Amino acid dipepetide frequency for Elizabethkingia phage TCUEAP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.595AlaAla: 6.595 ± 1.451
0.653AlaCys: 0.653 ± 0.25
5.42AlaAsp: 5.42 ± 1.018
6.334AlaGlu: 6.334 ± 0.756
2.416AlaPhe: 2.416 ± 0.408
5.159AlaGly: 5.159 ± 0.503
1.371AlaHis: 1.371 ± 0.336
5.877AlaIle: 5.877 ± 0.912
5.485AlaLys: 5.485 ± 0.843
5.877AlaLeu: 5.877 ± 0.824
1.437AlaMet: 1.437 ± 0.275
4.244AlaAsn: 4.244 ± 1.004
1.437AlaPro: 1.437 ± 0.324
3.2AlaGln: 3.2 ± 0.615
2.547AlaArg: 2.547 ± 0.363
3.526AlaSer: 3.526 ± 0.479
3.787AlaThr: 3.787 ± 0.593
4.767AlaVal: 4.767 ± 0.5
0.914AlaTrp: 0.914 ± 0.226
2.612AlaTyr: 2.612 ± 0.356
0.0AlaXaa: 0.0 ± 0.0
Cys
0.914CysAla: 0.914 ± 0.258
0.131CysCys: 0.131 ± 0.092
1.045CysAsp: 1.045 ± 0.261
0.392CysGlu: 0.392 ± 0.179
0.326CysPhe: 0.326 ± 0.133
0.457CysGly: 0.457 ± 0.151
0.131CysHis: 0.131 ± 0.088
0.588CysIle: 0.588 ± 0.202
1.306CysLys: 1.306 ± 0.325
0.457CysLeu: 0.457 ± 0.173
0.131CysMet: 0.131 ± 0.083
0.392CysAsn: 0.392 ± 0.143
0.588CysPro: 0.588 ± 0.224
0.261CysGln: 0.261 ± 0.123
0.457CysArg: 0.457 ± 0.128
0.196CysSer: 0.196 ± 0.116
0.653CysThr: 0.653 ± 0.261
0.653CysVal: 0.653 ± 0.2
0.065CysTrp: 0.065 ± 0.071
0.326CysTyr: 0.326 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
5.093AspAla: 5.093 ± 0.846
0.261AspCys: 0.261 ± 0.161
3.33AspAsp: 3.33 ± 0.603
4.31AspGlu: 4.31 ± 0.555
3.983AspPhe: 3.983 ± 0.484
4.636AspGly: 4.636 ± 0.598
0.979AspHis: 0.979 ± 0.249
5.289AspIle: 5.289 ± 0.568
4.049AspLys: 4.049 ± 0.502
5.746AspLeu: 5.746 ± 0.547
1.828AspMet: 1.828 ± 0.325
3.33AspAsn: 3.33 ± 0.391
2.481AspPro: 2.481 ± 0.544
1.632AspGln: 1.632 ± 0.311
3.461AspArg: 3.461 ± 0.589
2.743AspSer: 2.743 ± 0.457
3.396AspThr: 3.396 ± 0.304
3.722AspVal: 3.722 ± 0.495
1.306AspTrp: 1.306 ± 0.261
3.2AspTyr: 3.2 ± 0.338
0.0AspXaa: 0.0 ± 0.0
Glu
6.399GluAla: 6.399 ± 1.125
0.718GluCys: 0.718 ± 0.195
3.657GluAsp: 3.657 ± 0.541
4.244GluGlu: 4.244 ± 0.874
3.265GluPhe: 3.265 ± 0.352
4.832GluGly: 4.832 ± 0.541
1.11GluHis: 1.11 ± 0.222
5.355GluIle: 5.355 ± 0.575
4.31GluLys: 4.31 ± 0.504
6.856GluLeu: 6.856 ± 0.737
1.175GluMet: 1.175 ± 0.247
3.722GluAsn: 3.722 ± 0.456
1.698GluPro: 1.698 ± 0.411
2.547GluGln: 2.547 ± 0.372
3.722GluArg: 3.722 ± 0.514
3.657GluSer: 3.657 ± 0.55
4.571GluThr: 4.571 ± 0.764
5.093GluVal: 5.093 ± 0.736
1.306GluTrp: 1.306 ± 0.37
3.265GluTyr: 3.265 ± 0.485
0.0GluXaa: 0.0 ± 0.0
Phe
3.265PheAla: 3.265 ± 0.381
0.457PheCys: 0.457 ± 0.178
2.938PheAsp: 2.938 ± 0.477
3.983PheGlu: 3.983 ± 0.493
1.175PhePhe: 1.175 ± 0.261
3.2PheGly: 3.2 ± 0.39
0.326PheHis: 0.326 ± 0.132
2.22PheIle: 2.22 ± 0.36
3.526PheLys: 3.526 ± 0.506
2.808PheLeu: 2.808 ± 0.372
0.653PheMet: 0.653 ± 0.21
3.396PheAsn: 3.396 ± 0.508
0.849PhePro: 0.849 ± 0.224
1.11PheGln: 1.11 ± 0.273
1.632PheArg: 1.632 ± 0.426
1.632PheSer: 1.632 ± 0.275
3.33PheThr: 3.33 ± 0.671
2.155PheVal: 2.155 ± 0.369
0.392PheTrp: 0.392 ± 0.136
2.285PheTyr: 2.285 ± 0.433
0.0PheXaa: 0.0 ± 0.0
Gly
5.355GlyAla: 5.355 ± 0.833
0.588GlyCys: 0.588 ± 0.205
3.33GlyAsp: 3.33 ± 0.642
4.31GlyGlu: 4.31 ± 0.482
3.265GlyPhe: 3.265 ± 0.475
5.55GlyGly: 5.55 ± 0.771
1.045GlyHis: 1.045 ± 0.303
3.853GlyIle: 3.853 ± 0.524
4.571GlyLys: 4.571 ± 0.565
5.485GlyLeu: 5.485 ± 0.611
1.437GlyMet: 1.437 ± 0.254
3.134GlyAsn: 3.134 ± 0.53
1.632GlyPro: 1.632 ± 0.284
2.22GlyGln: 2.22 ± 0.301
1.828GlyArg: 1.828 ± 0.34
3.33GlySer: 3.33 ± 0.487
3.918GlyThr: 3.918 ± 0.364
5.485GlyVal: 5.485 ± 0.716
0.653GlyTrp: 0.653 ± 0.177
2.873GlyTyr: 2.873 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
0.849HisAla: 0.849 ± 0.243
0.065HisCys: 0.065 ± 0.074
0.784HisAsp: 0.784 ± 0.261
0.849HisGlu: 0.849 ± 0.287
0.718HisPhe: 0.718 ± 0.252
1.11HisGly: 1.11 ± 0.264
0.261HisHis: 0.261 ± 0.152
1.306HisIle: 1.306 ± 0.277
1.175HisLys: 1.175 ± 0.367
1.502HisLeu: 1.502 ± 0.345
0.261HisMet: 0.261 ± 0.142
1.371HisAsn: 1.371 ± 0.319
0.588HisPro: 0.588 ± 0.211
0.326HisGln: 0.326 ± 0.122
0.784HisArg: 0.784 ± 0.221
1.11HisSer: 1.11 ± 0.31
0.326HisThr: 0.326 ± 0.158
0.979HisVal: 0.979 ± 0.27
0.131HisTrp: 0.131 ± 0.088
1.175HisTyr: 1.175 ± 0.317
0.0HisXaa: 0.0 ± 0.0
Ile
4.832IleAla: 4.832 ± 0.575
0.522IleCys: 0.522 ± 0.141
6.008IleAsp: 6.008 ± 0.591
5.746IleGlu: 5.746 ± 0.768
2.416IlePhe: 2.416 ± 0.382
4.506IleGly: 4.506 ± 0.474
0.979IleHis: 0.979 ± 0.202
6.399IleIle: 6.399 ± 0.814
7.379IleLys: 7.379 ± 0.873
4.897IleLeu: 4.897 ± 0.62
1.632IleMet: 1.632 ± 0.354
5.877IleAsn: 5.877 ± 0.441
2.285IlePro: 2.285 ± 0.41
2.416IleGln: 2.416 ± 0.433
3.657IleArg: 3.657 ± 0.416
4.31IleSer: 4.31 ± 0.557
3.657IleThr: 3.657 ± 0.505
4.375IleVal: 4.375 ± 0.714
0.522IleTrp: 0.522 ± 0.197
2.938IleTyr: 2.938 ± 0.513
0.0IleXaa: 0.0 ± 0.0
Lys
6.595LysAla: 6.595 ± 0.833
0.522LysCys: 0.522 ± 0.209
5.877LysAsp: 5.877 ± 0.706
4.571LysGlu: 4.571 ± 0.744
2.873LysPhe: 2.873 ± 0.467
4.506LysGly: 4.506 ± 0.566
1.371LysHis: 1.371 ± 0.325
5.55LysIle: 5.55 ± 0.56
5.224LysLys: 5.224 ± 0.8
6.791LysLeu: 6.791 ± 0.758
2.938LysMet: 2.938 ± 0.413
3.396LysAsn: 3.396 ± 0.466
3.134LysPro: 3.134 ± 0.484
3.265LysGln: 3.265 ± 0.589
3.33LysArg: 3.33 ± 0.456
3.722LysSer: 3.722 ± 0.452
3.983LysThr: 3.983 ± 0.412
4.636LysVal: 4.636 ± 0.595
0.718LysTrp: 0.718 ± 0.217
4.049LysTyr: 4.049 ± 0.547
0.0LysXaa: 0.0 ± 0.0
Leu
6.073LeuAla: 6.073 ± 0.61
0.979LeuCys: 0.979 ± 0.297
5.224LeuAsp: 5.224 ± 0.642
5.877LeuGlu: 5.877 ± 0.521
2.481LeuPhe: 2.481 ± 0.312
3.918LeuGly: 3.918 ± 0.409
1.567LeuHis: 1.567 ± 0.31
5.42LeuIle: 5.42 ± 0.61
7.314LeuLys: 7.314 ± 0.81
5.681LeuLeu: 5.681 ± 0.643
1.502LeuMet: 1.502 ± 0.282
5.159LeuAsn: 5.159 ± 0.49
2.547LeuPro: 2.547 ± 0.432
2.677LeuGln: 2.677 ± 0.409
4.049LeuArg: 4.049 ± 0.53
4.963LeuSer: 4.963 ± 0.641
5.159LeuThr: 5.159 ± 0.605
4.44LeuVal: 4.44 ± 0.616
0.718LeuTrp: 0.718 ± 0.134
3.722LeuTyr: 3.722 ± 0.642
0.0LeuXaa: 0.0 ± 0.0
Met
2.285MetAla: 2.285 ± 0.42
0.261MetCys: 0.261 ± 0.11
0.653MetAsp: 0.653 ± 0.196
1.437MetGlu: 1.437 ± 0.247
1.502MetPhe: 1.502 ± 0.286
0.979MetGly: 0.979 ± 0.243
0.457MetHis: 0.457 ± 0.168
1.567MetIle: 1.567 ± 0.293
2.416MetLys: 2.416 ± 0.362
1.828MetLeu: 1.828 ± 0.377
0.522MetMet: 0.522 ± 0.188
1.632MetAsn: 1.632 ± 0.342
0.588MetPro: 0.588 ± 0.157
0.849MetGln: 0.849 ± 0.221
1.632MetArg: 1.632 ± 0.308
1.11MetSer: 1.11 ± 0.28
1.894MetThr: 1.894 ± 0.407
0.979MetVal: 0.979 ± 0.242
0.131MetTrp: 0.131 ± 0.088
0.784MetTyr: 0.784 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
3.722AsnAla: 3.722 ± 0.99
0.261AsnCys: 0.261 ± 0.145
4.179AsnAsp: 4.179 ± 0.512
3.657AsnGlu: 3.657 ± 0.443
2.09AsnPhe: 2.09 ± 0.442
4.31AsnGly: 4.31 ± 0.943
1.045AsnHis: 1.045 ± 0.237
4.963AsnIle: 4.963 ± 0.531
3.918AsnLys: 3.918 ± 0.46
4.31AsnLeu: 4.31 ± 0.476
2.09AsnMet: 2.09 ± 0.325
4.049AsnAsn: 4.049 ± 0.637
1.959AsnPro: 1.959 ± 0.308
1.567AsnGln: 1.567 ± 0.323
2.22AsnArg: 2.22 ± 0.354
3.853AsnSer: 3.853 ± 0.48
3.526AsnThr: 3.526 ± 0.574
3.657AsnVal: 3.657 ± 0.685
1.045AsnTrp: 1.045 ± 0.273
3.33AsnTyr: 3.33 ± 0.525
0.0AsnXaa: 0.0 ± 0.0
Pro
1.763ProAla: 1.763 ± 0.342
0.261ProCys: 0.261 ± 0.128
2.677ProAsp: 2.677 ± 0.413
3.004ProGlu: 3.004 ± 0.605
1.763ProPhe: 1.763 ± 0.302
0.065ProGly: 0.065 ± 0.061
0.196ProHis: 0.196 ± 0.102
2.677ProIle: 2.677 ± 0.449
3.134ProLys: 3.134 ± 0.707
1.894ProLeu: 1.894 ± 0.29
0.784ProMet: 0.784 ± 0.253
2.612ProAsn: 2.612 ± 0.501
0.522ProPro: 0.522 ± 0.182
1.306ProGln: 1.306 ± 0.259
1.045ProArg: 1.045 ± 0.235
2.024ProSer: 2.024 ± 0.284
1.567ProThr: 1.567 ± 0.253
1.567ProVal: 1.567 ± 0.249
0.392ProTrp: 0.392 ± 0.146
1.241ProTyr: 1.241 ± 0.383
0.0ProXaa: 0.0 ± 0.0
Gln
3.2GlnAla: 3.2 ± 0.593
0.522GlnCys: 0.522 ± 0.201
1.437GlnAsp: 1.437 ± 0.349
2.808GlnGlu: 2.808 ± 0.442
1.698GlnPhe: 1.698 ± 0.345
2.09GlnGly: 2.09 ± 0.35
0.392GlnHis: 0.392 ± 0.154
2.547GlnIle: 2.547 ± 0.413
2.481GlnLys: 2.481 ± 0.47
2.873GlnLeu: 2.873 ± 0.396
0.784GlnMet: 0.784 ± 0.232
1.763GlnAsn: 1.763 ± 0.334
1.045GlnPro: 1.045 ± 0.24
1.241GlnGln: 1.241 ± 0.372
1.306GlnArg: 1.306 ± 0.4
1.763GlnSer: 1.763 ± 0.278
1.632GlnThr: 1.632 ± 0.312
2.09GlnVal: 2.09 ± 0.343
0.457GlnTrp: 0.457 ± 0.225
1.567GlnTyr: 1.567 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
2.677ArgAla: 2.677 ± 0.416
0.457ArgCys: 0.457 ± 0.203
2.677ArgAsp: 2.677 ± 0.374
2.677ArgGlu: 2.677 ± 0.303
1.894ArgPhe: 1.894 ± 0.402
2.351ArgGly: 2.351 ± 0.35
0.653ArgHis: 0.653 ± 0.22
3.526ArgIle: 3.526 ± 0.555
3.134ArgLys: 3.134 ± 0.469
4.31ArgLeu: 4.31 ± 0.515
1.175ArgMet: 1.175 ± 0.272
2.743ArgAsn: 2.743 ± 0.479
1.371ArgPro: 1.371 ± 0.285
1.959ArgGln: 1.959 ± 0.299
1.763ArgArg: 1.763 ± 0.41
2.481ArgSer: 2.481 ± 0.323
3.069ArgThr: 3.069 ± 0.457
2.743ArgVal: 2.743 ± 0.386
0.784ArgTrp: 0.784 ± 0.191
2.024ArgTyr: 2.024 ± 0.411
0.0ArgXaa: 0.0 ± 0.0
Ser
3.004SerAla: 3.004 ± 0.521
0.522SerCys: 0.522 ± 0.19
4.31SerAsp: 4.31 ± 0.516
4.636SerGlu: 4.636 ± 0.543
2.285SerPhe: 2.285 ± 0.356
4.44SerGly: 4.44 ± 0.523
0.914SerHis: 0.914 ± 0.188
4.375SerIle: 4.375 ± 0.583
4.636SerLys: 4.636 ± 0.487
4.049SerLeu: 4.049 ± 0.487
1.437SerMet: 1.437 ± 0.268
3.2SerAsn: 3.2 ± 0.55
1.698SerPro: 1.698 ± 0.27
1.698SerGln: 1.698 ± 0.278
1.828SerArg: 1.828 ± 0.366
3.004SerSer: 3.004 ± 0.514
3.265SerThr: 3.265 ± 0.57
3.983SerVal: 3.983 ± 0.405
0.261SerTrp: 0.261 ± 0.103
2.09SerTyr: 2.09 ± 0.402
0.0SerXaa: 0.0 ± 0.0
Thr
3.657ThrAla: 3.657 ± 0.603
0.522ThrCys: 0.522 ± 0.174
3.657ThrAsp: 3.657 ± 0.375
4.963ThrGlu: 4.963 ± 0.578
2.743ThrPhe: 2.743 ± 0.473
4.375ThrGly: 4.375 ± 0.504
0.979ThrHis: 0.979 ± 0.316
4.963ThrIle: 4.963 ± 0.509
4.636ThrLys: 4.636 ± 0.501
4.767ThrLeu: 4.767 ± 0.501
0.914ThrMet: 0.914 ± 0.218
2.743ThrAsn: 2.743 ± 0.587
2.547ThrPro: 2.547 ± 0.398
1.371ThrGln: 1.371 ± 0.252
1.894ThrArg: 1.894 ± 0.386
3.853ThrSer: 3.853 ± 0.43
3.461ThrThr: 3.461 ± 0.474
4.049ThrVal: 4.049 ± 0.588
0.196ThrTrp: 0.196 ± 0.105
2.808ThrTyr: 2.808 ± 0.444
0.0ThrXaa: 0.0 ± 0.0
Val
3.983ValAla: 3.983 ± 0.549
0.849ValCys: 0.849 ± 0.281
4.31ValAsp: 4.31 ± 0.642
3.787ValGlu: 3.787 ± 0.756
2.416ValPhe: 2.416 ± 0.438
3.918ValGly: 3.918 ± 0.537
1.045ValHis: 1.045 ± 0.287
4.702ValIle: 4.702 ± 0.601
4.636ValLys: 4.636 ± 0.629
4.571ValLeu: 4.571 ± 0.529
1.175ValMet: 1.175 ± 0.285
3.722ValAsn: 3.722 ± 0.516
1.959ValPro: 1.959 ± 0.397
2.285ValGln: 2.285 ± 0.422
3.918ValArg: 3.918 ± 0.575
3.526ValSer: 3.526 ± 0.345
4.636ValThr: 4.636 ± 0.465
3.983ValVal: 3.983 ± 0.573
0.849ValTrp: 0.849 ± 0.228
3.004ValTyr: 3.004 ± 0.394
0.0ValXaa: 0.0 ± 0.0
Trp
1.11TrpAla: 1.11 ± 0.296
0.326TrpCys: 0.326 ± 0.143
0.522TrpAsp: 0.522 ± 0.171
0.784TrpGlu: 0.784 ± 0.195
0.326TrpPhe: 0.326 ± 0.126
0.196TrpGly: 0.196 ± 0.112
0.196TrpHis: 0.196 ± 0.104
0.914TrpIle: 0.914 ± 0.233
0.653TrpLys: 0.653 ± 0.216
0.849TrpLeu: 0.849 ± 0.209
0.131TrpMet: 0.131 ± 0.108
0.653TrpAsn: 0.653 ± 0.173
0.326TrpPro: 0.326 ± 0.149
0.261TrpGln: 0.261 ± 0.139
0.914TrpArg: 0.914 ± 0.342
0.979TrpSer: 0.979 ± 0.25
0.653TrpThr: 0.653 ± 0.199
1.11TrpVal: 1.11 ± 0.367
0.065TrpTrp: 0.065 ± 0.072
0.588TrpTyr: 0.588 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.285TyrAla: 2.285 ± 0.525
0.588TyrCys: 0.588 ± 0.229
2.743TyrAsp: 2.743 ± 0.348
3.134TyrGlu: 3.134 ± 0.52
1.698TyrPhe: 1.698 ± 0.337
3.265TyrGly: 3.265 ± 0.448
0.653TyrHis: 0.653 ± 0.191
3.265TyrIle: 3.265 ± 0.541
3.069TyrLys: 3.069 ± 0.489
3.918TyrLeu: 3.918 ± 0.511
1.437TyrMet: 1.437 ± 0.264
2.612TyrAsn: 2.612 ± 0.393
1.241TyrPro: 1.241 ± 0.331
1.502TyrGln: 1.502 ± 0.221
2.481TyrArg: 2.481 ± 0.485
3.853TyrSer: 3.853 ± 0.56
2.677TyrThr: 2.677 ± 0.427
2.808TyrVal: 2.808 ± 0.387
0.653TyrTrp: 0.653 ± 0.251
2.481TyrTyr: 2.481 ± 0.423
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (15315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski