Amino acid dipepetide frequency for Pectobacterium phage vB_PatP_CB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.378AlaAla: 9.378 ± 1.042
0.339AlaCys: 0.339 ± 0.123
5.559AlaAsp: 5.559 ± 0.815
5.644AlaGlu: 5.644 ± 0.58
3.14AlaPhe: 3.14 ± 0.394
6.832AlaGly: 6.832 ± 0.657
1.485AlaHis: 1.485 ± 0.223
4.753AlaIle: 4.753 ± 0.47
5.601AlaLys: 5.601 ± 0.545
7.171AlaLeu: 7.171 ± 0.974
3.14AlaMet: 3.14 ± 0.501
4.837AlaAsn: 4.837 ± 0.471
3.31AlaPro: 3.31 ± 0.509
5.686AlaGln: 5.686 ± 1.071
4.201AlaArg: 4.201 ± 0.584
5.007AlaSer: 5.007 ± 0.528
5.941AlaThr: 5.941 ± 0.791
5.983AlaVal: 5.983 ± 0.468
1.103AlaTrp: 1.103 ± 0.206
3.225AlaTyr: 3.225 ± 0.339
0.0AlaXaa: 0.0 ± 0.0
Cys
0.382CysAla: 0.382 ± 0.131
0.212CysCys: 0.212 ± 0.1
0.552CysAsp: 0.552 ± 0.169
0.891CysGlu: 0.891 ± 0.231
0.382CysPhe: 0.382 ± 0.14
0.509CysGly: 0.509 ± 0.203
0.339CysHis: 0.339 ± 0.12
0.594CysIle: 0.594 ± 0.186
0.806CysLys: 0.806 ± 0.233
0.721CysLeu: 0.721 ± 0.192
0.255CysMet: 0.255 ± 0.124
0.382CysAsn: 0.382 ± 0.131
0.339CysPro: 0.339 ± 0.135
0.042CysGln: 0.042 ± 0.052
0.424CysArg: 0.424 ± 0.125
0.382CysSer: 0.382 ± 0.126
0.467CysThr: 0.467 ± 0.166
0.339CysVal: 0.339 ± 0.121
0.085CysTrp: 0.085 ± 0.06
0.297CysTyr: 0.297 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
5.05AspAla: 5.05 ± 0.859
0.552AspCys: 0.552 ± 0.176
3.395AspAsp: 3.395 ± 0.519
4.456AspGlu: 4.456 ± 0.505
1.994AspPhe: 1.994 ± 0.28
4.965AspGly: 4.965 ± 0.536
1.4AspHis: 1.4 ± 0.319
3.437AspIle: 3.437 ± 0.387
3.267AspLys: 3.267 ± 0.374
6.11AspLeu: 6.11 ± 0.788
2.122AspMet: 2.122 ± 0.327
2.843AspAsn: 2.843 ± 0.287
3.437AspPro: 3.437 ± 0.383
1.91AspGln: 1.91 ± 0.293
2.419AspArg: 2.419 ± 0.408
3.352AspSer: 3.352 ± 0.359
3.055AspThr: 3.055 ± 0.561
3.225AspVal: 3.225 ± 0.369
1.018AspTrp: 1.018 ± 0.172
1.825AspTyr: 1.825 ± 0.315
0.0AspXaa: 0.0 ± 0.0
Glu
5.856GluAla: 5.856 ± 0.655
0.552GluCys: 0.552 ± 0.16
3.607GluAsp: 3.607 ± 0.467
3.904GluGlu: 3.904 ± 0.67
2.419GluPhe: 2.419 ± 0.332
3.607GluGly: 3.607 ± 0.354
1.315GluHis: 1.315 ± 0.269
3.14GluIle: 3.14 ± 0.305
2.291GluLys: 2.291 ± 0.339
6.535GluLeu: 6.535 ± 0.768
2.291GluMet: 2.291 ± 0.45
2.546GluAsn: 2.546 ± 0.306
2.419GluPro: 2.419 ± 0.633
3.395GluGln: 3.395 ± 0.81
3.395GluArg: 3.395 ± 0.413
3.522GluSer: 3.522 ± 0.425
3.48GluThr: 3.48 ± 0.538
4.328GluVal: 4.328 ± 0.382
0.891GluTrp: 0.891 ± 0.236
2.164GluTyr: 2.164 ± 0.279
0.0GluXaa: 0.0 ± 0.0
Phe
2.588PheAla: 2.588 ± 0.291
0.255PheCys: 0.255 ± 0.104
2.207PheAsp: 2.207 ± 0.43
2.291PheGlu: 2.291 ± 0.291
0.934PhePhe: 0.934 ± 0.224
2.334PheGly: 2.334 ± 0.283
0.594PheHis: 0.594 ± 0.183
2.207PheIle: 2.207 ± 0.408
2.716PheLys: 2.716 ± 0.387
2.97PheLeu: 2.97 ± 0.41
1.103PheMet: 1.103 ± 0.193
2.376PheAsn: 2.376 ± 0.348
1.103PhePro: 1.103 ± 0.289
1.4PheGln: 1.4 ± 0.194
1.994PheArg: 1.994 ± 0.357
1.91PheSer: 1.91 ± 0.28
2.673PheThr: 2.673 ± 0.367
2.207PheVal: 2.207 ± 0.35
0.552PheTrp: 0.552 ± 0.165
1.315PheTyr: 1.315 ± 0.273
0.0PheXaa: 0.0 ± 0.0
Gly
5.262GlyAla: 5.262 ± 0.488
0.806GlyCys: 0.806 ± 0.247
3.395GlyAsp: 3.395 ± 0.453
4.413GlyGlu: 4.413 ± 0.42
3.777GlyPhe: 3.777 ± 0.34
4.159GlyGly: 4.159 ± 0.6
1.018GlyHis: 1.018 ± 0.223
3.607GlyIle: 3.607 ± 0.383
5.135GlyLys: 5.135 ± 0.473
5.219GlyLeu: 5.219 ± 0.485
1.994GlyMet: 1.994 ± 0.293
3.649GlyAsn: 3.649 ± 0.507
1.315GlyPro: 1.315 ± 0.26
3.352GlyGln: 3.352 ± 0.55
2.886GlyArg: 2.886 ± 0.32
3.946GlySer: 3.946 ± 0.492
4.965GlyThr: 4.965 ± 0.456
4.922GlyVal: 4.922 ± 0.484
0.891GlyTrp: 0.891 ± 0.184
3.395GlyTyr: 3.395 ± 0.423
0.0GlyXaa: 0.0 ± 0.0
His
1.315HisAla: 1.315 ± 0.296
0.255HisCys: 0.255 ± 0.116
1.018HisAsp: 1.018 ± 0.255
1.103HisGlu: 1.103 ± 0.187
0.721HisPhe: 0.721 ± 0.211
1.655HisGly: 1.655 ± 0.355
0.721HisHis: 0.721 ± 0.224
1.612HisIle: 1.612 ± 0.311
1.485HisLys: 1.485 ± 0.195
1.612HisLeu: 1.612 ± 0.282
0.509HisMet: 0.509 ± 0.153
0.721HisAsn: 0.721 ± 0.175
1.061HisPro: 1.061 ± 0.253
0.849HisGln: 0.849 ± 0.242
0.849HisArg: 0.849 ± 0.218
0.806HisSer: 0.806 ± 0.198
0.976HisThr: 0.976 ± 0.258
1.103HisVal: 1.103 ± 0.237
0.297HisTrp: 0.297 ± 0.126
0.934HisTyr: 0.934 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
5.474IleAla: 5.474 ± 0.525
0.424IleCys: 0.424 ± 0.161
3.946IleAsp: 3.946 ± 0.472
3.395IleGlu: 3.395 ± 0.354
1.146IlePhe: 1.146 ± 0.229
3.267IleGly: 3.267 ± 0.427
1.146IleHis: 1.146 ± 0.271
2.461IleIle: 2.461 ± 0.378
3.649IleLys: 3.649 ± 0.579
3.989IleLeu: 3.989 ± 0.391
1.528IleMet: 1.528 ± 0.257
2.801IleAsn: 2.801 ± 0.323
3.055IlePro: 3.055 ± 0.333
2.376IleGln: 2.376 ± 0.331
3.183IleArg: 3.183 ± 0.312
1.867IleSer: 1.867 ± 0.305
4.074IleThr: 4.074 ± 0.526
3.395IleVal: 3.395 ± 0.367
0.849IleTrp: 0.849 ± 0.187
1.782IleTyr: 1.782 ± 0.374
0.0IleXaa: 0.0 ± 0.0
Lys
6.747LysAla: 6.747 ± 0.634
0.255LysCys: 0.255 ± 0.101
3.225LysAsp: 3.225 ± 0.405
3.437LysGlu: 3.437 ± 0.493
1.994LysPhe: 1.994 ± 0.312
3.225LysGly: 3.225 ± 0.365
1.485LysHis: 1.485 ± 0.32
2.546LysIle: 2.546 ± 0.351
3.267LysLys: 3.267 ± 0.553
5.559LysLeu: 5.559 ± 0.708
2.079LysMet: 2.079 ± 0.493
2.461LysAsn: 2.461 ± 0.381
3.734LysPro: 3.734 ± 0.511
3.183LysGln: 3.183 ± 0.425
2.928LysArg: 2.928 ± 0.469
3.777LysSer: 3.777 ± 0.438
3.607LysThr: 3.607 ± 0.407
3.989LysVal: 3.989 ± 0.462
0.891LysTrp: 0.891 ± 0.206
2.249LysTyr: 2.249 ± 0.367
0.0LysXaa: 0.0 ± 0.0
Leu
8.36LeuAla: 8.36 ± 0.525
0.764LeuCys: 0.764 ± 0.225
5.389LeuAsp: 5.389 ± 0.648
5.516LeuGlu: 5.516 ± 0.543
2.801LeuPhe: 2.801 ± 0.423
6.153LeuGly: 6.153 ± 0.595
1.994LeuHis: 1.994 ± 0.373
4.413LeuIle: 4.413 ± 0.542
5.05LeuLys: 5.05 ± 0.74
7.341LeuLeu: 7.341 ± 0.792
2.164LeuMet: 2.164 ± 0.298
4.88LeuAsn: 4.88 ± 0.478
4.074LeuPro: 4.074 ± 0.588
3.904LeuGln: 3.904 ± 0.463
4.456LeuArg: 4.456 ± 0.402
5.347LeuSer: 5.347 ± 0.483
5.686LeuThr: 5.686 ± 0.59
5.474LeuVal: 5.474 ± 0.547
0.637LeuTrp: 0.637 ± 0.157
2.801LeuTyr: 2.801 ± 0.37
0.0LeuXaa: 0.0 ± 0.0
Met
3.055MetAla: 3.055 ± 0.418
0.17MetCys: 0.17 ± 0.077
1.358MetAsp: 1.358 ± 0.278
1.103MetGlu: 1.103 ± 0.192
1.061MetPhe: 1.061 ± 0.25
2.079MetGly: 2.079 ± 0.32
0.509MetHis: 0.509 ± 0.13
1.612MetIle: 1.612 ± 0.233
1.74MetLys: 1.74 ± 0.358
2.164MetLeu: 2.164 ± 0.344
0.849MetMet: 0.849 ± 0.169
1.528MetAsn: 1.528 ± 0.242
1.315MetPro: 1.315 ± 0.237
1.57MetGln: 1.57 ± 0.328
1.867MetArg: 1.867 ± 0.307
1.867MetSer: 1.867 ± 0.272
2.122MetThr: 2.122 ± 0.341
1.697MetVal: 1.697 ± 0.268
0.17MetTrp: 0.17 ± 0.082
0.849MetTyr: 0.849 ± 0.146
0.0MetXaa: 0.0 ± 0.0
Asn
5.007AsnAla: 5.007 ± 0.624
0.552AsnCys: 0.552 ± 0.166
2.291AsnAsp: 2.291 ± 0.331
2.164AsnGlu: 2.164 ± 0.236
1.697AsnPhe: 1.697 ± 0.25
4.328AsnGly: 4.328 ± 0.448
1.103AsnHis: 1.103 ± 0.164
2.291AsnIle: 2.291 ± 0.302
3.395AsnLys: 3.395 ± 0.41
5.304AsnLeu: 5.304 ± 0.33
1.061AsnMet: 1.061 ± 0.218
3.013AsnAsn: 3.013 ± 0.445
3.31AsnPro: 3.31 ± 0.575
2.716AsnGln: 2.716 ± 0.417
3.14AsnArg: 3.14 ± 0.457
2.801AsnSer: 2.801 ± 0.374
3.692AsnThr: 3.692 ± 0.465
2.758AsnVal: 2.758 ± 0.33
0.721AsnTrp: 0.721 ± 0.163
1.273AsnTyr: 1.273 ± 0.207
0.0AsnXaa: 0.0 ± 0.0
Pro
4.286ProAla: 4.286 ± 0.587
0.424ProCys: 0.424 ± 0.127
3.225ProAsp: 3.225 ± 0.38
4.456ProGlu: 4.456 ± 0.558
1.655ProPhe: 1.655 ± 0.239
2.97ProGly: 2.97 ± 0.371
0.552ProHis: 0.552 ± 0.13
2.419ProIle: 2.419 ± 0.377
2.334ProLys: 2.334 ± 0.437
3.013ProLeu: 3.013 ± 0.381
1.315ProMet: 1.315 ± 0.222
2.164ProAsn: 2.164 ± 0.363
1.061ProPro: 1.061 ± 0.248
1.655ProGln: 1.655 ± 0.278
1.4ProArg: 1.4 ± 0.215
2.419ProSer: 2.419 ± 0.29
2.631ProThr: 2.631 ± 0.371
3.31ProVal: 3.31 ± 0.413
0.382ProTrp: 0.382 ± 0.147
1.358ProTyr: 1.358 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
4.286GlnAla: 4.286 ± 0.66
0.382GlnCys: 0.382 ± 0.141
2.461GlnAsp: 2.461 ± 0.355
1.994GlnGlu: 1.994 ± 0.262
1.952GlnPhe: 1.952 ± 0.3
2.97GlnGly: 2.97 ± 0.392
0.764GlnHis: 0.764 ± 0.172
2.928GlnIle: 2.928 ± 0.266
2.588GlnLys: 2.588 ± 0.281
5.05GlnLeu: 5.05 ± 0.703
1.315GlnMet: 1.315 ± 0.298
2.546GlnAsn: 2.546 ± 0.494
2.079GlnPro: 2.079 ± 0.484
3.098GlnGln: 3.098 ± 0.605
2.588GlnArg: 2.588 ± 0.571
2.334GlnSer: 2.334 ± 0.435
2.886GlnThr: 2.886 ± 0.434
2.631GlnVal: 2.631 ± 0.461
0.382GlnTrp: 0.382 ± 0.127
1.867GlnTyr: 1.867 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
4.922ArgAla: 4.922 ± 0.768
0.382ArgCys: 0.382 ± 0.143
3.183ArgAsp: 3.183 ± 0.498
3.098ArgGlu: 3.098 ± 0.466
2.164ArgPhe: 2.164 ± 0.349
2.334ArgGly: 2.334 ± 0.306
0.976ArgHis: 0.976 ± 0.214
3.31ArgIle: 3.31 ± 0.434
3.352ArgLys: 3.352 ± 0.416
4.031ArgLeu: 4.031 ± 0.47
1.188ArgMet: 1.188 ± 0.244
3.437ArgAsn: 3.437 ± 0.465
1.273ArgPro: 1.273 ± 0.203
2.079ArgGln: 2.079 ± 0.351
3.352ArgArg: 3.352 ± 0.375
2.588ArgSer: 2.588 ± 0.352
2.504ArgThr: 2.504 ± 0.31
3.267ArgVal: 3.267 ± 0.364
0.679ArgTrp: 0.679 ± 0.173
1.4ArgTyr: 1.4 ± 0.263
0.0ArgXaa: 0.0 ± 0.0
Ser
4.498SerAla: 4.498 ± 0.604
0.637SerCys: 0.637 ± 0.208
3.225SerAsp: 3.225 ± 0.441
3.013SerGlu: 3.013 ± 0.336
1.867SerPhe: 1.867 ± 0.229
4.922SerGly: 4.922 ± 0.591
0.552SerHis: 0.552 ± 0.17
2.843SerIle: 2.843 ± 0.38
3.649SerLys: 3.649 ± 0.336
5.347SerLeu: 5.347 ± 0.508
1.74SerMet: 1.74 ± 0.28
2.97SerAsn: 2.97 ± 0.373
2.122SerPro: 2.122 ± 0.309
2.758SerGln: 2.758 ± 0.376
2.079SerArg: 2.079 ± 0.253
3.098SerSer: 3.098 ± 0.387
3.649SerThr: 3.649 ± 0.392
4.074SerVal: 4.074 ± 0.452
1.018SerTrp: 1.018 ± 0.238
1.612SerTyr: 1.612 ± 0.341
0.0SerXaa: 0.0 ± 0.0
Thr
6.323ThrAla: 6.323 ± 0.907
0.424ThrCys: 0.424 ± 0.143
5.135ThrAsp: 5.135 ± 0.513
3.522ThrGlu: 3.522 ± 0.47
2.079ThrPhe: 2.079 ± 0.283
5.262ThrGly: 5.262 ± 0.57
1.443ThrHis: 1.443 ± 0.225
3.31ThrIle: 3.31 ± 0.389
4.074ThrLys: 4.074 ± 0.408
4.837ThrLeu: 4.837 ± 0.388
1.146ThrMet: 1.146 ± 0.225
3.48ThrAsn: 3.48 ± 0.648
3.013ThrPro: 3.013 ± 0.388
2.546ThrGln: 2.546 ± 0.354
2.504ThrArg: 2.504 ± 0.402
3.607ThrSer: 3.607 ± 0.431
5.304ThrThr: 5.304 ± 1.294
4.159ThrVal: 4.159 ± 0.473
0.806ThrTrp: 0.806 ± 0.185
1.57ThrTyr: 1.57 ± 0.271
0.0ThrXaa: 0.0 ± 0.0
Val
5.347ValAla: 5.347 ± 0.596
0.552ValCys: 0.552 ± 0.162
3.819ValAsp: 3.819 ± 0.394
4.71ValGlu: 4.71 ± 0.42
2.079ValPhe: 2.079 ± 0.261
3.522ValGly: 3.522 ± 0.356
1.188ValHis: 1.188 ± 0.248
3.819ValIle: 3.819 ± 0.473
3.607ValLys: 3.607 ± 0.481
5.474ValLeu: 5.474 ± 0.479
1.782ValMet: 1.782 ± 0.275
3.607ValAsn: 3.607 ± 0.521
3.14ValPro: 3.14 ± 0.292
2.419ValGln: 2.419 ± 0.364
3.14ValArg: 3.14 ± 0.443
4.371ValSer: 4.371 ± 0.351
4.71ValThr: 4.71 ± 0.468
4.243ValVal: 4.243 ± 0.531
0.721ValTrp: 0.721 ± 0.133
2.334ValTyr: 2.334 ± 0.403
0.0ValXaa: 0.0 ± 0.0
Trp
1.231TrpAla: 1.231 ± 0.239
0.127TrpCys: 0.127 ± 0.075
0.721TrpAsp: 0.721 ± 0.198
0.637TrpGlu: 0.637 ± 0.165
0.467TrpPhe: 0.467 ± 0.162
0.849TrpGly: 0.849 ± 0.188
0.212TrpHis: 0.212 ± 0.101
0.467TrpIle: 0.467 ± 0.183
0.764TrpLys: 0.764 ± 0.233
1.528TrpLeu: 1.528 ± 0.294
0.297TrpMet: 0.297 ± 0.129
0.552TrpAsn: 0.552 ± 0.136
0.721TrpPro: 0.721 ± 0.224
0.721TrpGln: 0.721 ± 0.2
0.552TrpArg: 0.552 ± 0.166
0.806TrpSer: 0.806 ± 0.173
0.552TrpThr: 0.552 ± 0.153
1.018TrpVal: 1.018 ± 0.188
0.085TrpTrp: 0.085 ± 0.062
0.467TrpTyr: 0.467 ± 0.161
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.97TyrAla: 2.97 ± 0.321
0.339TyrCys: 0.339 ± 0.139
2.122TyrAsp: 2.122 ± 0.346
1.91TyrGlu: 1.91 ± 0.322
1.4TyrPhe: 1.4 ± 0.333
2.164TyrGly: 2.164 ± 0.313
0.806TyrHis: 0.806 ± 0.183
2.037TyrIle: 2.037 ± 0.398
1.867TyrLys: 1.867 ± 0.332
3.267TyrLeu: 3.267 ± 0.433
0.764TyrMet: 0.764 ± 0.174
1.825TyrAsn: 1.825 ± 0.268
1.146TyrPro: 1.146 ± 0.215
1.443TyrGln: 1.443 ± 0.202
2.164TyrArg: 2.164 ± 0.345
1.867TyrSer: 1.867 ± 0.312
1.57TyrThr: 1.57 ± 0.234
2.461TyrVal: 2.461 ± 0.29
0.594TyrTrp: 0.594 ± 0.188
1.443TyrTyr: 1.443 ± 0.293
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 97 proteins (23567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski