Amino acid dipepetide frequency for Bosea sp. BK498

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.351AlaAla: 19.351 ± 0.183
1.101AlaCys: 1.101 ± 0.027
6.4AlaAsp: 6.4 ± 0.076
8.011AlaGlu: 8.011 ± 0.085
4.951AlaPhe: 4.951 ± 0.058
12.057AlaGly: 12.057 ± 0.118
2.148AlaHis: 2.148 ± 0.035
7.084AlaIle: 7.084 ± 0.065
4.434AlaLys: 4.434 ± 0.069
15.266AlaLeu: 15.266 ± 0.135
3.72AlaMet: 3.72 ± 0.055
2.804AlaAsn: 2.804 ± 0.047
6.175AlaPro: 6.175 ± 0.078
4.298AlaGln: 4.298 ± 0.059
9.509AlaArg: 9.509 ± 0.09
6.709AlaSer: 6.709 ± 0.074
6.496AlaThr: 6.496 ± 0.072
9.193AlaVal: 9.193 ± 0.082
1.532AlaTrp: 1.532 ± 0.035
2.641AlaTyr: 2.641 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.971CysAla: 0.971 ± 0.028
0.09CysCys: 0.09 ± 0.009
0.484CysAsp: 0.484 ± 0.018
0.419CysGlu: 0.419 ± 0.014
0.297CysPhe: 0.297 ± 0.013
0.914CysGly: 0.914 ± 0.023
0.206CysHis: 0.206 ± 0.012
0.393CysIle: 0.393 ± 0.016
0.165CysLys: 0.165 ± 0.011
0.768CysLeu: 0.768 ± 0.021
0.126CysMet: 0.126 ± 0.009
0.183CysAsn: 0.183 ± 0.011
0.39CysPro: 0.39 ± 0.017
0.196CysGln: 0.196 ± 0.011
0.565CysArg: 0.565 ± 0.018
0.41CysSer: 0.41 ± 0.017
0.335CysThr: 0.335 ± 0.014
0.602CysVal: 0.602 ± 0.019
0.114CysTrp: 0.114 ± 0.008
0.173CysTyr: 0.173 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.699AspAla: 6.699 ± 0.076
0.406AspCys: 0.406 ± 0.017
2.681AspAsp: 2.681 ± 0.045
3.226AspGlu: 3.226 ± 0.049
2.061AspPhe: 2.061 ± 0.032
4.989AspGly: 4.989 ± 0.061
1.075AspHis: 1.075 ± 0.026
2.879AspIle: 2.879 ± 0.041
1.708AspLys: 1.708 ± 0.038
5.73AspLeu: 5.73 ± 0.076
1.12AspMet: 1.12 ± 0.026
1.016AspAsn: 1.016 ± 0.028
3.466AspPro: 3.466 ± 0.055
1.437AspGln: 1.437 ± 0.028
3.996AspArg: 3.996 ± 0.051
1.969AspSer: 1.969 ± 0.037
2.198AspThr: 2.198 ± 0.041
3.842AspVal: 3.842 ± 0.05
0.921AspTrp: 0.921 ± 0.024
1.321AspTyr: 1.321 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.444GluAla: 8.444 ± 0.079
0.316GluCys: 0.316 ± 0.015
2.399GluAsp: 2.399 ± 0.04
3.011GluGlu: 3.011 ± 0.058
1.559GluPhe: 1.559 ± 0.035
4.263GluGly: 4.263 ± 0.058
1.131GluHis: 1.131 ± 0.03
3.535GluIle: 3.535 ± 0.048
2.097GluLys: 2.097 ± 0.044
5.254GluLeu: 5.254 ± 0.063
1.418GluMet: 1.418 ± 0.029
1.368GluAsn: 1.368 ± 0.033
3.03GluPro: 3.03 ± 0.044
1.929GluGln: 1.929 ± 0.037
5.304GluArg: 5.304 ± 0.068
2.209GluSer: 2.209 ± 0.037
3.423GluThr: 3.423 ± 0.042
3.542GluVal: 3.542 ± 0.051
0.605GluTrp: 0.605 ± 0.021
0.787GluTyr: 0.787 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
5.002PheAla: 5.002 ± 0.055
0.373PheCys: 0.373 ± 0.014
2.479PheAsp: 2.479 ± 0.04
2.041PheGlu: 2.041 ± 0.037
1.365PhePhe: 1.365 ± 0.032
3.833PheGly: 3.833 ± 0.05
0.754PheHis: 0.754 ± 0.02
1.63PheIle: 1.63 ± 0.033
1.021PheLys: 1.021 ± 0.027
3.371PheLeu: 3.371 ± 0.043
0.793PheMet: 0.793 ± 0.025
0.968PheAsn: 0.968 ± 0.026
1.71PhePro: 1.71 ± 0.034
1.026PheGln: 1.026 ± 0.024
2.383PheArg: 2.383 ± 0.04
2.102PheSer: 2.102 ± 0.034
1.886PheThr: 1.886 ± 0.033
2.951PheVal: 2.951 ± 0.044
0.567PheTrp: 0.567 ± 0.023
0.837PheTyr: 0.837 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.024GlyAla: 10.024 ± 0.089
0.831GlyCys: 0.831 ± 0.024
4.078GlyAsp: 4.078 ± 0.054
5.004GlyGlu: 5.004 ± 0.05
3.853GlyPhe: 3.853 ± 0.051
7.765GlyGly: 7.765 ± 0.123
1.955GlyHis: 1.955 ± 0.04
4.711GlyIle: 4.711 ± 0.055
3.392GlyLys: 3.392 ± 0.052
10.062GlyLeu: 10.062 ± 0.085
2.248GlyMet: 2.248 ± 0.036
2.022GlyAsn: 2.022 ± 0.045
3.905GlyPro: 3.905 ± 0.055
2.953GlyGln: 2.953 ± 0.048
6.753GlyArg: 6.753 ± 0.069
4.884GlySer: 4.884 ± 0.085
4.642GlyThr: 4.642 ± 0.085
6.027GlyVal: 6.027 ± 0.072
1.464GlyTrp: 1.464 ± 0.031
2.28GlyTyr: 2.28 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.367HisAla: 2.367 ± 0.037
0.194HisCys: 0.194 ± 0.011
1.195HisAsp: 1.195 ± 0.031
0.987HisGlu: 0.987 ± 0.025
0.784HisPhe: 0.784 ± 0.025
1.961HisGly: 1.961 ± 0.036
0.517HisHis: 0.517 ± 0.02
0.834HisIle: 0.834 ± 0.022
0.437HisLys: 0.437 ± 0.018
1.995HisLeu: 1.995 ± 0.038
0.419HisMet: 0.419 ± 0.015
0.381HisAsn: 0.381 ± 0.014
1.267HisPro: 1.267 ± 0.03
0.49HisGln: 0.49 ± 0.018
1.374HisArg: 1.374 ± 0.033
0.814HisSer: 0.814 ± 0.02
0.681HisThr: 0.681 ± 0.025
1.482HisVal: 1.482 ± 0.036
0.324HisTrp: 0.324 ± 0.015
0.459HisTyr: 0.459 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
8.069IleAla: 8.069 ± 0.086
0.511IleCys: 0.511 ± 0.019
3.379IleAsp: 3.379 ± 0.047
3.355IleGlu: 3.355 ± 0.046
1.566IlePhe: 1.566 ± 0.034
5.416IleGly: 5.416 ± 0.062
0.875IleHis: 0.875 ± 0.024
2.009IleIle: 2.009 ± 0.043
1.384IleLys: 1.384 ± 0.029
4.545IleLeu: 4.545 ± 0.062
0.957IleMet: 0.957 ± 0.026
1.195IleAsn: 1.195 ± 0.031
2.347IlePro: 2.347 ± 0.043
1.178IleGln: 1.178 ± 0.025
3.278IleArg: 3.278 ± 0.044
2.609IleSer: 2.609 ± 0.042
2.405IleThr: 2.405 ± 0.035
4.634IleVal: 4.634 ± 0.062
0.635IleTrp: 0.635 ± 0.024
1.054IleTyr: 1.054 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.773LysAla: 4.773 ± 0.071
0.122LysCys: 0.122 ± 0.009
1.614LysAsp: 1.614 ± 0.032
1.495LysGlu: 1.495 ± 0.033
0.815LysPhe: 0.815 ± 0.024
2.759LysGly: 2.759 ± 0.046
0.521LysHis: 0.521 ± 0.016
1.538LysIle: 1.538 ± 0.031
1.085LysLys: 1.085 ± 0.032
3.614LysLeu: 3.614 ± 0.049
0.621LysMet: 0.621 ± 0.019
0.766LysAsn: 0.766 ± 0.023
2.445LysPro: 2.445 ± 0.041
0.99LysGln: 0.99 ± 0.026
2.438LysArg: 2.438 ± 0.041
1.641LysSer: 1.641 ± 0.033
1.808LysThr: 1.808 ± 0.038
2.448LysVal: 2.448 ± 0.041
0.304LysTrp: 0.304 ± 0.015
0.5LysTyr: 0.5 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.617LeuAla: 15.617 ± 0.118
0.865LeuCys: 0.865 ± 0.026
6.22LeuAsp: 6.22 ± 0.071
4.809LeuGlu: 4.809 ± 0.062
3.681LeuPhe: 3.681 ± 0.059
9.274LeuGly: 9.274 ± 0.095
1.729LeuHis: 1.729 ± 0.037
5.213LeuIle: 5.213 ± 0.07
3.866LeuLys: 3.866 ± 0.053
10.078LeuLeu: 10.078 ± 0.109
2.287LeuMet: 2.287 ± 0.038
2.399LeuAsn: 2.399 ± 0.044
6.17LeuPro: 6.17 ± 0.064
2.716LeuGln: 2.716 ± 0.044
7.119LeuArg: 7.119 ± 0.075
6.515LeuSer: 6.515 ± 0.071
5.606LeuThr: 5.606 ± 0.065
8.021LeuVal: 8.021 ± 0.068
1.238LeuTrp: 1.238 ± 0.03
1.965LeuTyr: 1.965 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.129MetAla: 3.129 ± 0.049
0.119MetCys: 0.119 ± 0.009
0.992MetAsp: 0.992 ± 0.024
0.939MetGlu: 0.939 ± 0.025
0.638MetPhe: 0.638 ± 0.019
1.622MetGly: 1.622 ± 0.036
0.37MetHis: 0.37 ± 0.016
1.278MetIle: 1.278 ± 0.026
0.904MetLys: 0.904 ± 0.022
2.571MetLeu: 2.571 ± 0.043
0.6MetMet: 0.6 ± 0.02
0.678MetAsn: 0.678 ± 0.022
1.521MetPro: 1.521 ± 0.03
0.758MetGln: 0.758 ± 0.021
1.857MetArg: 1.857 ± 0.039
1.618MetSer: 1.618 ± 0.037
1.864MetThr: 1.864 ± 0.032
1.595MetVal: 1.595 ± 0.032
0.163MetTrp: 0.163 ± 0.01
0.264MetTyr: 0.264 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.067AsnAla: 3.067 ± 0.05
0.204AsnCys: 0.204 ± 0.012
1.164AsnAsp: 1.164 ± 0.03
1.109AsnGlu: 1.109 ± 0.029
0.861AsnPhe: 0.861 ± 0.023
2.231AsnGly: 2.231 ± 0.049
0.437AsnHis: 0.437 ± 0.016
1.156AsnIle: 1.156 ± 0.031
0.582AsnLys: 0.582 ± 0.018
2.503AsnLeu: 2.503 ± 0.047
0.513AsnMet: 0.513 ± 0.019
0.634AsnAsn: 0.634 ± 0.028
1.761AsnPro: 1.761 ± 0.032
0.651AsnGln: 0.651 ± 0.021
1.671AsnArg: 1.671 ± 0.026
1.037AsnSer: 1.037 ± 0.028
1.111AsnThr: 1.111 ± 0.028
1.736AsnVal: 1.736 ± 0.034
0.397AsnTrp: 0.397 ± 0.015
0.595AsnTyr: 0.595 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.486ProAla: 7.486 ± 0.089
0.306ProCys: 0.306 ± 0.012
3.39ProAsp: 3.39 ± 0.048
3.818ProGlu: 3.818 ± 0.047
2.129ProPhe: 2.129 ± 0.036
4.909ProGly: 4.909 ± 0.063
1.116ProHis: 1.116 ± 0.024
2.336ProIle: 2.336 ± 0.035
1.704ProLys: 1.704 ± 0.037
5.198ProLeu: 5.198 ± 0.064
1.235ProMet: 1.235 ± 0.027
1.292ProAsn: 1.292 ± 0.031
2.899ProPro: 2.899 ± 0.058
1.819ProGln: 1.819 ± 0.037
3.406ProArg: 3.406 ± 0.054
2.901ProSer: 2.901 ± 0.04
2.427ProThr: 2.427 ± 0.036
4.412ProVal: 4.412 ± 0.054
0.683ProTrp: 0.683 ± 0.018
1.198ProTyr: 1.198 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.443GlnAla: 4.443 ± 0.063
0.157GlnCys: 0.157 ± 0.011
1.393GlnAsp: 1.393 ± 0.029
1.401GlnGlu: 1.401 ± 0.028
0.973GlnPhe: 0.973 ± 0.026
2.538GlnGly: 2.538 ± 0.041
0.555GlnHis: 0.555 ± 0.02
1.793GlnIle: 1.793 ± 0.027
0.963GlnLys: 0.963 ± 0.025
2.665GlnLeu: 2.665 ± 0.04
0.774GlnMet: 0.774 ± 0.021
0.834GlnAsn: 0.834 ± 0.025
1.891GlnPro: 1.891 ± 0.032
1.211GlnGln: 1.211 ± 0.037
2.589GlnArg: 2.589 ± 0.046
1.66GlnSer: 1.66 ± 0.034
1.632GlnThr: 1.632 ± 0.031
2.083GlnVal: 2.083 ± 0.038
0.342GlnTrp: 0.342 ± 0.015
0.534GlnTyr: 0.534 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.189ArgAla: 8.189 ± 0.087
0.539ArgCys: 0.539 ± 0.021
4.007ArgAsp: 4.007 ± 0.059
4.467ArgGlu: 4.467 ± 0.061
3.163ArgPhe: 3.163 ± 0.049
5.152ArgGly: 5.152 ± 0.062
1.66ArgHis: 1.66 ± 0.035
4.211ArgIle: 4.211 ± 0.054
2.294ArgLys: 2.294 ± 0.036
8.475ArgLeu: 8.475 ± 0.084
1.841ArgMet: 1.841 ± 0.035
1.798ArgAsn: 1.798 ± 0.036
3.914ArgPro: 3.914 ± 0.054
2.631ArgGln: 2.631 ± 0.041
5.994ArgArg: 5.994 ± 0.076
3.921ArgSer: 3.921 ± 0.052
3.116ArgThr: 3.116 ± 0.045
4.656ArgVal: 4.656 ± 0.055
1.024ArgTrp: 1.024 ± 0.026
1.693ArgTyr: 1.693 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.203SerAla: 6.203 ± 0.076
0.405SerCys: 0.405 ± 0.017
2.653SerAsp: 2.653 ± 0.045
2.757SerGlu: 2.757 ± 0.045
2.47SerPhe: 2.47 ± 0.035
5.512SerGly: 5.512 ± 0.083
1.008SerHis: 1.008 ± 0.028
2.566SerIle: 2.566 ± 0.041
1.423SerLys: 1.423 ± 0.033
5.657SerLeu: 5.657 ± 0.062
1.156SerMet: 1.156 ± 0.028
1.199SerAsn: 1.199 ± 0.028
2.803SerPro: 2.803 ± 0.04
1.614SerGln: 1.614 ± 0.032
3.712SerArg: 3.712 ± 0.053
2.705SerSer: 2.705 ± 0.05
2.503SerThr: 2.503 ± 0.045
3.875SerVal: 3.875 ± 0.054
0.856SerTrp: 0.856 ± 0.024
1.322SerTyr: 1.322 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.304ThrAla: 6.304 ± 0.067
0.364ThrCys: 0.364 ± 0.016
2.381ThrAsp: 2.381 ± 0.037
2.493ThrGlu: 2.493 ± 0.04
1.821ThrPhe: 1.821 ± 0.031
5.015ThrGly: 5.015 ± 0.068
0.965ThrHis: 0.965 ± 0.026
2.945ThrIle: 2.945 ± 0.045
1.402ThrLys: 1.402 ± 0.029
5.946ThrLeu: 5.946 ± 0.073
1.123ThrMet: 1.123 ± 0.027
1.138ThrAsn: 1.138 ± 0.037
3.235ThrPro: 3.235 ± 0.04
1.43ThrGln: 1.43 ± 0.03
3.352ThrArg: 3.352 ± 0.042
2.602ThrSer: 2.602 ± 0.046
2.754ThrThr: 2.754 ± 0.048
4.298ThrVal: 4.298 ± 0.057
0.556ThrTrp: 0.556 ± 0.02
1.057ThrTyr: 1.057 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
10.047ValAla: 10.047 ± 0.081
0.556ValCys: 0.556 ± 0.018
3.874ValAsp: 3.874 ± 0.051
4.59ValGlu: 4.59 ± 0.056
2.721ValPhe: 2.721 ± 0.045
5.59ValGly: 5.59 ± 0.07
1.242ValHis: 1.242 ± 0.028
3.901ValIle: 3.901 ± 0.051
2.432ValLys: 2.432 ± 0.043
7.699ValLeu: 7.699 ± 0.072
1.854ValMet: 1.854 ± 0.034
1.792ValAsn: 1.792 ± 0.037
3.883ValPro: 3.883 ± 0.048
1.932ValGln: 1.932 ± 0.035
4.547ValArg: 4.547 ± 0.054
4.278ValSer: 4.278 ± 0.053
4.579ValThr: 4.579 ± 0.051
6.078ValVal: 6.078 ± 0.07
0.799ValTrp: 0.799 ± 0.024
1.34ValTyr: 1.34 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.032
0.133TrpCys: 0.133 ± 0.008
0.562TrpAsp: 0.562 ± 0.019
0.56TrpGlu: 0.56 ± 0.021
0.557TrpPhe: 0.557 ± 0.018
0.907TrpGly: 0.907 ± 0.023
0.308TrpHis: 0.308 ± 0.013
0.61TrpIle: 0.61 ± 0.02
0.43TrpLys: 0.43 ± 0.016
1.808TrpLeu: 1.808 ± 0.037
0.313TrpMet: 0.313 ± 0.012
0.43TrpAsn: 0.43 ± 0.017
0.733TrpPro: 0.733 ± 0.026
0.561TrpGln: 0.561 ± 0.022
1.203TrpArg: 1.203 ± 0.03
0.839TrpSer: 0.839 ± 0.024
0.768TrpThr: 0.768 ± 0.022
0.709TrpVal: 0.709 ± 0.022
0.242TrpTrp: 0.242 ± 0.012
0.258TrpTyr: 0.258 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.045
0.209TyrCys: 0.209 ± 0.013
1.393TyrAsp: 1.393 ± 0.027
1.134TyrGlu: 1.134 ± 0.027
0.826TyrPhe: 0.826 ± 0.022
2.147TyrGly: 2.147 ± 0.038
0.391TyrHis: 0.391 ± 0.016
0.776TyrIle: 0.776 ± 0.025
0.571TyrLys: 0.571 ± 0.019
2.184TyrLeu: 2.184 ± 0.035
0.36TyrMet: 0.36 ± 0.014
0.526TyrAsn: 0.526 ± 0.016
1.118TyrPro: 1.118 ± 0.029
0.612TyrGln: 0.612 ± 0.022
1.693TyrArg: 1.693 ± 0.035
0.979TyrSer: 0.979 ± 0.028
0.949TyrThr: 0.949 ± 0.024
1.553TyrVal: 1.553 ± 0.027
0.347TyrTrp: 0.347 ± 0.014
0.506TyrTyr: 0.506 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5154 proteins (1633446 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski