Amino acid dipepetide frequency for Nonlabens sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.717AlaAla: 4.717 ± 0.096	0.556AlaCys: 0.556 ± 0.028	3.307AlaAsp: 3.307 ± 0.084	3.114AlaGlu: 3.114 ± 0.068	3.194AlaPhe: 3.194 ± 0.057	4.695AlaGly: 4.695 ± 0.087	1.218AlaHis: 1.218 ± 0.037	5.306AlaIle: 5.306 ± 0.082	3.735AlaLys: 3.735 ± 0.091	6.063AlaLeu: 6.063 ± 0.089	1.59AlaMet: 1.59 ± 0.04	3.147AlaAsn: 3.147 ± 0.062	2.096AlaPro: 2.096 ± 0.061	3.337AlaGln: 3.337 ± 0.055	2.518AlaArg: 2.518 ± 0.056	4.301AlaSer: 4.301 ± 0.064	4.142AlaThr: 4.142 ± 0.084	4.505AlaVal: 4.505 ± 0.08	0.63AlaTrp: 0.63 ± 0.033	2.453AlaTyr: 2.453 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.458CysAla: 0.458 ± 0.024	0.104CysCys: 0.104 ± 0.012	0.522CysAsp: 0.522 ± 0.048	0.449CysGlu: 0.449 ± 0.023	0.369CysPhe: 0.369 ± 0.02	0.573CysGly: 0.573 ± 0.029	0.179CysHis: 0.179 ± 0.015	0.523CysIle: 0.523 ± 0.026	0.434CysLys: 0.434 ± 0.025	0.612CysLeu: 0.612 ± 0.027	0.129CysMet: 0.129 ± 0.013	0.403CysAsn: 0.403 ± 0.022	0.284CysPro: 0.284 ± 0.023	0.186CysGln: 0.186 ± 0.016	0.236CysArg: 0.236 ± 0.016	0.548CysSer: 0.548 ± 0.033	0.406CysThr: 0.406 ± 0.021	0.445CysVal: 0.445 ± 0.023	0.071CysTrp: 0.071 ± 0.011	0.311CysTyr: 0.311 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.874AspAla: 3.874 ± 0.087	0.466AspCys: 0.466 ± 0.039	3.523AspAsp: 3.523 ± 0.064	3.996AspGlu: 3.996 ± 0.069	3.429AspPhe: 3.429 ± 0.072	4.113AspGly: 4.113 ± 0.126	1.193AspHis: 1.193 ± 0.038	4.444AspIle: 4.444 ± 0.072	3.939AspLys: 3.939 ± 0.083	5.762AspLeu: 5.762 ± 0.082	1.201AspMet: 1.201 ± 0.044	3.323AspAsn: 3.323 ± 0.066	2.042AspPro: 2.042 ± 0.073	2.249AspGln: 2.249 ± 0.053	2.489AspArg: 2.489 ± 0.054	3.63AspSer: 3.63 ± 0.073	2.956AspThr: 2.956 ± 0.057	3.913AspVal: 3.913 ± 0.066	0.714AspTrp: 0.714 ± 0.03	3.013AspTyr: 3.013 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	3.698GluAla: 3.698 ± 0.071	0.299GluCys: 0.299 ± 0.019	3.632GluAsp: 3.632 ± 0.073	4.774GluGlu: 4.774 ± 0.097	2.987GluPhe: 2.987 ± 0.054	3.049GluGly: 3.049 ± 0.06	1.272GluHis: 1.272 ± 0.043	5.262GluIle: 5.262 ± 0.078	5.147GluLys: 5.147 ± 0.106	6.571GluLeu: 6.571 ± 0.105	1.608GluMet: 1.608 ± 0.046	4.527GluAsn: 4.527 ± 0.075	1.664GluPro: 1.664 ± 0.045	2.903GluGln: 2.903 ± 0.058	2.644GluArg: 2.644 ± 0.056	3.634GluSer: 3.634 ± 0.074	3.073GluThr: 3.073 ± 0.055	4.36GluVal: 4.36 ± 0.072	0.697GluTrp: 0.697 ± 0.031	2.576GluTyr: 2.576 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.971PheAla: 2.971 ± 0.062	0.37PheCys: 0.37 ± 0.02	3.098PheAsp: 3.098 ± 0.061	3.239PheGlu: 3.239 ± 0.054	2.496PhePhe: 2.496 ± 0.07	2.903PheGly: 2.903 ± 0.061	0.804PheHis: 0.804 ± 0.035	3.78PheIle: 3.78 ± 0.078	3.669PheLys: 3.669 ± 0.087	4.408PheLeu: 4.408 ± 0.095	1.149PheMet: 1.149 ± 0.037	3.255PheAsn: 3.255 ± 0.072	1.627PhePro: 1.627 ± 0.042	1.509PheGln: 1.509 ± 0.041	1.565PheArg: 1.565 ± 0.045	3.408PheSer: 3.408 ± 0.071	3.206PheThr: 3.206 ± 0.079	2.741PheVal: 2.741 ± 0.057	0.522PheTrp: 0.522 ± 0.025	2.2PheTyr: 2.2 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.315GlyAla: 4.315 ± 0.076	0.557GlyCys: 0.557 ± 0.031	3.834GlyAsp: 3.834 ± 0.095	3.43GlyGlu: 3.43 ± 0.061	3.459GlyPhe: 3.459 ± 0.065	4.209GlyGly: 4.209 ± 0.099	1.122GlyHis: 1.122 ± 0.037	5.305GlyIle: 5.305 ± 0.078	4.371GlyLys: 4.371 ± 0.076	5.508GlyLeu: 5.508 ± 0.087	1.677GlyMet: 1.677 ± 0.046	3.599GlyAsn: 3.599 ± 0.079	1.471GlyPro: 1.471 ± 0.05	2.017GlyGln: 2.017 ± 0.051	2.301GlyArg: 2.301 ± 0.057	4.255GlySer: 4.255 ± 0.085	4.255GlyThr: 4.255 ± 0.12	4.379GlyVal: 4.379 ± 0.086	0.787GlyTrp: 0.787 ± 0.035	2.837GlyTyr: 2.837 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.067HisAla: 1.067 ± 0.038	0.17HisCys: 0.17 ± 0.015	1.118HisAsp: 1.118 ± 0.038	1.054HisGlu: 1.054 ± 0.034	1.043HisPhe: 1.043 ± 0.039	1.147HisGly: 1.147 ± 0.039	0.512HisHis: 0.512 ± 0.026	1.379HisIle: 1.379 ± 0.039	1.237HisLys: 1.237 ± 0.041	1.919HisLeu: 1.919 ± 0.052	0.361HisMet: 0.361 ± 0.021	0.932HisAsn: 0.932 ± 0.031	0.863HisPro: 0.863 ± 0.035	0.688HisGln: 0.688 ± 0.026	0.764HisArg: 0.764 ± 0.028	1.08HisSer: 1.08 ± 0.04	0.98HisThr: 0.98 ± 0.035	1.168HisVal: 1.168 ± 0.035	0.222HisTrp: 0.222 ± 0.016	0.861HisTyr: 0.861 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.715IleAla: 5.715 ± 0.09	0.586IleCys: 0.586 ± 0.027	5.237IleAsp: 5.237 ± 0.089	5.641IleGlu: 5.641 ± 0.092	3.089IlePhe: 3.089 ± 0.07	4.944IleGly: 4.944 ± 0.074	1.338IleHis: 1.338 ± 0.043	5.511IleIle: 5.511 ± 0.095	5.566IleLys: 5.566 ± 0.1	6.348IleLeu: 6.348 ± 0.1	1.386IleMet: 1.386 ± 0.038	4.623IleAsn: 4.623 ± 0.074	3.157IlePro: 3.157 ± 0.062	2.535IleGln: 2.535 ± 0.059	2.345IleArg: 2.345 ± 0.064	5.184IleSer: 5.184 ± 0.074	4.994IleThr: 4.994 ± 0.081	4.545IleVal: 4.545 ± 0.079	0.678IleTrp: 0.678 ± 0.025	2.739IleTyr: 2.739 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.776LysAla: 4.776 ± 0.082	0.311LysCys: 0.311 ± 0.019	4.074LysAsp: 4.074 ± 0.087	5.856LysGlu: 5.856 ± 0.104	2.578LysPhe: 2.578 ± 0.063	3.953LysGly: 3.953 ± 0.086	1.333LysHis: 1.333 ± 0.042	4.944LysIle: 4.944 ± 0.077	5.982LysLys: 5.982 ± 0.122	6.012LysLeu: 6.012 ± 0.102	1.819LysMet: 1.819 ± 0.056	4.429LysAsn: 4.429 ± 0.084	2.241LysPro: 2.241 ± 0.06	2.813LysGln: 2.813 ± 0.052	2.999LysArg: 2.999 ± 0.062	4.192LysSer: 4.192 ± 0.081	3.804LysThr: 3.804 ± 0.066	4.225LysVal: 4.225 ± 0.079	0.823LysTrp: 0.823 ± 0.034	2.615LysTyr: 2.615 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.451LeuAla: 5.451 ± 0.082	0.673LeuCys: 0.673 ± 0.025	5.569LeuAsp: 5.569 ± 0.086	6.069LeuGlu: 6.069 ± 0.093	4.603LeuPhe: 4.603 ± 0.087	5.767LeuGly: 5.767 ± 0.098	1.575LeuHis: 1.575 ± 0.04	6.997LeuIle: 6.997 ± 0.105	6.961LeuLys: 6.961 ± 0.119	8.748LeuLeu: 8.748 ± 0.148	2.08LeuMet: 2.08 ± 0.052	5.691LeuAsn: 5.691 ± 0.091	3.564LeuPro: 3.564 ± 0.064	3.517LeuGln: 3.517 ± 0.067	3.5LeuArg: 3.5 ± 0.07	6.629LeuSer: 6.629 ± 0.09	4.979LeuThr: 4.979 ± 0.081	5.359LeuVal: 5.359 ± 0.084	0.876LeuTrp: 0.876 ± 0.037	3.249LeuTyr: 3.249 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.571MetAla: 1.571 ± 0.046	0.141MetCys: 0.141 ± 0.013	1.271MetAsp: 1.271 ± 0.033	1.299MetGlu: 1.299 ± 0.042	0.868MetPhe: 0.868 ± 0.037	1.417MetGly: 1.417 ± 0.044	0.395MetHis: 0.395 ± 0.021	1.739MetIle: 1.739 ± 0.042	2.02MetLys: 2.02 ± 0.052	1.895MetLeu: 1.895 ± 0.052	0.678MetMet: 0.678 ± 0.029	1.371MetAsn: 1.371 ± 0.04	0.838MetPro: 0.838 ± 0.031	0.829MetGln: 0.829 ± 0.028	1.019MetArg: 1.019 ± 0.039	1.577MetSer: 1.577 ± 0.048	1.192MetThr: 1.192 ± 0.041	1.398MetVal: 1.398 ± 0.045	0.187MetTrp: 0.187 ± 0.016	0.787MetTyr: 0.787 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.91AsnAla: 3.91 ± 0.082	0.414AsnCys: 0.414 ± 0.025	3.753AsnAsp: 3.753 ± 0.078	3.745AsnGlu: 3.745 ± 0.07	2.691AsnPhe: 2.691 ± 0.061	4.216AsnGly: 4.216 ± 0.096	1.15AsnHis: 1.15 ± 0.039	4.105AsnIle: 4.105 ± 0.069	4.069AsnLys: 4.069 ± 0.074	5.044AsnLeu: 5.044 ± 0.074	1.227AsnMet: 1.227 ± 0.033	3.911AsnAsn: 3.911 ± 0.091	2.823AsnPro: 2.823 ± 0.07	2.532AsnGln: 2.532 ± 0.059	2.45AsnArg: 2.45 ± 0.059	3.854AsnSer: 3.854 ± 0.073	3.545AsnThr: 3.545 ± 0.069	3.369AsnVal: 3.369 ± 0.068	0.799AsnTrp: 0.799 ± 0.032	2.831AsnTyr: 2.831 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.156ProAla: 2.156 ± 0.056	0.225ProCys: 0.225 ± 0.017	2.424ProAsp: 2.424 ± 0.054	2.674ProGlu: 2.674 ± 0.057	1.79ProPhe: 1.79 ± 0.046	2.103ProGly: 2.103 ± 0.061	0.644ProHis: 0.644 ± 0.024	2.624ProIle: 2.624 ± 0.052	2.122ProLys: 2.122 ± 0.05	2.964ProLeu: 2.964 ± 0.058	0.688ProMet: 0.688 ± 0.029	2.212ProAsn: 2.212 ± 0.06	0.804ProPro: 0.804 ± 0.034	1.345ProGln: 1.345 ± 0.044	1.015ProArg: 1.015 ± 0.031	2.274ProSer: 2.274 ± 0.053	1.945ProThr: 1.945 ± 0.056	2.758ProVal: 2.758 ± 0.059	0.348ProTrp: 0.348 ± 0.019	1.443ProTyr: 1.443 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.595GlnAla: 2.595 ± 0.063	0.176GlnCys: 0.176 ± 0.013	2.232GlnAsp: 2.232 ± 0.052	2.875GlnGlu: 2.875 ± 0.059	1.797GlnPhe: 1.797 ± 0.045	2.024GlnGly: 2.024 ± 0.058	0.68GlnHis: 0.68 ± 0.024	2.824GlnIle: 2.824 ± 0.057	2.489GlnLys: 2.489 ± 0.056	4.141GlnLeu: 4.141 ± 0.073	0.876GlnMet: 0.876 ± 0.03	2.199GlnAsn: 2.199 ± 0.061	1.434GlnPro: 1.434 ± 0.039	1.856GlnGln: 1.856 ± 0.054	1.54GlnArg: 1.54 ± 0.036	2.338GlnSer: 2.338 ± 0.058	2.027GlnThr: 2.027 ± 0.054	2.719GlnVal: 2.719 ± 0.056	0.435GlnTrp: 0.435 ± 0.025	1.439GlnTyr: 1.439 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.305ArgAla: 2.305 ± 0.042	0.223ArgCys: 0.223 ± 0.019	2.214ArgAsp: 2.214 ± 0.051	2.557ArgGlu: 2.557 ± 0.055	2.165ArgPhe: 2.165 ± 0.048	2.129ArgGly: 2.129 ± 0.048	0.652ArgHis: 0.652 ± 0.027	3.123ArgIle: 3.123 ± 0.064	3.015ArgLys: 3.015 ± 0.062	3.555ArgLeu: 3.555 ± 0.077	1.016ArgMet: 1.016 ± 0.038	2.362ArgAsn: 2.362 ± 0.054	1.149ArgPro: 1.149 ± 0.032	1.204ArgGln: 1.204 ± 0.038	1.62ArgArg: 1.62 ± 0.051	2.386ArgSer: 2.386 ± 0.06	2.025ArgThr: 2.025 ± 0.049	2.474ArgVal: 2.474 ± 0.054	0.413ArgTrp: 0.413 ± 0.021	1.75ArgTyr: 1.75 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.453SerAla: 3.453 ± 0.067	0.619SerCys: 0.619 ± 0.029	3.526SerAsp: 3.526 ± 0.066	3.315SerGlu: 3.315 ± 0.051	3.707SerPhe: 3.707 ± 0.065	4.671SerGly: 4.671 ± 0.098	1.153SerHis: 1.153 ± 0.036	5.354SerIle: 5.354 ± 0.085	4.437SerLys: 4.437 ± 0.082	6.207SerLeu: 6.207 ± 0.089	1.439SerMet: 1.439 ± 0.042	4.229SerAsn: 4.229 ± 0.086	2.137SerPro: 2.137 ± 0.054	2.672SerGln: 2.672 ± 0.054	2.662SerArg: 2.662 ± 0.054	4.725SerSer: 4.725 ± 0.112	4.033SerThr: 4.033 ± 0.088	3.75SerVal: 3.75 ± 0.059	0.771SerTrp: 0.771 ± 0.034	2.891SerTyr: 2.891 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.244ThrAla: 4.244 ± 0.091	0.378ThrCys: 0.378 ± 0.025	3.636ThrAsp: 3.636 ± 0.08	3.072ThrGlu: 3.072 ± 0.061	2.7ThrPhe: 2.7 ± 0.059	4.537ThrGly: 4.537 ± 0.104	1.064ThrHis: 1.064 ± 0.037	4.592ThrIle: 4.592 ± 0.073	2.964ThrLys: 2.964 ± 0.066	5.248ThrLeu: 5.248 ± 0.077	1.038ThrMet: 1.038 ± 0.034	3.15ThrAsn: 3.15 ± 0.078	2.447ThrPro: 2.447 ± 0.052	2.131ThrGln: 2.131 ± 0.054	2.001ThrArg: 2.001 ± 0.051	4.059ThrSer: 4.059 ± 0.082	3.952ThrThr: 3.952 ± 0.095	4.166ThrVal: 4.166 ± 0.095	0.577ThrTrp: 0.577 ± 0.03	2.492ThrTyr: 2.492 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.408ValAla: 4.408 ± 0.076	0.533ValCys: 0.533 ± 0.029	3.935ValAsp: 3.935 ± 0.077	4.057ValGlu: 4.057 ± 0.079	3.174ValPhe: 3.174 ± 0.069	3.738ValGly: 3.738 ± 0.071	1.102ValHis: 1.102 ± 0.037	5.075ValIle: 5.075 ± 0.075	4.049ValLys: 4.049 ± 0.079	5.826ValLeu: 5.826 ± 0.087	1.45ValMet: 1.45 ± 0.044	3.786ValAsn: 3.786 ± 0.075	2.281ValPro: 2.281 ± 0.043	2.219ValGln: 2.219 ± 0.055	2.296ValArg: 2.296 ± 0.053	4.252ValSer: 4.252 ± 0.074	4.068ValThr: 4.068 ± 0.092	4.502ValVal: 4.502 ± 0.079	0.569ValTrp: 0.569 ± 0.026	2.469ValTyr: 2.469 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.549TrpAla: 0.549 ± 0.026	0.12TrpCys: 0.12 ± 0.012	0.716TrpAsp: 0.716 ± 0.029	0.684TrpGlu: 0.684 ± 0.029	0.537TrpPhe: 0.537 ± 0.024	0.6TrpGly: 0.6 ± 0.032	0.227TrpHis: 0.227 ± 0.017	0.771TrpIle: 0.771 ± 0.037	0.736TrpLys: 0.736 ± 0.033	1.006TrpLeu: 1.006 ± 0.037	0.342TrpMet: 0.342 ± 0.021	0.749TrpAsn: 0.749 ± 0.031	0.268TrpPro: 0.268 ± 0.02	0.446TrpGln: 0.446 ± 0.022	0.495TrpArg: 0.495 ± 0.024	0.69TrpSer: 0.69 ± 0.033	0.584TrpThr: 0.584 ± 0.028	0.62TrpVal: 0.62 ± 0.029	0.183TrpTrp: 0.183 ± 0.017	0.467TrpTyr: 0.467 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.059	0.32TyrCys: 0.32 ± 0.019	2.648TyrAsp: 2.648 ± 0.05	2.475TyrGlu: 2.475 ± 0.053	2.245TyrPhe: 2.245 ± 0.051	2.902TyrGly: 2.902 ± 0.061	0.954TyrHis: 0.954 ± 0.033	2.501TyrIle: 2.501 ± 0.052	2.834TyrLys: 2.834 ± 0.059	4.021TyrLeu: 4.021 ± 0.082	0.74TyrMet: 0.74 ± 0.031	2.542TyrAsn: 2.542 ± 0.056	1.369TyrPro: 1.369 ± 0.041	1.71TyrGln: 1.71 ± 0.05	1.876TyrArg: 1.876 ± 0.047	2.733TyrSer: 2.733 ± 0.06	2.283TyrThr: 2.283 ± 0.054	2.39TyrVal: 2.39 ± 0.045	0.486TyrTrp: 0.486 ± 0.022	1.811TyrTyr: 1.811 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2951 proteins (886951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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