Amino acid dipepetide frequency for Menangle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.89AlaAla: 5.89 ± 2.006
1.015AlaCys: 1.015 ± 0.447
4.265AlaAsp: 4.265 ± 0.885
2.64AlaGlu: 2.64 ± 0.593
2.234AlaPhe: 2.234 ± 0.664
3.656AlaGly: 3.656 ± 0.929
1.625AlaHis: 1.625 ± 0.416
4.874AlaIle: 4.874 ± 0.913
4.062AlaLys: 4.062 ± 1.306
5.28AlaLeu: 5.28 ± 1.318
1.422AlaMet: 1.422 ± 0.73
2.234AlaAsn: 2.234 ± 0.535
2.437AlaPro: 2.437 ± 0.786
1.828AlaGln: 1.828 ± 0.423
3.859AlaArg: 3.859 ± 1.603
3.046AlaSer: 3.046 ± 0.515
3.656AlaThr: 3.656 ± 1.093
3.656AlaVal: 3.656 ± 0.511
0.812AlaTrp: 0.812 ± 0.359
1.219AlaTyr: 1.219 ± 0.254
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.482
0.203CysCys: 0.203 ± 0.119
1.219CysAsp: 1.219 ± 0.381
1.219CysGlu: 1.219 ± 0.25
1.015CysPhe: 1.015 ± 0.459
1.015CysGly: 1.015 ± 0.368
1.219CysHis: 1.219 ± 0.334
1.625CysIle: 1.625 ± 0.606
0.812CysLys: 0.812 ± 0.581
1.828CysLeu: 1.828 ± 0.512
0.609CysMet: 0.609 ± 0.249
1.015CysAsn: 1.015 ± 0.435
1.422CysPro: 1.422 ± 0.511
1.015CysGln: 1.015 ± 0.41
1.219CysArg: 1.219 ± 0.334
1.828CysSer: 1.828 ± 1.201
0.609CysThr: 0.609 ± 0.269
0.812CysVal: 0.812 ± 0.288
0.0CysTrp: 0.0 ± 0.0
1.219CysTyr: 1.219 ± 0.444
0.0CysXaa: 0.0 ± 0.0
Asp
2.843AspAla: 2.843 ± 0.401
0.406AspCys: 0.406 ± 0.214
2.234AspAsp: 2.234 ± 0.724
3.452AspGlu: 3.452 ± 1.082
1.015AspPhe: 1.015 ± 0.518
1.828AspGly: 1.828 ± 0.364
1.015AspHis: 1.015 ± 0.211
3.656AspIle: 3.656 ± 0.795
2.843AspLys: 2.843 ± 0.857
4.468AspLeu: 4.468 ± 1.111
1.625AspMet: 1.625 ± 0.755
4.874AspAsn: 4.874 ± 0.763
3.249AspPro: 3.249 ± 0.975
2.64AspGln: 2.64 ± 0.58
3.249AspArg: 3.249 ± 0.91
4.468AspSer: 4.468 ± 0.808
3.452AspThr: 3.452 ± 0.529
2.64AspVal: 2.64 ± 0.644
1.219AspTrp: 1.219 ± 0.338
2.234AspTyr: 2.234 ± 0.77
0.0AspXaa: 0.0 ± 0.0
Glu
1.422GluAla: 1.422 ± 0.473
1.828GluCys: 1.828 ± 0.388
1.422GluAsp: 1.422 ± 0.672
2.843GluGlu: 2.843 ± 0.474
1.828GluPhe: 1.828 ± 0.248
1.625GluGly: 1.625 ± 0.572
0.812GluHis: 0.812 ± 0.317
4.671GluIle: 4.671 ± 0.765
2.64GluLys: 2.64 ± 0.628
6.093GluLeu: 6.093 ± 1.131
1.828GluMet: 1.828 ± 0.501
2.64GluAsn: 2.64 ± 0.299
1.828GluPro: 1.828 ± 0.739
2.64GluGln: 2.64 ± 1.1
1.219GluArg: 1.219 ± 0.581
4.062GluSer: 4.062 ± 0.641
4.062GluThr: 4.062 ± 0.566
5.077GluVal: 5.077 ± 1.142
1.015GluTrp: 1.015 ± 0.325
0.203GluTyr: 0.203 ± 0.119
0.0GluXaa: 0.0 ± 0.0
Phe
1.625PheAla: 1.625 ± 0.514
1.015PheCys: 1.015 ± 0.298
0.812PheAsp: 0.812 ± 0.288
2.437PheGlu: 2.437 ± 0.608
1.625PhePhe: 1.625 ± 0.196
2.031PheGly: 2.031 ± 0.889
0.406PheHis: 0.406 ± 0.214
2.437PheIle: 2.437 ± 0.549
1.625PheLys: 1.625 ± 0.737
4.468PheLeu: 4.468 ± 0.946
1.219PheMet: 1.219 ± 0.416
2.234PheAsn: 2.234 ± 0.891
2.234PhePro: 2.234 ± 0.563
1.219PheGln: 1.219 ± 0.572
1.828PheArg: 1.828 ± 0.88
3.046PheSer: 3.046 ± 0.7
1.625PheThr: 1.625 ± 0.659
2.843PheVal: 2.843 ± 0.795
0.0PheTrp: 0.0 ± 0.0
1.828PheTyr: 1.828 ± 0.399
0.0PheXaa: 0.0 ± 0.0
Gly
2.843GlyAla: 2.843 ± 1.035
0.609GlyCys: 0.609 ± 0.486
4.671GlyAsp: 4.671 ± 1.104
2.64GlyGlu: 2.64 ± 0.346
2.64GlyPhe: 2.64 ± 0.684
3.452GlyGly: 3.452 ± 1.267
0.812GlyHis: 0.812 ± 0.372
4.874GlyIle: 4.874 ± 0.904
3.656GlyLys: 3.656 ± 1.324
4.671GlyLeu: 4.671 ± 0.729
1.219GlyMet: 1.219 ± 0.388
2.031GlyAsn: 2.031 ± 1.174
1.219GlyPro: 1.219 ± 0.865
1.828GlyGln: 1.828 ± 0.914
2.843GlyArg: 2.843 ± 0.708
4.874GlySer: 4.874 ± 0.663
1.422GlyThr: 1.422 ± 0.617
2.64GlyVal: 2.64 ± 0.775
0.609GlyTrp: 0.609 ± 0.44
1.828GlyTyr: 1.828 ± 0.7
0.0GlyXaa: 0.0 ± 0.0
His
1.422HisAla: 1.422 ± 0.319
0.609HisCys: 0.609 ± 0.233
1.625HisAsp: 1.625 ± 0.528
1.015HisGlu: 1.015 ± 0.277
0.609HisPhe: 0.609 ± 0.294
0.609HisGly: 0.609 ± 0.354
1.422HisHis: 1.422 ± 0.637
2.031HisIle: 2.031 ± 0.981
1.015HisLys: 1.015 ± 0.305
2.843HisLeu: 2.843 ± 1.27
0.203HisMet: 0.203 ± 0.27
0.406HisAsn: 0.406 ± 0.238
1.015HisPro: 1.015 ± 0.325
0.812HisGln: 0.812 ± 0.451
1.422HisArg: 1.422 ± 0.674
0.812HisSer: 0.812 ± 0.625
0.812HisThr: 0.812 ± 0.476
0.203HisVal: 0.203 ± 0.119
0.203HisTrp: 0.203 ± 0.119
0.406HisTyr: 0.406 ± 0.358
0.0HisXaa: 0.0 ± 0.0
Ile
3.656IleAla: 3.656 ± 0.463
1.422IleCys: 1.422 ± 0.67
4.874IleAsp: 4.874 ± 0.73
2.843IleGlu: 2.843 ± 0.788
3.046IlePhe: 3.046 ± 1.121
3.046IleGly: 3.046 ± 0.925
1.828IleHis: 1.828 ± 0.359
7.108IleIle: 7.108 ± 1.371
3.249IleLys: 3.249 ± 1.125
8.733IleLeu: 8.733 ± 2.303
3.046IleMet: 3.046 ± 0.468
4.671IleAsn: 4.671 ± 1.022
5.483IlePro: 5.483 ± 0.835
4.062IleGln: 4.062 ± 0.91
3.656IleArg: 3.656 ± 0.536
5.89IleSer: 5.89 ± 0.997
4.874IleThr: 4.874 ± 0.586
4.671IleVal: 4.671 ± 1.205
1.219IleTrp: 1.219 ± 0.456
1.828IleTyr: 1.828 ± 0.335
0.0IleXaa: 0.0 ± 0.0
Lys
2.234LysAla: 2.234 ± 0.728
1.015LysCys: 1.015 ± 0.267
1.828LysAsp: 1.828 ± 0.578
3.249LysGlu: 3.249 ± 0.78
1.625LysPhe: 1.625 ± 0.235
3.046LysGly: 3.046 ± 1.475
1.219LysHis: 1.219 ± 0.388
3.452LysIle: 3.452 ± 0.5
2.843LysLys: 2.843 ± 0.748
4.468LysLeu: 4.468 ± 1.012
1.828LysMet: 1.828 ± 0.594
2.031LysAsn: 2.031 ± 0.494
3.046LysPro: 3.046 ± 0.915
2.234LysGln: 2.234 ± 0.357
2.843LysArg: 2.843 ± 0.674
4.671LysSer: 4.671 ± 1.203
3.452LysThr: 3.452 ± 0.445
2.843LysVal: 2.843 ± 0.579
0.609LysTrp: 0.609 ± 0.249
1.625LysTyr: 1.625 ± 0.511
0.0LysXaa: 0.0 ± 0.0
Leu
6.093LeuAla: 6.093 ± 1.265
3.046LeuCys: 3.046 ± 0.525
7.514LeuAsp: 7.514 ± 1.578
3.859LeuGlu: 3.859 ± 0.598
4.062LeuPhe: 4.062 ± 1.026
5.483LeuGly: 5.483 ± 1.347
0.812LeuHis: 0.812 ± 0.311
7.514LeuIle: 7.514 ± 1.045
4.874LeuLys: 4.874 ± 1.193
7.108LeuLeu: 7.108 ± 1.431
1.422LeuMet: 1.422 ± 0.459
6.093LeuAsn: 6.093 ± 1.186
3.656LeuPro: 3.656 ± 0.616
4.265LeuGln: 4.265 ± 0.69
5.28LeuArg: 5.28 ± 0.823
11.982LeuSer: 11.982 ± 2.573
9.748LeuThr: 9.748 ± 0.932
4.874LeuVal: 4.874 ± 0.754
1.015LeuTrp: 1.015 ± 0.289
3.656LeuTyr: 3.656 ± 0.635
0.0LeuXaa: 0.0 ± 0.0
Met
1.828MetAla: 1.828 ± 0.761
0.406MetCys: 0.406 ± 0.193
1.625MetAsp: 1.625 ± 0.577
1.828MetGlu: 1.828 ± 0.427
0.812MetPhe: 0.812 ± 0.459
1.015MetGly: 1.015 ± 0.383
0.0MetHis: 0.0 ± 0.0
2.031MetIle: 2.031 ± 0.497
0.812MetLys: 0.812 ± 0.312
2.437MetLeu: 2.437 ± 0.547
2.031MetMet: 2.031 ± 1.075
0.406MetAsn: 0.406 ± 0.195
1.625MetPro: 1.625 ± 0.445
0.812MetGln: 0.812 ± 0.477
2.234MetArg: 2.234 ± 0.361
2.843MetSer: 2.843 ± 0.726
2.64MetThr: 2.64 ± 0.702
1.828MetVal: 1.828 ± 0.502
0.812MetTrp: 0.812 ± 0.273
0.406MetTyr: 0.406 ± 0.229
0.0MetXaa: 0.0 ± 0.0
Asn
2.437AsnAla: 2.437 ± 0.865
1.625AsnCys: 1.625 ± 0.916
1.625AsnAsp: 1.625 ± 0.514
1.828AsnGlu: 1.828 ± 0.482
1.828AsnPhe: 1.828 ± 0.86
3.249AsnGly: 3.249 ± 1.177
1.015AsnHis: 1.015 ± 0.448
3.859AsnIle: 3.859 ± 1.098
1.828AsnLys: 1.828 ± 0.599
6.702AsnLeu: 6.702 ± 1.356
0.812AsnMet: 0.812 ± 0.464
2.437AsnAsn: 2.437 ± 0.714
4.265AsnPro: 4.265 ± 1.182
2.64AsnGln: 2.64 ± 0.697
2.843AsnArg: 2.843 ± 0.582
4.468AsnSer: 4.468 ± 1.006
3.249AsnThr: 3.249 ± 0.305
3.046AsnVal: 3.046 ± 0.516
1.015AsnTrp: 1.015 ± 0.411
1.625AsnTyr: 1.625 ± 0.687
0.0AsnXaa: 0.0 ± 0.0
Pro
4.062ProAla: 4.062 ± 0.8
0.609ProCys: 0.609 ± 0.247
1.625ProAsp: 1.625 ± 0.687
3.249ProGlu: 3.249 ± 0.394
2.843ProPhe: 2.843 ± 1.113
3.249ProGly: 3.249 ± 1.13
0.609ProHis: 0.609 ± 0.307
5.077ProIle: 5.077 ± 0.799
3.452ProLys: 3.452 ± 0.803
5.077ProLeu: 5.077 ± 0.727
1.422ProMet: 1.422 ± 0.441
2.031ProAsn: 2.031 ± 0.299
3.452ProPro: 3.452 ± 0.861
2.031ProGln: 2.031 ± 0.933
1.828ProArg: 1.828 ± 0.574
4.062ProSer: 4.062 ± 2.171
2.234ProThr: 2.234 ± 0.395
2.64ProVal: 2.64 ± 0.623
0.203ProTrp: 0.203 ± 0.27
2.031ProTyr: 2.031 ± 0.403
0.0ProXaa: 0.0 ± 0.0
Gln
3.249GlnAla: 3.249 ± 1.216
0.406GlnCys: 0.406 ± 0.33
2.437GlnAsp: 2.437 ± 0.494
1.828GlnGlu: 1.828 ± 0.932
1.015GlnPhe: 1.015 ± 0.383
2.843GlnGly: 2.843 ± 1.235
0.609GlnHis: 0.609 ± 0.302
4.874GlnIle: 4.874 ± 0.89
3.046GlnLys: 3.046 ± 0.605
5.077GlnLeu: 5.077 ± 0.917
2.031GlnMet: 2.031 ± 0.425
3.656GlnAsn: 3.656 ± 0.853
1.828GlnPro: 1.828 ± 0.754
2.234GlnGln: 2.234 ± 0.813
1.015GlnArg: 1.015 ± 0.308
3.452GlnSer: 3.452 ± 0.906
3.046GlnThr: 3.046 ± 0.343
2.437GlnVal: 2.437 ± 1.242
0.203GlnTrp: 0.203 ± 0.119
1.015GlnTyr: 1.015 ± 0.454
0.0GlnXaa: 0.0 ± 0.0
Arg
1.422ArgAla: 1.422 ± 0.73
0.609ArgCys: 0.609 ± 0.3
2.437ArgAsp: 2.437 ± 0.873
2.437ArgGlu: 2.437 ± 0.469
1.422ArgPhe: 1.422 ± 0.309
2.843ArgGly: 2.843 ± 0.782
1.422ArgHis: 1.422 ± 0.579
4.468ArgIle: 4.468 ± 0.68
2.437ArgLys: 2.437 ± 0.547
6.499ArgLeu: 6.499 ± 1.316
0.609ArgMet: 0.609 ± 0.357
2.64ArgAsn: 2.64 ± 0.574
2.843ArgPro: 2.843 ± 0.688
1.828ArgGln: 1.828 ± 0.717
3.656ArgArg: 3.656 ± 0.947
4.874ArgSer: 4.874 ± 0.892
2.234ArgThr: 2.234 ± 0.909
3.452ArgVal: 3.452 ± 0.602
0.0ArgTrp: 0.0 ± 0.0
1.422ArgTyr: 1.422 ± 0.459
0.0ArgXaa: 0.0 ± 0.0
Ser
6.093SerAla: 6.093 ± 0.841
2.031SerCys: 2.031 ± 0.569
5.28SerAsp: 5.28 ± 1.14
3.859SerGlu: 3.859 ± 0.951
2.234SerPhe: 2.234 ± 0.717
4.468SerGly: 4.468 ± 0.62
1.625SerHis: 1.625 ± 0.951
4.671SerIle: 4.671 ± 1.098
3.656SerLys: 3.656 ± 1.845
8.936SerLeu: 8.936 ± 1.055
3.046SerMet: 3.046 ± 0.577
3.249SerAsn: 3.249 ± 0.805
3.656SerPro: 3.656 ± 1.072
5.483SerGln: 5.483 ± 1.67
3.452SerArg: 3.452 ± 1.162
6.296SerSer: 6.296 ± 1.439
5.483SerThr: 5.483 ± 1.436
6.296SerVal: 6.296 ± 0.65
0.406SerTrp: 0.406 ± 0.238
3.452SerTyr: 3.452 ± 0.896
0.0SerXaa: 0.0 ± 0.0
Thr
5.483ThrAla: 5.483 ± 1.005
1.422ThrCys: 1.422 ± 0.97
3.452ThrAsp: 3.452 ± 0.896
4.062ThrGlu: 4.062 ± 0.708
2.64ThrPhe: 2.64 ± 0.63
3.452ThrGly: 3.452 ± 0.695
1.015ThrHis: 1.015 ± 0.308
4.062ThrIle: 4.062 ± 0.687
3.046ThrLys: 3.046 ± 0.982
7.311ThrLeu: 7.311 ± 0.403
0.812ThrMet: 0.812 ± 0.254
3.046ThrAsn: 3.046 ± 0.804
4.062ThrPro: 4.062 ± 0.26
4.062ThrGln: 4.062 ± 0.749
2.437ThrArg: 2.437 ± 0.244
3.656ThrSer: 3.656 ± 1.236
5.686ThrThr: 5.686 ± 1.221
2.437ThrVal: 2.437 ± 1.367
0.812ThrTrp: 0.812 ± 0.372
1.828ThrTyr: 1.828 ± 0.713
0.0ThrXaa: 0.0 ± 0.0
Val
3.452ValAla: 3.452 ± 0.769
1.219ValCys: 1.219 ± 0.368
2.64ValAsp: 2.64 ± 0.562
3.452ValGlu: 3.452 ± 0.647
3.046ValPhe: 3.046 ± 0.368
2.031ValGly: 2.031 ± 0.378
1.625ValHis: 1.625 ± 0.196
3.656ValIle: 3.656 ± 0.748
2.64ValLys: 2.64 ± 1.128
5.28ValLeu: 5.28 ± 1.17
2.031ValMet: 2.031 ± 0.335
4.062ValAsn: 4.062 ± 1.287
2.437ValPro: 2.437 ± 1.054
2.234ValGln: 2.234 ± 0.726
3.249ValArg: 3.249 ± 0.714
4.874ValSer: 4.874 ± 1.586
4.874ValThr: 4.874 ± 1.701
3.452ValVal: 3.452 ± 0.475
0.406ValTrp: 0.406 ± 0.301
1.625ValTyr: 1.625 ± 0.415
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.273
0.406TrpCys: 0.406 ± 0.239
0.0TrpAsp: 0.0 ± 0.0
0.203TrpGlu: 0.203 ± 0.198
0.406TrpPhe: 0.406 ± 0.214
1.015TrpGly: 1.015 ± 0.482
0.203TrpHis: 0.203 ± 0.27
1.422TrpIle: 1.422 ± 0.496
0.812TrpLys: 0.812 ± 0.353
0.609TrpLeu: 0.609 ± 0.231
0.203TrpMet: 0.203 ± 0.119
1.015TrpAsn: 1.015 ± 0.289
1.015TrpPro: 1.015 ± 0.327
0.203TrpGln: 0.203 ± 0.119
0.203TrpArg: 0.203 ± 0.119
0.812TrpSer: 0.812 ± 0.273
0.203TrpThr: 0.203 ± 0.119
0.609TrpVal: 0.609 ± 0.252
0.0TrpTrp: 0.0 ± 0.0
0.406TrpTyr: 0.406 ± 0.229
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.828TyrAla: 1.828 ± 0.603
1.015TyrCys: 1.015 ± 0.211
2.031TyrAsp: 2.031 ± 0.302
0.812TyrGlu: 0.812 ± 0.359
0.609TyrPhe: 0.609 ± 0.249
1.422TyrGly: 1.422 ± 0.46
0.203TyrHis: 0.203 ± 0.119
2.843TyrIle: 2.843 ± 0.395
0.812TyrLys: 0.812 ± 0.276
4.468TyrLeu: 4.468 ± 0.962
0.812TyrMet: 0.812 ± 0.503
1.625TyrAsn: 1.625 ± 0.951
1.015TyrPro: 1.015 ± 0.459
2.234TyrGln: 2.234 ± 0.438
1.219TyrArg: 1.219 ± 0.554
3.656TyrSer: 3.656 ± 0.582
1.422TyrThr: 1.422 ± 0.538
1.828TyrVal: 1.828 ± 0.496
0.0TyrTrp: 0.0 ± 0.0
1.422TyrTyr: 1.422 ± 0.293
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski