Amino acid dipepetide frequency for Dethiosulfatarculus sandiegensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.11AlaAla: 9.11 ± 0.097	1.344AlaCys: 1.344 ± 0.032	4.512AlaAsp: 4.512 ± 0.058	5.797AlaGlu: 5.797 ± 0.075	3.741AlaPhe: 3.741 ± 0.059	7.869AlaGly: 7.869 ± 0.08	1.663AlaHis: 1.663 ± 0.033	4.193AlaIle: 4.193 ± 0.065	5.455AlaLys: 5.455 ± 0.065	10.923AlaLeu: 10.923 ± 0.104	2.981AlaMet: 2.981 ± 0.05	2.515AlaAsn: 2.515 ± 0.041	3.512AlaPro: 3.512 ± 0.052	3.603AlaGln: 3.603 ± 0.045	5.641AlaArg: 5.641 ± 0.074	4.862AlaSer: 4.862 ± 0.055	3.588AlaThr: 3.588 ± 0.052	6.402AlaVal: 6.402 ± 0.067	1.222AlaTrp: 1.222 ± 0.029	2.286AlaTyr: 2.286 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.025	0.223CysCys: 0.223 ± 0.014	0.497CysAsp: 0.497 ± 0.017	0.56CysGlu: 0.56 ± 0.019	0.592CysPhe: 0.592 ± 0.02	1.164CysGly: 1.164 ± 0.032	0.357CysHis: 0.357 ± 0.022	0.512CysIle: 0.512 ± 0.016	0.475CysLys: 0.475 ± 0.016	1.752CysLeu: 1.752 ± 0.032	0.289CysMet: 0.289 ± 0.013	0.351CysAsn: 0.351 ± 0.016	0.842CysPro: 0.842 ± 0.029	0.489CysGln: 0.489 ± 0.016	0.846CysArg: 0.846 ± 0.026	0.664CysSer: 0.664 ± 0.024	0.559CysThr: 0.559 ± 0.018	0.776CysVal: 0.776 ± 0.022	0.156CysTrp: 0.156 ± 0.01	0.325CysTyr: 0.325 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.641AspAla: 3.641 ± 0.044	0.598AspCys: 0.598 ± 0.02	2.243AspAsp: 2.243 ± 0.039	3.131AspGlu: 3.131 ± 0.05	2.455AspPhe: 2.455 ± 0.04	3.053AspGly: 3.053 ± 0.051	1.2AspHis: 1.2 ± 0.03	2.91AspIle: 2.91 ± 0.04	2.823AspLys: 2.823 ± 0.04	6.935AspLeu: 6.935 ± 0.08	1.435AspMet: 1.435 ± 0.027	1.573AspAsn: 1.573 ± 0.032	3.177AspPro: 3.177 ± 0.05	2.615AspGln: 2.615 ± 0.046	2.799AspArg: 2.799 ± 0.043	2.584AspSer: 2.584 ± 0.044	2.028AspThr: 2.028 ± 0.034	2.799AspVal: 2.799 ± 0.05	0.767AspTrp: 0.767 ± 0.024	1.852AspTyr: 1.852 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.002GluAla: 6.002 ± 0.08	0.51GluCys: 0.51 ± 0.017	3.031GluAsp: 3.031 ± 0.053	4.431GluGlu: 4.431 ± 0.067	2.203GluPhe: 2.203 ± 0.04	3.647GluGly: 3.647 ± 0.043	1.174GluHis: 1.174 ± 0.031	4.112GluIle: 4.112 ± 0.05	5.271GluLys: 5.271 ± 0.061	7.064GluLeu: 7.064 ± 0.077	2.056GluMet: 2.056 ± 0.032	2.661GluAsn: 2.661 ± 0.041	2.725GluPro: 2.725 ± 0.045	2.567GluGln: 2.567 ± 0.043	3.281GluArg: 3.281 ± 0.046	3.112GluSer: 3.112 ± 0.043	3.075GluThr: 3.075 ± 0.05	4.611GluVal: 4.611 ± 0.054	0.527GluTrp: 0.527 ± 0.017	1.662GluTyr: 1.662 