Amino acid dipepetide frequency for Edwardsiella phage KF-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.861AlaAla: 9.861 ± 1.029
0.688AlaCys: 0.688 ± 0.243
5.962AlaAsp: 5.962 ± 0.757
5.886AlaGlu: 5.886 ± 0.492
3.134AlaPhe: 3.134 ± 0.598
6.88AlaGly: 6.88 ± 0.819
1.299AlaHis: 1.299 ± 0.327
4.204AlaIle: 4.204 ± 0.643
5.274AlaLys: 5.274 ± 0.736
7.644AlaLeu: 7.644 ± 0.803
4.128AlaMet: 4.128 ± 0.492
4.434AlaAsn: 4.434 ± 0.524
3.287AlaPro: 3.287 ± 0.552
4.051AlaGln: 4.051 ± 0.564
5.58AlaArg: 5.58 ± 0.62
6.192AlaSer: 6.192 ± 0.976
5.427AlaThr: 5.427 ± 0.688
6.345AlaVal: 6.345 ± 0.558
1.835AlaTrp: 1.835 ± 0.409
3.822AlaTyr: 3.822 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
1.452CysAla: 1.452 ± 0.373
0.153CysCys: 0.153 ± 0.103
0.688CysAsp: 0.688 ± 0.205
0.535CysGlu: 0.535 ± 0.18
0.382CysPhe: 0.382 ± 0.156
0.459CysGly: 0.459 ± 0.239
0.382CysHis: 0.382 ± 0.196
0.688CysIle: 0.688 ± 0.21
1.07CysLys: 1.07 ± 0.278
0.917CysLeu: 0.917 ± 0.262
0.153CysMet: 0.153 ± 0.089
0.612CysAsn: 0.612 ± 0.21
0.229CysPro: 0.229 ± 0.139
0.459CysGln: 0.459 ± 0.178
0.076CysArg: 0.076 ± 0.084
0.612CysSer: 0.612 ± 0.246
0.459CysThr: 0.459 ± 0.195
0.917CysVal: 0.917 ± 0.284
0.076CysTrp: 0.076 ± 0.082
0.382CysTyr: 0.382 ± 0.171
0.0CysXaa: 0.0 ± 0.0
Asp
6.345AspAla: 6.345 ± 0.658
0.612AspCys: 0.612 ± 0.214
4.204AspAsp: 4.204 ± 0.673
3.746AspGlu: 3.746 ± 0.676
2.981AspPhe: 2.981 ± 0.461
4.204AspGly: 4.204 ± 0.508
0.306AspHis: 0.306 ± 0.115
3.975AspIle: 3.975 ± 0.516
4.204AspLys: 4.204 ± 0.623
4.969AspLeu: 4.969 ± 0.63
1.987AspMet: 1.987 ± 0.509
2.37AspAsn: 2.37 ± 0.451
3.058AspPro: 3.058 ± 0.428
1.223AspGln: 1.223 ± 0.315
2.14AspArg: 2.14 ± 0.371
3.822AspSer: 3.822 ± 0.471
4.051AspThr: 4.051 ± 0.575
4.969AspVal: 4.969 ± 0.554
0.917AspTrp: 0.917 ± 0.245
2.446AspTyr: 2.446 ± 0.431
0.0AspXaa: 0.0 ± 0.0
Glu
6.268GluAla: 6.268 ± 0.792
0.764GluCys: 0.764 ± 0.28
3.44GluAsp: 3.44 ± 0.361
3.669GluGlu: 3.669 ± 0.489
2.599GluPhe: 2.599 ± 0.369
3.669GluGly: 3.669 ± 0.478
1.452GluHis: 1.452 ± 0.387
1.835GluIle: 1.835 ± 0.398
2.446GluLys: 2.446 ± 0.365
8.485GluLeu: 8.485 ± 0.816
1.452GluMet: 1.452 ± 0.277
1.376GluAsn: 1.376 ± 0.262
1.605GluPro: 1.605 ± 0.351
2.828GluGln: 2.828 ± 0.55
2.675GluArg: 2.675 ± 0.557
2.37GluSer: 2.37 ± 0.342
3.516GluThr: 3.516 ± 0.483
5.045GluVal: 5.045 ± 0.655
0.764GluTrp: 0.764 ± 0.178
