Amino acid dipepetide frequency for Rhodanobacter sp. C06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.315AlaAla: 19.315 ± 0.195
1.393AlaCys: 1.393 ± 0.036
7.178AlaAsp: 7.178 ± 0.088
6.761AlaGlu: 6.761 ± 0.101
4.001AlaPhe: 4.001 ± 0.069
11.37AlaGly: 11.37 ± 0.13
3.162AlaHis: 3.162 ± 0.056
5.56AlaIle: 5.56 ± 0.072
3.86AlaLys: 3.86 ± 0.081
16.08AlaLeu: 16.08 ± 0.173
3.582AlaMet: 3.582 ± 0.064
3.226AlaAsn: 3.226 ± 0.069
6.658AlaPro: 6.658 ± 0.112
5.662AlaGln: 5.662 ± 0.091
9.136AlaArg: 9.136 ± 0.114
6.572AlaSer: 6.572 ± 0.08
6.593AlaThr: 6.593 ± 0.08
9.036AlaVal: 9.036 ± 0.105
2.34AlaTrp: 2.34 ± 0.052
2.511AlaTyr: 2.511 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.153CysAla: 1.153 ± 0.031
0.12CysCys: 0.12 ± 0.01
0.496CysAsp: 0.496 ± 0.021
0.469CysGlu: 0.469 ± 0.02
0.311CysPhe: 0.311 ± 0.016
0.974CysGly: 0.974 ± 0.029
0.292CysHis: 0.292 ± 0.018
0.35CysIle: 0.35 ± 0.019
0.192CysLys: 0.192 ± 0.012
0.884CysLeu: 0.884 ± 0.025
0.172CysMet: 0.172 ± 0.012
0.24CysAsn: 0.24 ± 0.014
0.396CysPro: 0.396 ± 0.02
0.218CysGln: 0.218 ± 0.013
0.61CysArg: 0.61 ± 0.023
0.439CysSer: 0.439 ± 0.02
0.458CysThr: 0.458 ± 0.019
0.7CysVal: 0.7 ± 0.025
0.138CysTrp: 0.138 ± 0.01
0.23CysTyr: 0.23 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.367AspAla: 8.367 ± 0.105
0.466AspCys: 0.466 ± 0.02
3.261AspAsp: 3.261 ± 0.059
3.133AspGlu: 3.133 ± 0.059
2.185AspPhe: 2.185 ± 0.05
5.679AspGly: 5.679 ± 0.093
1.359AspHis: 1.359 ± 0.037
2.26AspIle: 2.26 ± 0.048
1.644AspLys: 1.644 ± 0.047
5.181AspLeu: 5.181 ± 0.077
1.074AspMet: 1.074 ± 0.029
1.389AspAsn: 1.389 ± 0.039
3.358AspPro: 3.358 ± 0.062
1.694AspGln: 1.694 ± 0.038
3.46AspArg: 3.46 ± 0.05
2.422AspSer: 2.422 ± 0.048
2.73AspThr: 2.73 ± 0.05
3.95AspVal: 3.95 ± 0.055
1.174AspTrp: 1.174 ± 0.036
1.811AspTyr: 1.811 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
6.355GluAla: 6.355 ± 0.095
0.369GluCys: 0.369 ± 0.019
1.984GluAsp: 1.984 ± 0.047
2.034GluGlu: 2.034 ± 0.053
1.528GluPhe: 1.528 ± 0.031
3.344GluGly: 3.344 ± 0.061
1.664GluHis: 1.664 ± 0.041
2.178GluIle: 2.178 ± 0.051
1.399GluLys: 1.399 ± 0.043
6.381GluLeu: 6.381 ± 0.11
0.928GluMet: 0.928 ± 0.028
1.087GluAsn: 1.087 ± 0.03
2.422GluPro: 2.422 ± 0.052
2.632GluGln: 2.632 ± 0.055
4.724GluArg: 4.724 ± 0.084
2.206GluSer: 2.206 ± 0.051
2.281GluThr: 2.281 ± 0.043
3.504GluVal: 3.504 ± 0.066
0.646GluTrp: 0.646 ± 0.023
1.041GluTyr: 1.041 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.519PheAla: 4.519 ± 0.068
0.3PheCys: 0.3 ± 0.018
2.55PheAsp: 2.55 ± 0.05
1.665PheGlu: 1.665 ± 0.043
1.152PhePhe: 1.152 ± 0.039
3.44PheGly: 3.44 ± 0.063
0.874PheHis: 0.874 ± 0.029
1.173PheIle: 1.173 ± 0.035
0.915PheLys: 0.915 ± 0.027
2.939PheLeu: 2.939 ± 0.05
0.671PheMet: 0.671 ± 0.023
1.036PheAsn: 1.036 ± 0.029
1.412PhePro: 1.412 ± 0.031
0.98PheGln: 0.98 ± 0.029
2.165PheArg: 2.165 ± 0.041
1.784PheSer: 1.784 ± 0.045
1.716PheThr: 1.716 ± 0.041
2.664PheVal: 2.664 ± 0.053
0.488PheTrp: 0.488 ± 0.022
0.866PheTyr: 0.866 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.649GlyAla: 9.649 ± 0.134
0.878GlyCys: 0.878 ± 0.028
4.666GlyAsp: 4.666 ± 0.062
4.669GlyGlu: 4.669 ± 0.067
3.313GlyPhe: 3.313 ± 0.049
7.27GlyGly: 7.27 ± 0.133
2.389GlyHis: 2.389 ± 0.049
4.013GlyIle: 4.013 ± 0.062
3.402GlyLys: 3.402 ± 0.069
8.551GlyLeu: 8.551 ± 0.101
2.377GlyMet: 2.377 ± 0.051
2.55GlyAsn: 2.55 ± 0.071
2.941GlyPro: 2.941 ± 0.054
3.146GlyGln: 3.146 ± 0.061
5.627GlyArg: 5.627 ± 0.085
4.977GlySer: 4.977 ± 0.107
4.676GlyThr: 4.676 ± 0.095
6.63GlyVal: 6.63 ± 0.083
1.742GlyTrp: 1.742 ± 0.04
2.618GlyTyr: 2.618 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
3.818HisAla: 3.818 ± 0.063
0.265HisCys: 0.265 ± 0.013
1.615HisAsp: 1.615 ± 0.039
1.331HisGlu: 1.331 ± 0.032
0.943HisPhe: 0.943 ± 0.028
2.821HisGly: 2.821 ± 0.053
0.744HisHis: 0.744 ± 0.032
0.829HisIle: 0.829 ± 0.027
0.554HisLys: 0.554 ± 0.023
2.431HisLeu: 2.431 ± 0.051
0.581HisMet: 0.581 ± 0.022
0.515HisAsn: 0.515 ± 0.02
1.646HisPro: 1.646 ± 0.035
0.698HisGln: 0.698 ± 0.022
1.757HisArg: 1.757 ± 0.045
1.075HisSer: 1.075 ± 0.027
1.121HisThr: 1.121 ± 0.033
1.864HisVal: 1.864 ± 0.04
0.554HisTrp: 0.554 ± 0.022
0.814HisTyr: 0.814 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.263IleAla: 6.263 ± 0.075
0.376IleCys: 0.376 ± 0.019
3.079IleAsp: 3.079 ± 0.051
2.594IleGlu: 2.594 ± 0.057
1.087IlePhe: 1.087 ± 0.031
4.117IleGly: 4.117 ± 0.064
0.906IleHis: 0.906 ± 0.027
1.18IleIle: 1.18 ± 0.037
1.134IleLys: 1.134 ± 0.034
3.026IleLeu: 3.026 ± 0.057
0.542IleMet: 0.542 ± 0.022
1.206IleAsn: 1.206 ± 0.039
2.02IlePro: 2.02 ± 0.04
1.013IleGln: 1.013 ± 0.035
2.569IleArg: 2.569 ± 0.056
1.952IleSer: 1.952 ± 0.049
2.149IleThr: 2.149 ± 0.052
3.265IleVal: 3.265 ± 0.054
0.467IleTrp: 0.467 ± 0.021
0.94IleTyr: 0.94 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.551LysAla: 3.551 ± 0.08
0.134LysCys: 0.134 ± 0.01
1.473LysAsp: 1.473 ± 0.046
1.141LysGlu: 1.141 ± 0.041
0.779LysPhe: 0.779 ± 0.026
2.059LysGly: 2.059 ± 0.051
0.744LysHis: 0.744 ± 0.024
1.081LysIle: 1.081 ± 0.04
0.989LysLys: 0.989 ± 0.048
3.643LysLeu: 3.643 ± 0.061
0.569LysMet: 0.569 ± 0.021
0.74LysAsn: 0.74 ± 0.028
2.139LysPro: 2.139 ± 0.051
1.316LysGln: 1.316 ± 0.04
1.983LysArg: 1.983 ± 0.045
1.455LysSer: 1.455 ± 0.04
1.545LysThr: 1.545 ± 0.041
2.182LysVal: 2.182 ± 0.051
0.307LysTrp: 0.307 ± 0.016
0.673LysTyr: 0.673 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
16.905LeuAla: 16.905 ± 0.189
1.04LeuCys: 1.04 ± 0.031
6.947LeuAsp: 6.947 ± 0.089
4.95LeuGlu: 4.95 ± 0.09
3.464LeuPhe: 3.464 ± 0.068
9.545LeuGly: 9.545 ± 0.107
2.798LeuHis: 2.798 ± 0.054
3.845LeuIle: 3.845 ± 0.058
3.299LeuLys: 3.299 ± 0.058
12.958LeuLeu: 12.958 ± 0.188
2.076LeuMet: 2.076 ± 0.043
2.369LeuAsn: 2.369 ± 0.053
6.974LeuPro: 6.974 ± 0.089
3.948LeuGln: 3.948 ± 0.066
8.714LeuArg: 8.714 ± 0.116
5.364LeuSer: 5.364 ± 0.077
4.901LeuThr: 4.901 ± 0.072
7.86LeuVal: 7.86 ± 0.1
1.544LeuTrp: 1.544 ± 0.043
2.367LeuTyr: 2.367 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.632MetAla: 2.632 ± 0.052
0.139MetCys: 0.139 ± 0.012
1.112MetAsp: 1.112 ± 0.032
0.882MetGlu: 0.882 ± 0.026
0.673MetPhe: 0.673 ± 0.022
1.497MetGly: 1.497 ± 0.038
0.578MetHis: 0.578 ± 0.024
0.84MetIle: 0.84 ± 0.028
0.799MetLys: 0.799 ± 0.03
2.602MetLeu: 2.602 ± 0.052
0.405MetMet: 0.405 ± 0.019
0.742MetAsn: 0.742 ± 0.025
1.464MetPro: 1.464 ± 0.039
1.0MetGln: 1.0 ± 0.029
1.656MetArg: 1.656 ± 0.036
1.516MetSer: 1.516 ± 0.038
1.194MetThr: 1.194 ± 0.033
1.419MetVal: 1.419 ± 0.034
0.213MetTrp: 0.213 ± 0.014
0.418MetTyr: 0.418 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.332AsnAla: 3.332 ± 0.065
0.198AsnCys: 0.198 ± 0.013
1.402AsnAsp: 1.402 ± 0.042
1.085AsnGlu: 1.085 ± 0.034
0.914AsnPhe: 0.914 ± 0.034
2.567AsnGly: 2.567 ± 0.081
0.569AsnHis: 0.569 ± 0.024
1.043AsnIle: 1.043 ± 0.038
0.601AsnLys: 0.601 ± 0.026
2.712AsnLeu: 2.712 ± 0.052
0.463AsnMet: 0.463 ± 0.021
0.758AsnAsn: 0.758 ± 0.037
1.804AsnPro: 1.804 ± 0.046
0.863AsnGln: 0.863 ± 0.029
1.687AsnArg: 1.687 ± 0.043
1.173AsnSer: 1.173 ± 0.045
1.332AsnThr: 1.332 ± 0.045
1.897AsnVal: 1.897 ± 0.043
0.431AsnTrp: 0.431 ± 0.017
0.809AsnTyr: 0.809 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
8.068ProAla: 8.068 ± 0.112
0.366ProCys: 0.366 ± 0.02
3.432ProAsp: 3.432 ± 0.054
2.888ProGlu: 2.888 ± 0.053
1.731ProPhe: 1.731 ± 0.044
4.988ProGly: 4.988 ± 0.074
1.329ProHis: 1.329 ± 0.032
1.783ProIle: 1.783 ± 0.036
1.449ProLys: 1.449 ± 0.041
5.725ProLeu: 5.725 ± 0.08
1.229ProMet: 1.229 ± 0.031
1.313ProAsn: 1.313 ± 0.034
3.092ProPro: 3.092 ± 0.079
2.186ProGln: 2.186 ± 0.052
3.36ProArg: 3.36 ± 0.06
2.553ProSer: 2.553 ± 0.051
2.405ProThr: 2.405 ± 0.047
4.263ProVal: 4.263 ± 0.068
0.929ProTrp: 0.929 ± 0.029
1.309ProTyr: 1.309 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.357GlnAla: 5.357 ± 0.09
0.264GlnCys: 0.264 ± 0.014
1.543GlnAsp: 1.543 ± 0.041
1.287GlnGlu: 1.287 ± 0.035
1.166GlnPhe: 1.166 ± 0.031
2.907GlnGly: 2.907 ± 0.05
1.062GlnHis: 1.062 ± 0.027
1.469GlnIle: 1.469 ± 0.033
0.872GlnLys: 0.872 ± 0.032
4.759GlnLeu: 4.759 ± 0.074
0.804GlnMet: 0.804 ± 0.027
0.824GlnAsn: 0.824 ± 0.032
2.545GlnPro: 2.545 ± 0.05
2.196GlnGln: 2.196 ± 0.059
3.5GlnArg: 3.5 ± 0.066
1.821GlnSer: 1.821 ± 0.042
1.611GlnThr: 1.611 ± 0.035
2.83GlnVal: 2.83 ± 0.046
0.607GlnTrp: 0.607 ± 0.024
0.911GlnTyr: 0.911 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
8.143ArgAla: 8.143 ± 0.104
0.597ArgCys: 0.597 ± 0.025
4.083ArgAsp: 4.083 ± 0.074
4.395ArgGlu: 4.395 ± 0.083
2.636ArgPhe: 2.636 ± 0.05
5.077ArgGly: 5.077 ± 0.073
2.311ArgHis: 2.311 ± 0.051
3.506ArgIle: 3.506 ± 0.056
2.079ArgLys: 2.079 ± 0.046
8.441ArgLeu: 8.441 ± 0.108
1.869ArgMet: 1.869 ± 0.044
1.752ArgAsn: 1.752 ± 0.042
3.236ArgPro: 3.236 ± 0.055
2.94ArgGln: 2.94 ± 0.054
5.963ArgArg: 5.963 ± 0.1
3.325ArgSer: 3.325 ± 0.048
3.09ArgThr: 3.09 ± 0.053
5.098ArgVal: 5.098 ± 0.075
1.386ArgTrp: 1.386 ± 0.042
2.204ArgTyr: 2.204 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.999SerAla: 5.999 ± 0.09
0.444SerCys: 0.444 ± 0.019
2.603SerAsp: 2.603 ± 0.055
2.079SerGlu: 2.079 ± 0.037
1.937SerPhe: 1.937 ± 0.041
5.063SerGly: 5.063 ± 0.1
1.223SerHis: 1.223 ± 0.034
2.038SerIle: 2.038 ± 0.045
1.283SerLys: 1.283 ± 0.042
5.402SerLeu: 5.402 ± 0.075
1.116SerMet: 1.116 ± 0.028
1.365SerAsn: 1.365 ± 0.048
2.718SerPro: 2.718 ± 0.053
1.657SerGln: 1.657 ± 0.037
3.267SerArg: 3.267 ± 0.056
2.83SerSer: 2.83 ± 0.069
2.836SerThr: 2.836 ± 0.066
3.658SerVal: 3.658 ± 0.064
0.855SerTrp: 0.855 ± 0.025
1.466SerTyr: 1.466 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.947ThrAla: 5.947 ± 0.074
0.375ThrCys: 0.375 ± 0.019
2.506ThrAsp: 2.506 ± 0.047
1.949ThrGlu: 1.949 ± 0.039
1.422ThrPhe: 1.422 ± 0.04
4.55ThrGly: 4.55 ± 0.09
1.186ThrHis: 1.186 ± 0.032
2.057ThrIle: 2.057 ± 0.045
1.081ThrLys: 1.081 ± 0.033
6.354ThrLeu: 6.354 ± 0.085
0.958ThrMet: 0.958 ± 0.029
1.222ThrAsn: 1.222 ± 0.047
3.511ThrPro: 3.511 ± 0.059
1.736ThrGln: 1.736 ± 0.049
3.302ThrArg: 3.302 ± 0.056
2.411ThrSer: 2.411 ± 0.061
2.681ThrThr: 2.681 ± 0.068
4.007ThrVal: 4.007 ± 0.07
0.734ThrTrp: 0.734 ± 0.028
1.169ThrTyr: 1.169 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.901ValAla: 9.901 ± 0.117
0.701ValCys: 0.701 ± 0.027
4.46ValAsp: 4.46 ± 0.062
3.836ValGlu: 3.836 ± 0.075
2.499ValPhe: 2.499 ± 0.057
5.519ValGly: 5.519 ± 0.081
1.732ValHis: 1.732 ± 0.04
3.156ValIle: 3.156 ± 0.059
1.862ValLys: 1.862 ± 0.048
8.577ValLeu: 8.577 ± 0.112
1.523ValMet: 1.523 ± 0.039
2.034ValAsn: 2.034 ± 0.052
3.976ValPro: 3.976 ± 0.07
2.603ValGln: 2.603 ± 0.05
5.05ValArg: 5.05 ± 0.078
3.785ValSer: 3.785 ± 0.067
3.789ValThr: 3.789 ± 0.064
5.944ValVal: 5.944 ± 0.089
0.972ValTrp: 0.972 ± 0.031
1.686ValTyr: 1.686 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.404TrpAla: 1.404 ± 0.035
0.184TrpCys: 0.184 ± 0.012
0.711TrpAsp: 0.711 ± 0.029
0.498TrpGlu: 0.498 ± 0.021
0.635TrpPhe: 0.635 ± 0.028
0.971TrpGly: 0.971 ± 0.031
0.48TrpHis: 0.48 ± 0.02
0.708TrpIle: 0.708 ± 0.027
0.477TrpLys: 0.477 ± 0.019
2.552TrpLeu: 2.552 ± 0.066
0.424TrpMet: 0.424 ± 0.02
0.572TrpAsn: 0.572 ± 0.023
0.838TrpPro: 0.838 ± 0.03
0.917TrpGln: 0.917 ± 0.028
1.506TrpArg: 1.506 ± 0.041
0.955TrpSer: 0.955 ± 0.025
0.768TrpThr: 0.768 ± 0.029
0.951TrpVal: 0.951 ± 0.031
0.339TrpTrp: 0.339 ± 0.019
0.419TrpTyr: 0.419 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.318TyrAla: 3.318 ± 0.059
0.23TyrCys: 0.23 ± 0.015
1.496TyrAsp: 1.496 ± 0.042
1.06TyrGlu: 1.06 ± 0.036
0.933TyrPhe: 0.933 ± 0.03
2.325TyrGly: 2.325 ± 0.054
0.575TyrHis: 0.575 ± 0.024
0.814TyrIle: 0.814 ± 0.029
0.61TyrLys: 0.61 ± 0.023
2.67TyrLeu: 2.67 ± 0.054
0.417TyrMet: 0.417 ± 0.02
0.7TyrAsn: 0.7 ± 0.026
1.247TyrPro: 1.247 ± 0.033
0.93TyrGln: 0.93 ± 0.027
2.095TyrArg: 2.095 ± 0.046
1.229TyrSer: 1.229 ± 0.036
1.283TyrThr: 1.283 ± 0.041
1.885TyrVal: 1.885 ± 0.039
0.444TyrTrp: 0.444 ± 0.02
0.776TyrTyr: 0.776 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3484 proteins (1183550 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski