Amino acid dipepetide frequency for Microbacterium kyungheense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.059AlaAla: 23.059 ± 0.266
0.648AlaCys: 0.648 ± 0.026
9.283AlaAsp: 9.283 ± 0.099
7.997AlaGlu: 7.997 ± 0.107
4.13AlaPhe: 4.13 ± 0.051
13.06AlaGly: 13.06 ± 0.165
2.62AlaHis: 2.62 ± 0.046
5.747AlaIle: 5.747 ± 0.074
2.381AlaLys: 2.381 ± 0.049
14.243AlaLeu: 14.243 ± 0.156
2.676AlaMet: 2.676 ± 0.048
2.187AlaAsn: 2.187 ± 0.048
7.27AlaPro: 7.27 ± 0.098
3.838AlaGln: 3.838 ± 0.054
9.619AlaArg: 9.619 ± 0.118
7.653AlaSer: 7.653 ± 0.106
7.873AlaThr: 7.873 ± 0.145
12.525AlaVal: 12.525 ± 0.153
2.193AlaTrp: 2.193 ± 0.049
2.588AlaTyr: 2.588 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.023
0.054CysCys: 0.054 ± 0.006
0.308CysAsp: 0.308 ± 0.015
0.238CysGlu: 0.238 ± 0.012
0.161CysPhe: 0.161 ± 0.009
0.485CysGly: 0.485 ± 0.019
0.101CysHis: 0.101 ± 0.01
0.161CysIle: 0.161 ± 0.013
0.059CysLys: 0.059 ± 0.007
0.415CysLeu: 0.415 ± 0.018
0.058CysMet: 0.058 ± 0.006
0.103CysAsn: 0.103 ± 0.009
0.264CysPro: 0.264 ± 0.015
0.11CysGln: 0.11 ± 0.012
0.336CysArg: 0.336 ± 0.017
0.302CysSer: 0.302 ± 0.016
0.314CysThr: 0.314 ± 0.026
0.387CysVal: 0.387 ± 0.019
0.066CysTrp: 0.066 ± 0.007
0.104CysTyr: 0.104 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
10.693AspAla: 10.693 ± 0.112
0.228AspCys: 0.228 ± 0.015
4.939AspAsp: 4.939 ± 0.069
4.716AspGlu: 4.716 ± 0.076
1.7AspPhe: 1.7 ± 0.035
6.708AspGly: 6.708 ± 0.098
1.225AspHis: 1.225 ± 0.032
2.423AspIle: 2.423 ± 0.046
0.976AspLys: 0.976 ± 0.034
6.237AspLeu: 6.237 ± 0.068
0.846AspMet: 0.846 ± 0.027
0.974AspAsn: 0.974 ± 0.032
4.47AspPro: 4.47 ± 0.06
1.468AspGln: 1.468 ± 0.032
4.579AspArg: 4.579 ± 0.066
2.397AspSer: 2.397 ± 0.048
3.076AspThr: 3.076 ± 0.069
5.928AspVal: 5.928 ± 0.07
1.071AspTrp: 1.071 ± 0.032
1.297AspTyr: 1.297 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.23GluAla: 7.23 ± 0.103
0.241GluCys: 0.241 ± 0.015
2.805GluAsp: 2.805 ± 0.057
2.525GluGlu: 2.525 ± 0.061
1.681GluPhe: 1.681 ± 0.036
4.042GluGly: 4.042 ± 0.063
1.319GluHis: 1.319 ± 0.032
2.38GluIle: 2.38 ± 0.048
1.229GluLys: 1.229 ± 0.04
6.423GluLeu: 6.423 ± 0.089
0.766GluMet: 0.766 ± 0.028
1.085GluAsn: 1.085 ± 0.027
3.143GluPro: 3.143 ± 0.064
2.013GluGln: 2.013 ± 0.045
5.108GluArg: 5.108 ± 0.078
2.662GluSer: 2.662 ± 0.051
2.88GluThr: 2.88 ± 0.051
4.52GluVal: 4.52 ± 0.066
0.996GluTrp: 0.996 ± 0.035
