Amino acid dipepetide frequency for Haloactinobacterium album

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.777AlaAla: 18.777 ± 0.189	0.838AlaCys: 0.838 ± 0.025	8.535AlaAsp: 8.535 ± 0.089	9.035AlaGlu: 9.035 ± 0.096	3.458AlaPhe: 3.458 ± 0.052	12.547AlaGly: 12.547 ± 0.119	2.67AlaHis: 2.67 ± 0.052	4.899AlaIle: 4.899 ± 0.074	1.7AlaLys: 1.7 ± 0.045	13.124AlaLeu: 13.124 ± 0.123	2.768AlaMet: 2.768 ± 0.045	2.079AlaAsn: 2.079 ± 0.038	6.446AlaPro: 6.446 ± 0.076	4.025AlaGln: 4.025 ± 0.056	9.106AlaArg: 9.106 ± 0.09	6.393AlaSer: 6.393 ± 0.079	7.871AlaThr: 7.871 ± 0.08	11.652AlaVal: 11.652 ± 0.105	2.015AlaTrp: 2.015 ± 0.039	2.23AlaTyr: 2.23 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.76CysAla: 0.76 ± 0.021	0.065CysCys: 0.065 ± 0.006	0.388CysAsp: 0.388 ± 0.016	0.349CysGlu: 0.349 ± 0.017	0.17CysPhe: 0.17 ± 0.011	0.67CysGly: 0.67 ± 0.02	0.154CysHis: 0.154 ± 0.009	0.186CysIle: 0.186 ± 0.013	0.047CysLys: 0.047 ± 0.005	0.556CysLeu: 0.556 ± 0.018	0.095CysMet: 0.095 ± 0.009	0.12CysAsn: 0.12 ± 0.01	0.347CysPro: 0.347 ± 0.015	0.14CysGln: 0.14 ± 0.01	0.402CysArg: 0.402 ± 0.02	0.423CysSer: 0.423 ± 0.018	0.5CysThr: 0.5 ± 0.019	0.504CysVal: 0.504 ± 0.019	0.099CysTrp: 0.099 ± 0.008	0.132CysTyr: 0.132 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.065AspAla: 8.065 ± 0.098	0.297AspCys: 0.297 ± 0.015	4.139AspAsp: 4.139 ± 0.066	4.293AspGlu: 4.293 ± 0.061	1.565AspPhe: 1.565 ± 0.034	7.369AspGly: 7.369 ± 0.155	1.545AspHis: 1.545 ± 0.037	1.955AspIle: 1.955 ± 0.04	0.611AspLys: 0.611 ± 0.019	7.136AspLeu: 7.136 ± 0.086	0.866AspMet: 0.866 ± 0.024	0.904AspAsn: 0.904 ± 0.025	4.785AspPro: 4.785 ± 0.07	2.0AspGln: 2.0 ± 0.04	4.471AspArg: 4.471 ± 0.062	2.891AspSer: 2.891 ± 0.058	3.049AspThr: 3.049 ± 0.056	5.841AspVal: 5.841 ± 0.085	1.015AspTrp: 1.015 ± 0.029	1.277AspTyr: 1.277 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.463GluAla: 7.463 ± 0.087	0.306GluCys: 0.306 ± 0.019	3.288GluAsp: 3.288 ± 0.054	3.419GluGlu: 3.419 ± 0.057	1.605GluPhe: 1.605 ± 0.036	4.105GluGly: 4.105 ± 0.063	1.82GluHis: 1.82 ± 0.036	2.702GluIle: 2.702 ± 0.04	0.905GluLys: 0.905 ± 0.025	6.568GluLeu: 6.568 ± 0.067	1.079GluMet: 1.079 ± 0.029	1.294GluAsn: 1.294 ± 0.027	3.608GluPro: 3.608 ± 0.073	2.574GluGln: 2.574 ± 0.044	5.136GluArg: 5.136 ± 0.071	3.106GluSer: 3.106 ± 0.047	3.191GluThr: 3.191 ± 0.048	5.365GluVal: 5.365 ± 0.085	0.859GluTrp: 0.859 ± 0.024	1.208GluTyr: 1.208 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.717PheAla: 3.717 ± 0.056	0.199PheCys: 0.199 ± 0.012	2.145PheAsp: 2.145 ± 0.04	1.581PheGlu: 1.581 ± 0.034	1.024PhePhe: 1.024 ± 0.031	2.974PheGly: 2.974 ± 0.052	0.594PheHis: 0.594 ± 0.018	0.999PheIle: 0.999 ± 0.03	0.311PheLys: 0.311 ± 0.017	2.695PheLeu: 2.695 ± 0.047	0.412PheMet: 0.412 ± 0.018	0.58PheAsn: 0.58 ± 0.02	1.275PhePro: 1.275 ± 0.03	0.729PheGln: 0.729 ± 0.028	1.634PheArg: 1.634 ± 0.027	1.626PheSer: 1.626 ± 0.035	2.286PheThr: 2.286 ± 0.045	2.515PheVal: 2.515 ± 0.049	0.476PheTrp: 0.476 ± 0.022	0.67PheTyr: 0.67 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.923GlyAla: 10.923 ± 0.107	0.684GlyCys: 0.684 ± 0.023	5.151GlyAsp: 5.151 ± 0.076	5.546GlyGlu: 5.546 ± 0.075	2.737GlyPhe: 2.737 ± 0.048	7.943GlyGly: 7.943 ± 0.1	1.999GlyHis: 1.999 ± 0.046	3.892GlyIle: 3.892 ± 0.057	1.527GlyLys: 1.527 ± 0.036	9.041GlyLeu: 9.041 ± 0.115	2.068GlyMet: 2.068 ± 0.039	1.753GlyAsn: 1.753 ± 0.042	4.609GlyPro: 4.609 ± 0.062	2.863GlyGln: 2.863 ± 0.052	6.356GlyArg: 6.356 ± 0.066	5.559GlySer: 5.559 ± 0.069	6.419GlyThr: 6.419 ± 0.121	7.923GlyVal: 7.923 ± 0.095	1.779GlyTrp: 1.779 ± 0.043	2.421GlyTyr: 2.421 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.737HisAla: 2.737 ± 0.052	0.151HisCys: 0.151 ± 0.011	1.355HisAsp: 1.355 ± 0.032	1.313HisGlu: 1.313 ± 0.036	0.555HisPhe: 0.555 ± 0.019	2.267HisGly: 2.267 ± 0.047	0.674HisHis: 0.674 ± 0.022	0.654HisIle: 0.654 ± 0.024	0.217HisLys: 0.217 ± 0.013	2.621HisLeu: 2.621 ± 0.049	0.309HisMet: 0.309 ± 0.014	0.349HisAsn: 0.349 ± 0.016	1.708HisPro: 1.708 ± 0.032	0.712HisGln: 0.712 ± 0.019	1.902HisArg: 1.902 ± 0.035	1.006HisSer: 1.006 ± 0.027	1.311HisThr: 1.311 ± 0.032	1.911HisVal: 1.911 ± 0.037	0.369HisTrp: 0.369 ± 0.016	0.487HisTyr: 0.487 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.905IleAla: 5.905 ± 0.064	0.268IleCys: 0.268 ± 0.015	3.038IleAsp: 3.038 ± 0.052	2.491IleGlu: 2.491 ± 0.045	1.067IlePhe: 1.067 ± 0.034	4.175IleGly: 4.175 ± 0.062	0.616IleHis: 0.616 ± 0.021	1.326IleIle: 1.326 ± 0.037	0.515IleLys: 0.515 ± 0.019	3.061IleLeu: 3.061 ± 0.047	0.543IleMet: 0.543 ± 0.017	0.777IleAsn: 0.777 ± 0.03	2.175IlePro: 2.175 ± 0.04	0.83IleGln: 0.83 ± 0.022	2.342IleArg: 2.342 ± 0.041	2.243IleSer: 2.243 ± 0.044	2.831IleThr: 2.831 ± 0.043	3.56IleVal: 3.56 ± 0.057	0.516IleTrp: 0.516 ± 0.02	0.739IleTyr: 0.739 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	1.571LysAla: 1.571 ± 0.036	0.052LysCys: 0.052 ± 0.006	0.79LysAsp: 0.79 ± 0.025	0.716LysGlu: 0.716 ± 0.024	0.345LysPhe: 0.345 ± 0.015	1.082LysGly: 1.082 ± 0.028	0.356LysHis: 0.356 ± 0.017	0.606LysIle: 0.606 ± 0.02	0.409LysLys: 0.409 ± 0.028	1.11LysLeu: 1.11 ± 0.031	0.269LysMet: 0.269 ± 0.012	0.364LysAsn: 0.364 ± 0.017	0.754LysPro: 0.754 ± 0.024	0.447LysGln: 0.447 ± 0.018	1.015LysArg: 1.015 ± 0.029	0.789LysSer: 0.789 ± 0.027	0.77LysThr: 0.77 ± 0.024	1.197LysVal: 1.197 ± 0.035	0.168LysTrp: 0.168 ± 0.011	0.333LysTyr: 0.333 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.793LeuAla: 14.793 ± 0.128	0.606LeuCys: 0.606 ± 0.022	6.835LeuAsp: 6.835 ± 0.074	5.202LeuGlu: 5.202 ± 0.065	2.624LeuPhe: 2.624 ± 0.048	9.042LeuGly: 9.042 ± 0.105	2.143LeuHis: 2.143 ± 0.043	3.867LeuIle: 3.867 ± 0.054	1.138LeuLys: 1.138 ± 0.032	10.285LeuLeu: 10.285 ± 0.13	1.665LeuMet: 1.665 ± 0.033	1.809LeuAsn: 1.809 ± 0.035	5.894LeuPro: 5.894 ± 0.125	2.49LeuGln: 2.49 ± 0.041	7.47LeuArg: 7.47 ± 0.085	5.236LeuSer: 5.236 ± 0.061	7.384LeuThr: 7.384 ± 0.085	9.159LeuVal: 9.159 ± 0.093	1.349LeuTrp: 1.349 ± 0.033	1.749LeuTyr: 1.749 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.378MetAla: 2.378 ± 0.049	0.11MetCys: 0.11 ± 0.01	0.906MetAsp: 0.906 ± 0.028	0.694MetGlu: 0.694 ± 0.021	0.579MetPhe: 0.579 ± 0.022	1.316MetGly: 1.316 ± 0.034	0.362MetHis: 0.362 ± 0.016	0.909MetIle: 0.909 ± 0.03	0.339MetLys: 0.339 ± 0.015	2.021MetLeu: 2.021 ± 0.035	0.325MetMet: 0.325 ± 0.016	0.493MetAsn: 0.493 ± 0.018	1.149MetPro: 1.149 ± 0.032	0.516MetGln: 0.516 ± 0.017	1.448MetArg: 1.448 ± 0.026	1.489MetSer: 1.489 ± 0.032	1.714MetThr: 1.714 ± 0.036	1.621MetVal: 1.621 ± 0.031	0.233MetTrp: 0.233 ± 0.013	0.344MetTyr: 0.344 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.254AsnAla: 2.254 ± 0.038	0.099AsnCys: 0.099 ± 0.009	1.135AsnAsp: 1.135 ± 0.03	1.041AsnGlu: 1.041 ± 0.03	0.6AsnPhe: 0.6 ± 0.026	1.815AsnGly: 1.815 ± 0.047	0.409AsnHis: 0.409 ± 0.017	0.701AsnIle: 0.701 ± 0.022	0.248AsnLys: 0.248 ± 0.015	1.831AsnLeu: 1.831 ± 0.037	0.294AsnMet: 0.294 ± 0.015	0.424AsnAsn: 0.424 ± 0.018	1.458AsnPro: 1.458 ± 0.031	0.554AsnGln: 0.554 ± 0.024	1.207AsnArg: 1.207 ± 0.03	1.037AsnSer: 1.037 ± 0.03	1.187AsnThr: 1.187 ± 0.032	1.609AsnVal: 1.609 ± 0.036	0.313AsnTrp: 0.313 ± 0.017	0.548AsnTyr: 0.548 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.256ProAla: 7.256 ± 0.079	0.257ProCys: 0.257 ± 0.013	4.786ProAsp: 4.786 ± 0.068	4.525ProGlu: 4.525 ± 0.084	1.639ProPhe: 1.639 ± 0.034	5.872ProGly: 5.872 ± 0.117	1.325ProHis: 1.325 ± 0.037	1.853ProIle: 1.853 ± 0.034	0.663ProLys: 0.663 ± 0.023	4.712ProLeu: 4.712 ± 0.067	1.131ProMet: 1.131 ± 0.027	1.104ProAsn: 1.104 ± 0.029	3.068ProPro: 3.068 ± 0.066	1.7ProGln: 1.7 ± 0.036	3.416ProArg: 3.416 ± 0.049	3.281ProSer: 3.281 ± 0.049	3.788ProThr: 3.788 ± 0.054	5.102ProVal: 5.102 ± 0.069	1.006ProTrp: 1.006 ± 0.025	1.159ProTyr: 1.159 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.774GlnAla: 3.774 ± 0.058	0.146GlnCys: 0.146 ± 0.01	1.49GlnAsp: 1.49 ± 0.033	1.459GlnGlu: 1.459 ± 0.032	0.971GlnPhe: 0.971 ± 0.025	2.09GlnGly: 2.09 ± 0.036	0.781GlnHis: 0.781 ± 0.025	1.487GlnIle: 1.487 ± 0.032	0.403GlnLys: 0.403 ± 0.017	3.177GlnLeu: 3.177 ± 0.046	0.658GlnMet: 0.658 ± 0.023	0.595GlnAsn: 0.595 ± 0.021	1.708GlnPro: 1.708 ± 0.04	1.262GlnGln: 1.262 ± 0.039	2.376GlnArg: 2.376 ± 0.045	1.427GlnSer: 1.427 ± 0.027	1.568GlnThr: 1.568 ± 0.034	3.38GlnVal: 3.38 ± 0.049	0.555GlnTrp: 0.555 ± 0.019	0.629GlnTyr: 0.629 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.805ArgAla: 8.805 ± 0.098	0.468ArgCys: 0.468 ± 0.019	4.097ArgAsp: 4.097 ± 0.054	4.293ArgGlu: 4.293 ± 0.057	2.076ArgPhe: 2.076 ± 0.04	5.241ArgGly: 5.241 ± 0.069	1.828ArgHis: 1.828 ± 0.038	3.11ArgIle: 3.11 ± 0.053	1.076ArgLys: 1.076 ± 0.032	7.269ArgLeu: 7.269 ± 0.079	1.743ArgMet: 1.743 ± 0.036	1.257ArgAsn: 1.257 ± 0.027	4.035ArgPro: 4.035 ± 0.059	2.183ArgGln: 2.183 ± 0.044	6.88ArgArg: 6.88 ± 0.099	4.328ArgSer: 4.328 ± 0.054	4.985ArgThr: 4.985 ± 0.071	5.736ArgVal: 5.736 ± 0.059	1.392ArgTrp: 1.392 ± 0.031	1.668ArgTyr: 1.668 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.952SerAla: 6.952 ± 0.077	0.313SerCys: 0.313 ± 0.015	3.366SerAsp: 3.366 ± 0.059	2.984SerGlu: 2.984 ± 0.047	1.685SerPhe: 1.685 ± 0.036	6.042SerGly: 6.042 ± 0.077	1.046SerHis: 1.046 ± 0.026	2.123SerIle: 2.123 ± 0.042	0.707SerLys: 0.707 ± 0.024	5.1SerLeu: 5.1 ± 0.07	1.311SerMet: 1.311 ± 0.028	1.024SerAsn: 1.024 ± 0.028	3.125SerPro: 3.125 ± 0.052	1.383SerGln: 1.383 ± 0.034	3.666SerArg: 3.666 ± 0.051	3.286SerSer: 3.286 ± 0.07	3.958SerThr: 3.958 ± 0.059	4.567SerVal: 4.567 ± 0.055	1.026SerTrp: 1.026 ± 0.031	1.213SerTyr: 1.213 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.383ThrAla: 8.383 ± 0.079	0.417ThrCys: 0.417 ± 0.019	4.62ThrAsp: 4.62 ± 0.148	3.806ThrGlu: 3.806 ± 0.051	2.111ThrPhe: 2.111 ± 0.043	6.318ThrGly: 6.318 ± 0.073	1.302ThrHis: 1.302 ± 0.031	2.751ThrIle: 2.751 ± 0.047	0.834ThrLys: 0.834 ± 0.026	6.236ThrLeu: 6.236 ± 0.064	1.256ThrMet: 1.256 ± 0.028	1.186ThrAsn: 1.186 ± 0.036	4.014ThrPro: 4.014 ± 0.055	1.631ThrGln: 1.631 ± 0.039	3.881ThrArg: 3.881 ± 0.057	3.842ThrSer: 3.842 ± 0.06	4.279ThrThr: 4.279 ± 0.06	6.163ThrVal: 6.163 ± 0.082	1.227ThrTrp: 1.227 ± 0.033	1.428ThrTyr: 1.428 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.458ValAla: 11.458 ± 0.104	0.544ValCys: 0.544 ± 0.022	5.663ValAsp: 5.663 ± 0.07	4.918ValGlu: 4.918 ± 0.068	2.39ValPhe: 2.39 ± 0.042	7.223ValGly: 7.223 ± 0.101	2.157ValHis: 2.157 ± 0.038	3.75ValIle: 3.75 ± 0.055	1.015ValLys: 1.015 ± 0.029	10.148ValLeu: 10.148 ± 0.1	1.538ValMet: 1.538 ± 0.035	1.71ValAsn: 1.71 ± 0.034	5.389ValPro: 5.389 ± 0.069	2.506ValGln: 2.506 ± 0.045	6.663ValArg: 6.663 ± 0.076	4.745ValSer: 4.745 ± 0.056	6.326ValThr: 6.326 ± 0.097	8.747ValVal: 8.747 ± 0.089	1.191ValTrp: 1.191 ± 0.029	1.488ValTyr: 1.488 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.032	0.137TrpCys: 0.137 ± 0.009	0.95TrpAsp: 0.95 ± 0.028	0.833TrpGlu: 0.833 ± 0.025	0.56TrpPhe: 0.56 ± 0.021	1.142TrpGly: 1.142 ± 0.032	0.438TrpHis: 0.438 ± 0.018	0.643TrpIle: 0.643 ± 0.022	0.239TrpLys: 0.239 ± 0.013	1.788TrpLeu: 1.788 ± 0.034	0.358TrpMet: 0.358 ± 0.015	0.499TrpAsn: 0.499 ± 0.021	0.921TrpPro: 0.921 ± 0.027	0.674TrpGln: 0.674 ± 0.021	1.374TrpArg: 1.374 ± 0.034	1.095TrpSer: 1.095 ± 0.028	1.014TrpThr: 1.014 ± 0.026	1.328TrpVal: 1.328 ± 0.03	0.451TrpTrp: 0.451 ± 0.018	0.324TrpTyr: 0.324 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.517TyrAla: 2.517 ± 0.037	0.147TyrCys: 0.147 ± 0.01	1.397TyrAsp: 1.397 ± 0.031	1.104TyrGlu: 1.104 ± 0.027	0.681TyrPhe: 0.681 ± 0.023	1.961TyrGly: 1.961 ± 0.035	0.389TyrHis: 0.389 ± 0.017	0.603TyrIle: 0.603 ± 0.02	0.236TyrLys: 0.236 ± 0.011	2.261TyrLeu: 2.261 ± 0.043	0.259TyrMet: 0.259 ± 0.013	0.444TyrAsn: 0.444 ± 0.017	1.173TyrPro: 1.173 ± 0.026	0.721TyrGln: 0.721 ± 0.021	1.726TyrArg: 1.726 ± 0.042	1.077TyrSer: 1.077 ± 0.031	1.256TyrThr: 1.256 ± 0.032	1.689TyrVal: 1.689 ± 0.036	0.408TyrTrp: 0.408 ± 0.017	0.52TyrTyr: 0.52 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4192 proteins (1448774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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