Amino acid dipepetide frequency for Bradyrhizobium phage BDU-MI-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.149AlaAla: 13.149 ± 1.202
1.082AlaCys: 1.082 ± 0.172
6.489AlaAsp: 6.489 ± 0.372
6.119AlaGlu: 6.119 ± 0.526
3.529AlaPhe: 3.529 ± 0.313
7.542AlaGly: 7.542 ± 0.523
1.935AlaHis: 1.935 ± 0.231
5.465AlaIle: 5.465 ± 0.485
6.432AlaLys: 6.432 ± 0.555
7.742AlaLeu: 7.742 ± 0.611
3.7AlaMet: 3.7 ± 0.306
4.212AlaAsn: 4.212 ± 0.345
4.212AlaPro: 4.212 ± 0.464
3.586AlaGln: 3.586 ± 0.323
6.062AlaArg: 6.062 ± 0.419
5.578AlaSer: 5.578 ± 0.611
4.725AlaThr: 4.725 ± 0.535
6.262AlaVal: 6.262 ± 0.446
1.708AlaTrp: 1.708 ± 0.203
2.476AlaTyr: 2.476 ± 0.269
0.0AlaXaa: 0.0 ± 0.0
Cys
1.082CysAla: 1.082 ± 0.205
0.142CysCys: 0.142 ± 0.051
0.939CysAsp: 0.939 ± 0.178
0.512CysGlu: 0.512 ± 0.106
0.455CysPhe: 0.455 ± 0.119
0.939CysGly: 0.939 ± 0.225
0.37CysHis: 0.37 ± 0.092
0.569CysIle: 0.569 ± 0.15
0.712CysLys: 0.712 ± 0.176
0.882CysLeu: 0.882 ± 0.179
0.37CysMet: 0.37 ± 0.113
0.313CysAsn: 0.313 ± 0.092
0.854CysPro: 0.854 ± 0.158
0.484CysGln: 0.484 ± 0.105
0.484CysArg: 0.484 ± 0.129
0.712CysSer: 0.712 ± 0.137
0.569CysThr: 0.569 ± 0.12
0.825CysVal: 0.825 ± 0.151
0.427CysTrp: 0.427 ± 0.113
0.37CysTyr: 0.37 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
6.318AspAla: 6.318 ± 0.461
0.768AspCys: 0.768 ± 0.151
4.81AspAsp: 4.81 ± 0.491
4.725AspGlu: 4.725 ± 0.448
2.135AspPhe: 2.135 ± 0.217
6.119AspGly: 6.119 ± 0.388
1.679AspHis: 1.679 ± 0.317
3.444AspIle: 3.444 ± 0.289
3.871AspLys: 3.871 ± 0.292
6.318AspLeu: 6.318 ± 0.463
1.565AspMet: 1.565 ± 0.189
2.078AspAsn: 2.078 ± 0.268
3.842AspPro: 3.842 ± 0.373
2.362AspGln: 2.362 ± 0.257
4.782AspArg: 4.782 ± 0.394
2.59AspSer: 2.59 ± 0.26
2.988AspThr: 2.988 ± 0.314
4.241AspVal: 4.241 ± 0.384
1.594AspTrp: 1.594 ± 0.192
1.793AspTyr: 1.793 ± 0.251
0.0AspXaa: 0.0 ± 0.0
Glu
6.688GluAla: 6.688 ± 0.578
0.455GluCys: 0.455 ± 0.112
4.383GluAsp: 4.383 ± 0.388
4.184GluGlu: 4.184 ± 0.474
1.651GluPhe: 1.651 ± 0.228
3.472GluGly: 3.472 ± 0.313
1.594GluHis: 1.594 ± 0.248
3.814GluIle: 3.814 ± 0.286
3.615GluLys: 3.615 ± 0.359
6.233GluLeu: 6.233 ± 0.476
1.907GluMet: 1.907 ± 0.222
2.305GluAsn: 2.305 ± 0.271
2.647GluPro: 2.647 ± 0.354
2.533GluGln: 2.533 ± 0.251
4.07GluArg: 4.07 ± 0.353
2.248GluSer: 2.248 ± 0.247
3.33GluThr: 3.33 ± 0.312
4.127GluVal: 4.127 ± 0.364
1.395GluTrp: 1.395 ± 0.209
1.679GluTyr: 1.679 ± 0.219
0.0GluXaa: 0.0 ± 0.0
Phe
3.558PheAla: 3.558 ± 0.319
0.569PheCys: 0.569 ± 0.137
3.102PheAsp: 3.102 ± 0.328
2.675PheGlu: 2.675 ± 0.36
1.025PhePhe: 1.025 ± 0.144
2.533PheGly: 2.533 ± 0.29
0.854PheHis: 0.854 ± 0.149
1.935PheIle: 1.935 ± 0.216
1.822PheLys: 1.822 ± 0.267
2.277PheLeu: 2.277 ± 0.243
1.082PheMet: 1.082 ± 0.157
1.224PheAsn: 1.224 ± 0.193
1.309PhePro: 1.309 ± 0.191
0.968PheGln: 0.968 ± 0.201
2.476PheArg: 2.476 ± 0.316
1.822PheSer: 1.822 ± 0.235
1.822PheThr: 1.822 ± 0.245
2.419PheVal: 2.419 ± 0.272
0.626PheTrp: 0.626 ± 0.165
1.395PheTyr: 1.395 ± 0.217
0.0PheXaa: 0.0 ± 0.0
Gly
6.461GlyAla: 6.461 ± 0.515
0.768GlyCys: 0.768 ± 0.172
5.493GlyAsp: 5.493 ± 0.522
4.753GlyGlu: 4.753 ± 0.355
3.159GlyPhe: 3.159 ± 0.271
6.717GlyGly: 6.717 ± 0.914
1.452GlyHis: 1.452 ± 0.224
4.127GlyIle: 4.127 ± 0.487
4.525GlyLys: 4.525 ± 0.414
5.522GlyLeu: 5.522 ± 0.36
2.021GlyMet: 2.021 ± 0.207
2.932GlyAsn: 2.932 ± 0.357
2.647GlyPro: 2.647 ± 0.295
2.96GlyGln: 2.96 ± 0.287
4.298GlyArg: 4.298 ± 0.371
4.81GlySer: 4.81 ± 0.509
4.412GlyThr: 4.412 ± 0.37
5.322GlyVal: 5.322 ± 0.363
1.48GlyTrp: 1.48 ± 0.215
2.59GlyTyr: 2.59 ± 0.315
0.0GlyXaa: 0.0 ± 0.0
His
1.594HisAla: 1.594 ± 0.23
0.285HisCys: 0.285 ± 0.099
1.395HisAsp: 1.395 ± 0.205
1.252HisGlu: 1.252 ± 0.195
0.797HisPhe: 0.797 ± 0.137
1.907HisGly: 1.907 ± 0.292
0.569HisHis: 0.569 ± 0.149
1.252HisIle: 1.252 ± 0.176
0.882HisLys: 0.882 ± 0.175
1.736HisLeu: 1.736 ± 0.212
0.285HisMet: 0.285 ± 0.098
0.655HisAsn: 0.655 ± 0.122
1.366HisPro: 1.366 ± 0.183
0.74HisGln: 0.74 ± 0.15
1.622HisArg: 1.622 ± 0.219
1.167HisSer: 1.167 ± 0.21
1.025HisThr: 1.025 ± 0.182
1.309HisVal: 1.309 ± 0.201
0.541HisTrp: 0.541 ± 0.11
0.512HisTyr: 0.512 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
4.981IleAla: 4.981 ± 0.353
0.797IleCys: 0.797 ± 0.159
4.611IleAsp: 4.611 ± 0.352
4.241IleGlu: 4.241 ± 0.371
1.708IlePhe: 1.708 ± 0.217
4.298IleGly: 4.298 ± 0.342
1.395IleHis: 1.395 ± 0.182
2.704IleIle: 2.704 ± 0.286
3.358IleLys: 3.358 ± 0.379
2.846IleLeu: 2.846 ± 0.361
1.309IleMet: 1.309 ± 0.18
2.021IleAsn: 2.021 ± 0.212
2.106IlePro: 2.106 ± 0.219
1.964IleGln: 1.964 ± 0.241
3.188IleArg: 3.188 ± 0.284
3.017IleSer: 3.017 ± 0.315
3.358IleThr: 3.358 ± 0.277
3.899IleVal: 3.899 ± 0.312
0.683IleTrp: 0.683 ± 0.176
1.508IleTyr: 1.508 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
6.575LysAla: 6.575 ± 0.501
0.598LysCys: 0.598 ± 0.145
3.159LysAsp: 3.159 ± 0.416
3.131LysGlu: 3.131 ± 0.328
1.85LysPhe: 1.85 ± 0.25
3.159LysGly: 3.159 ± 0.322
1.366LysHis: 1.366 ± 0.189
2.818LysIle: 2.818 ± 0.266
3.501LysLys: 3.501 ± 0.389
4.867LysLeu: 4.867 ± 0.37
1.765LysMet: 1.765 ± 0.204
1.935LysAsn: 1.935 ± 0.31
3.216LysPro: 3.216 ± 0.321
1.85LysGln: 1.85 ± 0.231
4.212LysArg: 4.212 ± 0.407
3.102LysSer: 3.102 ± 0.389
3.017LysThr: 3.017 ± 0.269
4.212LysVal: 4.212 ± 0.385
0.911LysTrp: 0.911 ± 0.16
1.565LysTyr: 1.565 ± 0.248
0.0LysXaa: 0.0 ± 0.0
Leu
7.685LeuAla: 7.685 ± 0.499
1.025LeuCys: 1.025 ± 0.196
5.208LeuAsp: 5.208 ± 0.329
4.326LeuGlu: 4.326 ± 0.366
2.419LeuPhe: 2.419 ± 0.252
6.375LeuGly: 6.375 ± 0.528
1.594LeuHis: 1.594 ± 0.207
4.127LeuIle: 4.127 ± 0.292
4.582LeuLys: 4.582 ± 0.414
5.522LeuLeu: 5.522 ± 0.415
2.305LeuMet: 2.305 ± 0.255
3.074LeuAsn: 3.074 ± 0.371
3.615LeuPro: 3.615 ± 0.332
2.192LeuGln: 2.192 ± 0.232
4.725LeuArg: 4.725 ± 0.353
4.838LeuSer: 4.838 ± 0.346
4.554LeuThr: 4.554 ± 0.375
4.952LeuVal: 4.952 ± 0.411
1.281LeuTrp: 1.281 ± 0.189
1.765LeuTyr: 1.765 ± 0.211
0.0LeuXaa: 0.0 ± 0.0
Met
2.761MetAla: 2.761 ± 0.278
0.171MetCys: 0.171 ± 0.068
1.366MetAsp: 1.366 ± 0.171
1.366MetGlu: 1.366 ± 0.222
1.309MetPhe: 1.309 ± 0.185
1.537MetGly: 1.537 ± 0.206
0.512MetHis: 0.512 ± 0.129
1.48MetIle: 1.48 ± 0.229
2.021MetLys: 2.021 ± 0.234
2.021MetLeu: 2.021 ± 0.254
0.683MetMet: 0.683 ± 0.145
0.968MetAsn: 0.968 ± 0.139
1.822MetPro: 1.822 ± 0.236
1.082MetGln: 1.082 ± 0.141
1.793MetArg: 1.793 ± 0.242
2.22MetSer: 2.22 ± 0.219
2.391MetThr: 2.391 ± 0.25
1.992MetVal: 1.992 ± 0.203
0.085MetTrp: 0.085 ± 0.056
0.512MetTyr: 0.512 ± 0.133
0.0MetXaa: 0.0 ± 0.0
Asn
4.525AsnAla: 4.525 ± 0.471
0.541AsnCys: 0.541 ± 0.143
2.932AsnAsp: 2.932 ± 0.293
1.85AsnGlu: 1.85 ± 0.206
1.338AsnPhe: 1.338 ± 0.175
3.529AsnGly: 3.529 ± 0.392
0.74AsnHis: 0.74 ± 0.163
1.736AsnIle: 1.736 ± 0.245
1.508AsnLys: 1.508 ± 0.215
2.789AsnLeu: 2.789 ± 0.237
0.968AsnMet: 0.968 ± 0.162
0.939AsnAsn: 0.939 ± 0.15
1.935AsnPro: 1.935 ± 0.263
1.366AsnGln: 1.366 ± 0.231
2.248AsnArg: 2.248 ± 0.248
1.651AsnSer: 1.651 ± 0.269
1.793AsnThr: 1.793 ± 0.26
2.647AsnVal: 2.647 ± 0.307
0.683AsnTrp: 0.683 ± 0.131
0.996AsnTyr: 0.996 ± 0.15
0.0AsnXaa: 0.0 ± 0.0
Pro
5.066ProAla: 5.066 ± 0.443
0.598ProCys: 0.598 ± 0.132
3.586ProAsp: 3.586 ± 0.318
3.871ProGlu: 3.871 ± 0.368
1.85ProPhe: 1.85 ± 0.251
3.672ProGly: 3.672 ± 0.341
0.996ProHis: 0.996 ± 0.166
1.964ProIle: 1.964 ± 0.238
2.732ProLys: 2.732 ± 0.329
3.216ProLeu: 3.216 ± 0.359
1.138ProMet: 1.138 ± 0.195
1.679ProAsn: 1.679 ± 0.229
2.248ProPro: 2.248 ± 0.268
1.622ProGln: 1.622 ± 0.198
2.106ProArg: 2.106 ± 0.268
2.818ProSer: 2.818 ± 0.296
2.818ProThr: 2.818 ± 0.286
3.472ProVal: 3.472 ± 0.359
0.939ProTrp: 0.939 ± 0.146
1.508ProTyr: 1.508 ± 0.206
0.0ProXaa: 0.0 ± 0.0
Gln
3.558GlnAla: 3.558 ± 0.352
0.626GlnCys: 0.626 ± 0.131
1.964GlnAsp: 1.964 ± 0.216
2.078GlnGlu: 2.078 ± 0.249
1.537GlnPhe: 1.537 ± 0.179
1.907GlnGly: 1.907 ± 0.258
0.598GlnHis: 0.598 ± 0.129
2.078GlnIle: 2.078 ± 0.223
1.935GlnLys: 1.935 ± 0.282
3.529GlnLeu: 3.529 ± 0.373
1.167GlnMet: 1.167 ± 0.174
0.911GlnAsn: 0.911 ± 0.152
1.679GlnPro: 1.679 ± 0.213
1.252GlnGln: 1.252 ± 0.183
2.277GlnArg: 2.277 ± 0.223
1.651GlnSer: 1.651 ± 0.221
1.594GlnThr: 1.594 ± 0.255
2.533GlnVal: 2.533 ± 0.284
0.854GlnTrp: 0.854 ± 0.134
1.11GlnTyr: 1.11 ± 0.195
0.0GlnXaa: 0.0 ± 0.0
Arg
5.123ArgAla: 5.123 ± 0.363
0.626ArgCys: 0.626 ± 0.132
4.497ArgAsp: 4.497 ± 0.384
3.7ArgGlu: 3.7 ± 0.309
2.789ArgPhe: 2.789 ± 0.274
4.44ArgGly: 4.44 ± 0.57
1.565ArgHis: 1.565 ± 0.233
3.273ArgIle: 3.273 ± 0.295
3.444ArgLys: 3.444 ± 0.336
4.782ArgLeu: 4.782 ± 0.462
1.793ArgMet: 1.793 ± 0.211
2.618ArgAsn: 2.618 ± 0.302
2.903ArgPro: 2.903 ± 0.34
2.248ArgGln: 2.248 ± 0.327
4.981ArgArg: 4.981 ± 0.621
3.615ArgSer: 3.615 ± 0.3
3.415ArgThr: 3.415 ± 0.363
4.412ArgVal: 4.412 ± 0.417
1.138ArgTrp: 1.138 ± 0.173
1.992ArgTyr: 1.992 ± 0.273
0.0ArgXaa: 0.0 ± 0.0
Ser
5.55SerAla: 5.55 ± 0.577
0.712SerCys: 0.712 ± 0.153
3.045SerAsp: 3.045 ± 0.295
3.188SerGlu: 3.188 ± 0.331
2.106SerPhe: 2.106 ± 0.224
5.265SerGly: 5.265 ± 0.505
0.484SerHis: 0.484 ± 0.1
2.988SerIle: 2.988 ± 0.267
3.501SerLys: 3.501 ± 0.367
3.501SerLeu: 3.501 ± 0.344
1.793SerMet: 1.793 ± 0.284
2.476SerAsn: 2.476 ± 0.352
2.078SerPro: 2.078 ± 0.251
1.935SerGln: 1.935 ± 0.267
3.358SerArg: 3.358 ± 0.313
2.789SerSer: 2.789 ± 0.432
3.245SerThr: 3.245 ± 0.323
3.302SerVal: 3.302 ± 0.271
1.167SerTrp: 1.167 ± 0.185
1.423SerTyr: 1.423 ± 0.237
0.0SerXaa: 0.0 ± 0.0
Thr
5.522ThrAla: 5.522 ± 0.526
0.598ThrCys: 0.598 ± 0.134
3.444ThrAsp: 3.444 ± 0.346
2.988ThrGlu: 2.988 ± 0.278
2.192ThrPhe: 2.192 ± 0.215
5.123ThrGly: 5.123 ± 0.457
0.825ThrHis: 0.825 ± 0.166
3.302ThrIle: 3.302 ± 0.285
3.045ThrLys: 3.045 ± 0.31
3.928ThrLeu: 3.928 ± 0.395
1.423ThrMet: 1.423 ± 0.209
2.419ThrAsn: 2.419 ± 0.315
3.472ThrPro: 3.472 ± 0.394
1.85ThrGln: 1.85 ± 0.237
2.875ThrArg: 2.875 ± 0.313
3.159ThrSer: 3.159 ± 0.481
3.415ThrThr: 3.415 ± 0.325
4.298ThrVal: 4.298 ± 0.401
0.911ThrTrp: 0.911 ± 0.141
1.338ThrTyr: 1.338 ± 0.183
0.0ThrXaa: 0.0 ± 0.0
Val
7.514ValAla: 7.514 ± 0.536
0.768ValCys: 0.768 ± 0.155
4.412ValAsp: 4.412 ± 0.367
4.838ValGlu: 4.838 ± 0.399
2.22ValPhe: 2.22 ± 0.255
4.241ValGly: 4.241 ± 0.415
1.224ValHis: 1.224 ± 0.217
4.468ValIle: 4.468 ± 0.428
3.501ValLys: 3.501 ± 0.345
4.782ValLeu: 4.782 ± 0.368
1.85ValMet: 1.85 ± 0.243
2.049ValAsn: 2.049 ± 0.227
3.757ValPro: 3.757 ± 0.363
2.334ValGln: 2.334 ± 0.214
4.468ValArg: 4.468 ± 0.38
3.558ValSer: 3.558 ± 0.361
4.753ValThr: 4.753 ± 0.35
4.696ValVal: 4.696 ± 0.417
0.996ValTrp: 0.996 ± 0.151
2.22ValTyr: 2.22 ± 0.27
0.0ValXaa: 0.0 ± 0.0
Trp
1.765TrpAla: 1.765 ± 0.218
0.484TrpCys: 0.484 ± 0.126
1.167TrpAsp: 1.167 ± 0.18
0.854TrpGlu: 0.854 ± 0.174
0.626TrpPhe: 0.626 ± 0.143
0.825TrpGly: 0.825 ± 0.209
0.74TrpHis: 0.74 ± 0.153
0.882TrpIle: 0.882 ± 0.174
0.996TrpLys: 0.996 ± 0.169
1.48TrpLeu: 1.48 ± 0.254
0.484TrpMet: 0.484 ± 0.127
0.854TrpAsn: 0.854 ± 0.159
0.626TrpPro: 0.626 ± 0.15
0.655TrpGln: 0.655 ± 0.159
1.423TrpArg: 1.423 ± 0.198
1.224TrpSer: 1.224 ± 0.197
1.195TrpThr: 1.195 ± 0.167
1.138TrpVal: 1.138 ± 0.165
0.342TrpTrp: 0.342 ± 0.09
0.512TrpTyr: 0.512 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.533TyrAla: 2.533 ± 0.251
0.398TyrCys: 0.398 ± 0.104
2.021TyrAsp: 2.021 ± 0.279
1.679TyrGlu: 1.679 ± 0.23
0.797TyrPhe: 0.797 ± 0.164
2.846TyrGly: 2.846 ± 0.277
0.398TyrHis: 0.398 ± 0.092
1.565TyrIle: 1.565 ± 0.2
0.825TyrLys: 0.825 ± 0.164
2.192TyrLeu: 2.192 ± 0.266
0.455TyrMet: 0.455 ± 0.098
1.053TyrAsn: 1.053 ± 0.176
1.565TyrPro: 1.565 ± 0.213
0.854TyrGln: 0.854 ± 0.16
1.935TyrArg: 1.935 ± 0.238
1.338TyrSer: 1.338 ± 0.204
1.708TyrThr: 1.708 ± 0.208
2.59TyrVal: 2.59 ± 0.292
0.512TyrTrp: 0.512 ± 0.129
0.712TyrTyr: 0.712 ± 0.152
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 207 proteins (35136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski