Amino acid dipepetide frequency for Xanthomonadaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.277AlaAla: 18.277 ± 0.206	1.223AlaCys: 1.223 ± 0.036	7.141AlaAsp: 7.141 ± 0.102	7.145AlaGlu: 7.145 ± 0.099	3.948AlaPhe: 3.948 ± 0.077	12.102AlaGly: 12.102 ± 0.161	2.516AlaHis: 2.516 ± 0.062	5.386AlaIle: 5.386 ± 0.098	3.024AlaLys: 3.024 ± 0.084	15.181AlaLeu: 15.181 ± 0.161	3.321AlaMet: 3.321 ± 0.063	2.848AlaAsn: 2.848 ± 0.067	6.385AlaPro: 6.385 ± 0.105	4.925AlaGln: 4.925 ± 0.087	10.261AlaArg: 10.261 ± 0.128	7.207AlaSer: 7.207 ± 0.116	6.134AlaThr: 6.134 ± 0.082	8.586AlaVal: 8.586 ± 0.114	2.126AlaTrp: 2.126 ± 0.049	2.591AlaTyr: 2.591 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.038	0.11CysCys: 0.11 ± 0.012	0.431CysAsp: 0.431 ± 0.022	0.44CysGlu: 0.44 ± 0.025	0.279CysPhe: 0.279 ± 0.019	0.906CysGly: 0.906 ± 0.035	0.221CysHis: 0.221 ± 0.017	0.349CysIle: 0.349 ± 0.02	0.211CysLys: 0.211 ± 0.016	0.812CysLeu: 0.812 ± 0.027	0.147CysMet: 0.147 ± 0.012	0.198CysAsn: 0.198 ± 0.018	0.411CysPro: 0.411 ± 0.021	0.24CysGln: 0.24 ± 0.018	0.609CysArg: 0.609 ± 0.025	0.465CysSer: 0.465 ± 0.026	0.435CysThr: 0.435 ± 0.027	0.693CysVal: 0.693 ± 0.029	0.135CysTrp: 0.135 ± 0.012	0.192CysTyr: 0.192 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.883AspAla: 7.883 ± 0.099	0.441AspCys: 0.441 ± 0.022	3.04AspAsp: 3.04 ± 0.064	3.265AspGlu: 3.265 ± 0.069	2.124AspPhe: 2.124 ± 0.053	5.47AspGly: 5.47 ± 0.089	1.193AspHis: 1.193 ± 0.042	2.186AspIle: 2.186 ± 0.046	1.598AspLys: 1.598 ± 0.045	5.738AspLeu: 5.738 ± 0.079	1.057AspMet: 1.057 ± 0.035	1.295AspAsn: 1.295 ± 0.041	3.782AspPro: 3.782 ± 0.074	1.844AspGln: 1.844 ± 0.054	4.131AspArg: 4.131 ± 0.068	2.66AspSer: 2.66 ± 0.051	2.467AspThr: 2.467 ± 0.052	3.763AspVal: 3.763 ± 0.066	1.104AspTrp: 1.104 ± 0.035	1.617AspTyr: 1.617 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.09GluAla: 7.09 ± 0.103	0.342GluCys: 0.342 ± 0.022	2.547GluAsp: 2.547 ± 0.059	2.702GluGlu: 2.702 ± 0.063	1.847GluPhe: 1.847 ± 0.052	4.191GluGly: 4.191 ± 0.069	1.317GluHis: 1.317 ± 0.038	2.536GluIle: 2.536 ± 0.06	1.569GluLys: 1.569 ± 0.045	6.127GluLeu: 6.127 ± 0.098	1.154GluMet: 1.154 ± 0.042	1.278GluAsn: 1.278 ± 0.037	2.615GluPro: 2.615 ± 0.06	2.569GluGln: 2.569 ± 0.057	4.794GluArg: 4.794 ± 0.074	2.796GluSer: 2.796 ± 0.058	2.621GluThr: 2.621 ± 0.056	4.167GluVal: 4.167 ± 0.061	0.762GluTrp: 0.762 ± 0.032	1.194GluTyr: 1.194 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.241PheAla: 4.241 ± 0.078	0.338PheCys: 0.338 ± 0.019	2.645PheAsp: 2.645 ± 0.057	2.017PheGlu: 2.017 ± 0.051	1.219PhePhe: 1.219 ± 0.036	3.362PheGly: 3.362 ± 0.063	0.809PheHis: 0.809 ± 0.028	1.295PheIle: 1.295 ± 0.044	0.949PheLys: 0.949 ± 0.036	3.286PheLeu: 3.286 ± 0.063	0.624PheMet: 0.624 ± 0.027	1.114PheAsn: 1.114 ± 0.036	1.481PhePro: 1.481 ± 0.04	0.995PheGln: 0.995 ± 0.034	2.102PheArg: 2.102 ± 0.049	2.095PheSer: 2.095 ± 0.053	1.668PheThr: 1.668 ± 0.045	2.519PheVal: 2.519 ± 0.051	0.513PheTrp: 0.513 ± 0.025	0.84PheTyr: 0.84 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.266GlyAla: 9.266 ± 0.136	0.835GlyCys: 0.835 ± 0.03	4.889GlyAsp: 4.889 ± 0.082	5.018GlyGlu: 5.018 ± 0.079	3.541GlyPhe: 3.541 ± 0.064	7.416GlyGly: 7.416 ± 0.126	2.081GlyHis: 2.081 ± 0.056	4.131GlyIle: 4.131 ± 0.071	3.403GlyLys: 3.403 ± 0.07	9.279GlyLeu: 9.279 ± 0.089	2.474GlyMet: 2.474 ± 0.047	2.518GlyAsn: 2.518 ± 0.062	3.375GlyPro: 3.375 ± 0.067	3.434GlyGln: 3.434 ± 0.06	6.379GlyArg: 6.379 ± 0.091	5.203GlySer: 5.203 ± 0.086	4.335GlyThr: 4.335 ± 0.093	6.358GlyVal: 6.358 ± 0.085	1.686GlyTrp: 1.686 ± 0.043	2.457GlyTyr: 2.457 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.133HisAla: 3.133 ± 0.063	0.279HisCys: 0.279 ± 0.017	1.277HisAsp: 1.277 ± 0.041	1.112HisGlu: 1.112 ± 0.035	0.798HisPhe: 0.798 ± 0.029	2.385HisGly: 2.385 ± 0.06	0.562HisHis: 0.562 ± 0.025	0.661HisIle: 0.661 ± 0.028	0.433HisLys: 0.433 ± 0.023	2.166HisLeu: 2.166 ± 0.057	0.41HisMet: 0.41 ± 0.021	0.466HisAsn: 0.466 ± 0.022	1.45HisPro: 1.45 ± 0.042	0.663HisGln: 0.663 ± 0.027	1.699HisArg: 1.699 ± 0.045	1.056HisSer: 1.056 ± 0.031	0.837HisThr: 0.837 ± 0.031	1.584HisVal: 1.584 ± 0.047	0.428HisTrp: 0.428 ± 0.021	0.596HisTyr: 0.596 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.097IleAla: 6.097 ± 0.08	0.309IleCys: 0.309 ± 0.02	3.126IleAsp: 3.126 ± 0.067	2.904IleGlu: 2.904 ± 0.061	1.076IlePhe: 1.076 ± 0.035	4.322IleGly: 4.322 ± 0.085	0.856IleHis: 0.856 ± 0.034	1.375IleIle: 1.375 ± 0.044	1.086IleLys: 1.086 ± 0.039	3.14IleLeu: 3.14 ± 0.064	0.5IleMet: 0.5 ± 0.026	1.144IleAsn: 1.144 ± 0.039	2.113IlePro: 2.113 ± 0.054	1.07IleGln: 1.07 ± 0.038	2.635IleArg: 2.635 ± 0.051	2.245IleSer: 2.245 ± 0.052	2.049IleThr: 2.049 ± 0.053	3.11IleVal: 3.11 ± 0.064	0.408IleTrp: 0.408 ± 0.024	0.777IleTyr: 0.777 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.412LysAla: 3.412 ± 0.085	0.152LysCys: 0.152 ± 0.014	1.405LysAsp: 1.405 ± 0.041	1.183LysGlu: 1.183 ± 0.04	0.809LysPhe: 0.809 ± 0.032	2.133LysGly: 2.133 ± 0.049	0.549LysHis: 0.549 ± 0.029	1.1LysIle: 1.1 ± 0.037	1.045LysLys: 1.045 ± 0.058	3.226LysLeu: 3.226 ± 0.062	0.596LysMet: 0.596 ± 0.026	0.604LysAsn: 0.604 ± 0.025	2.094LysPro: 2.094 ± 0.059	1.14LysGln: 1.14 ± 0.037	2.13LysArg: 2.13 ± 0.053	1.506LysSer: 1.506 ± 0.046	1.401LysThr: 1.401 ± 0.047	2.16LysVal: 2.16 ± 0.063	0.319LysTrp: 0.319 ± 0.019	0.633LysTyr: 0.633 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.706LeuAla: 15.706 ± 0.151	0.929LeuCys: 0.929 ± 0.035	6.538LeuAsp: 6.538 ± 0.105	5.726LeuGlu: 5.726 ± 0.099	3.543LeuPhe: 3.543 ± 0.07	9.148LeuGly: 9.148 ± 0.11	2.429LeuHis: 2.429 ± 0.055	3.559LeuIle: 3.559 ± 0.07	3.114LeuLys: 3.114 ± 0.072	12.446LeuLeu: 12.446 ± 0.186	2.165LeuMet: 2.165 ± 0.052	2.332LeuAsn: 2.332 ± 0.054	6.72LeuPro: 6.72 ± 0.098	4.459LeuGln: 4.459 ± 0.078	8.818LeuArg: 8.818 ± 0.123	6.023LeuSer: 6.023 ± 0.096	4.241LeuThr: 4.241 ± 0.068	8.473LeuVal: 8.473 ± 0.106	1.38LeuTrp: 1.38 ± 0.041	2.134LeuTyr: 2.134 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.7MetAla: 2.7 ± 0.061	0.146MetCys: 0.146 ± 0.012	1.115MetAsp: 1.115 ± 0.036	0.993MetGlu: 0.993 ± 0.034	0.663MetPhe: 0.663 ± 0.032	1.61MetGly: 1.61 ± 0.04	0.472MetHis: 0.472 ± 0.023	0.83MetIle: 0.83 ± 0.032	0.835MetLys: 0.835 ± 0.029	2.433MetLeu: 2.433 ± 0.049	0.475MetMet: 0.475 ± 0.021	0.667MetAsn: 0.667 ± 0.026	1.409MetPro: 1.409 ± 0.044	1.003MetGln: 1.003 ± 0.035	1.677MetArg: 1.677 ± 0.05	1.471MetSer: 1.471 ± 0.038	1.302MetThr: 1.302 ± 0.039	1.442MetVal: 1.442 ± 0.039	0.206MetTrp: 0.206 ± 0.014	0.357MetTyr: 0.357 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.054	0.216AsnCys: 0.216 ± 0.016	1.419AsnAsp: 1.419 ± 0.039	1.158AsnGlu: 1.158 ± 0.033	0.944AsnPhe: 0.944 ± 0.032	2.274AsnGly: 2.274 ± 0.062	0.501AsnHis: 0.501 ± 0.023	0.996AsnIle: 0.996 ± 0.039	0.613AsnLys: 0.613 ± 0.028	2.602AsnLeu: 2.602 ± 0.056	0.397AsnMet: 0.397 ± 0.024	0.655AsnAsn: 0.655 ± 0.03	1.827AsnPro: 1.827 ± 0.045	0.81AsnGln: 0.81 ± 0.035	1.75AsnArg: 1.75 ± 0.048	1.154AsnSer: 1.154 ± 0.038	1.208AsnThr: 1.208 ± 0.042	1.72AsnVal: 1.72 ± 0.056	0.369AsnTrp: 0.369 ± 0.022	0.662AsnTyr: 0.662 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	8.075ProAla: 8.075 ± 0.117	0.352ProCys: 0.352 ± 0.021	3.269ProAsp: 3.269 ± 0.064	3.26ProGlu: 3.26 ± 0.059	1.651ProPhe: 1.651 ± 0.042	5.454ProGly: 5.454 ± 0.088	1.095ProHis: 1.095 ± 0.032	1.852ProIle: 1.852 ± 0.047	1.247ProLys: 1.247 ± 0.041	5.526ProLeu: 5.526 ± 0.084	1.328ProMet: 1.328 ± 0.039	1.093ProAsn: 1.093 ± 0.041	2.896ProPro: 2.896 ± 0.074	2.158ProGln: 2.158 ± 0.052	3.832ProArg: 3.832 ± 0.075	2.832ProSer: 2.832 ± 0.059	2.211ProThr: 2.211 ± 0.053	4.458ProVal: 4.458 ± 0.073	0.904ProTrp: 0.904 ± 0.037	1.18ProTyr: 1.18 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.864GlnAla: 5.864 ± 0.107	0.281GlnCys: 0.281 ± 0.018	1.658GlnAsp: 1.658 ± 0.04	1.593GlnGlu: 1.593 ± 0.049	1.136GlnPhe: 1.136 ± 0.031	2.984GlnGly: 2.984 ± 0.059	0.831GlnHis: 0.831 ± 0.033	1.356GlnIle: 1.356 ± 0.041	1.019GlnLys: 1.019 ± 0.037	4.165GlnLeu: 4.165 ± 0.074	0.781GlnMet: 0.781 ± 0.031	0.725GlnAsn: 0.725 ± 0.035	2.203GlnPro: 2.203 ± 0.048	1.884GlnGln: 1.884 ± 0.05	3.589GlnArg: 3.589 ± 0.069	1.813GlnSer: 1.813 ± 0.045	1.474GlnThr: 1.474 ± 0.038	3.256GlnVal: 3.256 ± 0.059	0.64GlnTrp: 0.64 ± 0.03	0.8GlnTyr: 0.8 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	8.277ArgAla: 8.277 ± 0.114	0.574ArgCys: 0.574 ± 0.028	4.439ArgAsp: 4.439 ± 0.074	4.744ArgGlu: 4.744 ± 0.082	2.952ArgPhe: 2.952 ± 0.055	5.579ArgGly: 5.579 ± 0.074	2.037ArgHis: 2.037 ± 0.049	4.047ArgIle: 4.047 ± 0.069	2.331ArgLys: 2.331 ± 0.05	8.685ArgLeu: 8.685 ± 0.115	1.98ArgMet: 1.98 ± 0.046	2.056ArgAsn: 2.056 ± 0.051	3.645ArgPro: 3.645 ± 0.073	3.314ArgGln: 3.314 ± 0.068	6.038ArgArg: 6.038 ± 0.11	3.944ArgSer: 3.944 ± 0.073	3.115ArgThr: 3.115 ± 0.056	5.378ArgVal: 5.378 ± 0.081	1.395ArgTrp: 1.395 ± 0.045	2.201ArgTyr: 2.201 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.525SerAla: 6.525 ± 0.104	0.439SerCys: 0.439 ± 0.025	2.755SerAsp: 2.755 ± 0.051	2.546SerGlu: 2.546 ± 0.061	1.965SerPhe: 1.965 ± 0.053	5.632SerGly: 5.632 ± 0.091	1.153SerHis: 1.153 ± 0.039	2.266SerIle: 2.266 ± 0.049	1.408SerLys: 1.408 ± 0.043	5.977SerLeu: 5.977 ± 0.082	1.157SerMet: 1.157 ± 0.041	1.426SerAsn: 1.426 ± 0.043	3.061SerPro: 3.061 ± 0.077	1.935SerGln: 1.935 ± 0.047	4.15SerArg: 4.15 ± 0.057	2.957SerSer: 2.957 ± 0.064	2.723SerThr: 2.723 ± 0.058	3.814SerVal: 3.814 ± 0.069	0.833SerTrp: 0.833 ± 0.032	1.404SerTyr: 1.404 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.531ThrAla: 5.531 ± 0.093	0.375ThrCys: 0.375 ± 0.022	2.418ThrAsp: 2.418 ± 0.057	2.094ThrGlu: 2.094 ± 0.048	1.431ThrPhe: 1.431 ± 0.046	4.492ThrGly: 4.492 ± 0.082	1.043ThrHis: 1.043 ± 0.036	1.805ThrIle: 1.805 ± 0.055	0.822ThrLys: 0.822 ± 0.034	5.773ThrLeu: 5.773 ± 0.086	0.788ThrMet: 0.788 ± 0.03	0.943ThrAsn: 0.943 ± 0.032	3.198ThrPro: 3.198 ± 0.06	1.455ThrGln: 1.455 ± 0.041	3.533ThrArg: 3.533 ± 0.056	2.305ThrSer: 2.305 ± 0.057	2.373ThrThr: 2.373 ± 0.058	3.762ThrVal: 3.762 ± 0.075	0.671ThrTrp: 0.671 ± 0.029	1.065ThrTyr: 1.065 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.799ValAla: 9.799 ± 0.112	0.628ValCys: 0.628 ± 0.028	4.457ValAsp: 4.457 ± 0.063	4.491ValGlu: 4.491 ± 0.081	2.687ValPhe: 2.687 ± 0.066	5.628ValGly: 5.628 ± 0.088	1.53ValHis: 1.53 ± 0.042	3.193ValIle: 3.193 ± 0.067	1.795ValLys: 1.795 ± 0.048	8.533ValLeu: 8.533 ± 0.114	1.6ValMet: 1.6 ± 0.046	1.881ValAsn: 1.881 ± 0.052	3.975ValPro: 3.975 ± 0.067	2.486ValGln: 2.486 ± 0.06	5.126ValArg: 5.126 ± 0.084	4.159ValSer: 4.159 ± 0.075	3.436ValThr: 3.436 ± 0.062	6.351ValVal: 6.351 ± 0.1	0.841ValTrp: 0.841 ± 0.03	1.536ValTyr: 1.536 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.347TrpAla: 1.347 ± 0.041	0.162TrpCys: 0.162 ± 0.012	0.664TrpAsp: 0.664 ± 0.026	0.622TrpGlu: 0.622 ± 0.028	0.608TrpPhe: 0.608 ± 0.028	0.891TrpGly: 0.891 ± 0.035	0.351TrpHis: 0.351 ± 0.019	0.736TrpIle: 0.736 ± 0.029	0.574TrpLys: 0.574 ± 0.027	2.255TrpLeu: 2.255 ± 0.061	0.446TrpMet: 0.446 ± 0.022	0.517TrpAsn: 0.517 ± 0.024	0.852TrpPro: 0.852 ± 0.034	0.748TrpGln: 0.748 ± 0.029	1.445TrpArg: 1.445 ± 0.044	0.937TrpSer: 0.937 ± 0.034	0.682TrpThr: 0.682 ± 0.024	0.957TrpVal: 0.957 ± 0.033	0.305TrpTrp: 0.305 ± 0.019	0.343TrpTyr: 0.343 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.899TyrAla: 2.899 ± 0.062	0.211TyrCys: 0.211 ± 0.014	1.422TyrAsp: 1.422 ± 0.044	1.206TyrGlu: 1.206 ± 0.036	0.889TyrPhe: 0.889 ± 0.031	2.099TyrGly: 2.099 ± 0.051	0.448TyrHis: 0.448 ± 0.025	0.682TyrIle: 0.682 ± 0.03	0.519TyrLys: 0.519 ± 0.027	2.535TyrLeu: 2.535 ± 0.061	0.406TyrMet: 0.406 ± 0.02	0.663TyrAsn: 0.663 ± 0.025	1.182TyrPro: 1.182 ± 0.039	0.921TyrGln: 0.921 ± 0.032	2.029TyrArg: 2.029 ± 0.051	1.299TyrSer: 1.299 ± 0.046	1.165TyrThr: 1.165 ± 0.042	1.583TyrVal: 1.583 ± 0.042	0.419TyrTrp: 0.419 ± 0.024	0.617TyrTyr: 0.617 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3169 proteins (897507 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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