2.905GluTyr: 2.905 ± 0.608
0.0GluXaa: 0.0 ± 0.0
Phe
2.217PheAla: 2.217 ± 0.396
0.535PheCys: 0.535 ± 0.207
3.211PheAsp: 3.211 ± 0.521
2.37PheGlu: 2.37 ± 0.484
0.841PhePhe: 0.841 ± 0.245
3.516PheGly: 3.516 ± 0.593
0.535PheHis: 0.535 ± 0.251
2.217PheIle: 2.217 ± 0.44
1.758PheLys: 1.758 ± 0.449
3.058PheLeu: 3.058 ± 0.525
0.382PheMet: 0.382 ± 0.186
2.217PheAsn: 2.217 ± 0.468
0.841PhePro: 0.841 ± 0.295
0.841PheGln: 0.841 ± 0.201
1.987PheArg: 1.987 ± 0.341
1.987PheSer: 1.987 ± 0.333
2.446PheThr: 2.446 ± 0.548
1.911PheVal: 1.911 ± 0.35
0.764PheTrp: 0.764 ± 0.23
1.147PheTyr: 1.147 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
5.962GlyAla: 5.962 ± 0.853
0.917GlyCys: 0.917 ± 0.27
3.746GlyAsp: 3.746 ± 0.539
5.045GlyGlu: 5.045 ± 0.662
2.905GlyPhe: 2.905 ± 0.488
4.892GlyGly: 4.892 ± 0.81
0.994GlyHis: 0.994 ± 0.253
4.204GlyIle: 4.204 ± 0.556
5.122GlyLys: 5.122 ± 0.707
6.268GlyLeu: 6.268 ± 0.758
1.452GlyMet: 1.452 ± 0.305
4.357GlyAsn: 4.357 ± 0.626
1.299GlyPro: 1.299 ± 0.252
2.599GlyGln: 2.599 ± 0.476
3.058GlyArg: 3.058 ± 0.421
5.198GlySer: 5.198 ± 0.641
4.739GlyThr: 4.739 ± 0.854
5.657GlyVal: 5.657 ± 0.763
0.994GlyTrp: 0.994 ± 0.275
2.828GlyTyr: 2.828 ± 0.449
0.0GlyXaa: 0.0 ± 0.0
His
1.223HisAla: 1.223 ± 0.352
0.076HisCys: 0.076 ± 0.081
0.688HisAsp: 0.688 ± 0.232
0.535HisGlu: 0.535 ± 0.19
0.917HisPhe: 0.917 ± 0.297
0.917HisGly: 0.917 ± 0.257
0.229HisHis: 0.229 ± 0.12
1.147HisIle: 1.147 ± 0.312
1.529HisLys: 1.529 ± 0.334
0.994HisLeu: 0.994 ± 0.28
0.306HisMet: 0.306 ± 0.146
1.299HisAsn: 1.299 ± 0.312
0.459HisPro: 0.459 ± 0.18
0.612HisGln: 0.612 ± 0.272
0.612HisArg: 0.612 ± 0.206
1.147HisSer: 1.147 ± 0.262
0.764HisThr: 0.764 ± 0.211
1.07HisVal: 1.07 ± 0.32
0.0HisTrp: 0.0 ± 0.0
1.299HisTyr: 1.299 ± 0.316
0.0HisXaa: 0.0 ± 0.0
Ile
4.51IleAla: 4.51 ± 0.4
0.535IleCys: 0.535 ± 0.191
3.975IleAsp: 3.975 ± 0.483
3.363IleGlu: 3.363 ± 0.465
1.376IlePhe: 1.376 ± 0.274
2.752IleGly: 2.752 ± 0.461
0.535IleHis: 0.535 ± 0.169
2.446IleIle: 2.446 ± 0.475
3.287IleLys: 3.287 ± 0.579
3.287IleLeu: 3.287 ± 0.688
1.376IleMet: 1.376 ± 0.355
2.752IleAsn: 2.752 ± 0.467
1.376IlePro: 1.376 ± 0.261
1.682IleGln: 1.682 ± 0.386
1.987IleArg: 1.987 ± 0.285
2.752IleSer: 2.752 ± 0.382
3.211IleThr: 3.211 ± 0.465
3.898IleVal: 3.898 ± 0.383
0.382IleTrp: 0.382 ± 0.159
1.529IleTyr: 1.529 ± 0.301
0.0IleXaa: 0.0 ± 0.0
Lys
6.803LysAla: 6.803 ± 0.657
0.612LysCys: 0.612 ± 0.196
3.363LysAsp: 3.363 ± 0.418
3.058LysGlu: 3.058 ± 0.57
1.911LysPhe: 1.911 ± 0.411
4.204LysGly: 4.204 ± 0.751
1.452LysHis: 1.452 ± 0.4
1.987LysIle: 1.987 ± 0.415
2.446LysLys: 2.446 ± 0.476
8.103LysLeu: 8.103 ± 0.69
1.223LysMet: 1.223 ± 0.312
1.682LysAsn: 1.682 ± 0.367
2.675LysPro: 2.675 ± 0.587
2.599LysGln: 2.599 ± 0.434
3.44LysArg: 3.44 ± 0.552
3.058LysSer: 3.058 ± 0.379
3.44LysThr: 3.44 ± 0.469
4.586LysVal: 4.586 ± 0.477
0.764LysTrp: 0.764 ± 0.218
2.523LysTyr: 2.523 ± 0.374
0.0LysXaa: 0.0 ± 0.0
Leu
10.014LeuAla: 10.014 ± 0.849
0.612LeuCys: 0.612 ± 0.186
6.497LeuAsp: 6.497 ± 0.668
5.427LeuGlu: 5.427 ± 0.578
1.605LeuPhe: 1.605 ± 0.331
5.657LeuGly: 5.657 ± 0.778
2.064LeuHis: 2.064 ± 0.431
3.058LeuIle: 3.058 ± 0.522
4.739LeuLys: 4.739 ± 0.625
7.644LeuLeu: 7.644 ± 0.734
2.293LeuMet: 2.293 ± 0.329
4.051LeuAsn: 4.051 ± 0.447
4.128LeuPro: 4.128 ± 0.589
4.892LeuGln: 4.892 ± 0.547
4.51LeuArg: 4.51 ± 0.454
5.962LeuSer: 5.962 ± 0.705
5.274LeuThr: 5.274 ± 0.59
6.88LeuVal: 6.88 ± 0.74
0.994LeuTrp: 0.994 ± 0.231
3.593LeuTyr: 3.593 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
2.446MetAla: 2.446 ± 0.495
0.229MetCys: 0.229 ± 0.122
1.682MetAsp: 1.682 ± 0.445
0.764MetGlu: 0.764 ± 0.222
0.994MetPhe: 0.994 ± 0.237
0.994MetGly: 0.994 ± 0.229
0.459MetHis: 0.459 ± 0.175
0.994MetIle: 0.994 ± 0.321
1.223MetLys: 1.223 ± 0.335
2.675MetLeu: 2.675 ± 0.389
0.535MetMet: 0.535 ± 0.265
1.147MetAsn: 1.147 ± 0.329
1.452MetPro: 1.452 ± 0.416
1.376MetGln: 1.376 ± 0.34
1.987MetArg: 1.987 ± 0.411
2.446MetSer: 2.446 ± 0.461
2.446MetThr: 2.446 ± 0.347
0.917MetVal: 0.917 ± 0.279
0.306MetTrp: 0.306 ± 0.134
0.917MetTyr: 0.917 ± 0.254
0.0MetXaa: 0.0 ± 0.0
Asn
3.898AsnAla: 3.898 ± 0.577
0.994AsnCys: 0.994 ± 0.331
1.987AsnAsp: 1.987 ± 0.412
2.905AsnGlu: 2.905 ± 0.488
1.147AsnPhe: 1.147 ± 0.408
4.586AsnGly: 4.586 ± 0.667
0.535AsnHis: 0.535 ± 0.217
2.293AsnIle: 2.293 ± 0.348
2.752AsnLys: 2.752 ± 0.514
4.128AsnLeu: 4.128 ± 0.44
1.376AsnMet: 1.376 ± 0.354
1.758AsnAsn: 1.758 ± 0.386
2.064AsnPro: 2.064 ± 0.405
1.987AsnGln: 1.987 ± 0.361
1.223AsnArg: 1.223 ± 0.416
2.981AsnSer: 2.981 ± 0.472
2.752AsnThr: 2.752 ± 0.412
3.44AsnVal: 3.44 ± 0.468
0.459AsnTrp: 0.459 ± 0.174
1.835AsnTyr: 1.835 ± 0.378
0.0AsnXaa: 0.0 ± 0.0
Pro
3.058ProAla: 3.058 ± 0.506
0.229ProCys: 0.229 ± 0.127
2.523ProAsp: 2.523 ± 0.561
2.752ProGlu: 2.752 ± 0.479
0.688ProPhe: 0.688 ± 0.262
2.599ProGly: 2.599 ± 0.494
0.229ProHis: 0.229 ± 0.161
1.529ProIle: 1.529 ± 0.32
2.752ProLys: 2.752 ± 0.466
2.064ProLeu: 2.064 ± 0.44
1.299ProMet: 1.299 ± 0.316
1.911ProAsn: 1.911 ± 0.365
0.917ProPro: 0.917 ± 0.261
1.758ProGln: 1.758 ± 0.388
1.452ProArg: 1.452 ± 0.292
3.363ProSer: 3.363 ± 0.677
2.981ProThr: 2.981 ± 0.577
3.593ProVal: 3.593 ± 0.545
0.382ProTrp: 0.382 ± 0.157
0.917ProTyr: 0.917 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
5.198GlnAla: 5.198 ± 0.839
0.459GlnCys: 0.459 ± 0.199
1.911GlnAsp: 1.911 ± 0.469
2.446GlnGlu: 2.446 ± 0.386
1.529GlnPhe: 1.529 ± 0.325
2.293GlnGly: 2.293 ± 0.396
0.612GlnHis: 0.612 ± 0.185
1.452GlnIle: 1.452 ± 0.323
1.376GlnLys: 1.376 ± 0.259
4.357GlnLeu: 4.357 ± 0.542
0.994GlnMet: 0.994 ± 0.208
1.605GlnAsn: 1.605 ± 0.338
1.758GlnPro: 1.758 ± 0.293
3.898GlnGln: 3.898 ± 0.667
2.905GlnArg: 2.905 ± 0.535
2.14GlnSer: 2.14 ± 0.336
1.987GlnThr: 1.987 ± 0.356
3.058GlnVal: 3.058 ± 0.448
0.764GlnTrp: 0.764 ± 0.217
1.835GlnTyr: 1.835 ± 0.474
0.0GlnXaa: 0.0 ± 0.0
Arg
4.204ArgAla: 4.204 ± 0.589
0.382ArgCys: 0.382 ± 0.149
2.523ArgAsp: 2.523 ± 0.5
3.363ArgGlu: 3.363 ± 0.473
1.682ArgPhe: 1.682 ± 0.339
3.669ArgGly: 3.669 ± 0.465
0.841ArgHis: 0.841 ± 0.239
2.981ArgIle: 2.981 ± 0.412
2.752ArgLys: 2.752 ± 0.564
3.44ArgLeu: 3.44 ± 0.49
0.917ArgMet: 0.917 ± 0.288
2.14ArgAsn: 2.14 ± 0.411
1.835ArgPro: 1.835 ± 0.351
2.599ArgGln: 2.599 ± 0.376
1.987ArgArg: 1.987 ± 0.408
2.523ArgSer: 2.523 ± 0.494
3.058ArgThr: 3.058 ± 0.472
4.663ArgVal: 4.663 ± 0.59
0.841ArgTrp: 0.841 ± 0.241
1.758ArgTyr: 1.758 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
5.81SerAla: 5.81 ± 0.737
0.535SerCys: 0.535 ± 0.184
4.816SerAsp: 4.816 ± 0.598
3.287SerGlu: 3.287 ± 0.453
3.363SerPhe: 3.363 ± 0.546
6.192SerGly: 6.192 ± 0.756
0.764SerHis: 0.764 ± 0.217
2.752SerIle: 2.752 ± 0.36
4.051SerLys: 4.051 ± 0.474
4.892SerLeu: 4.892 ± 0.647
1.223SerMet: 1.223 ± 0.299
2.14SerAsn: 2.14 ± 0.428
2.064SerPro: 2.064 ± 0.406
2.217SerGln: 2.217 ± 0.409
2.981SerArg: 2.981 ± 0.623
4.586SerSer: 4.586 ± 0.703
3.975SerThr: 3.975 ± 0.604
3.593SerVal: 3.593 ± 0.586
0.688SerTrp: 0.688 ± 0.206
2.523SerTyr: 2.523 ± 0.482
0.0SerXaa: 0.0 ± 0.0
Thr
5.58ThrAla: 5.58 ± 0.645
0.306ThrCys: 0.306 ± 0.147
3.822ThrAsp: 3.822 ± 0.363
2.675ThrGlu: 2.675 ± 0.454
2.828ThrPhe: 2.828 ± 0.391
6.803ThrGly: 6.803 ± 1.119
0.764ThrHis: 0.764 ± 0.231
3.898ThrIle: 3.898 ± 0.421
4.969ThrLys: 4.969 ± 0.614
5.122ThrLeu: 5.122 ± 0.573
1.529ThrMet: 1.529 ± 0.415
2.217ThrAsn: 2.217 ± 0.288
2.675ThrPro: 2.675 ± 0.449
2.293ThrGln: 2.293 ± 0.336
3.058ThrArg: 3.058 ± 0.375
3.211ThrSer: 3.211 ± 0.538
3.898ThrThr: 3.898 ± 0.671
3.975ThrVal: 3.975 ± 0.527
0.917ThrTrp: 0.917 ± 0.318
2.064ThrTyr: 2.064 ± 0.341
0.0ThrXaa: 0.0 ± 0.0
Val
7.033ValAla: 7.033 ± 0.61
1.147ValCys: 1.147 ± 0.371
4.204ValAsp: 4.204 ± 0.603
4.586ValGlu: 4.586 ± 0.497
2.523ValPhe: 2.523 ± 0.456
4.357ValGly: 4.357 ± 0.526
1.299ValHis: 1.299 ± 0.242
3.211ValIle: 3.211 ± 0.501
4.434ValLys: 4.434 ± 0.412
6.803ValLeu: 6.803 ± 0.617
2.14ValMet: 2.14 ± 0.462
3.593ValAsn: 3.593 ± 0.554
3.746ValPro: 3.746 ± 0.56
3.058ValGln: 3.058 ± 0.499
3.211ValArg: 3.211 ± 0.598
5.427ValSer: 5.427 ± 0.805
4.739ValThr: 4.739 ± 0.633
6.115ValVal: 6.115 ± 0.928
0.688ValTrp: 0.688 ± 0.197
3.058ValTyr: 3.058 ± 0.669
0.0ValXaa: 0.0 ± 0.0
Trp
0.688TrpAla: 0.688 ± 0.292
0.229TrpCys: 0.229 ± 0.118
0.994TrpAsp: 0.994 ± 0.332
0.688TrpGlu: 0.688 ± 0.218
0.382TrpPhe: 0.382 ± 0.174
0.688TrpGly: 0.688 ± 0.192
0.382TrpHis: 0.382 ± 0.196
0.306TrpIle: 0.306 ± 0.122
0.688TrpLys: 0.688 ± 0.239
1.682TrpLeu: 1.682 ± 0.422
0.306TrpMet: 0.306 ± 0.147
0.917TrpAsn: 0.917 ± 0.27
0.612TrpPro: 0.612 ± 0.204
0.153TrpGln: 0.153 ± 0.091
0.917TrpArg: 0.917 ± 0.248
0.382TrpSer: 0.382 ± 0.155
0.917TrpThr: 0.917 ± 0.268
1.605TrpVal: 1.605 ± 0.452
0.076TrpTrp: 0.076 ± 0.079
0.459TrpTyr: 0.459 ± 0.194
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.363TyrAla: 3.363 ± 0.497
0.688TyrCys: 0.688 ± 0.189
2.293TyrAsp: 2.293 ± 0.487
2.064TyrGlu: 2.064 ± 0.429
1.07TyrPhe: 1.07 ± 0.287
2.905TyrGly: 2.905 ± 0.408
0.688TyrHis: 0.688 ± 0.176
1.835TyrIle: 1.835 ± 0.41
3.058TyrLys: 3.058 ± 0.42
3.363TyrLeu: 3.363 ± 0.447
0.841TyrMet: 0.841 ± 0.233
2.523TyrAsn: 2.523 ± 0.392
0.917TyrPro: 0.917 ± 0.306
1.452TyrGln: 1.452 ± 0.294
2.37TyrArg: 2.37 ± 0.386
2.293TyrSer: 2.293 ± 0.396
2.523TyrThr: 2.523 ± 0.32
3.134TyrVal: 3.134 ± 0.552
0.459TyrTrp: 0.459 ± 0.156
1.835TyrTyr: 1.835 ± 0.416
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (13083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski