Amino acid dipepetide frequency for Kwoniella shandongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.693AlaAla: 8.693 ± 0.089	0.791AlaCys: 0.791 ± 0.015	3.813AlaAsp: 3.813 ± 0.036	5.227AlaGlu: 5.227 ± 0.048	2.832AlaPhe: 2.832 ± 0.031	6.247AlaGly: 6.247 ± 0.043	1.696AlaHis: 1.696 ± 0.021	4.032AlaIle: 4.032 ± 0.037	4.332AlaLys: 4.332 ± 0.046	7.565AlaLeu: 7.565 ± 0.053	1.912AlaMet: 1.912 ± 0.023	2.658AlaAsn: 2.658 ± 0.028	5.32AlaPro: 5.32 ± 0.06	3.352AlaGln: 3.352 ± 0.037	4.841AlaArg: 4.841 ± 0.038	8.028AlaSer: 8.028 ± 0.071	5.308AlaThr: 5.308 ± 0.042	5.065AlaVal: 5.065 ± 0.046	1.063AlaTrp: 1.063 ± 0.02	2.0AlaTyr: 2.0 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.682CysAla: 0.682 ± 0.013	0.156CysCys: 0.156 ± 0.008	0.483CysAsp: 0.483 ± 0.013	0.483CysGlu: 0.483 ± 0.012	0.416CysPhe: 0.416 ± 0.01	0.739CysGly: 0.739 ± 0.016	0.225CysHis: 0.225 ± 0.007	0.491CysIle: 0.491 ± 0.012	0.401CysLys: 0.401 ± 0.01	0.97CysLeu: 0.97 ± 0.018	0.192CysMet: 0.192 ± 0.006	0.282CysAsn: 0.282 ± 0.008	0.511CysPro: 0.511 ± 0.013	0.337CysGln: 0.337 ± 0.01	0.504CysArg: 0.504 ± 0.013	0.645CysSer: 0.645 ± 0.014	0.532CysThr: 0.532 ± 0.013	0.628CysVal: 0.628 ± 0.013	0.156CysTrp: 0.156 ± 0.006	0.271CysTyr: 0.271 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.132AspAla: 4.132 ± 0.036	0.47AspCys: 0.47 ± 0.013	4.641AspAsp: 4.641 ± 0.054	5.209AspGlu: 5.209 ± 0.05	1.83AspPhe: 1.83 ± 0.021	4.338AspGly: 4.338 ± 0.035	1.237AspHis: 1.237 ± 0.021	2.638AspIle: 2.638 ± 0.025	2.445AspLys: 2.445 ± 0.03	5.025AspLeu: 5.025 ± 0.038	1.165AspMet: 1.165 ± 0.017	1.64AspAsn: 1.64 ± 0.022	3.292AspPro: 3.292 ± 0.028	1.89AspGln: 1.89 ± 0.023	3.001AspArg: 3.001 ± 0.033	3.8AspSer: 3.8 ± 0.036	2.663AspThr: 2.663 ± 0.029	3.755AspVal: 3.755 ± 0.032	0.877AspTrp: 0.877 ± 0.016	1.362AspTyr: 1.362 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.212GluAla: 5.212 ± 0.045	0.488GluCys: 0.488 ± 0.012	4.552GluAsp: 4.552 ± 0.046	7.039GluGlu: 7.039 ± 0.082	1.572GluPhe: 1.572 ± 0.021	5.012GluGly: 5.012 ± 0.042	1.26GluHis: 1.26 ± 0.02	2.908GluIle: 2.908 ± 0.036	4.047GluLys: 4.047 ± 0.05	4.973GluLeu: 4.973 ± 0.04	1.608GluMet: 1.608 ± 0.022	1.885GluAsn: 1.885 ± 0.022	2.552GluPro: 2.552 ± 0.029	2.382GluGln: 2.382 ± 0.025	4.325GluArg: 4.325 ± 0.042	4.268GluSer: 4.268 ± 0.04	3.326GluThr: 3.326 ± 0.03	4.187GluVal: 4.187 ± 0.043	0.971GluTrp: 0.971 ± 0.017	1.48GluTyr: 1.48 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.846PheAla: 2.846 ± 0.03	0.413PheCys: 0.413 ± 0.012	2.088PheAsp: 2.088 ± 0.023	1.87PheGlu: 1.87 ± 0.023	1.332PhePhe: 1.332 ± 0.022	2.766PheGly: 2.766 ± 0.038	0.773PheHis: 0.773 ± 0.016	1.531PheIle: 1.531 ± 0.024	1.347PheLys: 1.347 ± 0.022	2.986PheLeu: 2.986 ± 0.034	0.63PheMet: 0.63 ± 0.012	1.198PheAsn: 1.198 ± 0.02	1.884PhePro: 1.884 ± 0.024	1.065PheGln: 1.065 ± 0.017	1.649PheArg: 1.649 ± 0.024	2.71PheSer: 2.71 ± 0.03	1.98PheThr: 1.98 ± 0.023	2.159PheVal: 2.159 ± 0.027	0.522PheTrp: 0.522 ± 0.013	0.899PheTyr: 0.899 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.471GlyAla: 5.471 ± 0.05	0.713GlyCys: 0.713 ± 0.015	3.837GlyAsp: 3.837 ± 0.031	4.744GlyGlu: 4.744 ± 0.041	2.495GlyPhe: 2.495 ± 0.028	8.33GlyGly: 8.33 ± 0.095	1.686GlyHis: 1.686 ± 0.022	3.213GlyIle: 3.213 ± 0.034	4.347GlyLys: 4.347 ± 0.04	6.359GlyLeu: 6.359 ± 0.043	1.892GlyMet: 1.892 ± 0.028	2.39GlyAsn: 2.39 ± 0.028	3.544GlyPro: 3.544 ± 0.036	2.813GlyGln: 2.813 ± 0.038	4.485GlyArg: 4.485 ± 0.04	6.555GlySer: 6.555 ± 0.056	4.038GlyThr: 4.038 ± 0.034	4.829GlyVal: 4.829 ± 0.038	1.383GlyTrp: 1.383 ± 0.019	2.066GlyTyr: 2.066 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.715HisAla: 1.715 ± 0.022	0.221HisCys: 0.221 ± 0.009	1.23HisAsp: 1.23 ± 0.019	1.169HisGlu: 1.169 ± 0.019	0.826HisPhe: 0.826 ± 0.014	1.549HisGly: 1.549 ± 0.019	1.019HisHis: 1.019 ± 0.025	1.101HisIle: 1.101 ± 0.016	0.798HisLys: 0.798 ± 0.014	2.426HisLeu: 2.426 ± 0.03	0.383HisMet: 0.383 ± 0.01	0.756HisAsn: 0.756 ± 0.014	1.971HisPro: 1.971 ± 0.029	0.949HisGln: 0.949 ± 0.02	1.423HisArg: 1.423 ± 0.018	2.002HisSer: 2.002 ± 0.031	1.372HisThr: 1.372 ± 0.018	1.319HisVal: 1.319 ± 0.018	0.27HisTrp: 0.27 ± 0.008	0.602HisTyr: 0.602 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.088IleAla: 4.088 ± 0.038	0.563IleCys: 0.563 ± 0.013	2.752IleAsp: 2.752 ± 0.028	2.669IleGlu: 2.669 ± 0.028	1.64IlePhe: 1.64 ± 0.024	3.164IleGly: 3.164 ± 0.033	1.115IleHis: 1.115 ± 0.019	2.231IleIle: 2.231 ± 0.03	2.166IleLys: 2.166 ± 0.027	4.127IleLeu: 4.127 ± 0.047	0.892IleMet: 0.892 ± 0.015	1.642IleAsn: 1.642 ± 0.02	3.36IlePro: 3.36 ± 0.032	1.544IleGln: 1.544 ± 0.022	2.594IleArg: 2.594 ± 0.027	3.837IleSer: 3.837 ± 0.04	2.832IleThr: 2.832 ± 0.03	3.072IleVal: 3.072 ± 0.034	0.638IleTrp: 0.638 ± 0.014	1.161IleTyr: 1.161 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.439LysAla: 4.439 ± 0.045	0.372LysCys: 0.372 ± 0.01	2.71LysAsp: 2.71 ± 0.029	3.859LysGlu: 3.859 ± 0.043	1.239LysPhe: 1.239 ± 0.021	3.828LysGly: 3.828 ± 0.039	0.992LysHis: 0.992 ± 0.017	2.117LysIle: 2.117 ± 0.032	3.719LysLys: 3.719 ± 0.053	3.833LysLeu: 3.833 ± 0.04	1.048LysMet: 1.048 ± 0.018	1.442LysAsn: 1.442 ± 0.021	2.717LysPro: 2.717 ± 0.038	1.677LysGln: 1.677 ± 0.022	3.703LysArg: 3.703 ± 0.036	3.65LysSer: 3.65 ± 0.041	2.781LysThr: 2.781 ± 0.031	3.163LysVal: 3.163 ± 0.032	0.723LysTrp: 0.723 ± 0.013	1.168LysTyr: 1.168 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.745LeuAla: 7.745 ± 0.056	0.923LeuCys: 0.923 ± 0.016	4.953LeuAsp: 4.953 ± 0.046	5.258LeuGlu: 5.258 ± 0.048	3.018LeuPhe: 3.018 ± 0.036	6.111LeuGly: 6.111 ± 0.048	2.111LeuHis: 2.111 ± 0.026	3.942LeuIle: 3.942 ± 0.038	3.909LeuLys: 3.909 ± 0.038	8.275LeuLeu: 8.275 ± 0.077	1.565LeuMet: 1.565 ± 0.022	2.931LeuAsn: 2.931 ± 0.029	6.612LeuPro: 6.612 ± 0.046	3.165LeuGln: 3.165 ± 0.03	5.411LeuArg: 5.411 ± 0.052	7.861LeuSer: 7.861 ± 0.052	5.088LeuThr: 5.088 ± 0.042	5.29LeuVal: 5.29 ± 0.047	1.006LeuTrp: 1.006 ± 0.018	2.066LeuTyr: 2.066 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	1.811MetAla: 1.811 ± 0.021	0.184MetCys: 0.184 ± 0.007	1.174MetAsp: 1.174 ± 0.017	1.277MetGlu: 1.277 ± 0.018	0.665MetPhe: 0.665 ± 0.013	1.611MetGly: 1.611 ± 0.023	0.34MetHis: 0.34 ± 0.01	0.977MetIle: 0.977 ± 0.02	0.941MetLys: 0.941 ± 0.016	1.641MetLeu: 1.641 ± 0.023	0.583MetMet: 0.583 ± 0.013	0.684MetAsn: 0.684 ± 0.014	1.202MetPro: 1.202 ± 0.017	0.671MetGln: 0.671 ± 0.015	1.188MetArg: 1.188 ± 0.018	2.192MetSer: 2.192 ± 0.024	1.396MetThr: 1.396 ± 0.019	1.214MetVal: 1.214 ± 0.017	0.231MetTrp: 0.231 ± 0.007	0.453MetTyr: 0.453 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.887AsnAla: 2.887 ± 0.032	0.282AsnCys: 0.282 ± 0.009	1.901AsnAsp: 1.901 ± 0.025	1.838AsnGlu: 1.838 ± 0.022	1.068AsnPhe: 1.068 ± 0.018	3.166AsnGly: 3.166 ± 0.038	0.782AsnHis: 0.782 ± 0.016	1.548AsnIle: 1.548 ± 0.022	1.422AsnLys: 1.422 ± 0.02	2.925AsnLeu: 2.925 ± 0.029	0.643AsnMet: 0.643 ± 0.011	1.282AsnAsn: 1.282 ± 0.021	2.375AsnPro: 2.375 ± 0.026	1.163AsnGln: 1.163 ± 0.02	1.71AsnArg: 1.71 ± 0.022	2.505AsnSer: 2.505 ± 0.033	2.036AsnThr: 2.036 ± 0.023	2.136AsnVal: 2.136 ± 0.022	0.427AsnTrp: 0.427 ± 0.012	0.838AsnTyr: 0.838 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.659ProAla: 5.659 ± 0.057	0.37ProCys: 0.37 ± 0.011	2.974ProAsp: 2.974 ± 0.032	3.439ProGlu: 3.439 ± 0.031	2.118ProPhe: 2.118 ± 0.025	3.812ProGly: 3.812 ± 0.042	1.59ProHis: 1.59 ± 0.026	3.142ProIle: 3.142 ± 0.03	2.679ProLys: 2.679 ± 0.033	5.596ProLeu: 5.596 ± 0.048	1.029ProMet: 1.029 ± 0.02	2.342ProAsn: 2.342 ± 0.026	7.393ProPro: 7.393 ± 0.112	2.424ProGln: 2.424 ± 0.038	3.557ProArg: 3.557 ± 0.037	8.564ProSer: 8.564 ± 0.074	5.387ProThr: 5.387 ± 0.048	3.718ProVal: 3.718 ± 0.036	0.608ProTrp: 0.608 ± 0.013	1.532ProTyr: 1.532 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.509GlnAla: 3.509 ± 0.038	0.33GlnCys: 0.33 ± 0.01	1.695GlnAsp: 1.695 ± 0.022	2.047GlnGlu: 2.047 ± 0.024	1.021GlnPhe: 1.021 ± 0.018	2.464GlnGly: 2.464 ± 0.031	0.995GlnHis: 0.995 ± 0.019	1.708GlnIle: 1.708 ± 0.018	1.549GlnLys: 1.549 ± 0.022	3.144GlnLeu: 3.144 ± 0.033	0.818GlnMet: 0.818 ± 0.018	1.254GlnAsn: 1.254 ± 0.02	2.742GlnPro: 2.742 ± 0.041	2.491GlnGln: 2.491 ± 0.102	2.368GlnArg: 2.368 ± 0.028	3.24GlnSer: 3.24 ± 0.032	2.336GlnThr: 2.336 ± 0.025	2.122GlnVal: 2.122 ± 0.024	0.477GlnTrp: 0.477 ± 0.011	0.985GlnTyr: 0.985 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.756ArgAla: 4.756 ± 0.036	0.521ArgCys: 0.521 ± 0.013	3.243ArgAsp: 3.243 ± 0.036	3.974ArgGlu: 3.974 ± 0.039	1.843ArgPhe: 1.843 ± 0.02	4.121ArgGly: 4.121 ± 0.044	1.413ArgHis: 1.413 ± 0.02	2.611ArgIle: 2.611 ± 0.027	3.502ArgLys: 3.502 ± 0.037	5.212ArgLeu: 5.212 ± 0.041	1.295ArgMet: 1.295 ± 0.018	1.869ArgAsn: 1.869 ± 0.022	3.919ArgPro: 3.919 ± 0.038	2.419ArgGln: 2.419 ± 0.025	5.264ArgArg: 5.264 ± 0.05	5.316ArgSer: 5.316 ± 0.051	3.311ArgThr: 3.311 ± 0.033	3.328ArgVal: 3.328 ± 0.032	0.86ArgTrp: 0.86 ± 0.017	1.488ArgTyr: 1.488 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.784SerAla: 7.784 ± 0.067	0.638SerCys: 0.638 ± 0.013	4.355SerAsp: 4.355 ± 0.045	4.194SerGlu: 4.194 ± 0.036	2.929SerPhe: 2.929 ± 0.031	6.394SerGly: 6.394 ± 0.062	2.19SerHis: 2.19 ± 0.03	3.948SerIle: 3.948 ± 0.035	3.818SerLys: 3.818 ± 0.039	7.729SerLeu: 7.729 ± 0.057	1.611SerMet: 1.611 ± 0.018	3.043SerAsn: 3.043 ± 0.033	7.118SerPro: 7.118 ± 0.075	3.26SerGln: 3.26 ± 0.034	5.302SerArg: 5.302 ± 0.046	12.802SerSer: 12.802 ± 0.141	7.578SerThr: 7.578 ± 0.068	4.746SerVal: 4.746 ± 0.038	1.0SerTrp: 1.0 ± 0.017	2.035SerTyr: 2.035 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.392ThrAla: 5.392 ± 0.045	0.575ThrCys: 0.575 ± 0.015	2.735ThrAsp: 2.735 ± 