Amino acid dipepetide frequency for Streptomyces zinciresistens K42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.788AlaAla: 22.788 ± 0.167	1.107AlaCys: 1.107 ± 0.024	8.598AlaAsp: 8.598 ± 0.062	8.898AlaGlu: 8.898 ± 0.084	3.529AlaPhe: 3.529 ± 0.044	13.729AlaGly: 13.729 ± 0.098	3.013AlaHis: 3.013 ± 0.041	3.115AlaIle: 3.115 ± 0.041	2.64AlaLys: 2.64 ± 0.044	15.18AlaLeu: 15.18 ± 0.11	2.487AlaMet: 2.487 ± 0.034	1.832AlaAsn: 1.832 ± 0.033	7.598AlaPro: 7.598 ± 0.072	3.928AlaGln: 3.928 ± 0.037	11.71AlaArg: 11.71 ± 0.091	5.937AlaSer: 5.937 ± 0.068	6.666AlaThr: 6.666 ± 0.061	12.773AlaVal: 12.773 ± 0.09	1.934AlaTrp: 1.934 ± 0.032	2.728AlaTyr: 2.728 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.157CysAla: 1.157 ± 0.026	0.091CysCys: 0.091 ± 0.007	0.476CysAsp: 0.476 ± 0.015	0.427CysGlu: 0.427 ± 0.014	0.208CysPhe: 0.208 ± 0.009	0.954CysGly: 0.954 ± 0.019	0.182CysHis: 0.182 ± 0.01	0.145CysIle: 0.145 ± 0.009	0.118CysLys: 0.118 ± 0.007	0.756CysLeu: 0.756 ± 0.019	0.126CysMet: 0.126 ± 0.006	0.13CysAsn: 0.13 ± 0.008	0.528CysPro: 0.528 ± 0.016	0.165CysGln: 0.165 ± 0.008	0.648CysArg: 0.648 ± 0.018	0.432CysSer: 0.432 ± 0.016	0.51CysThr: 0.51 ± 0.014	0.674CysVal: 0.674 ± 0.017	0.127CysTrp: 0.127 ± 0.006	0.143CysTyr: 0.143 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.021AspAla: 8.021 ± 0.075	0.436AspCys: 0.436 ± 0.015	3.62AspAsp: 3.62 ± 0.044	3.813AspGlu: 3.813 ± 0.045	1.594AspPhe: 1.594 ± 0.025	6.534AspGly: 6.534 ± 0.054	1.362AspHis: 1.362 ± 0.026	1.794AspIle: 1.794 ± 0.032	1.128AspLys: 1.128 ± 0.029	6.306AspLeu: 6.306 ± 0.056	0.782AspMet: 0.782 ± 0.019	0.907AspAsn: 0.907 ± 0.023	4.449AspPro: 4.449 ± 0.05	1.546AspGln: 1.546 ± 0.026	5.113AspArg: 5.113 ± 0.05	2.477AspSer: 2.477 ± 0.034	3.157AspThr: 3.157 ± 0.04	4.767AspVal: 4.767 ± 0.051	1.031AspTrp: 1.031 ± 0.02	1.081AspTyr: 1.081 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.537GluAla: 7.537 ± 0.072	0.372GluCys: 0.372 ± 0.014	2.929GluAsp: 2.929 ± 0.041	3.569GluGlu: 3.569 ± 0.046	1.401GluPhe: 1.401 ± 0.029	4.4GluGly: 4.4 ± 0.051	1.521GluHis: 1.521 ± 0.028	2.245GluIle: 2.245 ± 0.035	1.375GluLys: 1.375 ± 0.027	6.601GluLeu: 6.601 ± 0.06	0.852GluMet: 0.852 ± 0.02	0.986GluAsn: 0.986 ± 0.02	3.471GluPro: 3.471 ± 0.037	2.184GluGln: 2.184 ± 0.033	5.797GluArg: 5.797 ± 0.06	2.538GluSer: 2.538 ± 0.035	2.801GluThr: 2.801 ± 0.036	4.464GluVal: 4.464 ± 0.05	0.726GluTrp: 0.726 ± 0.019	1.054GluTyr: 1.054 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.698PheAla: 3.698 ± 0.042	0.249PheCys: 0.249 ± 0.01	1.879PheAsp: 1.879 ± 0.031	1.406PheGlu: 1.406 ± 0.029	0.82PhePhe: 0.82 ± 0.024	2.905PheGly: 2.905 ± 0.042	0.554PheHis: 0.554 ± 0.016	0.619PheIle: 0.619 ± 0.017	0.488PheLys: 0.488 ± 0.015	2.555PheLeu: 2.555 ± 0.038	0.389PheMet: 0.389 ± 0.014	0.495PheAsn: 0.495 ± 0.016	1.366PhePro: 1.366 ± 0.025	0.647PheGln: 0.647 ± 0.017	1.85PheArg: 1.85 ± 0.028	1.387PheSer: 1.387 ± 0.025	1.941PheThr: 1.941 ± 0.028	2.148PheVal: 2.148 ± 0.036	0.41PheTrp: 0.41 ± 0.014	0.536PheTyr: 0.536 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.588GlyAla: 11.588 ± 0.091	0.837GlyCys: 0.837 ± 0.024	5.197GlyAsp: 5.197 ± 0.058	5.306GlyGlu: 5.306 ± 0.049	2.834GlyPhe: 2.834 ± 0.039	9.127GlyGly: 9.127 ± 0.097	2.302GlyHis: 2.302 ± 0.032	3.202GlyIle: 3.202 ± 0.039	2.3GlyLys: 2.3 ± 0.034	9.437GlyLeu: 9.437 ± 0.072	2.055GlyMet: 2.055 ± 0.03	1.63GlyAsn: 1.63 ± 0.035	5.396GlyPro: 5.396 ± 0.056	2.64GlyGln: 2.64 ± 0.041	8.487GlyArg: 8.487 ± 0.066	5.126GlySer: 5.126 ± 0.061	6.4GlyThr: 6.4 ± 0.059	7.669GlyVal: 7.669 ± 0.078	1.764GlyTrp: 1.764 ± 0.026	2.146GlyTyr: 2.146 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.748HisAla: 2.748 ± 0.037	0.215HisCys: 0.215 ± 0.01	1.329HisAsp: 1.329 ± 0.026	1.197HisGlu: 1.197 ± 0.024	0.609HisPhe: 0.609 ± 0.017	2.364HisGly: 2.364 ± 0.032	0.682HisHis: 0.682 ± 0.02	0.639HisIle: 0.639 ± 0.019	0.33HisLys: 0.33 ± 0.012	2.461HisLeu: 2.461 ± 0.035	0.297HisMet: 0.297 ± 0.012	0.334HisAsn: 0.334 ± 0.014	1.817HisPro: 1.817 ± 0.027	0.644HisGln: 0.644 ± 0.016	2.24HisArg: 2.24 ± 0.035	0.94HisSer: 0.94 ± 0.019	1.365HisThr: 1.365 ± 0.028	1.673HisVal: 1.673 ± 0.031	0.342HisTrp: 0.342 ± 0.012	0.439HisTyr: 0.439 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.484IleAla: 4.484 ± 0.048	0.258IleCys: 0.258 ± 0.012	2.06IleAsp: 2.06 ± 0.032	1.83IleGlu: 1.83 ± 0.034	0.597IlePhe: 0.597 ± 0.015	3.302IleGly: 3.302 ± 0.045	0.529IleHis: 0.529 ± 0.016	0.766IleIle: 0.766 ± 0.023	0.675IleLys: 0.675 ± 0.021	2.23IleLeu: 2.23 ± 0.035	0.431IleMet: 0.431 ± 0.016	0.602IleAsn: 0.602 ± 0.017	1.605IlePro: 1.605 ± 0.024	0.659IleGln: 0.659 ± 0.019	2.224IleArg: 2.224 ± 0.034	1.506IleSer: 1.506 ± 0.026	2.077IleThr: 2.077 ± 0.031	2.547IleVal: 2.547 ± 0.038	0.358IleTrp: 0.358 ± 0.013	0.453IleTyr: 0.453 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.825LysAla: 2.825 ± 0.038	0.1LysCys: 0.1 ± 0.006	1.295LysAsp: 1.295 ± 0.027	1.148LysGlu: 1.148 ± 0.023	0.413LysPhe: 0.413 ± 0.015	1.789LysGly: 1.789 ± 0.03	0.372LysHis: 0.372 ± 0.012	0.783LysIle: 0.783 ± 0.023	0.833LysLys: 0.833 ± 0.03	1.869LysLeu: 1.869 ± 0.032	0.358LysMet: 0.358 ± 0.012	0.486LysAsn: 0.486 ± 0.018	1.273LysPro: 1.273 ± 0.028	0.674LysGln: 0.674 ± 0.02	1.448LysArg: 1.448 ± 0.029	1.063LysSer: 1.063 ± 0.025	1.213LysThr: 1.213 ± 0.029	1.782LysVal: 1.782 ± 0.03	0.26LysTrp: 0.26 ± 0.01	0.416LysTyr: 0.416 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.533LeuAla: 15.533 ± 0.109	0.857LeuCys: 0.857 ± 0.019	6.798LeuAsp: 6.798 ± 0.066	4.743LeuGlu: 4.743 ± 0.051	2.519LeuPhe: 2.519 ± 0.038	9.247LeuGly: 9.247 ± 0.073	2.333LeuHis: 2.333 ± 0.033	3.113LeuIle: 3.113 ± 0.037	2.018LeuLys: 2.018 ± 0.035	11.261LeuLeu: 11.261 ± 0.096	1.647LeuMet: 1.647 ± 0.028	1.595LeuAsn: 1.595 ± 0.028	6.574LeuPro: 6.574 ± 0.064	2.169LeuGln: 2.169 ± 0.029	9.109LeuArg: 9.109 ± 0.066	5.212LeuSer: 5.212 ± 0.049	6.793LeuThr: 6.793 ± 0.055	8.762LeuVal: 8.762 ± 0.073	1.34LeuTrp: 1.34 ± 0.023	1.829LeuTyr: 1.829 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.235MetAla: 2.235 ± 0.033	0.132MetCys: 0.132 ± 0.008	0.924MetAsp: 0.924 ± 0.022	0.751MetGlu: 0.751 ± 0.022	0.443MetPhe: 0.443 ± 0.015	1.302MetGly: 1.302 ± 0.025	0.334MetHis: 0.334 ± 0.013	0.654MetIle: 0.654 ± 0.018	0.411MetLys: 0.411 ± 0.014	1.636MetLeu: 1.636 ± 0.025	0.291MetMet: 0.291 ± 0.012	0.427MetAsn: 0.427 ± 0.015	1.117MetPro: 1.117 ± 0.022	0.452MetGln: 0.452 ± 0.015	1.425MetArg: 1.425 ± 0.024	1.277MetSer: 1.277 ± 0.024	1.528MetThr: 1.528 ± 0.028	1.244MetVal: 1.244 ± 0.025	0.219MetTrp: 0.219 ± 0.009	0.32MetTyr: 0.32 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.118AsnAla: 2.118 ± 0.035	0.156AsnCys: 0.156 ± 0.009	0.905AsnAsp: 0.905 ± 0.02	0.751AsnGlu: 0.751 ± 0.021	0.446AsnPhe: 0.446 ± 0.014	1.786AsnGly: 1.786 ± 0.038	0.345AsnHis: 0.345 ± 0.013	0.572AsnIle: 0.572 ± 0.015	0.383AsnLys: 0.383 ± 0.014	1.573AsnLeu: 1.573 ± 0.027	0.28AsnMet: 0.28 ± 0.011	0.393AsnAsn: 0.393 ± 0.014	1.29AsnPro: 1.29 ± 0.027	0.518AsnGln: 0.518 ± 0.016	1.277AsnArg: 1.277 ± 0.025	0.865AsnSer: 0.865 ± 0.023	1.001AsnThr: 1.001 ± 0.026	1.263AsnVal: 1.263 ± 0.025	0.271AsnTrp: 0.271 ± 0.011	0.377AsnTyr: 0.377 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.398ProAla: 9.398 ± 0.089	0.376ProCys: 0.376 ± 0.012	4.539ProAsp: 4.539 ± 0.049	4.3ProGlu: 4.3 ± 0.045	1.512ProPhe: 1.512 ± 0.026	6.996ProGly: 6.996 ± 0.068	1.39ProHis: 1.39 ± 0.025	1.136ProIle: 1.136 ± 0.022	1.087ProLys: 1.087 ± 0.028	5.43ProLeu: 5.43 ± 0.051	0.967ProMet: 0.967 ± 0.021	0.839ProAsn: 0.839 ± 0.018	3.76ProPro: 3.76 ± 0.056	1.791ProGln: 1.791 ± 0.034	4.516ProArg: 4.516 ± 0.047	3.07ProSer: 3.07 ± 0.042	2.985ProThr: 2.985 ± 0.044	5.528ProVal: 5.528 ± 0.055	0.891ProTrp: 0.891 ± 0.021	1.368ProTyr: 1.368 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.777GlnAla: 3.777 ± 0.052	0.187GlnCys: 0.187 ± 0.009	1.462GlnAsp: 1.462 ± 0.025	1.508GlnGlu: 1.508 ± 0.027	0.662GlnPhe: 0.662 ± 0.017	2.292GlnGly: 2.292 ± 0.042	0.68GlnHis: 0.68 ± 0.021	1.033GlnIle: 1.033 ± 0.027	0.586GlnLys: 0.586 ± 0.019	2.951GlnLeu: 2.951 ± 0.034	0.501GlnMet: 0.501 ± 0.015	0.501GlnAsn: 0.501 ± 0.018	1.676GlnPro: 1.676 ± 0.031	1.217GlnGln: 1.217 ± 0.032	2.481GlnArg: 2.481 ± 0.036	1.255GlnSer: 1.255 ± 0.028	1.308GlnThr: 1.308 ± 0.026	2.344GlnVal: 2.344 ± 0.034	0.465GlnTrp: 0.465 ± 0.016	0.603GlnTyr: 0.603 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.105ArgAla: 11.105 ± 0.089	0.65ArgCys: 0.65 ± 0.018	4.567ArgAsp: 4.567 ± 0.049	5.132ArgGlu: 5.132 ± 0.052	2.366ArgPhe: 2.366 ± 0.03	6.524ArgGly: 6.524 ± 0.063	2.276ArgHis: 2.276 ± 0.04	3.05ArgIle: 3.05 ± 0.037	1.641ArgLys: 1.641 ± 0.026	9.493ArgLeu: 9.493 ± 0.07	1.792ArgMet: 1.792 ± 0.028	1.338ArgAsn: 1.338 ± 0.025	5.532ArgPro: 5.532 ± 0.057	2.434ArgGln: 2.434 ± 0.031	8.515ArgArg: 8.515 ± 0.082	4.176ArgSer: 4.176 ± 0.043	5.805ArgThr: 5.805 ± 0.045	6.304ArgVal: 6.304 ± 0.049	1.468ArgTrp: 1.468 ± 0.025	1.813ArgTyr: 1.813 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.842SerAla: 6.842 ± 0.057	0.408SerCys: 0.408 ± 0.015	2.573SerAsp: 2.573 ± 0.038	2.337SerGlu: 2.337 ± 0.036	1.42SerPhe: 1.42 ± 0.027	5.802SerGly: 5.802 ± 0.061	0.979SerHis: 0.979 ± 0.018	1.19SerIle: 1.19 ± 0.025	0.946SerLys: 0.946 ± 0.022	4.798SerLeu: 4.798 ± 0.049	0.998SerMet: 0.998 ± 0.022	0.794SerAsn: 0.794 ± 0.021	3.136SerPro: 3.136 ± 0.042	1.21SerGln: 1.21 ± 0.027	3.803SerArg: 3.803 ± 0.04	2.642SerSer: 2.642 ± 0.042	2.869SerThr: 2.869 ± 0.039	4.202SerVal: 4.202 ± 0.045	0.869SerTrp: 0.869 ± 0.019	1.162SerTyr: 1.162 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	9.087ThrAla: 9.087 ± 0.066	0.43ThrCys: 0.43 ± 0.015	3.479ThrAsp: 3.479 ± 0.044	3.104ThrGlu: 3.104 ± 0.035	1.517ThrPhe: 1.517 ± 0.025	6.719ThrGly: 6.719 ± 0.055	1.131ThrHis: 1.131 ± 0.022	1.496ThrIle: 1.496 ± 0.027	1.046ThrLys: 1.046 ± 0.027	5.623ThrLeu: 5.623 ± 0.047	0.924ThrMet: 0.924 ± 0.018	0.924ThrAsn: 0.924 ± 0.023	4.064ThrPro: 4.064 ± 0.043	1.315ThrGln: 1.315 ± 0.024	4.202ThrArg: 4.202 ± 0.042	3.007ThrSer: 3.007 ± 0.037	3.602ThrThr: 3.602 ± 0.05	5.865ThrVal: 5.865 ± 0.058	0.907ThrTrp: 0.907 ± 0.019	1.302ThrTyr: 1.302 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.723ValAla: 10.723 ± 0.077	0.779ValCys: 0.779 ± 0.021	4.987ValAsp: 4.987 ± 0.046	4.671ValGlu: 4.671 ± 0.045	2.368ValPhe: 2.368 ± 0.037	6.407ValGly: 6.407 ± 0.058	1.937ValHis: 1.937 ± 0.032	2.657ValIle: 2.657 ± 0.036	1.65ValLys: 1.65 ± 0.032	9.535ValLeu: 9.535 ± 0.073	1.412ValMet: 1.412 ± 0.024	1.583ValAsn: 1.583 ± 0.025	5.382ValPro: 5.382 ± 0.057	2.087ValGln: 2.087 ± 0.032	7.881ValArg: 7.881 ± 0.067	4.209ValSer: 4.209 ± 0.055	5.532ValThr: 5.532 ± 0.057	7.887ValVal: 7.887 ± 0.066	1.21ValTrp: 1.21 ± 0.024	1.544ValTyr: 1.544 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.725TrpAla: 1.725 ± 0.031	0.176TrpCys: 0.176 ± 0.009	0.845TrpAsp: 0.845 ± 0.021	0.746TrpGlu: 0.746 ± 0.019	0.482TrpPhe: 0.482 ± 0.014	1.029TrpGly: 1.029 ± 0.022	0.359TrpHis: 0.359 ± 0.013	0.525TrpIle: 0.525 ± 0.017	0.366TrpLys: 0.366 ± 0.013	1.789TrpLeu: 1.789 ± 0.027	0.286TrpMet: 0.286 ± 0.012	0.422TrpAsn: 0.422 ± 0.013	0.794TrpPro: 0.794 ± 0.019	0.627TrpGln: 0.627 ± 0.017	1.426TrpArg: 1.426 ± 0.022	0.949TrpSer: 0.949 ± 0.024	1.042TrpThr: 1.042 ± 0.02	0.987TrpVal: 0.987 ± 0.024	0.341TrpTrp: 0.341 ± 0.013	0.365TrpTyr: 0.365 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.803TyrAla: 2.803 ± 0.036	0.178TyrCys: 0.178 ± 0.009	1.456TyrAsp: 1.456 ± 0.028	1.186TyrGlu: 1.186 ± 0.024	0.6TyrPhe: 0.6 ± 0.017	2.236TyrGly: 2.236 ± 0.032	0.384TyrHis: 0.384 ± 0.015	0.458TyrIle: 0.458 ± 0.017	0.378TyrLys: 0.378 ± 0.014	1.968TyrLeu: 1.968 ± 0.031	0.249TyrMet: 0.249 ± 0.011	0.353TyrAsn: 0.353 ± 0.013	1.053TyrPro: 1.053 ± 0.023	0.585TyrGln: 0.585 ± 0.015	1.829TyrArg: 1.829 ± 0.03	0.909TyrSer: 0.909 ± 0.021	1.151TyrThr: 1.151 ± 0.02	1.553TyrVal: 1.553 ± 0.025	0.351TyrTrp: 0.351 ± 0.014	0.405TyrTyr: 0.405 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7577 proteins (2321544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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