1.176GluTyr: 1.176 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.477PheAla: 4.477 ± 0.064
0.148PheCys: 0.148 ± 0.01
2.399PheAsp: 2.399 ± 0.041
1.75PheGlu: 1.75 ± 0.039
1.1PhePhe: 1.1 ± 0.033
3.398PheGly: 3.398 ± 0.06
0.547PheHis: 0.547 ± 0.023
1.082PheIle: 1.082 ± 0.03
0.401PheLys: 0.401 ± 0.018
2.814PheLeu: 2.814 ± 0.051
0.429PheMet: 0.429 ± 0.02
0.655PheAsn: 0.655 ± 0.024
1.383PhePro: 1.383 ± 0.033
0.777PheGln: 0.777 ± 0.025
1.844PheArg: 1.844 ± 0.045
1.674PheSer: 1.674 ± 0.039
2.148PheThr: 2.148 ± 0.046
3.041PheVal: 3.041 ± 0.053
0.561PheTrp: 0.561 ± 0.018
0.632PheTyr: 0.632 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.547GlyAla: 11.547 ± 0.16
0.521GlyCys: 0.521 ± 0.019
5.702GlyAsp: 5.702 ± 0.088
4.906GlyGlu: 4.906 ± 0.078
3.274GlyPhe: 3.274 ± 0.058
8.017GlyGly: 8.017 ± 0.164
1.776GlyHis: 1.776 ± 0.037
4.794GlyIle: 4.794 ± 0.061
1.828GlyLys: 1.828 ± 0.046
8.653GlyLeu: 8.653 ± 0.107
1.992GlyMet: 1.992 ± 0.046
1.61GlyAsn: 1.61 ± 0.044
3.927GlyPro: 3.927 ± 0.062
2.34GlyGln: 2.34 ± 0.049
6.567GlyArg: 6.567 ± 0.087
5.151GlySer: 5.151 ± 0.09
5.634GlyThr: 5.634 ± 0.097
8.362GlyVal: 8.362 ± 0.09
1.742GlyTrp: 1.742 ± 0.037
2.279GlyTyr: 2.279 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.49HisAla: 2.49 ± 0.05
0.105HisCys: 0.105 ± 0.009
1.338HisAsp: 1.338 ± 0.032
1.145HisGlu: 1.145 ± 0.035
0.585HisPhe: 0.585 ± 0.022
2.006HisGly: 2.006 ± 0.044
0.543HisHis: 0.543 ± 0.02
0.675HisIle: 0.675 ± 0.024
0.264HisLys: 0.264 ± 0.013
1.883HisLeu: 1.883 ± 0.036
0.275HisMet: 0.275 ± 0.015
0.356HisAsn: 0.356 ± 0.017
1.504HisPro: 1.504 ± 0.034
0.436HisGln: 0.436 ± 0.017
1.558HisArg: 1.558 ± 0.038
0.913HisSer: 0.913 ± 0.027
0.971HisThr: 0.971 ± 0.028
1.732HisVal: 1.732 ± 0.036
0.323HisTrp: 0.323 ± 0.016
0.407HisTyr: 0.407 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.061IleAla: 7.061 ± 0.084
0.174IleCys: 0.174 ± 0.011
3.372IleAsp: 3.372 ± 0.05
2.551IleGlu: 2.551 ± 0.045
1.084IlePhe: 1.084 ± 0.032
4.556IleGly: 4.556 ± 0.074
0.716IleHis: 0.716 ± 0.025
1.55IleIle: 1.55 ± 0.043
0.648IleLys: 0.648 ± 0.024
3.455IleLeu: 3.455 ± 0.061
0.562IleMet: 0.562 ± 0.024
0.79IleAsn: 0.79 ± 0.026
2.44IlePro: 2.44 ± 0.043
0.898IleGln: 0.898 ± 0.027
2.521IleArg: 2.521 ± 0.049
2.033IleSer: 2.033 ± 0.042
2.545IleThr: 2.545 ± 0.059
4.665IleVal: 4.665 ± 0.075
0.475IleTrp: 0.475 ± 0.018
0.687IleTyr: 0.687 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.173LysAla: 2.173 ± 0.045
0.057LysCys: 0.057 ± 0.006
1.092LysAsp: 1.092 ± 0.037
0.801LysGlu: 0.801 ± 0.032
0.396LysPhe: 0.396 ± 0.017
1.442LysGly: 1.442 ± 0.038
0.36LysHis: 0.36 ± 0.017
0.747LysIle: 0.747 ± 0.03
0.626LysLys: 0.626 ± 0.029
1.632LysLeu: 1.632 ± 0.042
0.297LysMet: 0.297 ± 0.016
0.395LysAsn: 0.395 ± 0.018
1.12LysPro: 1.12 ± 0.035
0.576LysGln: 0.576 ± 0.025
1.304LysArg: 1.304 ± 0.039
0.944LysSer: 0.944 ± 0.028
1.22LysThr: 1.22 ± 0.03
1.509LysVal: 1.509 ± 0.04
0.221LysTrp: 0.221 ± 0.013
0.423LysTyr: 0.423 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.438LeuAla: 14.438 ± 0.136
0.474LeuCys: 0.474 ± 0.02
6.802LeuAsp: 6.802 ± 0.1
4.96LeuGlu: 4.96 ± 0.093
2.915LeuPhe: 2.915 ± 0.055
8.962LeuGly: 8.962 ± 0.088
1.794LeuHis: 1.794 ± 0.043
4.128LeuIle: 4.128 ± 0.079
1.535LeuLys: 1.535 ± 0.037
9.495LeuLeu: 9.495 ± 0.135
1.573LeuMet: 1.573 ± 0.037
1.609LeuAsn: 1.609 ± 0.037
5.508LeuPro: 5.508 ± 0.064
2.595LeuGln: 2.595 ± 0.046
7.553LeuArg: 7.553 ± 0.105
5.482LeuSer: 5.482 ± 0.071
6.283LeuThr: 6.283 ± 0.08
9.515LeuVal: 9.515 ± 0.111
1.462LeuTrp: 1.462 ± 0.042
1.75LeuTyr: 1.75 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.023MetAla: 2.023 ± 0.042
0.092MetCys: 0.092 ± 0.009
0.795MetAsp: 0.795 ± 0.029
0.54MetGlu: 0.54 ± 0.021
0.515MetPhe: 0.515 ± 0.022
1.204MetGly: 1.204 ± 0.032
0.304MetHis: 0.304 ± 0.014
0.79MetIle: 0.79 ± 0.027
0.385MetLys: 0.385 ± 0.018
1.821MetLeu: 1.821 ± 0.04
0.311MetMet: 0.311 ± 0.017
0.412MetAsn: 0.412 ± 0.016
1.213MetPro: 1.213 ± 0.033
0.488MetGln: 0.488 ± 0.02
1.323MetArg: 1.323 ± 0.033
1.347MetSer: 1.347 ± 0.036
1.734MetThr: 1.734 ± 0.033
1.228MetVal: 1.228 ± 0.031
0.226MetTrp: 0.226 ± 0.013
0.297MetTyr: 0.297 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.336AsnAla: 2.336 ± 0.05
0.094AsnCys: 0.094 ± 0.009
1.124AsnAsp: 1.124 ± 0.031
0.861AsnGlu: 0.861 ± 0.023
0.605AsnPhe: 0.605 ± 0.02
1.829AsnGly: 1.829 ± 0.055
0.346AsnHis: 0.346 ± 0.018
0.756AsnIle: 0.756 ± 0.028
0.325AsnLys: 0.325 ± 0.018
1.72AsnLeu: 1.72 ± 0.039
0.28AsnMet: 0.28 ± 0.017
0.419AsnAsn: 0.419 ± 0.019
1.516AsnPro: 1.516 ± 0.032
0.488AsnGln: 0.488 ± 0.021
1.116AsnArg: 1.116 ± 0.031
0.877AsnSer: 0.877 ± 0.035
1.113AsnThr: 1.113 ± 0.039
1.586AsnVal: 1.586 ± 0.042
0.293AsnTrp: 0.293 ± 0.016
0.429AsnTyr: 0.429 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
8.253ProAla: 8.253 ± 0.105
0.18ProCys: 0.18 ± 0.012
4.391ProAsp: 4.391 ± 0.064
3.792ProGlu: 3.792 ± 0.061
1.795ProPhe: 1.795 ± 0.037
5.313ProGly: 5.313 ± 0.08
1.12ProHis: 1.12 ± 0.031
2.044ProIle: 2.044 ± 0.043
0.901ProLys: 0.901 ± 0.031
5.014ProLeu: 5.014 ± 0.073
0.846ProMet: 0.846 ± 0.028
0.933ProAsn: 0.933 ± 0.029
2.555ProPro: 2.555 ± 0.059
1.565ProGln: 1.565 ± 0.037
3.567ProArg: 3.567 ± 0.067
3.035ProSer: 3.035 ± 0.053
3.407ProThr: 3.407 ± 0.065
5.122ProVal: 5.122 ± 0.068
0.952ProTrp: 0.952 ± 0.03
1.103ProTyr: 1.103 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.369GlnAla: 3.369 ± 0.052
0.105GlnCys: 0.105 ± 0.01
1.311GlnAsp: 1.311 ± 0.031
1.155GlnGlu: 1.155 ± 0.032
0.849GlnPhe: 0.849 ± 0.027
2.025GlnGly: 2.025 ± 0.041
0.591GlnHis: 0.591 ± 0.023
1.238GlnIle: 1.238 ± 0.029
0.57GlnLys: 0.57 ± 0.022
3.074GlnLeu: 3.074 ± 0.054
0.442GlnMet: 0.442 ± 0.021
0.625GlnAsn: 0.625 ± 0.024
1.549GlnPro: 1.549 ± 0.04
1.126GlnGln: 1.126 ± 0.037
2.336GlnArg: 2.336 ± 0.055
1.44GlnSer: 1.44 ± 0.032
1.618GlnThr: 1.618 ± 0.037
2.216GlnVal: 2.216 ± 0.045
0.509GlnTrp: 0.509 ± 0.021
0.651GlnTyr: 0.651 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
9.399ArgAla: 9.399 ± 0.108
0.29ArgCys: 0.29 ± 0.017
4.59ArgAsp: 4.59 ± 0.067
4.317ArgGlu: 4.317 ± 0.082
2.43ArgPhe: 2.43 ± 0.049
5.687ArgGly: 5.687 ± 0.096
1.615ArgHis: 1.615 ± 0.037
3.461ArgIle: 3.461 ± 0.054
1.157ArgLys: 1.157 ± 0.032
7.392ArgLeu: 7.392 ± 0.108
1.661ArgMet: 1.661 ± 0.033
1.198ArgAsn: 1.198 ± 0.029
3.771ArgPro: 3.771 ± 0.059
1.869ArgGln: 1.869 ± 0.04
6.946ArgArg: 6.946 ± 0.129
3.857ArgSer: 3.857 ± 0.054
4.382ArgThr: 4.382 ± 0.067
6.267ArgVal: 6.267 ± 0.081
1.25ArgTrp: 1.25 ± 0.036
1.558ArgTyr: 1.558 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.117SerAla: 7.117 ± 0.116
0.266SerCys: 0.266 ± 0.016
3.167SerAsp: 3.167 ± 0.054
2.469SerGlu: 2.469 ± 0.045
1.832SerPhe: 1.832 ± 0.036
5.559SerGly: 5.559 ± 0.079
0.999SerHis: 0.999 ± 0.029
2.385SerIle: 2.385 ± 0.047
0.908SerLys: 0.908 ± 0.027
5.165SerLeu: 5.165 ± 0.069
1.031SerMet: 1.031 ± 0.025
0.962SerAsn: 0.962 ± 0.027
3.109SerPro: 3.109 ± 0.048
1.348SerGln: 1.348 ± 0.035
3.638SerArg: 3.638 ± 0.054
3.102SerSer: 3.102 ± 0.068
3.539SerThr: 3.539 ± 0.075
4.49SerVal: 4.49 ± 0.071
0.944SerTrp: 0.944 ± 0.029
1.152SerTyr: 1.152 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
8.343ThrAla: 8.343 ± 0.154
0.266ThrCys: 0.266 ± 0.016
3.816ThrAsp: 3.816 ± 0.065
2.813ThrGlu: 2.813 ± 0.051
1.916ThrPhe: 1.916 ± 0.046
5.876ThrGly: 5.876 ± 0.098
1.105ThrHis: 1.105 ± 0.026
2.803ThrIle: 2.803 ± 0.066
1.051ThrLys: 1.051 ± 0.031
5.923ThrLeu: 5.923 ± 0.079
0.95ThrMet: 0.95 ± 0.029
1.082ThrAsn: 1.082 ± 0.039
4.178ThrPro: 4.178 ± 0.069
1.48ThrGln: 1.48 ± 0.039
3.717ThrArg: 3.717 ± 0.052
3.375ThrSer: 3.375 ± 0.065
3.951ThrThr: 3.951 ± 0.083
5.996ThrVal: 5.996 ± 0.108
0.992ThrTrp: 0.992 ± 0.027
1.266ThrTyr: 1.266 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
12.645ValAla: 12.645 ± 0.147
0.501ValCys: 0.501 ± 0.021
6.265ValAsp: 6.265 ± 0.067
4.884ValGlu: 4.884 ± 0.069
2.942ValPhe: 2.942 ± 0.049
7.24ValGly: 7.24 ± 0.089
1.725ValHis: 1.725 ± 0.039
4.11ValIle: 4.11 ± 0.057
1.536ValLys: 1.536 ± 0.04
9.479ValLeu: 9.479 ± 0.098
1.428ValMet: 1.428 ± 0.039
1.772ValAsn: 1.772 ± 0.05
5.131ValPro: 5.131 ± 0.07
2.236ValGln: 2.236 ± 0.043
6.402ValArg: 6.402 ± 0.078
4.851ValSer: 4.851 ± 0.097
5.908ValThr: 5.908 ± 0.119
9.503ValVal: 9.503 ± 0.093
1.327ValTrp: 1.327 ± 0.032
1.67ValTyr: 1.67 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.734TrpAla: 1.734 ± 0.04
0.105TrpCys: 0.105 ± 0.008
0.944TrpAsp: 0.944 ± 0.026
0.682TrpGlu: 0.682 ± 0.024
0.628TrpPhe: 0.628 ± 0.022
1.208TrpGly: 1.208 ± 0.032
0.409TrpHis: 0.409 ± 0.019
0.776TrpIle: 0.776 ± 0.026
0.235TrpLys: 0.235 ± 0.013
1.889TrpLeu: 1.889 ± 0.047
0.366TrpMet: 0.366 ± 0.016
0.484TrpAsn: 0.484 ± 0.02
0.787TrpPro: 0.787 ± 0.027
0.603TrpGln: 0.603 ± 0.021
1.369TrpArg: 1.369 ± 0.037
1.044TrpSer: 1.044 ± 0.029
1.082TrpThr: 1.082 ± 0.033
1.281TrpVal: 1.281 ± 0.036
0.413TrpTrp: 0.413 ± 0.021
0.321TrpTyr: 0.321 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.564TyrAla: 2.564 ± 0.048
0.116TyrCys: 0.116 ± 0.009
1.508TyrAsp: 1.508 ± 0.039
1.121TyrGlu: 1.121 ± 0.035
0.721TyrPhe: 0.721 ± 0.02
2.007TyrGly: 2.007 ± 0.047
0.293TyrHis: 0.293 ± 0.018
0.734TyrIle: 0.734 ± 0.028
0.322TyrLys: 0.322 ± 0.014
2.105TyrLeu: 2.105 ± 0.043
0.259TyrMet: 0.259 ± 0.012
0.459TyrAsn: 0.459 ± 0.022
1.051TyrPro: 1.051 ± 0.035
0.543TyrGln: 0.543 ± 0.023
1.693TyrArg: 1.693 ± 0.037
1.045TyrSer: 1.045 ± 0.034
1.218TyrThr: 1.218 ± 0.035
1.683TyrVal: 1.683 ± 0.039
0.346TyrTrp: 0.346 ± 0.02
0.493TyrTyr: 0.493 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3787 proteins (1287887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski