Amino acid dipepetide frequency for Mycoplasma bovoculi M165/69

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.321AlaAla: 3.321 ± 0.188
0.264AlaCys: 0.264 ± 0.033
2.558AlaAsp: 2.558 ± 0.115
2.731AlaGlu: 2.731 ± 0.141
2.896AlaPhe: 2.896 ± 0.127
2.996AlaGly: 2.996 ± 0.134
0.949AlaHis: 0.949 ± 0.075
5.597AlaIle: 5.597 ± 0.191
5.81AlaLys: 5.81 ± 0.17
4.969AlaLeu: 4.969 ± 0.146
0.949AlaMet: 0.949 ± 0.071
4.153AlaAsn: 4.153 ± 0.157
1.617AlaPro: 1.617 ± 0.088
2.679AlaGln: 2.679 ± 0.127
1.821AlaArg: 1.821 ± 0.093
4.019AlaSer: 4.019 ± 0.148
3.668AlaThr: 3.668 ± 0.221
2.562AlaVal: 2.562 ± 0.115
0.356AlaTrp: 0.356 ± 0.04
1.669AlaTyr: 1.669 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.204CysAla: 0.204 ± 0.029
0.039CysCys: 0.039 ± 0.014
0.282CysAsp: 0.282 ± 0.041
0.286CysGlu: 0.286 ± 0.045
0.269CysPhe: 0.269 ± 0.038
0.356CysGly: 0.356 ± 0.041
0.113CysHis: 0.113 ± 0.027
0.256CysIle: 0.256 ± 0.035
0.369CysLys: 0.369 ± 0.051
0.36CysLeu: 0.36 ± 0.04
0.026CysMet: 0.026 ± 0.01
0.195CysAsn: 0.195 ± 0.029
0.178CysPro: 0.178 ± 0.033
0.26CysGln: 0.26 ± 0.048
0.121CysArg: 0.121 ± 0.024
0.251CysSer: 0.251 ± 0.034
0.139CysThr: 0.139 ± 0.027
0.182CysVal: 0.182 ± 0.031
0.035CysTrp: 0.035 ± 0.012
0.147CysTyr: 0.147 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.974AspAla: 2.974 ± 0.136
0.186AspCys: 0.186 ± 0.032
2.545AspAsp: 2.545 ± 0.145
3.659AspGlu: 3.659 ± 0.143
4.492AspPhe: 4.492 ± 0.176
2.762AspGly: 2.762 ± 0.155
0.663AspHis: 0.663 ± 0.05
4.045AspIle: 4.045 ± 0.139
5.827AspLys: 5.827 ± 0.184
5.658AspLeu: 5.658 ± 0.17
0.546AspMet: 0.546 ± 0.041
3.568AspAsn: 3.568 ± 0.153
1.665AspPro: 1.665 ± 0.104
2.15AspGln: 2.15 ± 0.109
1.383AspArg: 1.383 ± 0.083
3.997AspSer: 3.997 ± 0.19
2.215AspThr: 2.215 ± 0.121
2.896AspVal: 2.896 ± 0.108
0.512AspTrp: 0.512 ± 0.049
2.497AspTyr: 2.497 ± 0.113
0.0AspXaa: 0.0 ± 0.0
Glu
2.749GluAla: 2.749 ± 0.135
0.208GluCys: 0.208 ± 0.052
2.736GluAsp: 2.736 ± 0.125
3.698GluGlu: 3.698 ± 0.201
3.603GluPhe: 3.603 ± 0.128
2.042GluGly: 2.042 ± 0.105
0.919GluHis: 0.919 ± 0.077
6.581GluIle: 6.581 ± 0.17
6.82GluLys: 6.82 ± 0.26
5.649GluLeu: 5.649 ± 0.189
0.962GluMet: 0.962 ± 0.064
5.25GluAsn: 5.25 ± 0.171
1.5GluPro: 1.5 ± 0.108
3.763GluGln: 3.763 ± 0.149
1.639GluArg: 1.639 ± 0.104
3.651GluSer: 3.651 ± 0.126
2.97GluThr: 2.97 ± 0.108
3.356GluVal: 3.356 ± 0.119
0.451GluTrp: 0.451 ± 0.043
1.942GluTyr: 1.942 ± 0.109
0.0GluXaa: 0.0 ± 0.0
Phe
4.119PheAla: 4.119 ± 0.157
0.377PheCys: 0.377 ± 0.048
4.11PheAsp: 4.11 ± 0.158
4.114PheGlu: 4.114 ± 0.136
4.054PhePhe: 4.054 ± 0.199
3.117PheGly: 3.117 ± 0.131
0.642PheHis: 0.642 ± 0.049
4.864PheIle: 4.864 ± 0.203
4.756PheLys: 4.756 ± 0.156
6.33PheLeu: 6.33 ± 0.243
0.65PheMet: 0.65 ± 0.055
4.093PheAsn: 4.093 ± 0.139
1.422PhePro: 1.422 ± 0.076
1.96PheGln: 1.96 ± 0.103
1.288PheArg: 1.288 ± 0.085
5.242PheSer: 5.242 ± 0.176
2.627PheThr: 2.627 ± 0.127
4.275PheVal: 4.275 ± 0.171
0.893PheTrp: 0.893 ± 0.071
2.61PheTyr: 2.61 ± 0.127
0.0PheXaa: 0.0 ± 0.0
Gly
2.84GlyAla: 2.84 ± 0.159
0.182GlyCys: 0.182 ± 0.03
2.58GlyAsp: 2.58 ± 0.125
2.601GlyGlu: 2.601 ± 0.128
3.291GlyPhe: 3.291 ± 0.127
2.905GlyGly: 2.905 ± 0.135
0.971GlyHis: 0.971 ± 0.062
4.197GlyIle: 4.197 ± 0.19
4.639GlyLys: 4.639 ± 0.15
4.249GlyLeu: 4.249 ± 0.14
0.75GlyMet: 0.75 ± 0.058
2.84GlyAsn: 2.84 ± 0.122
1.093GlyPro: 1.093 ± 0.069
2.584GlyGln: 2.584 ± 0.124
1.504GlyArg: 1.504 ± 0.102
3.703GlySer: 3.703 ± 0.141
2.983GlyThr: 2.983 ± 0.142
3.282GlyVal: 3.282 ± 0.123
0.416GlyTrp: 0.416 ± 0.049
1.773GlyTyr: 1.773 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.659HisAla: 0.659 ± 0.061
0.087HisCys: 0.087 ± 0.021
0.551HisAsp: 0.551 ± 0.054
0.594HisGlu: 0.594 ± 0.044
1.041HisPhe: 1.041 ± 0.07
0.689HisGly: 0.689 ± 0.053
0.343HisHis: 0.343 ± 0.035
1.379HisIle: 1.379 ± 0.086
1.422HisLys: 1.422 ± 0.077
1.348HisLeu: 1.348 ± 0.078
0.178HisMet: 0.178 ± 0.03
1.123HisAsn: 1.123 ± 0.078
0.607HisPro: 0.607 ± 0.057
0.65HisGln: 0.65 ± 0.05
0.525HisArg: 0.525 ± 0.046
1.101HisSer: 1.101 ± 0.082
0.637HisThr: 0.637 ± 0.053
0.477HisVal: 0.477 ± 0.044
0.173HisTrp: 0.173 ± 0.025
0.525HisTyr: 0.525 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
5.805IleAla: 5.805 ± 0.196
0.49IleCys: 0.49 ± 0.048
5.779IleAsp: 5.779 ± 0.16
5.736IleGlu: 5.736 ± 0.213
5.68IlePhe: 5.68 ± 0.297
4.379IleGly: 4.379 ± 0.151
1.192IleHis: 1.192 ± 0.071
7.761IleIle: 7.761 ± 0.311
8.407IleLys: 8.407 ± 0.222
8.324IleLeu: 8.324 ± 0.304
1.002IleMet: 1.002 ± 0.079
6.798IleAsn: 6.798 ± 0.182
2.77IlePro: 2.77 ± 0.135
3.226IleGln: 3.226 ± 0.118
2.289IleArg: 2.289 ± 0.104
7.327IleSer: 7.327 ± 0.203
4.548IleThr: 4.548 ± 0.168
5.302IleVal: 5.302 ± 0.181
0.746IleTrp: 0.746 ± 0.061
3.161IleTyr: 3.161 ± 0.119
0.0IleXaa: 0.0 ± 0.0
Lys
4.47LysAla: 4.47 ± 0.16
0.277LysCys: 0.277 ± 0.045
5.125LysAsp: 5.125 ± 0.178
6.282LysGlu: 6.282 ± 0.239
4.882LysPhe: 4.882 ± 0.143
3.798LysGly: 3.798 ± 0.15
1.448LysHis: 1.448 ± 0.076
10.73LysIle: 10.73 ± 0.28
9.083LysLys: 9.083 ± 0.283
8.914LysLeu: 8.914 ± 0.211
1.916LysMet: 1.916 ± 0.103
8.558LysAsn: 8.558 ± 0.237
3.074LysPro: 3.074 ± 0.15
4.877LysGln: 4.877 ± 0.174
2.241LysArg: 2.241 ± 0.104
6.169LysSer: 6.169 ± 0.174
5.849LysThr: 5.849 ± 0.145
5.315LysVal: 5.315 ± 0.151
0.932LysTrp: 0.932 ± 0.062
3.828LysTyr: 3.828 ± 0.126
0.0LysXaa: 0.0 ± 0.0
Leu
6.096LeuAla: 6.096 ± 0.173
0.295LeuCys: 0.295 ± 0.045
5.883LeuAsp: 5.883 ± 0.18
6.508LeuGlu: 6.508 ± 0.186
5.237LeuPhe: 5.237 ± 0.213
4.509LeuGly: 4.509 ± 0.169
1.114LeuHis: 1.114 ± 0.069
8.207LeuIle: 8.207 ± 0.288
9.1LeuLys: 9.1 ± 0.26
7.709LeuLeu: 7.709 ± 0.252
1.322LeuMet: 1.322 ± 0.063
7.05LeuAsn: 7.05 ± 0.205
2.896LeuPro: 2.896 ± 0.108
3.599LeuGln: 3.599 ± 0.122
2.367LeuArg: 2.367 ± 0.094
6.842LeuSer: 6.842 ± 0.165
5.086LeuThr: 5.086 ± 0.164
5.727LeuVal: 5.727 ± 0.18
0.815LeuTrp: 0.815 ± 0.061
2.614LeuTyr: 2.614 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.023MetAla: 1.023 ± 0.08
0.065MetCys: 0.065 ± 0.018
0.594MetAsp: 0.594 ± 0.046
0.91MetGlu: 0.91 ± 0.062
0.845MetPhe: 0.845 ± 0.07
0.598MetGly: 0.598 ± 0.058
0.256MetHis: 0.256 ± 0.033
1.114MetIle: 1.114 ± 0.066
1.27MetLys: 1.27 ± 0.071
1.331MetLeu: 1.331 ± 0.069
0.225MetMet: 0.225 ± 0.033
0.993MetAsn: 0.993 ± 0.072
0.555MetPro: 0.555 ± 0.052
0.637MetGln: 0.637 ± 0.051
0.351MetArg: 0.351 ± 0.046
1.019MetSer: 1.019 ± 0.072
0.629MetThr: 0.629 ± 0.063
0.728MetVal: 0.728 ± 0.066
0.13MetTrp: 0.13 ± 0.023
0.421MetTyr: 0.421 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.304AsnAla: 3.304 ± 0.125
0.251AsnCys: 0.251 ± 0.036
3.694AsnAsp: 3.694 ± 0.158
4.049AsnGlu: 4.049 ± 0.17
5.38AsnPhe: 5.38 ± 0.201
3.247AsnGly: 3.247 ± 0.141
1.075AsnHis: 1.075 ± 0.071
6.356AsnIle: 6.356 ± 0.2
7.977AsnLys: 7.977 ± 0.247
7.943AsnLeu: 7.943 ± 0.218
0.932AsnMet: 0.932 ± 0.068
5.944AsnAsn: 5.944 ± 0.218
2.671AsnPro: 2.671 ± 0.119
3.971AsnGln: 3.971 ± 0.16
1.769AsnArg: 1.769 ± 0.081
5.779AsnSer: 5.779 ± 0.204
3.252AsnThr: 3.252 ± 0.131
3.434AsnVal: 3.434 ± 0.16
0.811AsnTrp: 0.811 ± 0.061
3.299AsnTyr: 3.299 ± 0.125
0.0AsnXaa: 0.0 ± 0.0
Pro
1.465ProAla: 1.465 ± 0.104
0.095ProCys: 0.095 ± 0.021
1.574ProAsp: 1.574 ± 0.097
1.994ProGlu: 1.994 ± 0.112
1.648ProPhe: 1.648 ± 0.087
1.6ProGly: 1.6 ± 0.097
0.39ProHis: 0.39 ± 0.038
3.048ProIle: 3.048 ± 0.112
2.809ProLys: 2.809 ± 0.122
2.584ProLeu: 2.584 ± 0.107
0.39ProMet: 0.39 ± 0.044
2.272ProAsn: 2.272 ± 0.112
0.668ProPro: 0.668 ± 0.065
1.275ProGln: 1.275 ± 0.084
0.663ProArg: 0.663 ± 0.06
2.32ProSer: 2.32 ± 0.107
2.103ProThr: 2.103 ± 0.121
1.621ProVal: 1.621 ± 0.089
0.282ProTrp: 0.282 ± 0.034
1.114ProTyr: 1.114 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.48GlnAla: 2.48 ± 0.119
0.104GlnCys: 0.104 ± 0.02
2.241GlnAsp: 2.241 ± 0.109
2.619GlnGlu: 2.619 ± 0.128
2.051GlnPhe: 2.051 ± 0.09
2.241GlnGly: 2.241 ± 0.121
0.559GlnHis: 0.559 ± 0.053
4.938GlnIle: 4.938 ± 0.144
4.86GlnLys: 4.86 ± 0.168
3.815GlnLeu: 3.815 ± 0.129
0.772GlnMet: 0.772 ± 0.058
4.019GlnAsn: 4.019 ± 0.15
1.413GlnPro: 1.413 ± 0.077
2.415GlnGln: 2.415 ± 0.135
1.14GlnArg: 1.14 ± 0.077
2.961GlnSer: 2.961 ± 0.133
2.671GlnThr: 2.671 ± 0.151
2.519GlnVal: 2.519 ± 0.127
0.399GlnTrp: 0.399 ± 0.043
1.279GlnTyr: 1.279 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
1.565ArgAla: 1.565 ± 0.091
0.126ArgCys: 0.126 ± 0.028
1.491ArgAsp: 1.491 ± 0.075
1.509ArgGlu: 1.509 ± 0.093
1.621ArgPhe: 1.621 ± 0.082
1.34ArgGly: 1.34 ± 0.092
0.373ArgHis: 0.373 ± 0.043
2.367ArgIle: 2.367 ± 0.117
2.424ArgLys: 2.424 ± 0.107
2.415ArgLeu: 2.415 ± 0.132
0.486ArgMet: 0.486 ± 0.052
1.665ArgAsn: 1.665 ± 0.086
0.767ArgPro: 0.767 ± 0.067
1.283ArgGln: 1.283 ± 0.085
1.019ArgArg: 1.019 ± 0.083
1.756ArgSer: 1.756 ± 0.086
1.262ArgThr: 1.262 ± 0.068
1.635ArgVal: 1.635 ± 0.09
0.243ArgTrp: 0.243 ± 0.032
1.088ArgTyr: 1.088 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
3.737SerAla: 3.737 ± 0.143
0.369SerCys: 0.369 ± 0.051
3.833SerAsp: 3.833 ± 0.147
4.175SerGlu: 4.175 ± 0.13
4.721SerPhe: 4.721 ± 0.181
4.188SerGly: 4.188 ± 0.144
0.967SerHis: 0.967 ± 0.072
6.109SerIle: 6.109 ± 0.202
7.605SerLys: 7.605 ± 0.208
7.253SerLeu: 7.253 ± 0.187
0.841SerMet: 0.841 ± 0.058
5.333SerAsn: 5.333 ± 0.187
1.951SerPro: 1.951 ± 0.103
3.963SerGln: 3.963 ± 0.149
1.869SerArg: 1.869 ± 0.085
5.792SerSer: 5.792 ± 0.195
4.318SerThr: 4.318 ± 0.16
3.577SerVal: 3.577 ± 0.132
0.642SerTrp: 0.642 ± 0.053
2.558SerTyr: 2.558 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
2.471ThrAla: 2.471 ± 0.129
0.134ThrCys: 0.134 ± 0.024
2.376ThrAsp: 2.376 ± 0.131
2.267ThrGlu: 2.267 ± 0.119
3.148ThrPhe: 3.148 ± 0.143
3.031ThrGly: 3.031 ± 0.16
0.789ThrHis: 0.789 ± 0.063
5.333ThrIle: 5.333 ± 0.162
5.432ThrLys: 5.432 ± 0.154
4.765ThrLeu: 4.765 ± 0.185
0.477ThrMet: 0.477 ± 0.037
4.492ThrAsn: 4.492 ± 0.172
2.124ThrPro: 2.124 ± 0.114
2.159ThrGln: 2.159 ± 0.127
1.457ThrArg: 1.457 ± 0.08
4.635ThrSer: 4.635 ± 0.194
3.85ThrThr: 3.85 ± 0.199
2.61ThrVal: 2.61 ± 0.135
0.412ThrTrp: 0.412 ± 0.041
1.704ThrTyr: 1.704 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
4.067ValAla: 4.067 ± 0.132
0.308ValCys: 0.308 ± 0.045
3.772ValAsp: 3.772 ± 0.132
4.002ValGlu: 4.002 ± 0.166
3.425ValPhe: 3.425 ± 0.147
3.304ValGly: 3.304 ± 0.145
0.763ValHis: 0.763 ± 0.059
4.47ValIle: 4.47 ± 0.157
4.5ValLys: 4.5 ± 0.152
4.791ValLeu: 4.791 ± 0.179
0.694ValMet: 0.694 ± 0.068
3.334ValAsn: 3.334 ± 0.124
1.717ValPro: 1.717 ± 0.094
1.851ValGln: 1.851 ± 0.102
1.509ValArg: 1.509 ± 0.092
4.127ValSer: 4.127 ± 0.135
2.723ValThr: 2.723 ± 0.171
3.815ValVal: 3.815 ± 0.144
0.477ValTrp: 0.477 ± 0.046
1.895ValTyr: 1.895 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.486TrpAla: 0.486 ± 0.046
0.026TrpCys: 0.026 ± 0.009
0.477TrpAsp: 0.477 ± 0.048
0.507TrpGlu: 0.507 ± 0.055
0.551TrpPhe: 0.551 ± 0.057
0.451TrpGly: 0.451 ± 0.046
0.074TrpHis: 0.074 ± 0.019
0.958TrpIle: 0.958 ± 0.071
0.962TrpLys: 0.962 ± 0.068
0.945TrpLeu: 0.945 ± 0.079
0.13TrpMet: 0.13 ± 0.027
0.811TrpAsn: 0.811 ± 0.06
0.256TrpPro: 0.256 ± 0.031
0.438TrpGln: 0.438 ± 0.05
0.269TrpArg: 0.269 ± 0.033
0.486TrpSer: 0.486 ± 0.054
0.46TrpThr: 0.46 ± 0.046
0.481TrpVal: 0.481 ± 0.05
0.108TrpTrp: 0.108 ± 0.021
0.403TrpTyr: 0.403 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.752TyrAla: 1.752 ± 0.088
0.182TyrCys: 0.182 ± 0.028
2.042TyrAsp: 2.042 ± 0.114
2.246TyrGlu: 2.246 ± 0.131
2.71TyrPhe: 2.71 ± 0.142
1.83TyrGly: 1.83 ± 0.109
0.507TyrHis: 0.507 ± 0.037
2.411TyrIle: 2.411 ± 0.111
3.698TyrLys: 3.698 ± 0.13
3.625TyrLeu: 3.625 ± 0.121
0.442TyrMet: 0.442 ± 0.042
2.653TyrAsn: 2.653 ± 0.119
0.971TyrPro: 0.971 ± 0.062
1.756TyrGln: 1.756 ± 0.084
1.21TyrArg: 1.21 ± 0.072
2.623TyrSer: 2.623 ± 0.119
1.678TyrThr: 1.678 ± 0.096
1.747TyrVal: 1.747 ± 0.089
0.447TyrTrp: 0.447 ± 0.042
1.617TyrTyr: 1.617 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 579 proteins (230652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski