Amino acid dipepetide frequency for Haloarcula hispanica pleomorphic virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.822AlaAla: 6.822 ± 1.693
0.44AlaCys: 0.44 ± 0.282
6.602AlaAsp: 6.602 ± 1.447
5.282AlaGlu: 5.282 ± 1.096
1.981AlaPhe: 1.981 ± 0.662
6.822AlaGly: 6.822 ± 1.331
1.54AlaHis: 1.54 ± 0.672
4.842AlaIle: 4.842 ± 1.084
3.081AlaLys: 3.081 ± 0.712
3.961AlaLeu: 3.961 ± 1.117
2.201AlaMet: 2.201 ± 0.728
3.301AlaAsn: 3.301 ± 0.723
3.081AlaPro: 3.081 ± 0.769
3.521AlaGln: 3.521 ± 1.195
4.842AlaArg: 4.842 ± 1.2
4.621AlaSer: 4.621 ± 1.672
4.181AlaThr: 4.181 ± 1.12
4.842AlaVal: 4.842 ± 1.462
1.32AlaTrp: 1.32 ± 0.455
3.521AlaTyr: 3.521 ± 0.99
0.0AlaXaa: 0.0 ± 0.0
Cys
0.22CysAla: 0.22 ± 0.195
0.22CysCys: 0.22 ± 0.252
0.66CysAsp: 0.66 ± 0.336
1.1CysGlu: 1.1 ± 0.589
0.88CysPhe: 0.88 ± 0.408
0.88CysGly: 0.88 ± 0.407
0.22CysHis: 0.22 ± 0.195
0.44CysIle: 0.44 ± 0.374
0.66CysLys: 0.66 ± 0.393
0.88CysLeu: 0.88 ± 0.369
0.22CysMet: 0.22 ± 0.253
0.66CysAsn: 0.66 ± 0.491
1.1CysPro: 1.1 ± 0.608
0.44CysGln: 0.44 ± 0.303
0.44CysArg: 0.44 ± 0.301
0.66CysSer: 0.66 ± 0.387
0.44CysThr: 0.44 ± 0.329
1.1CysVal: 1.1 ± 0.422
0.44CysTrp: 0.44 ± 0.32
0.22CysTyr: 0.22 ± 0.215
0.0CysXaa: 0.0 ± 0.0
Asp
6.602AspAla: 6.602 ± 0.977
0.88AspCys: 0.88 ± 0.419
5.062AspAsp: 5.062 ± 1.082
5.942AspGlu: 5.942 ± 1.226
1.981AspPhe: 1.981 ± 0.759
6.602AspGly: 6.602 ± 1.134
0.88AspHis: 0.88 ± 0.381
4.181AspIle: 4.181 ± 1.023
0.88AspLys: 0.88 ± 0.377
6.382AspLeu: 6.382 ± 0.915
1.981AspMet: 1.981 ± 0.719
1.981AspAsn: 1.981 ± 0.715
4.181AspPro: 4.181 ± 1.155
3.521AspGln: 3.521 ± 0.778
5.062AspArg: 5.062 ± 0.78
3.741AspSer: 3.741 ± 0.886
4.401AspThr: 4.401 ± 0.901
3.081AspVal: 3.081 ± 0.955
1.1AspTrp: 1.1 ± 0.433
3.741AspTyr: 3.741 ± 0.837
0.0AspXaa: 0.0 ± 0.0
Glu
3.961GluAla: 3.961 ± 0.689
1.32GluCys: 1.32 ± 0.658
5.942GluAsp: 5.942 ± 1.208
4.401GluGlu: 4.401 ± 1.05
1.761GluPhe: 1.761 ± 0.698
5.502GluGly: 5.502 ± 1.033
1.32GluHis: 1.32 ± 0.587
6.162GluIle: 6.162 ± 1.229
3.521GluLys: 3.521 ± 0.649
6.382GluLeu: 6.382 ± 1.23
1.1GluMet: 1.1 ± 0.443
2.861GluAsn: 2.861 ± 0.808
4.401GluPro: 4.401 ± 0.908
4.842GluGln: 4.842 ± 1.29
4.181GluArg: 4.181 ± 1.118
5.062GluSer: 5.062 ± 1.428
5.942GluThr: 5.942 ± 1.148
5.722GluVal: 5.722 ± 1.374
1.761GluTrp: 1.761 ± 0.809
3.961GluTyr: 3.961 ± 0.788
0.0GluXaa: 0.0 ± 0.0
Phe
1.54PheAla: 1.54 ± 0.506
0.44PheCys: 0.44 ± 0.331
3.301PheAsp: 3.301 ± 0.784
3.081PheGlu: 3.081 ± 1.032
0.44PhePhe: 0.44 ± 0.297
1.761PheGly: 1.761 ± 0.547
0.22PheHis: 0.22 ± 0.225
0.88PheIle: 0.88 ± 0.486
0.66PheLys: 0.66 ± 0.461
1.54PheLeu: 1.54 ± 0.562
0.66PheMet: 0.66 ± 0.349
1.32PheAsn: 1.32 ± 0.625
0.44PhePro: 0.44 ± 0.289
1.54PheGln: 1.54 ± 0.584
0.88PheArg: 0.88 ± 0.316
2.201PheSer: 2.201 ± 0.64
2.421PheThr: 2.421 ± 0.749
2.641PheVal: 2.641 ± 0.508
0.44PheTrp: 0.44 ± 0.234
0.88PheTyr: 0.88 ± 0.446
0.0PheXaa: 0.0 ± 0.0
Gly
3.741GlyAla: 3.741 ± 1.022
1.761GlyCys: 1.761 ± 0.761
5.062GlyAsp: 5.062 ± 1.542
5.282GlyGlu: 5.282 ± 0.896
0.88GlyPhe: 0.88 ± 0.479
6.382GlyGly: 6.382 ± 1.559
0.66GlyHis: 0.66 ± 0.301
3.301GlyIle: 3.301 ± 0.737
3.521GlyLys: 3.521 ± 0.696
4.621GlyLeu: 4.621 ± 0.893
1.32GlyMet: 1.32 ± 0.537
3.081GlyAsn: 3.081 ± 1.136
3.301GlyPro: 3.301 ± 0.665
3.741GlyGln: 3.741 ± 0.993
5.502GlyArg: 5.502 ± 1.318
5.062GlySer: 5.062 ± 1.183
4.621GlyThr: 4.621 ± 1.35
4.842GlyVal: 4.842 ± 0.962
1.761GlyTrp: 1.761 ± 0.547
3.301GlyTyr: 3.301 ± 0.925
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.469
0.44HisCys: 0.44 ± 0.304
1.32HisAsp: 1.32 ± 0.564
1.761HisGlu: 1.761 ± 0.535
0.66HisPhe: 0.66 ± 0.318
1.54HisGly: 1.54 ± 0.475
0.66HisHis: 0.66 ± 0.335
0.66HisIle: 0.66 ± 0.432
0.66HisLys: 0.66 ± 0.324
1.32HisLeu: 1.32 ± 0.443
0.22HisMet: 0.22 ± 0.253
0.66HisAsn: 0.66 ± 0.354
1.54HisPro: 1.54 ± 0.745
0.44HisGln: 0.44 ± 0.303
2.861HisArg: 2.861 ± 0.79
0.66HisSer: 0.66 ± 0.334
2.201HisThr: 2.201 ± 0.562
1.32HisVal: 1.32 ± 0.6
0.44HisTrp: 0.44 ± 0.322
1.32HisTyr: 1.32 ± 0.462
0.0HisXaa: 0.0 ± 0.0
Ile
3.521IleAla: 3.521 ± 0.983
0.22IleCys: 0.22 ± 0.207
4.181IleAsp: 4.181 ± 0.888
4.181IleGlu: 4.181 ± 0.563
2.421IlePhe: 2.421 ± 0.76
4.401IleGly: 4.401 ± 1.087
0.88IleHis: 0.88 ± 0.557
2.421IleIle: 2.421 ± 0.7
1.981IleLys: 1.981 ± 0.501
4.181IleLeu: 4.181 ± 1.013
0.22IleMet: 0.22 ± 0.195
2.201IleAsn: 2.201 ± 0.768
1.981IlePro: 1.981 ± 0.687
2.421IleGln: 2.421 ± 0.922
4.621IleArg: 4.621 ± 0.808
3.521IleSer: 3.521 ± 1.008
4.181IleThr: 4.181 ± 0.874
3.521IleVal: 3.521 ± 0.956
0.22IleTrp: 0.22 ± 0.238
1.54IleTyr: 1.54 ± 0.625
0.0IleXaa: 0.0 ± 0.0
Lys
3.081LysAla: 3.081 ± 0.731
0.88LysCys: 0.88 ± 0.41
1.54LysAsp: 1.54 ± 0.498
4.401LysGlu: 4.401 ± 1.372
0.88LysPhe: 0.88 ± 0.423
2.421LysGly: 2.421 ± 0.583
1.54LysHis: 1.54 ± 0.562
3.301LysIle: 3.301 ± 0.677
1.54LysLys: 1.54 ± 0.538
3.741LysLeu: 3.741 ± 0.902
0.66LysMet: 0.66 ± 0.364
1.54LysAsn: 1.54 ± 0.752
1.1LysPro: 1.1 ± 0.532
2.421LysGln: 2.421 ± 0.91
1.761LysArg: 1.761 ± 0.745
1.981LysSer: 1.981 ± 0.532
2.641LysThr: 2.641 ± 0.7
2.201LysVal: 2.201 ± 0.592
0.22LysTrp: 0.22 ± 0.26
1.32LysTyr: 1.32 ± 0.559
0.0LysXaa: 0.0 ± 0.0
Leu
6.822LeuAla: 6.822 ± 1.662
0.66LeuCys: 0.66 ± 0.36
4.401LeuAsp: 4.401 ± 0.961
5.722LeuGlu: 5.722 ± 1.179
2.421LeuPhe: 2.421 ± 0.891
2.861LeuGly: 2.861 ± 0.961
1.32LeuHis: 1.32 ± 0.657
2.861LeuIle: 2.861 ± 0.767
4.181LeuLys: 4.181 ± 0.979
5.062LeuLeu: 5.062 ± 0.872
1.981LeuMet: 1.981 ± 0.916
3.961LeuAsn: 3.961 ± 0.88
3.521LeuPro: 3.521 ± 0.746
2.861LeuGln: 2.861 ± 0.872
5.062LeuArg: 5.062 ± 1.326
4.842LeuSer: 4.842 ± 1.108
4.842LeuThr: 4.842 ± 0.875
5.282LeuVal: 5.282 ± 1.103
1.1LeuTrp: 1.1 ± 0.385
1.54LeuTyr: 1.54 ± 0.458
0.0LeuXaa: 0.0 ± 0.0
Met
1.1MetAla: 1.1 ± 0.556
0.44MetCys: 0.44 ± 0.306
0.88MetAsp: 0.88 ± 0.437
0.66MetGlu: 0.66 ± 0.586
0.88MetPhe: 0.88 ± 0.37
1.32MetGly: 1.32 ± 0.566
0.44MetHis: 0.44 ± 0.288
1.1MetIle: 1.1 ± 0.512
0.88MetLys: 0.88 ± 0.463
0.88MetLeu: 0.88 ± 0.477
0.22MetMet: 0.22 ± 0.176
0.22MetAsn: 0.22 ± 0.194
0.44MetPro: 0.44 ± 0.251
0.66MetGln: 0.66 ± 0.314
1.981MetArg: 1.981 ± 0.778
1.761MetSer: 1.761 ± 0.467
2.421MetThr: 2.421 ± 0.647
1.981MetVal: 1.981 ± 1.086
0.22MetTrp: 0.22 ± 0.266
1.1MetTyr: 1.1 ± 0.686
0.0MetXaa: 0.0 ± 0.0
Asn
2.421AsnAla: 2.421 ± 0.76
0.44AsnCys: 0.44 ± 0.287
1.761AsnAsp: 1.761 ± 0.626
2.641AsnGlu: 2.641 ± 0.743
1.1AsnPhe: 1.1 ± 0.492
4.181AsnGly: 4.181 ± 1.29
1.1AsnHis: 1.1 ± 0.433
2.421AsnIle: 2.421 ± 0.577
1.761AsnLys: 1.761 ± 0.582
2.201AsnLeu: 2.201 ± 0.475
0.66AsnMet: 0.66 ± 0.468
2.641AsnAsn: 2.641 ± 0.977
1.981AsnPro: 1.981 ± 0.653
1.761AsnGln: 1.761 ± 0.657
2.641AsnArg: 2.641 ± 0.989
3.081AsnSer: 3.081 ± 1.432
3.521AsnThr: 3.521 ± 1.134
1.981AsnVal: 1.981 ± 0.55
0.22AsnTrp: 0.22 ± 0.215
2.201AsnTyr: 2.201 ± 0.73
0.0AsnXaa: 0.0 ± 0.0
Pro
4.401ProAla: 4.401 ± 0.804
0.44ProCys: 0.44 ± 0.297
4.842ProAsp: 4.842 ± 1.171
3.961ProGlu: 3.961 ± 1.027
0.22ProPhe: 0.22 ± 0.195
3.301ProGly: 3.301 ± 0.62
1.981ProHis: 1.981 ± 0.668
0.88ProIle: 0.88 ± 0.361
2.201ProLys: 2.201 ± 0.733
3.521ProLeu: 3.521 ± 1.169
1.1ProMet: 1.1 ± 0.634
2.421ProAsn: 2.421 ± 0.752
1.981ProPro: 1.981 ± 0.792
1.761ProGln: 1.761 ± 0.587
2.861ProArg: 2.861 ± 0.645
2.421ProSer: 2.421 ± 0.974
4.181ProThr: 4.181 ± 1.304
3.081ProVal: 3.081 ± 0.951
0.22ProTrp: 0.22 ± 0.26
1.761ProTyr: 1.761 ± 0.595
0.0ProXaa: 0.0 ± 0.0
Gln
2.861GlnAla: 2.861 ± 0.772
0.22GlnCys: 0.22 ± 0.195
3.961GlnAsp: 3.961 ± 1.121
3.301GlnGlu: 3.301 ± 0.784
2.201GlnPhe: 2.201 ± 0.58
2.421GlnGly: 2.421 ± 0.727
0.44GlnHis: 0.44 ± 0.354
2.201GlnIle: 2.201 ± 0.712
1.54GlnLys: 1.54 ± 0.557
3.961GlnLeu: 3.961 ± 0.955
1.761GlnMet: 1.761 ± 0.654
3.301GlnAsn: 3.301 ± 1.414
3.081GlnPro: 3.081 ± 1.084
2.201GlnGln: 2.201 ± 0.516
1.761GlnArg: 1.761 ± 0.676
4.401GlnSer: 4.401 ± 1.267
2.641GlnThr: 2.641 ± 0.891
1.981GlnVal: 1.981 ± 0.623
0.66GlnTrp: 0.66 ± 0.479
1.761GlnTyr: 1.761 ± 0.672
0.0GlnXaa: 0.0 ± 0.0
Arg
6.162ArgAla: 6.162 ± 0.794
1.1ArgCys: 1.1 ± 0.51
5.062ArgAsp: 5.062 ± 1.403
8.363ArgGlu: 8.363 ± 1.958
2.201ArgPhe: 2.201 ± 0.743
3.961ArgGly: 3.961 ± 1.259
1.32ArgHis: 1.32 ± 0.566
4.181ArgIle: 4.181 ± 1.064
2.201ArgLys: 2.201 ± 0.781
2.861ArgLeu: 2.861 ± 0.887
1.1ArgMet: 1.1 ± 0.392
2.641ArgAsn: 2.641 ± 0.672
3.521ArgPro: 3.521 ± 1.17
2.641ArgGln: 2.641 ± 0.798
4.842ArgArg: 4.842 ± 1.399
4.401ArgSer: 4.401 ± 0.985
2.641ArgThr: 2.641 ± 0.766
4.401ArgVal: 4.401 ± 1.501
1.761ArgTrp: 1.761 ± 0.857
2.421ArgTyr: 2.421 ± 0.898
0.0ArgXaa: 0.0 ± 0.0
Ser
6.382SerAla: 6.382 ± 1.449
0.0SerCys: 0.0 ± 0.0
3.521SerAsp: 3.521 ± 0.861
4.621SerGlu: 4.621 ± 1.144
0.88SerPhe: 0.88 ± 0.453
6.822SerGly: 6.822 ± 1.458
1.761SerHis: 1.761 ± 0.533
2.421SerIle: 2.421 ± 0.911
2.861SerLys: 2.861 ± 0.628
4.181SerLeu: 4.181 ± 0.762
0.66SerMet: 0.66 ± 0.318
3.521SerAsn: 3.521 ± 0.735
3.741SerPro: 3.741 ± 0.79
2.641SerGln: 2.641 ± 0.978
3.961SerArg: 3.961 ± 0.913
5.502SerSer: 5.502 ± 1.394
3.301SerThr: 3.301 ± 1.223
4.621SerVal: 4.621 ± 1.069
1.54SerTrp: 1.54 ± 0.634
1.981SerTyr: 1.981 ± 0.784
0.0SerXaa: 0.0 ± 0.0
Thr
7.042ThrAla: 7.042 ± 1.797
0.88ThrCys: 0.88 ± 0.348
4.621ThrAsp: 4.621 ± 0.899
5.942ThrGlu: 5.942 ± 1.348
2.641ThrPhe: 2.641 ± 0.811
3.521ThrGly: 3.521 ± 0.747
0.88ThrHis: 0.88 ± 0.354
4.181ThrIle: 4.181 ± 0.918
2.641ThrLys: 2.641 ± 0.697
5.502ThrLeu: 5.502 ± 1.206
1.1ThrMet: 1.1 ± 0.473
1.32ThrAsn: 1.32 ± 0.587
3.081ThrPro: 3.081 ± 0.723
2.201ThrGln: 2.201 ± 0.857
2.421ThrArg: 2.421 ± 0.772
3.961ThrSer: 3.961 ± 0.971
3.741ThrThr: 3.741 ± 0.911
5.062ThrVal: 5.062 ± 1.311
0.88ThrTrp: 0.88 ± 0.401
4.181ThrTyr: 4.181 ± 0.986
0.0ThrXaa: 0.0 ± 0.0
Val
4.621ValAla: 4.621 ± 1.332
0.44ValCys: 0.44 ± 0.251
3.961ValAsp: 3.961 ± 0.666
5.722ValGlu: 5.722 ± 1.229
1.54ValPhe: 1.54 ± 0.446
3.301ValGly: 3.301 ± 0.742
2.641ValHis: 2.641 ± 0.676
4.401ValIle: 4.401 ± 1.084
2.201ValLys: 2.201 ± 0.708
3.961ValLeu: 3.961 ± 0.899
1.1ValMet: 1.1 ± 0.51
1.54ValAsn: 1.54 ± 0.681
3.521ValPro: 3.521 ± 0.793
2.861ValGln: 2.861 ± 0.858
6.822ValArg: 6.822 ± 1.622
4.842ValSer: 4.842 ± 0.857
4.842ValThr: 4.842 ± 0.959
4.842ValVal: 4.842 ± 1.396
0.66ValTrp: 0.66 ± 0.36
1.981ValTyr: 1.981 ± 0.935
0.0ValXaa: 0.0 ± 0.0
Trp
1.1TrpAla: 1.1 ± 0.451
0.44TrpCys: 0.44 ± 0.287
1.1TrpAsp: 1.1 ± 0.443
0.66TrpGlu: 0.66 ± 0.31
0.22TrpPhe: 0.22 ± 0.231
0.44TrpGly: 0.44 ± 0.391
0.66TrpHis: 0.66 ± 0.448
0.44TrpIle: 0.44 ± 0.263
0.88TrpLys: 0.88 ± 0.4
1.981TrpLeu: 1.981 ± 0.904
0.88TrpMet: 0.88 ± 0.586
0.88TrpAsn: 0.88 ± 0.358
0.44TrpPro: 0.44 ± 0.319
0.22TrpGln: 0.22 ± 0.194
1.761TrpArg: 1.761 ± 0.619
0.88TrpSer: 0.88 ± 0.459
0.88TrpThr: 0.88 ± 0.473
0.66TrpVal: 0.66 ± 0.323
0.0TrpTrp: 0.0 ± 0.0
0.44TrpTyr: 0.44 ± 0.291
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.301TyrAla: 3.301 ± 0.854
0.22TyrCys: 0.22 ± 0.252
4.401TyrAsp: 4.401 ± 1.161
3.301TyrGlu: 3.301 ± 0.787
1.1TyrPhe: 1.1 ± 0.469
3.301TyrGly: 3.301 ± 0.94
1.32TyrHis: 1.32 ± 0.609
1.54TyrIle: 1.54 ± 0.401
1.32TyrLys: 1.32 ± 0.478
4.181TyrLeu: 4.181 ± 0.842
0.22TyrMet: 0.22 ± 0.225
0.66TyrAsn: 0.66 ± 0.376
1.1TyrPro: 1.1 ± 0.396
3.961TyrGln: 3.961 ± 1.144
3.521TyrArg: 3.521 ± 0.967
1.32TyrSer: 1.32 ± 0.365
1.761TyrThr: 1.761 ± 0.642
2.641TyrVal: 2.641 ± 0.493
0.0TyrTrp: 0.0 ± 0.0
1.981TyrTyr: 1.981 ± 0.835
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (4545 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski