Amino acid dipepetide frequency for Nitrolancea hollandica Lb

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.183AlaAla: 13.183 ± 0.146
0.91AlaCys: 0.91 ± 0.037
5.459AlaAsp: 5.459 ± 0.078
6.743AlaGlu: 6.743 ± 0.106
3.584AlaPhe: 3.584 ± 0.069
10.361AlaGly: 10.361 ± 0.119
1.958AlaHis: 1.958 ± 0.044
6.237AlaIle: 6.237 ± 0.089
2.593AlaLys: 2.593 ± 0.056
11.593AlaLeu: 11.593 ± 0.129
2.557AlaMet: 2.557 ± 0.042
2.641AlaAsn: 2.641 ± 0.06
4.733AlaPro: 4.733 ± 0.078
3.32AlaGln: 3.32 ± 0.062
8.246AlaArg: 8.246 ± 0.106
5.751AlaSer: 5.751 ± 0.079
5.656AlaThr: 5.656 ± 0.071
8.433AlaVal: 8.433 ± 0.103
1.54AlaTrp: 1.54 ± 0.045
2.527AlaTyr: 2.527 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.774CysAla: 0.774 ± 0.031
0.127CysCys: 0.127 ± 0.013
0.486CysAsp: 0.486 ± 0.023
0.388CysGlu: 0.388 ± 0.022
0.278CysPhe: 0.278 ± 0.017
0.852CysGly: 0.852 ± 0.031
0.269CysHis: 0.269 ± 0.016
0.3CysIle: 0.3 ± 0.019
0.154CysLys: 0.154 ± 0.012
0.765CysLeu: 0.765 ± 0.029
0.133CysMet: 0.133 ± 0.012
0.211CysAsn: 0.211 ± 0.014
0.643CysPro: 0.643 ± 0.028
0.314CysGln: 0.314 ± 0.018
0.739CysArg: 0.739 ± 0.031
0.523CysSer: 0.523 ± 0.027
0.43CysThr: 0.43 ± 0.022
0.483CysVal: 0.483 ± 0.022
0.18CysTrp: 0.18 ± 0.014
0.236CysTyr: 0.236 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.473AspAla: 5.473 ± 0.082
0.452AspCys: 0.452 ± 0.021
2.956AspAsp: 2.956 ± 0.06
3.475AspGlu: 3.475 ± 0.06
1.719AspPhe: 1.719 ± 0.043
4.873AspGly: 4.873 ± 0.083
1.313AspHis: 1.313 ± 0.04
2.842AspIle: 2.842 ± 0.056
1.02AspLys: 1.02 ± 0.035
6.342AspLeu: 6.342 ± 0.097
0.887AspMet: 0.887 ± 0.03
1.073AspAsn: 1.073 ± 0.039
3.694AspPro: 3.694 ± 0.073
2.195AspGln: 2.195 ± 0.048
4.59AspArg: 4.59 ± 0.077
2.396AspSer: 2.396 ± 0.053
2.586AspThr: 2.586 ± 0.058
4.084AspVal: 4.084 ± 0.078
1.006AspTrp: 1.006 ± 0.036
1.367AspTyr: 1.367 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.467GluAla: 6.467 ± 0.1
0.435GluCys: 0.435 ± 0.024
2.632GluAsp: 2.632 ± 0.052
3.873GluGlu: 3.873 ± 0.08
1.87GluPhe: 1.87 ± 0.044
3.719GluGly: 3.719 ± 0.069
1.59GluHis: 1.59 ± 0.04
3.724GluIle: 3.724 ± 0.068
1.479GluLys: 1.479 ± 0.042
5.998GluLeu: 5.998 ± 0.091
1.426GluMet: 1.426 ± 0.04
1.31GluAsn: 1.31 ± 0.038
3.491GluPro: 3.491 ± 0.071
3.01GluGln: 3.01 ± 0.069
6.265GluArg: 6.265 ± 0.095
2.997GluSer: 2.997 ± 0.054
3.309GluThr: 3.309 ± 0.063
4.155GluVal: 4.155 ± 0.077
0.768GluTrp: 0.768 ± 0.031
1.229GluTyr: 1.229 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.314PheAla: 3.314 ± 0.063
0.299PheCys: 0.299 ± 0.019
2.133PheAsp: 2.133 ± 0.047
1.843PheGlu: 1.843 ± 0.046
1.281PhePhe: 1.281 ± 0.045
3.168PheGly: 3.168 ± 0.066
0.769PheHis: 0.769 ± 0.027
1.607PheIle: 1.607 ± 0.045
0.673PheLys: 0.673 ± 0.03
3.305PheLeu: 3.305 ± 0.066
0.589PheMet: 0.589 ± 0.023
0.911PheAsn: 0.911 ± 0.029
1.852PhePro: 1.852 ± 0.047
1.147PheGln: 1.147 ± 0.035
2.321PheArg: 2.321 ± 0.054
2.13PheSer: 2.13 ± 0.058
2.052PheThr: 2.052 ± 0.05
2.51PheVal: 2.51 ± 0.052
0.573PheTrp: 0.573 ± 0.028
0.952PheTyr: 0.952 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.802GlyAla: 7.802 ± 0.098
0.847GlyCys: 0.847 ± 0.032
4.354GlyAsp: 4.354 ± 0.063
4.693GlyGlu: 4.693 ± 0.08
3.058GlyPhe: 3.058 ± 0.058
6.665GlyGly: 6.665 ± 0.11
1.955GlyHis: 1.955 ± 0.047
5.124GlyIle: 5.124 ± 0.075
2.662GlyLys: 2.662 ± 0.062
8.487GlyLeu: 8.487 ± 0.11
2.271GlyMet: 2.271 ± 0.05
2.348GlyAsn: 2.348 ± 0.062
3.792GlyPro: 3.792 ± 0.073
3.168GlyGln: 3.168 ± 0.065
6.363GlyArg: 6.363 ± 0.083
5.13GlySer: 5.13 ± 0.089
5.267GlyThr: 5.267 ± 0.087
5.971GlyVal: 5.971 ± 0.087
1.581GlyTrp: 1.581 ± 0.041
2.484GlyTyr: 2.484 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.109HisAla: 2.109 ± 0.048
0.224HisCys: 0.224 ± 0.016
1.26HisAsp: 1.26 ± 0.033
1.222HisGlu: 1.222 ± 0.039
0.756HisPhe: 0.756 ± 0.03
2.104HisGly: 2.104 ± 0.053
0.719HisHis: 0.719 ± 0.031
0.886HisIle: 0.886 ± 0.029
0.383HisLys: 0.383 ± 0.023
2.436HisLeu: 2.436 ± 0.052
0.345HisMet: 0.345 ± 0.018
0.504HisAsn: 0.504 ± 0.022
1.689HisPro: 1.689 ± 0.041
0.903HisGln: 0.903 ± 0.035
1.879HisArg: 1.879 ± 0.046
1.05HisSer: 1.05 ± 0.041
1.106HisThr: 1.106 ± 0.033
1.587HisVal: 1.587 ± 0.036
0.392HisTrp: 0.392 ± 0.023
0.692HisTyr: 0.692 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.432IleAla: 6.432 ± 0.088
0.451IleCys: 0.451 ± 0.021
3.616IleAsp: 3.616 ± 0.07
3.594IleGlu: 3.594 ± 0.064
1.645IlePhe: 1.645 ± 0.041
4.93IleGly: 4.93 ± 0.091
1.11IleHis: 1.11 ± 0.03
2.734IleIle: 2.734 ± 0.059
1.26IleLys: 1.26 ± 0.039
5.149IleLeu: 5.149 ± 0.079
0.87IleMet: 0.87 ± 0.032
1.371IleAsn: 1.371 ± 0.037
3.341IlePro: 3.341 ± 0.056
1.852IleGln: 1.852 ± 0.039
3.817IleArg: 3.817 ± 0.064
2.963IleSer: 2.963 ± 0.059
3.088IleThr: 3.088 ± 0.054
4.32IleVal: 4.32 ± 0.068
0.669IleTrp: 0.669 ± 0.026
1.223IleTyr: 1.223 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.459LysAla: 2.459 ± 0.051
0.151LysCys: 0.151 ± 0.012
1.221LysAsp: 1.221 ± 0.04
1.328LysGlu: 1.328 ± 0.042
0.614LysPhe: 0.614 ± 0.024
1.643LysGly: 1.643 ± 0.045
0.536LysHis: 0.536 ± 0.023
1.351LysIle: 1.351 ± 0.039
0.73LysLys: 0.73 ± 0.033
2.336LysLeu: 2.336 ± 0.054
0.514LysMet: 0.514 ± 0.022
0.675LysAsn: 0.675 ± 0.029
1.592LysPro: 1.592 ± 0.052
1.009LysGln: 1.009 ± 0.031
2.097LysArg: 2.097 ± 0.05
1.269LysSer: 1.269 ± 0.039
1.426LysThr: 1.426 ± 0.04
1.769LysVal: 1.769 ± 0.048
0.302LysTrp: 0.302 ± 0.014
0.542LysTyr: 0.542 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
12.797LeuAla: 12.797 ± 0.146
0.715LeuCys: 0.715 ± 0.028
5.708LeuAsp: 5.708 ± 0.087
5.705LeuGlu: 5.705 ± 0.107
3.441LeuPhe: 3.441 ± 0.076
8.488LeuGly: 8.488 ± 0.117
2.078LeuHis: 2.078 ± 0.046
5.53LeuIle: 5.53 ± 0.098
2.434LeuLys: 2.434 ± 0.051
11.194LeuLeu: 11.194 ± 0.155
1.911LeuMet: 1.911 ± 0.051
2.564LeuAsn: 2.564 ± 0.052
5.999LeuPro: 5.999 ± 0.095
3.221LeuGln: 3.221 ± 0.056
8.068LeuArg: 8.068 ± 0.101
5.955LeuSer: 5.955 ± 0.095
6.151LeuThr: 6.151 ± 0.084
8.057LeuVal: 8.057 ± 0.107
1.381LeuTrp: 1.381 ± 0.05
2.291LeuTyr: 2.291 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.613MetAla: 2.613 ± 0.056
0.116MetCys: 0.116 ± 0.01
0.992MetAsp: 0.992 ± 0.035
1.037MetGlu: 1.037 ± 0.028
0.561MetPhe: 0.561 ± 0.028
1.516MetGly: 1.516 ± 0.037
0.413MetHis: 0.413 ± 0.02
1.329MetIle: 1.329 ± 0.036
0.562MetLys: 0.562 ± 0.025
2.268MetLeu: 2.268 ± 0.051
0.487MetMet: 0.487 ± 0.024
0.632MetAsn: 0.632 ± 0.024
1.377MetPro: 1.377 ± 0.042
0.562MetGln: 0.562 ± 0.026
1.579MetArg: 1.579 ± 0.038
1.317MetSer: 1.317 ± 0.039
1.551MetThr: 1.551 ± 0.037
1.734MetVal: 1.734 ± 0.042
0.197MetTrp: 0.197 ± 0.017
0.376MetTyr: 0.376 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.674AsnAla: 2.674 ± 0.055
0.229AsnCys: 0.229 ± 0.016
1.311AsnAsp: 1.311 ± 0.044
1.281AsnGlu: 1.281 ± 0.039
0.715AsnPhe: 0.715 ± 0.031
2.487AsnGly: 2.487 ± 0.056
0.631AsnHis: 0.631 ± 0.029
1.177AsnIle: 1.177 ± 0.031
0.489AsnLys: 0.489 ± 0.027
2.533AsnLeu: 2.533 ± 0.056
0.413AsnMet: 0.413 ± 0.018
0.624AsnAsn: 0.624 ± 0.031
2.051AsnPro: 2.051 ± 0.051
1.037AsnGln: 1.037 ± 0.037
2.021AsnArg: 2.021 ± 0.045
1.193AsnSer: 1.193 ± 0.043
1.256AsnThr: 1.256 ± 0.047
1.919AsnVal: 1.919 ± 0.049
0.47AsnTrp: 0.47 ± 0.022
0.611AsnTyr: 0.611 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.664ProAla: 6.664 ± 0.092
0.42ProCys: 0.42 ± 0.02
4.086ProAsp: 4.086 ± 0.078
4.51ProGlu: 4.51 ± 0.074
1.969ProPhe: 1.969 ± 0.052
5.41ProGly: 5.41 ± 0.08
1.129ProHis: 1.129 ± 0.043
2.594ProIle: 2.594 ± 0.05
1.336ProLys: 1.336 ± 0.04
5.169ProLeu: 5.169 ± 0.081
1.074ProMet: 1.074 ± 0.033
1.533ProAsn: 1.533 ± 0.042
3.537ProPro: 3.537 ± 0.096
1.444ProGln: 1.444 ± 0.039
3.61ProArg: 3.61 ± 0.072
3.64ProSer: 3.64 ± 0.078
2.804ProThr: 2.804 ± 0.056
5.188ProVal: 5.188 ± 0.079
0.871ProTrp: 0.871 ± 0.029
1.349ProTyr: 1.349 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.29GlnAla: 4.29 ± 0.079
0.233GlnCys: 0.233 ± 0.016
1.56GlnAsp: 1.56 ± 0.043
2.139GlnGlu: 2.139 ± 0.05
1.111GlnPhe: 1.111 ± 0.035
2.46GlnGly: 2.46 ± 0.053
0.9GlnHis: 0.9 ± 0.028
1.905GlnIle: 1.905 ± 0.047
0.73GlnLys: 0.73 ± 0.032
3.416GlnLeu: 3.416 ± 0.064
0.795GlnMet: 0.795 ± 0.031
0.777GlnAsn: 0.777 ± 0.028
2.429GlnPro: 2.429 ± 0.051
1.76GlnGln: 1.76 ± 0.058
3.205GlnArg: 3.205 ± 0.056
1.89GlnSer: 1.89 ± 0.043
1.893GlnThr: 1.893 ± 0.046
2.983GlnVal: 2.983 ± 0.065
0.499GlnTrp: 0.499 ± 0.024
0.868GlnTyr: 0.868 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
7.537ArgAla: 7.537 ± 0.093
0.659ArgCys: 0.659 ± 0.028
4.322ArgAsp: 4.322 ± 0.082
5.309ArgGlu: 5.309 ± 0.077
3.031ArgPhe: 3.031 ± 0.062
5.336ArgGly: 5.336 ± 0.071
1.859ArgHis: 1.859 ± 0.046
4.377ArgIle: 4.377 ± 0.077
2.004ArgLys: 2.004 ± 0.053
8.917ArgLeu: 8.917 ± 0.12
1.981ArgMet: 1.981 ± 0.041
1.905ArgAsn: 1.905 ± 0.043
4.12ArgPro: 4.12 ± 0.066
3.237ArgGln: 3.237 ± 0.065
7.402ArgArg: 7.402 ± 0.117
4.344ArgSer: 4.344 ± 0.064
3.696ArgThr: 3.696 ± 0.064
5.717ArgVal: 5.717 ± 0.088
1.377ArgTrp: 1.377 ± 0.046
2.332ArgTyr: 2.332 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.479SerAla: 5.479 ± 0.086
0.508SerCys: 0.508 ± 0.024
2.815SerAsp: 2.815 ± 0.061
2.898SerGlu: 2.898 ± 0.054
1.952SerPhe: 1.952 ± 0.051
5.637SerGly: 5.637 ± 0.088
1.203SerHis: 1.203 ± 0.037
2.94SerIle: 2.94 ± 0.057
1.151SerLys: 1.151 ± 0.036
5.487SerLeu: 5.487 ± 0.089
1.394SerMet: 1.394 ± 0.038
1.374SerAsn: 1.374 ± 0.037
3.754SerPro: 3.754 ± 0.079
1.853SerGln: 1.853 ± 0.047
4.434SerArg: 4.434 ± 0.074
3.455SerSer: 3.455 ± 0.079
3.077SerThr: 3.077 ± 0.06
3.88SerVal: 3.88 ± 0.064
0.91SerTrp: 0.91 ± 0.035
1.407SerTyr: 1.407 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.857ThrAla: 5.857 ± 0.087
0.47ThrCys: 0.47 ± 0.023
2.783ThrAsp: 2.783 ± 0.055
2.867ThrGlu: 2.867 ± 0.057
1.884ThrPhe: 1.884 ± 0.05
5.688ThrGly: 5.688 ± 0.084
1.12ThrHis: 1.12 ± 0.034
3.251ThrIle: 3.251 ± 0.059
1.211ThrLys: 1.211 ± 0.035
5.707ThrLeu: 5.707 ± 0.079
1.163ThrMet: 1.163 ± 0.037
1.48ThrAsn: 1.48 ± 0.041
3.538ThrPro: 3.538 ± 0.061
1.607ThrGln: 1.607 ± 0.041
3.639ThrArg: 3.639 ± 0.07
3.045ThrSer: 3.045 ± 0.058
3.231ThrThr: 3.231 ± 0.068
4.747ThrVal: 4.747 ± 0.079
0.933ThrTrp: 0.933 ± 0.031
1.393ThrTyr: 1.393 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
8.511ValAla: 8.511 ± 0.111
0.629ValCys: 0.629 ± 0.024
4.349ValAsp: 4.349 ± 0.068
4.667ValGlu: 4.667 ± 0.078
2.467ValPhe: 2.467 ± 0.058
5.505ValGly: 5.505 ± 0.083
1.591ValHis: 1.591 ± 0.041
4.746ValIle: 4.746 ± 0.079
1.784ValLys: 1.784 ± 0.039
7.943ValLeu: 7.943 ± 0.11
1.602ValMet: 1.602 ± 0.04
2.084ValAsn: 2.084 ± 0.046
4.465ValPro: 4.465 ± 0.076
2.4ValGln: 2.4 ± 0.05
5.641ValArg: 5.641 ± 0.085
4.394ValSer: 4.394 ± 0.069
4.857ValThr: 4.857 ± 0.086
6.53ValVal: 6.53 ± 0.094
0.971ValTrp: 0.971 ± 0.036
1.724ValTyr: 1.724 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.23TrpAla: 1.23 ± 0.04
0.15TrpCys: 0.15 ± 0.012
0.82TrpAsp: 0.82 ± 0.036
0.896TrpGlu: 0.896 ± 0.034
0.516TrpPhe: 0.516 ± 0.027
1.023TrpGly: 1.023 ± 0.035
0.406TrpHis: 0.406 ± 0.022
0.772TrpIle: 0.772 ± 0.029
0.424TrpLys: 0.424 ± 0.021
1.879TrpLeu: 1.879 ± 0.05
0.439TrpMet: 0.439 ± 0.023
0.5TrpAsn: 0.5 ± 0.024
0.753TrpPro: 0.753 ± 0.034
0.656TrpGln: 0.656 ± 0.029
1.295TrpArg: 1.295 ± 0.037
0.918TrpSer: 0.918 ± 0.033
0.886TrpThr: 0.886 ± 0.037
1.094TrpVal: 1.094 ± 0.032
0.315TrpTrp: 0.315 ± 0.019
0.417TrpTyr: 0.417 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.358TyrAla: 2.358 ± 0.047
0.261TyrCys: 0.261 ± 0.018
1.48TyrAsp: 1.48 ± 0.043
1.281TyrGlu: 1.281 ± 0.038
0.978TyrPhe: 0.978 ± 0.034
2.159TyrGly: 2.159 ± 0.045
0.7TyrHis: 0.7 ± 0.029
1.008TyrIle: 1.008 ± 0.033
0.481TyrLys: 0.481 ± 0.022
2.766TyrLeu: 2.766 ± 0.054
0.367TyrMet: 0.367 ± 0.019
0.602TyrAsn: 0.602 ± 0.026
1.487TyrPro: 1.487 ± 0.036
1.147TyrGln: 1.147 ± 0.04
2.251TyrArg: 2.251 ± 0.05
1.25TyrSer: 1.25 ± 0.036
1.29TyrThr: 1.29 ± 0.052
1.698TyrVal: 1.698 ± 0.045
0.455TyrTrp: 0.455 ± 0.024
0.742TyrTyr: 0.742 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3969 proteins (962534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski