Amino acid dipepetide frequency for Toxoplasma gondii (strain ATCC 50861 / VEG)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.542AlaAla: 13.542 ± 0.085	2.307AlaCys: 2.307 ± 0.027	4.448AlaAsp: 4.448 ± 0.029	7.338AlaGlu: 7.338 ± 0.048	3.796AlaPhe: 3.796 ± 0.03	7.684AlaGly: 7.684 ± 0.05	1.85AlaHis: 1.85 ± 0.019	2.084AlaIle: 2.084 ± 0.023	3.537AlaLys: 3.537 ± 0.033	8.687AlaLeu: 8.687 ± 0.052	1.278AlaMet: 1.278 ± 0.018	2.135AlaAsn: 2.135 ± 0.019	6.238AlaPro: 6.238 ± 0.053	3.271AlaGln: 3.271 ± 0.026	6.747AlaArg: 6.747 ± 0.041	13.233AlaSer: 13.233 ± 0.087	5.259AlaThr: 5.259 ± 0.032	6.341AlaVal: 6.341 ± 0.036	0.953AlaTrp: 0.953 ± 0.014	1.364AlaTyr: 1.364 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	1.782CysAla: 1.782 ± 0.023	0.629CysCys: 0.629 ± 0.012	0.82CysAsp: 0.82 ± 0.013	1.116CysGlu: 1.116 ± 0.016	0.846CysPhe: 0.846 ± 0.014	1.649CysGly: 1.649 ± 0.02	0.413CysHis: 0.413 ± 0.009	0.58CysIle: 0.58 ± 0.009	0.574CysLys: 0.574 ± 0.01	2.136CysLeu: 2.136 ± 0.022	0.389CysMet: 0.389 ± 0.009	0.389CysAsn: 0.389 ± 0.009	1.333CysPro: 1.333 ± 0.031	0.616CysGln: 0.616 ± 0.011	1.711CysArg: 1.711 ± 0.021	2.337CysSer: 2.337 ± 0.026	1.004CysThr: 1.004 ± 0.015	1.463CysVal: 1.463 ± 0.019	0.23CysTrp: 0.23 ± 0.006	0.309CysTyr: 0.309 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.706AspAla: 5.706 ± 0.037	0.873AspCys: 0.873 ± 0.016	2.741AspAsp: 2.741 ± 0.028	4.462AspGlu: 4.462 ± 0.036	1.735AspPhe: 1.735 ± 0.018	4.014AspGly: 4.014 ± 0.03	0.683AspHis: 0.683 ± 0.01	1.413AspIle: 1.413 ± 0.018	1.713AspLys: 1.713 ± 0.021	3.878AspLeu: 3.878 ± 0.028	0.738AspMet: 0.738 ± 0.013	1.005AspAsn: 1.005 ± 0.015	2.436AspPro: 2.436 ± 0.019	1.283AspGln: 1.283 ± 0.014	3.533AspArg: 3.533 ± 0.029	4.585AspSer: 4.585 ± 0.032	2.312AspThr: 2.312 ± 0.024	2.984AspVal: 2.984 ± 0.023	0.523AspTrp: 0.523 ± 0.009	0.641AspTyr: 0.641 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	8.524GluAla: 8.524 ± 0.054	0.963GluCys: 0.963 ± 0.016	4.479GluAsp: 4.479 ± 0.035	9.976GluGlu: 9.976 ± 0.101	1.568GluPhe: 1.568 ± 0.017	6.322GluGly: 6.322 ± 0.045	1.23GluHis: 1.23 ± 0.015	1.868GluIle: 1.868 ± 0.02	5.183GluLys: 5.183 ± 0.052	4.649GluLeu: 4.649 ± 0.038	1.2GluMet: 1.2 ± 0.015	2.364GluAsn: 2.364 ± 0.025	2.709GluPro: 2.709 ± 0.024	3.104GluGln: 3.104 ± 0.03	7.206GluArg: 7.206 ± 0.063	5.265GluSer: 5.265 ± 0.034	5.452GluThr: 5.452 ± 0.037	3.656GluVal: 3.656 ± 0.028	0.592GluTrp: 0.592 ± 0.009	0.778GluTyr: 0.778 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	3.226PheAla: 3.226 ± 0.026	0.9PheCys: 0.9 ± 0.013	1.605PheAsp: 1.605 ± 0.018	1.701PheGlu: 1.701 ± 0.017	2.009PhePhe: 2.009 ± 0.024	2.079PheGly: 2.079 ± 0.023	0.827PheHis: 0.827 ± 0.011	0.868PheIle: 0.868 ± 0.014	0.861PheLys: 0.861 ± 0.013	4.211PheLeu: 4.211 ± 0.034	0.445PheMet: 0.445 ± 0.01	0.663PheAsn: 0.663 ± 0.012	2.561PhePro: 2.561 ± 0.026	1.191PheGln: 1.191 ± 0.014	2.179PheArg: 2.179 ± 0.019	4.676PheSer: 4.676 ± 0.035	1.334PheThr: 1.334 ± 0.017	2.306PheVal: 2.306 ± 0.024	0.418PheTrp: 0.418 ± 0.009	0.688PheTyr: 0.688 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	7.419GlyAla: 7.419 ± 0.06	1.389GlyCys: 1.389 ± 0.017	4.855GlyAsp: 4.855 ± 0.042	6.928GlyGlu: 6.928 ± 0.06	2.175GlyPhe: 2.175 ± 0.02	7.481GlyGly: 7.481 ± 0.067	1.361GlyHis: 1.361 ± 0.02	1.775GlyIle: 1.775 ± 0.019	3.254GlyLys: 3.254 ± 0.033	5.13GlyLeu: 5.13 ± 0.033	0.999GlyMet: 0.999 ± 0.014	2.041GlyAsn: 2.041 ± 0.019	3.605GlyPro: 3.605 ± 0.04	2.404GlyGln: 2.404 ± 0.019	6.412GlyArg: 6.412 ± 0.047	6.991GlySer: 6.991 ± 0.048	3.77GlyThr: 3.77 ± 0.03	4.709GlyVal: 4.709 ± 0.029	0.696GlyTrp: 0.696 ± 0.012	1.019GlyTyr: 1.019 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.582HisAla: 2.582 ± 0.02	0.45HisCys: 0.45 ± 0.009	0.81HisAsp: 0.81 ± 0.014	1.267HisGlu: 1.267 ± 0.016	0.846HisPhe: 0.846 ± 0.012	1.539HisGly: 1.539 ± 0.016	0.585HisHis: 0.585 ± 0.014	0.614HisIle: 0.614 ± 0.01	0.653HisLys: 0.653 ± 0.011	2.278HisLeu: 2.278 ± 0.02	0.352HisMet: 0.352 ± 0.008	0.44HisAsn: 0.44 ± 0.009	1.589HisPro: 1.589 ± 0.018	0.87HisGln: 0.87 ± 0.014	1.865HisArg: 1.865 ± 0.019	2.107HisSer: 2.107 ± 0.019	1.104HisThr: 1.104 ± 0.014	1.288HisVal: 1.288 ± 0.016	0.232HisTrp: 0.232 ± 0.006	0.335HisTyr: 0.335 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.035IleAla: 2.035 ± 0.021	0.634IleCys: 0.634 ± 0.011	1.283IleAsp: 1.283 ± 0.018	1.554IleGlu: 1.554 ± 0.018	1.055IlePhe: 1.055 ± 0.015	1.43IleGly: 1.43 ± 0.02	0.67IleHis: 0.67 ± 0.011	0.737IleIle: 0.737 ± 0.013	0.883IleLys: 0.883 ± 0.014	2.452IleLeu: 2.452 ± 0.024	0.361IleMet: 0.361 ± 0.009	0.597IleAsn: 0.597 ± 0.012	1.535IlePro: 1.535 ± 0.016	1.086IleGln: 1.086 ± 0.017	1.825IleArg: 1.825 ± 0.022	2.229IleSer: 2.229 ± 0.024	0.975IleThr: 0.975 ± 0.016	1.58IleVal: 1.58 ± 0.02	0.285IleTrp: 0.285 ± 0.008	0.523IleTyr: 0.523 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.754LysAla: 3.754 ± 0.035	0.587LysCys: 0.587 ± 0.01	1.988LysAsp: 1.988 ± 0.024	3.908LysGlu: 3.908 ± 0.044	0.899LysPhe: 0.899 ± 0.014	2.77LysGly: 2.77 ± 0.021	0.898LysHis: 0.898 ± 0.013	1.127LysIle: 1.127 ± 0.016	3.324LysLys: 3.324 ± 0.047	2.941LysLeu: 2.941 ± 0.031	0.712LysMet: 0.712 ± 0.012	1.305LysAsn: 1.305 ± 0.016	1.898LysPro: 1.898 ± 0.022	1.938LysGln: 1.938 ± 0.024	3.974LysArg: 3.974 ± 0.031	2.717LysSer: 2.717 ± 0.024	2.478LysThr: 2.478 ± 0.02	2.007LysVal: 2.007 ± 0.025	0.365LysTrp: 0.365 ± 0.009	0.59LysTyr: 0.59 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	8.24LeuAla: 8.24 ± 0.051	2.047LeuCys: 2.047 ± 0.021	3.655LeuAsp: 3.655 ± 0.026	5.409LeuGlu: 5.409 ± 0.04	3.66LeuPhe: 3.66 ± 0.035	5.154LeuGly: 5.154 ± 0.034	2.61LeuHis: 2.61 ± 0.021	1.961LeuIle: 1.961 ± 0.023	3.172LeuLys: 3.172 ± 0.032	10.896LeuLeu: 10.896 ± 0.09	1.189LeuMet: 1.189 ± 0.016	1.841LeuAsn: 1.841 ± 0.019	7.115LeuPro: 7.115 ± 0.052	4.484LeuGln: 4.484 ± 0.036	7.391LeuArg: 7.391 ± 0.041	10.112LeuSer: 10.112 ± 0.063	3.746LeuThr: 3.746 ± 0.027	4.817LeuVal: 4.817 ± 0.035	1.053LeuTrp: 1.053 ± 0.014	1.507LeuTyr: 1.507 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	1.324MetAla: 1.324 ± 0.016	0.259MetCys: 0.259 ± 0.006	0.629MetAsp: 0.629 ± 0.01	1.038MetGlu: 1.038 ± 0.019	0.426MetPhe: 0.426 ± 0.009	0.803MetGly: 0.803 ± 0.013	0.434MetHis: 0.434 ± 0.009	0.381MetIle: 0.381 ± 0.009	0.769MetLys: 0.769 ± 0.013	1.262MetLeu: 1.262 ± 0.017	0.307MetMet: 0.307 ± 0.007	0.432MetAsn: 0.432 ± 0.009	0.872MetPro: 0.872 ± 0.013	0.839MetGln: 0.839 ± 0.012	1.217MetArg: 1.217 ± 0.015	1.124MetSer: 1.124 ± 0.014	0.697MetThr: 0.697 ± 0.012	0.725MetVal: 0.725 ± 0.012	0.164MetTrp: 0.164 ± 0.005	0.293MetTyr: 0.293 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.747AsnAla: 2.747 ± 0.023	0.494AsnCys: 0.494 ± 0.01	1.091AsnAsp: 1.091 ± 0.015	1.776AsnGlu: 1.776 ± 0.018	0.838AsnPhe: 0.838 ± 0.014	1.882AsnGly: 1.882 ± 0.017	0.433AsnHis: 0.433 ± 0.01	0.737AsnIle: 0.737 ± 0.014	0.916AsnLys: 0.916 ± 0.014	1.975AsnLeu: 1.975 ± 0.02	0.423AsnMet: 0.423 ± 0.01	0.568AsnAsn: 0.568 ± 0.012	1.369AsnPro: 1.369 ± 0.016	0.769AsnGln: 0.769 ± 0.011	1.751AsnArg: 1.751 ± 0.019	2.191AsnSer: 2.191 ± 0.02	1.11AsnThr: 1.11 ± 0.016	1.497AsnVal: 1.497 ± 0.016	0.264AsnTrp: 0.264 ± 0.006	0.389AsnTyr: 0.389 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	6.743ProAla: 6.743 ± 0.044	1.287ProCys: 1.287 ± 0.02	2.414ProAsp: 2.414 ± 0.023	3.883ProGlu: 3.883 ± 0.03	2.461ProPhe: 2.461 ± 0.023	4.669ProGly: 4.669 ± 0.042	1.564ProHis: 1.564 ± 0.016	1.121ProIle: 1.121 ± 0.016	1.704ProLys: 1.704 ± 0.023	5.989ProLeu: 5.989 ± 0.039	0.607ProMet: 0.607 ± 0.01	1.165ProAsn: 1.165 ± 0.016	6.108ProPro: 6.108 ± 0.057	2.593ProGln: 2.593 ± 0.026	4.784ProArg: 4.784 ± 0.035	9.152ProSer: 9.152 ± 0.076	3.024ProThr: 3.024 ± 0.024	3.895ProVal: 3.895 ± 0.032	0.601ProTrp: 0.601 ± 0.01	0.872ProTyr: 0.872 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.825GlnAla: 3.825 ± 0.031	0.584GlnCys: 0.584 ± 0.012	1.64GlnAsp: 1.64 ± 0.017	3.232GlnGlu: 3.232 ± 0.03	0.985GlnPhe: 0.985 ± 0.013	2.728GlnGly: 2.728 ± 0.025	0.939GlnHis: 0.939 ± 0.014	1.087GlnIle: 1.087 ± 0.013	2.067GlnLys: 2.067 ± 0.024	3.644GlnLeu: 3.644 ± 0.032	0.731GlnMet: 0.731 ± 0.011	1.082GlnAsn: 1.082 ± 0.014	2.093GlnPro: 2.093 ± 0.025	2.507GlnGln: 2.507 ± 0.034	3.931GlnArg: 3.931 ± 0.031	3.02GlnSer: 3.02 ± 0.026	2.466GlnThr: 2.466 ± 0.018	2.117GlnVal: 2.117 ± 0.021	0.408GlnTrp: 0.408 ± 0.009	0.499GlnTyr: 0.499 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	6.43ArgAla: 6.43 ± 0.033	1.519ArgCys: 1.519 ± 0.017	4.179ArgAsp: 4.179 ± 0.032	7.895ArgGlu: 7.895 ± 0.07	2.379ArgPhe: 2.379 ± 0.019	6.868ArgGly: 6.868 ± 0.054	2.067ArgHis: 2.067 ± 0.019	1.938ArgIle: 1.938 ± 0.02	3.75ArgLys: 3.75 ± 0.034	7.409ArgLeu: 7.409 ± 0.045	1.246ArgMet: 1.246 ± 0.014	2.095ArgAsn: 2.095 ± 0.019	4.293ArgPro: 4.293 ± 0.033	3.952ArgGln: 3.952 ± 0.033	9.771ArgArg: 9.771 ± 0.074	6.95ArgSer: 6.95 ± 0.052	3.753ArgThr: 3.753 ± 0.024	4.333ArgVal: 4.333 ± 0.026	0.81ArgTrp: 0.81 ± 0.011	1.017ArgTyr: 1.017 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	10.945SerAla: 10.945 ± 0.07	2.337SerCys: 2.337 ± 0.026	4.094SerAsp: 4.094 ± 0.031	6.04SerGlu: 6.04 ± 0.039	4.251SerPhe: 4.251 ± 0.035	7.663SerGly: 7.663 ± 0.052	2.063SerHis: 2.063 ± 0.022	1.976SerIle: 1.976 ± 0.023	2.654SerLys: 2.654 ± 0.023	10.555SerLeu: 10.555 ± 0.069	1.069SerMet: 1.069 ± 0.016	1.803SerAsn: 1.803 ± 0.018	10.081SerPro: 10.081 ± 0.092	3.457SerGln: 3.457 ± 0.027	8.411SerArg: 8.411 ± 0.059	20.174SerSer: 20.174 ± 0.244	4.945SerThr: 4.945 ± 0.034	6.166SerVal: 6.166 ± 0.033	1.003SerTrp: 1.003 ± 0.014	1.168SerTyr: 1.168 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	5.248ThrAla: 5.248 ± 0.031	1.007ThrCys: 1.007 ± 0.016	2.349ThrAsp: 2.349 ± 0.017	3.845ThrGlu: 3.845 ± 0.03	1.629ThrPhe: 1.629 ± 0.019	4.065ThrGly: 4.065 ± 0.029	1.171ThrHis: 1.171 ± 0.013	1.138ThrIle: 1.138 ± 0.017	1.908ThrLys: 1.908 ± 0.02	4.344ThrLeu: 4.344 ± 0.028	0.648ThrMet: 0.648 ± 0.01	1.195ThrAsn: 1.195 ± 0.015	3.74ThrPro: 3.74 ± 0.029	2.086ThrGln: 2.086 ± 0.02	3.868ThrArg: 3.868 ± 0.026	5.032ThrSer: 5.032 ± 0.031	2.687ThrThr: 2.687 ± 0.034	3.195ThrVal: 3.195 ± 0.023	0.507ThrTrp: 0.507 ± 0.008	0.761ThrTyr: 0.761 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	6.037ValAla: 6.037 ± 0.034	1.517ValCys: 1.517 ± 0.016	3.102ValAsp: 3.102 ± 0.022	4.233ValGlu: 4.233 ± 0.028	2.272ValPhe: 2.272 ± 0.022	3.786ValGly: 3.786 ± 0.03	1.444ValHis: 1.444 ± 0.016	1.397ValIle: 1.397 ± 0.02	2.178ValLys: 2.178 ± 0.025	5.218ValLeu: 5.218 ± 0.036	0.785ValMet: 0.785 ± 0.014	1.375ValAsn: 1.375 ± 0.017	3.74ValPro: 3.74 ± 0.031	2.183ValGln: 2.183 ± 0.02	3.746ValArg: 3.746 ± 0.027	6.883ValSer: 6.883 ± 0.04	2.803ValThr: 2.803 ± 0.027	3.735ValVal: 3.735 ± 0.029	0.67ValTrp: 0.67 ± 0.011	1.206ValTyr: 1.206 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.012	0.209TrpCys: 0.209 ± 0.005	0.384TrpAsp: 0.384 ± 0.008	0.606TrpGlu: 0.606 ± 0.011	0.282TrpPhe: 0.282 ± 0.007	0.759TrpGly: 0.759 ± 0.012	0.225TrpHis: 0.225 ± 0.006	0.392TrpIle: 0.392 ± 0.008	0.552TrpLys: 0.552 ± 0.01	0.987TrpLeu: 0.987 ± 0.015	0.233TrpMet: 0.233 ± 0.006	0.344TrpAsn: 0.344 ± 0.009	0.483TrpPro: 0.483 ± 0.008	0.443TrpGln: 0.443 ± 0.008	1.157TrpArg: 1.157 ± 0.014	0.853TrpSer: 0.853 ± 0.013	0.677TrpThr: 0.677 ± 0.01	0.501TrpVal: 0.501 ± 0.01	0.181TrpTrp: 0.181 ± 0.006	0.165TrpTyr: 0.165 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.285TyrAla: 1.285 ± 0.015	0.333TyrCys: 0.333 ± 0.014	0.691TyrAsp: 0.691 ± 0.011	0.88TyrGlu: 0.88 ± 0.014	0.636TyrPhe: 0.636 ± 0.012	1.066TyrGly: 1.066 ± 0.016	0.342TyrHis: 0.342 ± 0.008	0.537TyrIle: 0.537 ± 0.011	0.527TyrLys: 0.527 ± 0.011	1.416TyrLeu: 1.416 ± 0.016	0.283TyrMet: 0.283 ± 0.008	0.381TyrAsn: 0.381 ± 0.009	0.838TyrPro: 0.838 ± 0.013	0.507TyrGln: 0.507 ± 0.011	1.172TyrArg: 1.172 ± 0.016	1.223TyrSer: 1.223 ± 0.016	0.83TyrThr: 0.83 ± 0.013	0.996TyrVal: 0.996 ± 0.015	0.18TyrTrp: 0.18 ± 0.006	0.365TyrTyr: 0.365 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8404 proteins (6625207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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