0.025	2.957ThrGlu: 2.957 ± 0.029	2.239ThrPhe: 2.239 ± 0.024	4.18ThrGly: 4.18 ± 0.034	1.404ThrHis: 1.404 ± 0.021	3.105ThrIle: 3.105 ± 0.031	2.702ThrLys: 2.702 ± 0.029	5.524ThrLeu: 5.524 ± 0.039	1.066ThrMet: 1.066 ± 0.017	2.129ThrAsn: 2.129 ± 0.027	5.65ThrPro: 5.65 ± 0.057	2.026ThrGln: 2.026 ± 0.026	3.165ThrArg: 3.165 ± 0.03	7.13ThrSer: 7.13 ± 0.063	5.24ThrThr: 5.24 ± 0.065	3.473ThrVal: 3.473 ± 0.033	0.745ThrTrp: 0.745 ± 0.014	1.554ThrTyr: 1.554 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.91ValAla: 4.91 ± 0.039	0.634ValCys: 0.634 ± 0.014	3.824ValAsp: 3.824 ± 0.036	4.455ValGlu: 4.455 ± 0.051	2.116ValPhe: 2.116 ± 0.025	4.499ValGly: 4.499 ± 0.04	1.308ValHis: 1.308 ± 0.018	3.016ValIle: 3.016 ± 0.031	3.255ValLys: 3.255 ± 0.037	5.362ValLeu: 5.362 ± 0.046	1.276ValMet: 1.276 ± 0.02	2.052ValAsn: 2.052 ± 0.024	3.783ValPro: 3.783 ± 0.037	2.247ValGln: 2.247 ± 0.024	3.489ValArg: 3.489 ± 0.03	4.496ValSer: 4.496 ± 0.04	3.38ValThr: 3.38 ± 0.035	4.326ValVal: 4.326 ± 0.04	0.897ValTrp: 0.897 ± 0.016	1.501ValTyr: 1.501 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.024TrpAla: 1.024 ± 0.017	0.159TrpCys: 0.159 ± 0.006	0.874TrpAsp: 0.874 ± 0.017	0.934TrpGlu: 0.934 ± 0.016	0.471TrpPhe: 0.471 ± 0.012	0.981TrpGly: 0.981 ± 0.015	0.274TrpHis: 0.274 ± 0.009	0.65TrpIle: 0.65 ± 0.014	0.793TrpLys: 0.793 ± 0.015	1.18TrpLeu: 1.18 ± 0.018	0.346TrpMet: 0.346 ± 0.01	0.521TrpAsn: 0.521 ± 0.012	0.52TrpPro: 0.52 ± 0.014	0.484TrpGln: 0.484 ± 0.011	0.895TrpArg: 0.895 ± 0.017	1.06TrpSer: 1.06 ± 0.017	0.853TrpThr: 0.853 ± 0.016	0.82TrpVal: 0.82 ± 0.015	0.305TrpTrp: 0.305 ± 0.009	0.364TrpTyr: 0.364 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.021TyrAla: 2.021 ± 0.022	0.303TyrCys: 0.303 ± 0.009	1.577TyrAsp: 1.577 ± 0.022	1.403TyrGlu: 1.403 ± 0.02	0.976TyrPhe: 0.976 ± 0.017	1.875TyrGly: 1.875 ± 0.027	0.692TyrHis: 0.692 ± 0.014	1.179TyrIle: 1.179 ± 0.023	1.007TyrLys: 1.007 ± 0.016	2.388TyrLeu: 2.388 ± 0.025	0.48TyrMet: 0.48 ± 0.011	0.934TyrAsn: 0.934 ± 0.016	1.469TyrPro: 1.469 ± 0.024	0.938TyrGln: 0.938 ± 0.018	1.391TyrArg: 1.391 ± 0.019	1.812TyrSer: 1.812 ± 0.022	1.557TyrThr: 1.557 ± 0.023	1.476TyrVal: 1.476 ± 0.019	0.348TyrTrp: 0.348 ± 0.011	0.737TyrTyr: 0.737 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7422 proteins (3956821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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