Amino acid dipepetide frequency for Gluconobacter wancherniae NBRC 103581

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.91AlaAla: 12.91 ± 0.164	1.286AlaCys: 1.286 ± 0.041	5.674AlaAsp: 5.674 ± 0.083	6.233AlaGlu: 6.233 ± 0.112	3.92AlaPhe: 3.92 ± 0.078	9.345AlaGly: 9.345 ± 0.108	2.548AlaHis: 2.548 ± 0.057	5.899AlaIle: 5.899 ± 0.096	3.252AlaLys: 3.252 ± 0.068	13.034AlaLeu: 13.034 ± 0.16	2.956AlaMet: 2.956 ± 0.066	2.839AlaAsn: 2.839 ± 0.067	5.602AlaPro: 5.602 ± 0.1	4.356AlaGln: 4.356 ± 0.072	7.83AlaArg: 7.83 ± 0.116	6.785AlaSer: 6.785 ± 0.096	5.695AlaThr: 5.695 ± 0.095	7.446AlaVal: 7.446 ± 0.108	1.363AlaTrp: 1.363 ± 0.036	2.244AlaTyr: 2.244 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.231CysAla: 1.231 ± 0.041	0.135CysCys: 0.135 ± 0.013	0.518CysAsp: 0.518 ± 0.027	0.48CysGlu: 0.48 ± 0.025	0.317CysPhe: 0.317 ± 0.021	1.048CysGly: 1.048 ± 0.036	0.248CysHis: 0.248 ± 0.019	0.445CysIle: 0.445 ± 0.026	0.194CysLys: 0.194 ± 0.016	0.972CysLeu: 0.972 ± 0.035	0.208CysMet: 0.208 ± 0.016	0.244CysAsn: 0.244 ± 0.017	0.48CysPro: 0.48 ± 0.024	0.262CysGln: 0.262 ± 0.018	0.576CysArg: 0.576 ± 0.026	0.608CysSer: 0.608 ± 0.03	0.55CysThr: 0.55 ± 0.028	0.771CysVal: 0.771 ± 0.033	0.138CysTrp: 0.138 ± 0.014	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.314AspAla: 6.314 ± 0.106	0.457AspCys: 0.457 ± 0.023	2.785AspAsp: 2.785 ± 0.06	3.015AspGlu: 3.015 ± 0.071	1.983AspPhe: 1.983 ± 0.052	4.893AspGly: 4.893 ± 0.088	1.382AspHis: 1.382 ± 0.043	3.186AspIle: 3.186 ± 0.062	1.249AspLys: 1.249 ± 0.043	5.772AspLeu: 5.772 ± 0.093	1.492AspMet: 1.492 ± 0.042	1.386AspAsn: 1.386 ± 0.04	3.29AspPro: 3.29 ± 0.066	1.783AspGln: 1.783 ± 0.048	3.789AspArg: 3.789 ± 0.071	2.526AspSer: 2.526 ± 0.048	2.873AspThr: 2.873 ± 0.053	4.162AspVal: 4.162 ± 0.076	0.906AspTrp: 0.906 ± 0.035	1.389AspTyr: 1.389 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.61GluAla: 6.61 ± 0.122	0.409GluCys: 0.409 ± 0.02	2.782GluAsp: 2.782 ± 0.066	3.118GluGlu: 3.118 ± 0.066	1.544GluPhe: 1.544 ± 0.049	3.981GluGly: 3.981 ± 0.069	1.412GluHis: 1.412 ± 0.045	3.428GluIle: 3.428 ± 0.067	2.258GluLys: 2.258 ± 0.064	4.82GluLeu: 4.82 ± 0.087	1.495GluMet: 1.495 ± 0.04	2.04GluAsn: 2.04 ± 0.052	2.111GluPro: 2.111 ± 0.058	2.251GluGln: 2.251 ± 0.056	4.54GluArg: 4.54 ± 0.084	2.561GluSer: 2.561 ± 0.054	3.416GluThr: 3.416 ± 0.069	3.173GluVal: 3.173 ± 0.068	0.755GluTrp: 0.755 ± 0.033	1.011GluTyr: 1.011 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.653PheAla: 3.653 ± 0.068	0.471PheCys: 0.471 ± 0.025	2.371PheAsp: 2.371 ± 0.06	1.846PheGlu: 1.846 ± 0.046	1.339PhePhe: 1.339 ± 0.045	3.484PheGly: 3.484 ± 0.072	0.874PheHis: 0.874 ± 0.031	1.589PheIle: 1.589 ± 0.048	0.801PheLys: 0.801 ± 0.034	3.492PheLeu: 3.492 ± 0.075	0.898PheMet: 0.898 ± 0.03	1.143PheAsn: 1.143 ± 0.043	1.631PhePro: 1.631 ± 0.038	1.131PheGln: 1.131 ± 0.037	2.204PheArg: 2.204 ± 0.049	2.841PheSer: 2.841 ± 0.061	1.974PheThr: 1.974 ± 0.046	2.589PheVal: 2.589 ± 0.054	0.514PheTrp: 0.514 ± 0.028	0.906PheTyr: 0.906 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.363GlyAla: 8.363 ± 0.103	0.94GlyCys: 0.94 ± 0.033	3.862GlyAsp: 3.862 ± 0.071	3.997GlyGlu: 3.997 ± 0.07	3.393GlyPhe: 3.393 ± 0.072	7.137GlyGly: 7.137 ± 0.122	2.249GlyHis: 2.249 ± 0.061	4.79GlyIle: 4.79 ± 0.079	3.163GlyLys: 3.163 ± 0.068	8.733GlyLeu: 8.733 ± 0.119	2.476GlyMet: 2.476 ± 0.053	2.544GlyAsn: 2.544 ± 0.071	3.215GlyPro: 3.215 ± 0.063	3.139GlyGln: 3.139 ± 0.058	5.741GlyArg: 5.741 ± 0.087	5.185GlySer: 5.185 ± 0.078	5.0GlyThr: 5.0 ± 0.084	6.088GlyVal: 6.088 ± 0.099	1.392GlyTrp: 1.392 ± 0.049	2.259GlyTyr: 2.259 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.69HisAla: 2.69 ± 0.06	0.211HisCys: 0.211 ± 0.015	1.566HisAsp: 1.566 ± 0.04	1.263HisGlu: 1.263 ± 0.044	0.994HisPhe: 0.994 ± 0.038	2.208HisGly: 2.208 ± 0.053	0.784HisHis: 0.784 ± 0.034	1.26HisIle: 1.26 ± 0.043	0.568HisLys: 0.568 ± 0.027	2.482HisLeu: 2.482 ± 0.062	0.609HisMet: 0.609 ± 0.026	0.685HisAsn: 0.685 ± 0.034	1.486HisPro: 1.486 ± 0.045	0.825HisGln: 0.825 ± 0.03	1.497HisArg: 1.497 ± 0.039	1.264HisSer: 1.264 ± 0.041	1.177HisThr: 1.177 ± 0.036	1.852HisVal: 1.852 ± 0.04	0.371HisTrp: 0.371 ± 0.019	0.667HisTyr: 0.667 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.422IleAla: 6.422 ± 0.091	0.584IleCys: 0.584 ± 0.031	3.249IleAsp: 3.249 ± 0.066	3.321IleGlu: 3.321 ± 0.07	1.675IlePhe: 1.675 ± 0.049	4.811IleGly: 4.811 ± 0.085	1.127IleHis: 1.127 ± 0.04	2.505IleIle: 2.505 ± 0.062	1.292IleLys: 1.292 ± 0.048	5.039IleLeu: 5.039 ± 0.081	1.169IleMet: 1.169 ± 0.042	1.632IleAsn: 1.632 ± 0.047	2.726IlePro: 2.726 ± 0.064	1.491IleGln: 1.491 ± 0.046	3.555IleArg: 3.555 ± 0.064	3.746IleSer: 3.746 ± 0.074	3.039IleThr: 3.039 ± 0.069	4.11IleVal: 4.11 ± 0.066	0.62IleTrp: 0.62 ± 0.03	1.037IleTyr: 1.037 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.67LysAla: 3.67 ± 0.079	0.172LysCys: 0.172 ± 0.015	1.608LysAsp: 1.608 ± 0.048	1.406LysGlu: 1.406 ± 0.048	0.82LysPhe: 0.82 ± 0.034	2.453LysGly: 2.453 ± 0.059	0.62LysHis: 0.62 ± 0.026	1.914LysIle: 1.914 ± 0.054	1.25LysLys: 1.25 ± 0.049	3.169LysLeu: 3.169 ± 0.072	0.767LysMet: 0.767 ± 0.034	1.115LysAsn: 1.115 ± 0.04	1.846LysPro: 1.846 ± 0.046	1.111LysGln: 1.111 ± 0.041	2.128LysArg: 2.128 ± 0.052	1.863LysSer: 1.863 ± 0.052	1.967LysThr: 1.967 ± 0.049	1.935LysVal: 1.935 ± 0.06	0.322LysTrp: 0.322 ± 0.019	0.562LysTyr: 0.562 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.617LeuAla: 11.617 ± 0.143	1.155LeuCys: 1.155 ± 0.047	5.897LeuAsp: 5.897 ± 0.09	5.408LeuGlu: 5.408 ± 0.091	3.558LeuPhe: 3.558 ± 0.07	8.177LeuGly: 8.177 ± 0.101	2.581LeuHis: 2.581 ± 0.059	4.932LeuIle: 4.932 ± 0.086	3.484LeuLys: 3.484 ± 0.071	10.301LeuLeu: 10.301 ± 0.167	2.532LeuMet: 2.532 ± 0.063	3.035LeuAsn: 3.035 ± 0.068	6.408LeuPro: 6.408 ± 0.109	3.397LeuGln: 3.397 ± 0.062	7.496LeuArg: 7.496 ± 0.114	7.726LeuSer: 7.726 ± 0.105	6.183LeuThr: 6.183 ± 0.088	6.596LeuVal: 6.596 ± 0.102	1.215LeuTrp: 1.215 ± 0.036	2.152LeuTyr: 2.152 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.85MetAla: 2.85 ± 0.058	0.177MetCys: 0.177 ± 0.015	1.222MetAsp: 1.222 ± 0.037	1.188MetGlu: 1.188 ± 0.039	0.771MetPhe: 0.771 ± 0.028	1.943MetGly: 1.943 ± 0.051	0.502MetHis: 0.502 ± 0.024	1.388MetIle: 1.388 ± 0.042	0.952MetLys: 0.952 ± 0.035	2.634MetLeu: 2.634 ± 0.058	0.716MetMet: 0.716 ± 0.036	0.858MetAsn: 0.858 ± 0.033	1.608MetPro: 1.608 ± 0.043	0.948MetGln: 0.948 ± 0.036	1.808MetArg: 1.808 ± 0.051	2.002MetSer: 2.002 ± 0.049	1.938MetThr: 1.938 ± 0.049	1.601MetVal: 1.601 ± 0.046	0.207MetTrp: 0.207 ± 0.018	0.311MetTyr: 0.311 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.618AsnAla: 3.618 ± 0.066	0.275AsnCys: 0.275 ± 0.019	1.603AsnAsp: 1.603 ± 0.048	1.278AsnGlu: 1.278 ± 0.038	1.11AsnPhe: 1.11 ± 0.039	2.894AsnGly: 2.894 ± 0.074	0.642AsnHis: 0.642 ± 0.029	1.754AsnIle: 1.754 ± 0.051	0.703AsnLys: 0.703 ± 0.032	2.842AsnLeu: 2.842 ± 0.063	0.718AsnMet: 0.718 ± 0.028	1.007AsnAsn: 1.007 ± 0.045	1.876AsnPro: 1.876 ± 0.054	0.954AsnGln: 0.954 ± 0.041	1.832AsnArg: 1.832 ± 0.047	1.749AsnSer: 1.749 ± 0.056	1.743AsnThr: 1.743 ± 0.062	2.295AsnVal: 2.295 ± 0.052	0.49AsnTrp: 0.49 ± 0.026	0.829AsnTyr: 0.829 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	5.81ProAla: 5.81 ± 0.096	0.376ProCys: 0.376 ± 0.022	3.713ProAsp: 3.713 ± 0.071	3.926ProGlu: 3.926 ± 0.073	1.982ProPhe: 1.982 ± 0.047	4.26ProGly: 4.26 ± 0.065	1.323ProHis: 1.323 ± 0.042	2.339ProIle: 2.339 ± 0.048	1.595ProLys: 1.595 ± 0.052	4.968ProLeu: 4.968 ± 0.076	1.179ProMet: 1.179 ± 0.038	1.519ProAsn: 1.519 ± 0.048	2.531ProPro: 2.531 ± 0.078	1.936ProGln: 1.936 ± 0.053	2.671ProArg: 2.671 ± 0.063	3.478ProSer: 3.478 ± 0.06	2.714ProThr: 2.714 ± 0.058	4.456ProVal: 4.456 ± 0.082	0.72ProTrp: 0.72 ± 0.03	1.239ProTyr: 1.239 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.158GlnAla: 4.158 ± 0.076	0.22GlnCys: 0.22 ± 0.016	2.005GlnAsp: 2.005 ± 0.05	1.861GlnGlu: 1.861 ± 0.054	1.188GlnPhe: 1.188 ± 0.038	2.669GlnGly: 2.669 ± 0.061	0.837GlnHis: 0.837 ± 0.035	2.22GlnIle: 2.22 ± 0.051	1.439GlnLys: 1.439 ± 0.041	2.875GlnLeu: 2.875 ± 0.069	0.926GlnMet: 0.926 ± 0.035	1.336GlnAsn: 1.336 ± 0.042	1.868GlnPro: 1.868 ± 0.054	1.475GlnGln: 1.475 ± 0.061	2.232GlnArg: 2.232 ± 0.053	2.357GlnSer: 2.357 ± 0.058	2.254GlnThr: 2.254 ± 0.061	2.403GlnVal: 2.403 ± 0.058	0.432GlnTrp: 0.432 ± 0.022	0.794GlnTyr: 0.794 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.966ArgAla: 6.966 ± 0.103	0.535ArgCys: 0.535 ± 0.027	3.671ArgAsp: 3.671 ± 0.07	3.873ArgGlu: 3.873 ± 0.072	2.767ArgPhe: 2.767 ± 0.057	4.475ArgGly: 4.475 ± 0.089	1.948ArgHis: 1.948 ± 0.043	3.983ArgIle: 3.983 ± 0.066	2.295ArgLys: 2.295 ± 0.057	7.872ArgLeu: 7.872 ± 0.122	1.764ArgMet: 1.764 ± 0.051	2.226ArgAsn: 2.226 ± 0.051	3.349ArgPro: 3.349 ± 0.076	2.597ArgGln: 2.597 ± 0.059	5.176ArgArg: 5.176 ± 0.08	3.877ArgSer: 3.877 ± 0.063	3.488ArgThr: 3.488 ± 0.066	4.552ArgVal: 4.552 ± 0.079	0.921ArgTrp: 0.921 ± 0.032	1.707ArgTyr: 1.707 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.904SerAla: 6.904 ± 0.099	0.534SerCys: 0.534 ± 0.027	3.369SerAsp: 3.369 ± 0.071	3.301SerGlu: 3.301 ± 0.074	2.477SerPhe: 2.477 ± 0.054	6.329SerGly: 6.329 ± 0.1	1.47SerHis: 1.47 ± 0.045	3.196SerIle: 3.196 ± 0.065	1.625SerLys: 1.625 ± 0.049	6.578SerLeu: 6.578 ± 0.102	1.624SerMet: 1.624 ± 0.045	1.766SerAsn: 1.766 ± 0.057	3.276SerPro: 3.276 ± 0.06	2.09SerGln: 2.09 ± 0.051	4.129SerArg: 4.129 ± 0.069	4.111SerSer: 4.111 ± 0.095	3.465SerThr: 3.465 ± 0.079	4.817SerVal: 4.817 ± 0.081	0.85SerTrp: 0.85 ± 0.034	1.537SerTyr: 1.537 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.101ThrAla: 6.101 ± 0.096	0.474ThrCys: 0.474 ± 0.025	3.057ThrAsp: 3.057 ± 0.068	2.602ThrGlu: 2.602 ± 0.062	1.96ThrPhe: 1.96 ± 0.049	5.189ThrGly: 5.189 ± 0.089	1.363ThrHis: 1.363 ± 0.042	3.038ThrIle: 3.038 ± 0.066	1.536ThrLys: 1.536 ± 0.048	6.779ThrLeu: 6.779 ± 0.098	1.325ThrMet: 1.325 ± 0.044	1.63ThrAsn: 1.63 ± 0.061	3.855ThrPro: 3.855 ± 0.076	1.967ThrGln: 1.967 ± 0.048	3.424ThrArg: 3.424 ± 0.069	3.384ThrSer: 3.384 ± 0.076	3.351ThrThr: 3.351 ± 0.081	4.161ThrVal: 4.161 ± 0.072	0.668ThrTrp: 0.668 ± 0.033	1.321ThrTyr: 1.321 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.827ValAla: 7.827 ± 0.1	0.759ValCys: 0.759 ± 0.028	3.597ValAsp: 3.597 ± 0.07	3.901ValGlu: 3.901 ± 0.081	2.602ValPhe: 2.602 ± 0.058	5.189ValGly: 5.189 ± 0.087	1.582ValHis: 1.582 ± 0.041	3.621ValIle: 3.621 ± 0.073	1.932ValLys: 1.932 ± 0.058	7.706ValLeu: 7.706 ± 0.116	1.943ValMet: 1.943 ± 0.051	1.894ValAsn: 1.894 ± 0.053	3.846ValPro: 3.846 ± 0.074	2.464ValGln: 2.464 ± 0.047	4.616ValArg: 4.616 ± 0.086	5.223ValSer: 5.223 ± 0.078	4.447ValThr: 4.447 ± 0.079	5.424ValVal: 5.424 ± 0.086	0.909ValTrp: 0.909 ± 0.036	1.282ValTyr: 1.282 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.122TrpAla: 1.122 ± 0.037	0.162TrpCys: 0.162 ± 0.014	0.613TrpAsp: 0.613 ± 0.026	0.539TrpGlu: 0.539 ± 0.027	0.509TrpPhe: 0.509 ± 0.023	0.902TrpGly: 0.902 ± 0.038	0.438TrpHis: 0.438 ± 0.021	0.721TrpIle: 0.721 ± 0.029	0.556TrpLys: 0.556 ± 0.026	1.659TrpLeu: 1.659 ± 0.05	0.381TrpMet: 0.381 ± 0.023	0.514TrpAsn: 0.514 ± 0.025	0.597TrpPro: 0.597 ± 0.031	0.556TrpGln: 0.556 ± 0.028	1.129TrpArg: 1.129 ± 0.037	0.881TrpSer: 0.881 ± 0.034	0.735TrpThr: 0.735 ± 0.029	0.797TrpVal: 0.797 ± 0.031	0.207TrpTrp: 0.207 ± 0.018	0.316TrpTyr: 0.316 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.379TyrAla: 2.379 ± 0.058	0.267TyrCys: 0.267 ± 0.019	1.47TyrAsp: 1.47 ± 0.043	1.163TyrGlu: 1.163 ± 0.036	0.843TyrPhe: 0.843 ± 0.032	2.281TyrGly: 2.281 ± 0.051	0.53TyrHis: 0.53 ± 0.025	0.943TyrIle: 0.943 ± 0.039	0.556TyrLys: 0.556 ± 0.03	2.123TyrLeu: 2.123 ± 0.055	0.444TyrMet: 0.444 ± 0.023	0.799TyrAsn: 0.799 ± 0.034	1.135TyrPro: 1.135 ± 0.039	0.815TyrGln: 0.815 ± 0.033	1.67TyrArg: 1.67 ± 0.044	1.279TyrSer: 1.279 ± 0.044	1.173TyrThr: 1.173 ± 0.045	1.534TyrVal: 1.534 ± 0.041	0.333TyrTrp: 0.333 ± 0.019	0.633TyrTyr: 0.633 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2573 proteins (835224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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