053	1.912ValMet: 1.912 ± 0.028	2.16ValAsn: 2.16 ± 0.039	3.932ValPro: 3.932 ± 0.048	2.12ValGln: 2.12 ± 0.033	4.807ValArg: 4.807 ± 0.058	4.335ValSer: 4.335 ± 0.052	4.693ValThr: 4.693 ± 0.051	6.198ValVal: 6.198 ± 0.063	0.919ValTrp: 0.919 ± 0.023	1.547ValTyr: 1.547 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.183TrpAla: 1.183 ± 0.025	0.135TrpCys: 0.135 ± 0.007	0.603TrpAsp: 0.603 ± 0.021	0.483TrpGlu: 0.483 ± 0.015	0.548TrpPhe: 0.548 ± 0.017	0.93TrpGly: 0.93 ± 0.023	0.349TrpHis: 0.349 ± 0.015	0.75TrpIle: 0.75 ± 0.019	0.511TrpLys: 0.511 ± 0.014	1.639TrpLeu: 1.639 ± 0.031	0.377TrpMet: 0.377 ± 0.013	0.471TrpAsn: 0.471 ± 0.012	0.722TrpPro: 0.722 ± 0.02	0.584TrpGln: 0.584 ± 0.018	1.159TrpArg: 1.159 ± 0.024	0.892TrpSer: 0.892 ± 0.019	0.822TrpThr: 0.822 ± 0.021	0.796TrpVal: 0.796 ± 0.019	0.239TrpTrp: 0.239 ± 0.011	0.318TrpTyr: 0.318 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.034	0.243TyrCys: 0.243 ± 0.012	1.461TyrAsp: 1.461 ± 0.028	1.098TyrGlu: 1.098 ± 0.025	0.998TyrPhe: 0.998 ± 0.025	2.203TyrGly: 2.203 ± 0.04	0.472TyrHis: 0.472 ± 0.014	0.93TyrIle: 0.93 ± 0.024	0.681TyrLys: 0.681 ± 0.019	2.408TyrLeu: 2.408 ± 0.032	0.44TyrMet: 0.44 ± 0.016	0.604TyrAsn: 0.604 ± 0.019	1.192TyrPro: 1.192 ± 0.024	0.827TyrGln: 0.827 ± 0.021	1.781TyrArg: 1.781 ± 0.032	1.225TyrSer: 1.225 ± 0.026	1.149TyrThr: 1.149 ± 0.028	1.734TyrVal: 1.734 ± 0.029	0.399TyrTrp: 0.399 ± 0.015	0.64TyrTyr: 0.64 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6820 proteins (2117123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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