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.204PheAla: 3.204 ± 0.051	0.674PheCys: 0.674 ± 0.02	2.281PheAsp: 2.281 ± 0.038	2.339PheGlu: 2.339 ± 0.041	2.28PhePhe: 2.28 ± 0.045	3.108PheGly: 3.108 ± 0.054	0.79PheHis: 0.79 ± 0.023	2.254PheIle: 2.254 ± 0.039	2.394PheLys: 2.394 ± 0.041	4.582PheLeu: 4.582 ± 0.062	1.237PheMet: 1.237 ± 0.029	1.561PheAsn: 1.561 ± 0.031	1.601PhePro: 1.601 ± 0.034	1.257PheGln: 1.257 ± 0.026	1.886PheArg: 1.886 ± 0.04	3.042PheSer: 3.042 ± 0.047	2.278PheThr: 2.278 ± 0.041	2.557PheVal: 2.557 ± 0.044	0.644PheTrp: 0.644 ± 0.022	1.287PheTyr: 1.287 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	6.317GlyAla: 6.317 ± 0.075	1.129GlyCys: 1.129 ± 0.03	3.525GlyAsp: 3.525 ± 0.058	4.631GlyGlu: 4.631 ± 0.056	3.723GlyPhe: 3.723 ± 0.048	6.173GlyGly: 6.173 ± 0.079	1.727GlyHis: 1.727 ± 0.032	4.54GlyIle: 4.54 ± 0.055	4.931GlyLys: 4.931 ± 0.063	9.912GlyLeu: 9.912 ± 0.085	2.474GlyMet: 2.474 ± 0.039	2.339GlyAsn: 2.339 ± 0.047	3.116GlyPro: 3.116 ± 0.047	3.081GlyGln: 3.081 ± 0.046	4.674GlyArg: 4.674 ± 0.057	4.361GlySer: 4.361 ± 0.055	3.231GlyThr: 3.231 ± 0.06	5.978GlyVal: 5.978 ± 0.066	1.053GlyTrp: 1.053 ± 0.027	2.529GlyTyr: 2.529 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.393HisAla: 1.393 ± 0.03	0.3HisCys: 0.3 ± 0.015	0.977HisAsp: 0.977 ± 0.026	1.114HisGlu: 1.114 ± 0.029	0.883HisPhe: 0.883 ± 0.023	1.492HisGly: 1.492 ± 0.031	0.5HisHis: 0.5 ± 0.021	0.996HisIle: 0.996 ± 0.026	1.074HisLys: 1.074 ± 0.026	2.309HisLeu: 2.309 ± 0.037	0.51HisMet: 0.51 ± 0.018	0.661HisAsn: 0.661 ± 0.022	1.285HisPro: 1.285 ± 0.03	0.788HisGln: 0.788 ± 0.024	1.065HisArg: 1.065 ± 0.026	1.037HisSer: 1.037 ± 0.027	0.956HisThr: 0.956 ± 0.025	1.016HisVal: 1.016 ± 0.023	0.248HisTrp: 0.248 ± 0.013	0.618HisTyr: 0.618 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.135IleAla: 4.135 ± 0.054	0.876IleCys: 0.876 ± 0.024	2.573IleAsp: 2.573 ± 0.035	3.009IleGlu: 3.009 ± 0.05	2.401IlePhe: 2.401 ± 0.043	3.57IleGly: 3.57 ± 0.053	1.02IleHis: 1.02 ± 0.025	3.217IleIle: 3.217 ± 0.051	3.809IleLys: 3.809 ± 0.056	5.897IleLeu: 5.897 ± 0.076	1.571IleMet: 1.571 ± 0.037	2.368IleAsn: 2.368 ± 0.046	2.632IlePro: 2.632 ± 0.04	1.705IleGln: 1.705 ± 0.034	2.678IleArg: 2.678 ± 0.037	3.87IleSer: 3.87 ± 0.052	3.354IleThr: 3.354 ± 0.05	3.069IleVal: 3.069 ± 0.049	0.667IleTrp: 0.667 ± 0.02	1.562IleTyr: 1.562 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	6.694LysAla: 6.694 ± 0.07	0.513LysCys: 0.513 ± 0.017	3.456LysAsp: 3.456 ± 0.055	4.327LysGlu: 4.327 ± 0.053	1.486LysPhe: 1.486 ± 0.033	5.394LysGly: 5.394 ± 0.073	0.925LysHis: 0.925 ± 0.026	3.296LysIle: 3.296 ± 0.05	4.812LysLys: 4.812 ± 0.064	5.072LysLeu: 5.072 ± 0.058	1.617LysMet: 1.617 ± 0.031	2.621LysAsn: 2.621 ± 0.04	3.178LysPro: 3.178 ± 0.053	2.079LysGln: 2.079 ± 0.04	3.284LysArg: 3.284 ± 0.047	3.154LysSer: 3.154 ± 0.045	3.352LysThr: 3.352 ± 0.044	4.477LysVal: 4.477 ± 0.057	0.648LysTrp: 0.648 ± 0.02	1.38LysTyr: 1.38 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.571LeuAla: 12.571 ± 0.115	1.308LeuCys: 1.308 ± 0.031	6.261LeuAsp: 6.261 ± 0.065	7.504LeuGlu: 7.504 ± 0.076	4.594LeuPhe: 4.594 ± 0.067	9.475LeuGly: 9.475 ± 0.095	1.767LeuHis: 1.767 ± 0.039	5.65LeuIle: 5.65 ± 0.067	7.403LeuLys: 7.403 ± 0.075	11.061LeuLeu: 11.061 ± 0.111	2.706LeuMet: 2.706 ± 0.039	4.163LeuAsn: 4.163 ± 0.047	5.518LeuPro: 5.518 ± 0.06	2.564LeuGln: 2.564 ± 0.043	5.198LeuArg: 5.198 ± 0.063	6.973LeuSer: 6.973 ± 0.071	5.91LeuThr: 5.91 ± 0.065	7.852LeuVal: 7.852 ± 0.076	1.249LeuTrp: 1.249 ± 0.031	2.484LeuTyr: 2.484 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.353MetAla: 3.353 ± 0.05	0.216MetCys: 0.216 ± 0.012	1.653MetAsp: 1.653 ± 0.034	1.916MetGlu: 1.916 ± 0.032	0.759MetPhe: 0.759 ± 0.023	2.552MetGly: 2.552 ± 0.047	0.509MetHis: 0.509 ± 0.018	1.496MetIle: 1.496 ± 0.031	1.462MetLys: 1.462 ± 0.03	2.594MetLeu: 2.594 ± 0.045	0.63MetMet: 0.63 ± 0.02	1.003MetAsn: 1.003 ± 0.026	1.516MetPro: 1.516 ± 0.028	0.932MetGln: 0.932 ± 0.024	1.395MetArg: 1.395 ± 0.029	1.455MetSer: 1.455 ± 0.028	1.496MetThr: 1.496 ± 0.031	2.261MetVal: 2.261 ± 0.041	0.202MetTrp: 0.202 ± 0.011	0.47MetTyr: 0.47 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.549AsnAla: 2.549 ± 0.038	0.46AsnCys: 0.46 ± 0.019	1.317AsnAsp: 1.317 ± 0.031	1.625AsnGlu: 1.625 ± 0.033	1.315AsnPhe: 1.315 ± 0.029	2.377AsnGly: 2.377 ± 0.046	0.79AsnHis: 0.79 ± 0.023	1.948AsnIle: 1.948 ± 0.035	1.816AsnLys: 1.816 ± 0.036	4.579AsnLeu: 4.579 ± 0.057	0.923AsnMet: 0.923 ± 0.023	1.237AsnAsn: 1.237 ± 0.03	2.384AsnPro: 2.384 ± 0.039	1.95AsnGln: 1.95 ± 0.035	2.16AsnArg: 2.16 ± 0.037	1.92AsnSer: 1.92 ± 0.047	1.718AsnThr: 1.718 ± 0.047	1.806AsnVal: 1.806 ± 0.036	0.488AsnTrp: 0.488 ± 0.017	1.075AsnTyr: 1.075 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.045ProAla: 4.045 ± 0.056	0.528ProCys: 0.528 ± 0.019	2.973ProAsp: 2.973 ± 0.046	4.161ProGlu: 4.161 ± 0.057	1.998ProPhe: 1.998 ± 0.035	4.532ProGly: 4.532 ± 0.064	0.956ProHis: 0.956 ± 0.024	2.022ProIle: 2.022 ± 0.034	2.782ProLys: 2.782 ± 0.044	4.992ProLeu: 4.992 ± 0.059	1.153ProMet: 1.153 ± 0.028	1.413ProAsn: 1.413 ± 0.027	2.229ProPro: 2.229 ± 0.043	1.968ProGln: 1.968 ± 0.036	2.248ProArg: 2.248 ± 0.035	2.415ProSer: 2.415 ± 0.039	1.898ProThr: 1.898 ± 0.035	3.775ProVal: 3.775 ± 0.049	0.674ProTrp: 0.674 ± 0.02	1.315ProTyr: 1.315 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.722GlnAla: 4.722 ± 0.065	0.324GlnCys: 0.324 ± 0.017	1.858GlnAsp: 1.858 ± 0.033	2.54GlnGlu: 2.54 ± 0.042	0.946GlnPhe: 0.946 ± 0.026	3.564GlnGly: 3.564 ± 0.049	0.459GlnHis: 0.459 ± 0.017	1.974GlnIle: 1.974 ± 0.03	3.074GlnLys: 3.074 ± 0.045	2.726GlnLeu: 2.726 ± 0.045	1.032GlnMet: 1.032 ± 0.022	1.481GlnAsn: 1.481 ± 0.032	1.37GlnPro: 1.37 ± 0.028	0.98GlnGln: 0.98 ± 0.027	1.942GlnArg: 1.942 ± 0.033	1.877GlnSer: 1.877 ± 0.031	1.857GlnThr: 1.857 ± 0.034	3.21GlnVal: 3.21 ± 0.043	0.369GlnTrp: 0.369 ± 0.016	0.787GlnTyr: 0.787 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.594ArgAla: 4.594 ± 0.059	0.532ArgCys: 0.532 ± 0.021	2.529ArgAsp: 2.529 ± 0.041	3.818ArgGlu: 3.818 ± 0.049	2.447ArgPhe: 2.447 ± 0.039	3.362ArgGly: 3.362 ± 0.049	1.139ArgHis: 1.139 ± 0.028	3.318ArgIle: 3.318 ± 0.051	3.255ArgLys: 3.255 ± 0.052	7.025ArgLeu: 7.025 ± 0.068	1.54ArgMet: 1.54 ± 0.032	1.625ArgAsn: 1.625 ± 0.034	2.617ArgPro: 2.617 ± 0.042	2.479ArgGln: 2.479 ± 0.044	3.204ArgArg: 3.204 ± 0.055	2.59ArgSer: 2.59 ± 0.041	2.376ArgThr: 2.376 ± 0.037	3.694ArgVal: 3.694 ± 0.05	0.589ArgTrp: 0.589 ± 0.02	1.483ArgTyr: 1.483 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	4.497SerAla: 4.497 ± 0.052	0.703SerCys: 0.703 ± 0.022	2.641SerAsp: 2.641 ± 0.041	3.214SerGlu: 3.214 ± 0.047	2.62SerPhe: 2.62 ± 0.043	5.075SerGly: 5.075 ± 0.089	1.156SerHis: 1.156 ± 0.027	2.931SerIle: 2.931 ± 0.051	2.674SerLys: 2.674 ± 0.038	7.372SerLeu: 7.372 ± 0.083	1.514SerMet: 1.514 ± 0.031	1.505SerAsn: 1.505 ± 0.033	3.01SerPro: 3.01 ± 0.046	2.448SerGln: 2.448 ± 0.041	3.393SerArg: 3.393 ± 0.053	3.193SerSer: 3.193 ± 0.052	2.402SerThr: 2.402 ± 0.044	3.598SerVal: 3.598 ± 0.045	0.815SerTrp: 0.815 ± 0.024	1.555SerTyr: 1.555 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.306ThrAla: 4.306 ± 0.054	0.628ThrCys: 0.628 ± 0.02	2.45ThrAsp: 2.45 ± 0.039	2.753ThrGlu: 2.753 ± 0.046	1.755ThrPhe: 1.755 ± 0.037	4.777ThrGly: 4.777 ± 0.061	0.933ThrHis: 0.933 ± 0.023	2.653ThrIle: 2.653 ± 0.041	2.414ThrLys: 2.414 ± 0.036	5.01ThrLeu: 5.01 ± 0.053	1.216ThrMet: 1.216 ± 0.031	1.587ThrAsn: 1.587 ± 0.036	2.761ThrPro: 2.761 ± 0.041	1.584ThrGln: 1.584 ± 0.029	2.502ThrArg: 2.502 ± 0.04	2.664ThrSer: 2.664 ± 0.04	2.432ThrThr: 2.432 ± 0.043	3.316ThrVal: 3.316 ± 0.051	0.657ThrTrp: 0.657 ± 0.02	1.297ThrTyr: 1.297 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.032ValAla: 6.032 ± 0.076	0.974ValCys: 0.974 ± 0.025	3.711ValAsp: 3.711 ± 0.057	4.528ValGlu: 4.528 ± 0.057	3.262ValPhe: 3.262 ± 0.051	5.047ValGly: 5.047 ± 0.066	1.28ValHis: 1.28 ± 0.028	4.09ValIle: 4.09 ± 0.059	3.989ValLys: 3.989 ± 0.052	7.584ValLeu: 7.584 ± 0.069	2.091ValMet: 2.091 ± 0.039	2.464ValAsn: 2.464 ± 0.043	2.667ValPro: 2.667 ± 0.043	2.045ValGln: 2.045 ± 0.037	3.686ValArg: 3.686 ± 0.052	4.263ValSer: 4.263 ± 0.053	3.38ValThr: 3.38 ± 0.052	5.539ValVal: 5.539 ± 0.069	0.773ValTrp: 0.773 ± 0.023	1.766ValTyr: 1.766 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.035TrpAla: 1.035 ± 0.029	0.14TrpCys: 0.14 ± 0.009	0.631TrpAsp: 0.631 ± 0.02	0.729TrpGlu: 0.729 ± 0.021	0.534TrpPhe: 0.534 ± 0.017	1.018TrpGly: 1.018 ± 0.025	0.297TrpHis: 0.297 ± 0.014	0.597TrpIle: 0.597 ± 0.018	0.527TrpLys: 0.527 ± 0.02	1.535TrpLeu: 1.535 ± 0.035	0.269TrpMet: 0.269 ± 0.012	0.401TrpAsn: 0.401 ± 0.017	0.665TrpPro: 0.665 ± 0.025	0.74TrpGln: 0.74 ± 0.022	0.732TrpArg: 0.732 ± 0.021	0.685TrpSer: 0.685 ± 0.021	0.465TrpThr: 0.465 ± 0.018	0.883TrpVal: 0.883 ± 0.022	0.203TrpTrp: 0.203 ± 0.011	0.272TrpTyr: 0.272 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.06TyrAla: 2.06 ± 0.041	0.409TyrCys: 0.409 ± 0.017	1.498TyrAsp: 1.498 ± 0.03	1.593TyrGlu: 1.593 ± 0.032	1.266TyrPhe: 1.266 ± 0.028	2.196TyrGly: 2.196 ± 0.042	0.579TyrHis: 0.579 ± 0.017	1.272TyrIle: 1.272 ± 0.032	1.321TyrLys: 1.321 ± 0.034	3.287TyrLeu: 3.287 ± 0.051	0.627TyrMet: 0.627 ± 0.017	0.907TyrAsn: 0.907 ± 0.026	1.27TyrPro: 1.27 ± 0.032	1.219TyrGln: 1.219 ± 0.026	1.599TyrArg: 1.599 ± 0.03	1.598TyrSer: 1.598 ± 0.035	1.343TyrThr: 1.343 ± 0.032	1.553TyrVal: 1.553 ± 0.03	0.409TyrTrp: 0.409 ± 0.015	0.926TyrTyr: 0.926 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5388 proteins (1659360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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