Amino acid dipepetide frequency for Rhizobium deserti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.736AlaAla: 15.736 ± 0.187	0.893AlaCys: 0.893 ± 0.023	6.635AlaAsp: 6.635 ± 0.076	7.462AlaGlu: 7.462 ± 0.082	4.415AlaPhe: 4.415 ± 0.063	9.927AlaGly: 9.927 ± 0.093	2.046AlaHis: 2.046 ± 0.04	6.583AlaIle: 6.583 ± 0.083	4.403AlaLys: 4.403 ± 0.066	12.291AlaLeu: 12.291 ± 0.123	3.549AlaMet: 3.549 ± 0.048	2.934AlaAsn: 2.934 ± 0.048	4.729AlaPro: 4.729 ± 0.076	3.795AlaGln: 3.795 ± 0.067	7.414AlaArg: 7.414 ± 0.093	7.069AlaSer: 7.069 ± 0.085	5.528AlaThr: 5.528 ± 0.08	8.514AlaVal: 8.514 ± 0.087	1.295AlaTrp: 1.295 ± 0.033	2.521AlaTyr: 2.521 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.76CysAla: 0.76 ± 0.024	0.089CysCys: 0.089 ± 0.007	0.474CysAsp: 0.474 ± 0.021	0.411CysGlu: 0.411 ± 0.016	0.317CysPhe: 0.317 ± 0.017	0.848CysGly: 0.848 ± 0.026	0.22CysHis: 0.22 ± 0.013	0.374CysIle: 0.374 ± 0.017	0.178CysLys: 0.178 ± 0.013	0.815CysLeu: 0.815 ± 0.023	0.162CysMet: 0.162 ± 0.011	0.203CysAsn: 0.203 ± 0.013	0.356CysPro: 0.356 ± 0.016	0.225CysGln: 0.225 ± 0.013	0.543CysArg: 0.543 ± 0.018	0.453CysSer: 0.453 ± 0.019	0.36CysThr: 0.36 ± 0.015	0.541CysVal: 0.541 ± 0.021	0.104CysTrp: 0.104 ± 0.008	0.183CysTyr: 0.183 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.288AspAla: 6.288 ± 0.066	0.463AspCys: 0.463 ± 0.02	3.085AspAsp: 3.085 ± 0.059	3.555AspGlu: 3.555 ± 0.057	2.326AspPhe: 2.326 ± 0.04	4.853AspGly: 4.853 ± 0.066	1.258AspHis: 1.258 ± 0.035	3.439AspIle: 3.439 ± 0.058	2.034AspLys: 2.034 ± 0.045	6.083AspLeu: 6.083 ± 0.07	1.537AspMet: 1.537 ± 0.03	1.542AspAsn: 1.542 ± 0.036	3.198AspPro: 3.198 ± 0.057	1.945AspGln: 1.945 ± 0.041	4.035AspArg: 4.035 ± 0.069	2.181AspSer: 2.181 ± 0.044	2.409AspThr: 2.409 ± 0.042	4.212AspVal: 4.212 ± 0.059	0.911AspTrp: 0.911 ± 0.024	1.526AspTyr: 1.526 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.504GluAla: 7.504 ± 0.088	0.319GluCys: 0.319 ± 0.015	3.122GluAsp: 3.122 ± 0.048	3.701GluGlu: 3.701 ± 0.061	1.904GluPhe: 1.904 ± 0.039	4.24GluGly: 4.24 ± 0.061	1.213GluHis: 1.213 ± 0.032	3.792GluIle: 3.792 ± 0.056	2.764GluLys: 2.764 ± 0.046	5.622GluLeu: 5.622 ± 0.068	1.632GluMet: 1.632 ± 0.031	1.812GluAsn: 1.812 ± 0.043	2.703GluPro: 2.703 ± 0.053	2.28GluGln: 2.28 ± 0.046	4.654GluArg: 4.654 ± 0.063	2.409GluSer: 2.409 ± 0.045	3.648GluThr: 3.648 ± 0.049	3.968GluVal: 3.968 ± 0.059	0.695GluTrp: 0.695 ± 0.025	1.012GluTyr: 1.012 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.44PheAla: 4.44 ± 0.064	0.39PheCys: 0.39 ± 0.018	2.672PheAsp: 2.672 ± 0.047	2.323PheGlu: 2.323 ± 0.046	1.594PhePhe: 1.594 ± 0.043	3.801PheGly: 3.801 ± 0.059	0.781PheHis: 0.781 ± 0.023	1.968PheIle: 1.968 ± 0.036	1.17PheLys: 1.17 ± 0.028	3.596PheLeu: 3.596 ± 0.055	0.882PheMet: 0.882 ± 0.027	1.113PheAsn: 1.113 ± 0.026	1.644PhePro: 1.644 ± 0.033	1.144PheGln: 1.144 ± 0.03	2.305PheArg: 2.305 ± 0.04	2.608PheSer: 2.608 ± 0.045	1.987PheThr: 1.987 ± 0.036	2.845PheVal: 2.845 ± 0.043	0.557PheTrp: 0.557 ± 0.021	0.967PheTyr: 0.967 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.251GlyAla: 8.251 ± 0.097	0.735GlyCys: 0.735 ± 0.022	4.215GlyAsp: 4.215 ± 0.068	4.875GlyGlu: 4.875 ± 0.068	3.736GlyPhe: 3.736 ± 0.051	6.806GlyGly: 6.806 ± 0.081	1.791GlyHis: 1.791 ± 0.046	4.927GlyIle: 4.927 ± 0.063	3.64GlyLys: 3.64 ± 0.057	8.621GlyLeu: 8.621 ± 0.097	2.411GlyMet: 2.411 ± 0.043	2.308GlyAsn: 2.308 ± 0.05	3.124GlyPro: 3.124 ± 0.052	3.006GlyGln: 3.006 ± 0.053	5.794GlyArg: 5.794 ± 0.071	4.982GlySer: 4.982 ± 0.063	4.41GlyThr: 4.41 ± 0.063	5.559GlyVal: 5.559 ± 0.063	1.162GlyTrp: 1.162 ± 0.034	2.338GlyTyr: 2.338 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.127HisAla: 2.127 ± 0.04	0.211HisCys: 0.211 ± 0.014	1.222HisAsp: 1.222 ± 0.034	1.075HisGlu: 1.075 ± 0.026	0.893HisPhe: 0.893 ± 0.028	1.801HisGly: 1.801 ± 0.037	0.595HisHis: 0.595 ± 0.027	0.957HisIle: 0.957 ± 0.025	0.522HisLys: 0.522 ± 0.02	2.08HisLeu: 2.08 ± 0.04	0.55HisMet: 0.55 ± 0.023	0.481HisAsn: 0.481 ± 0.017	1.278HisPro: 1.278 ± 0.032	0.619HisGln: 0.619 ± 0.024	1.327HisArg: 1.327 ± 0.033	1.023HisSer: 1.023 ± 0.03	0.766HisThr: 0.766 ± 0.022	1.555HisVal: 1.555 ± 0.033	0.283HisTrp: 0.283 ± 0.015	0.557HisTyr: 0.557 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.456IleAla: 7.456 ± 0.101	0.539IleCys: 0.539 ± 0.019	3.715IleAsp: 3.715 ± 0.053	3.614IleGlu: 3.614 ± 0.054	2.127IlePhe: 2.127 ± 0.043	5.339IleGly: 5.339 ± 0.068	0.951IleHis: 0.951 ± 0.032	2.801IleIle: 2.801 ± 0.051	1.736IleLys: 1.736 ± 0.037	4.902IleLeu: 4.902 ± 0.069	1.234IleMet: 1.234 ± 0.029	1.637IleAsn: 1.637 ± 0.031	2.37IlePro: 2.37 ± 0.047	1.406IleGln: 1.406 ± 0.033	3.504IleArg: 3.504 ± 0.052	3.499IleSer: 3.499 ± 0.056	2.829IleThr: 2.829 ± 0.049	4.374IleVal: 4.374 ± 0.062	0.659IleTrp: 0.659 ± 0.022	1.259IleTyr: 1.259 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.757LysAla: 4.757 ± 0.062	0.165LysCys: 0.165 ± 0.011	1.998LysAsp: 1.998 ± 0.042	1.907LysGlu: 1.907 ± 0.042	1.047LysPhe: 1.047 ± 0.034	2.89LysGly: 2.89 ± 0.054	0.676LysHis: 0.676 ± 0.02	2.172LysIle: 2.172 ± 0.042	1.566LysLys: 1.566 ± 0.038	3.828LysLeu: 3.828 ± 0.057	0.969LysMet: 0.969 ± 0.026	1.118LysAsn: 1.118 ± 0.029	2.355LysPro: 2.355 ± 0.052	1.307LysGln: 1.307 ± 0.034	2.465LysArg: 2.465 ± 0.046	2.238LysSer: 2.238 ± 0.047	2.24LysThr: 2.24 ± 0.039	2.689LysVal: 2.689 ± 0.054	0.388LysTrp: 0.388 ± 0.017	0.651LysTyr: 0.651 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.737LeuAla: 12.737 ± 0.124	0.81LeuCys: 0.81 ± 0.024	5.933LeuAsp: 5.933 ± 0.071	5.559LeuGlu: 5.559 ± 0.078	3.694LeuPhe: 3.694 ± 0.067	7.942LeuGly: 7.942 ± 0.087	1.784LeuHis: 1.784 ± 0.037	5.219LeuIle: 5.219 ± 0.072	4.185LeuLys: 4.185 ± 0.065	9.473LeuLeu: 9.473 ± 0.109	2.504LeuMet: 2.504 ± 0.041	2.645LeuAsn: 2.645 ± 0.046	5.3LeuPro: 5.3 ± 0.069	3.068LeuGln: 3.068 ± 0.046	6.158LeuArg: 6.158 ± 0.078	7.209LeuSer: 7.209 ± 0.105	5.517LeuThr: 5.517 ± 0.075	7.497LeuVal: 7.497 ± 0.081	1.083LeuTrp: 1.083 ± 0.029	2.023LeuTyr: 2.023 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.145MetAla: 3.145 ± 0.049	0.127MetCys: 0.127 ± 0.01	1.267MetAsp: 1.267 ± 0.029	1.314MetGlu: 1.314 ± 0.03	0.764MetPhe: 0.764 ± 0.022	1.807MetGly: 1.807 ± 0.041	0.448MetHis: 0.448 ± 0.02	1.601MetIle: 1.601 ± 0.03	1.17MetLys: 1.17 ± 0.028	2.659MetLeu: 2.659 ± 0.047	0.718MetMet: 0.718 ± 0.026	0.906MetAsn: 0.906 ± 0.029	1.622MetPro: 1.622 ± 0.036	0.965MetGln: 0.965 ± 0.025	1.847MetArg: 1.847 ± 0.035	1.85MetSer: 1.85 ± 0.038	1.936MetThr: 1.936 ± 0.035	1.829MetVal: 1.829 ± 0.034	0.185MetTrp: 0.185 ± 0.012	0.309MetTyr: 0.309 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.151AsnAla: 3.151 ± 0.049	0.225AsnCys: 0.225 ± 0.014	1.503AsnAsp: 1.503 ± 0.035	1.468AsnGlu: 1.468 ± 0.034	1.082AsnPhe: 1.082 ± 0.031	2.57AsnGly: 2.57 ± 0.043	0.554AsnHis: 0.554 ± 0.02	1.551AsnIle: 1.551 ± 0.034	0.889AsnLys: 0.889 ± 0.028	2.746AsnLeu: 2.746 ± 0.046	0.703AsnMet: 0.703 ± 0.024	0.865AsnAsn: 0.865 ± 0.029	1.791AsnPro: 1.791 ± 0.033	0.892AsnGln: 0.892 ± 0.027	1.928AsnArg: 1.928 ± 0.04	1.561AsnSer: 1.561 ± 0.033	1.29AsnThr: 1.29 ± 0.032	2.048AsnVal: 2.048 ± 0.047	0.446AsnTrp: 0.446 ± 0.019	0.714AsnTyr: 0.714 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.668ProAla: 5.668 ± 0.086	0.266ProCys: 0.266 ± 0.013	3.383ProAsp: 3.383 ± 0.058	3.516ProGlu: 3.516 ± 0.053	1.985ProPhe: 1.985 ± 0.041	3.971ProGly: 3.971 ± 0.053	1.023ProHis: 1.023 ± 0.028	2.393ProIle: 2.393 ± 0.043	1.819ProLys: 1.819 ± 0.04	4.596ProLeu: 4.596 ± 0.067	1.167ProMet: 1.167 ± 0.03	1.368ProAsn: 1.368 ± 0.034	2.257ProPro: 2.257 ± 0.049	1.763ProGln: 1.763 ± 0.034	2.527ProArg: 2.527 ± 0.045	2.972ProSer: 2.972 ± 0.049	2.292ProThr: 2.292 ± 0.039	4.065ProVal: 4.065 ± 0.06	0.605ProTrp: 0.605 ± 0.022	1.196ProTyr: 1.196 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.286GlnAla: 4.286 ± 0.066	0.182GlnCys: 0.182 ± 0.012	1.596GlnAsp: 1.596 ± 0.036	1.779GlnGlu: 1.779 ± 0.039	1.143GlnPhe: 1.143 ± 0.026	2.434GlnGly: 2.434 ± 0.046	0.676GlnHis: 0.676 ± 0.023	2.054GlnIle: 2.054 ± 0.055	1.326GlnLys: 1.326 ± 0.032	3.054GlnLeu: 3.054 ± 0.057	0.992GlnMet: 0.992 ± 0.025	0.951GlnAsn: 0.951 ± 0.032	1.918GlnPro: 1.918 ± 0.045	1.474GlnGln: 1.474 ± 0.041	2.335GlnArg: 2.335 ± 0.052	2.028GlnSer: 2.028 ± 0.043	1.849GlnThr: 1.849 ± 0.04	2.44GlnVal: 2.44 ± 0.058	0.408GlnTrp: 0.408 ± 0.016	0.619GlnTyr: 0.619 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.555ArgAla: 6.555 ± 0.081	0.419ArgCys: 0.419 ± 0.019	3.8ArgAsp: 3.8 ± 0.057	3.866ArgGlu: 3.866 ± 0.055	2.789ArgPhe: 2.789 ± 0.047	4.329ArgGly: 4.329 ± 0.062	1.634ArgHis: 1.634 ± 0.037	4.019ArgIle: 4.019 ± 0.063	2.489ArgLys: 2.489 ± 0.044	7.492ArgLeu: 7.492 ± 0.085	1.893ArgMet: 1.893 ± 0.036	2.038ArgAsn: 2.038 ± 0.041	3.161ArgPro: 3.161 ± 0.053	2.738ArgGln: 2.738 ± 0.049	5.099ArgArg: 5.099 ± 0.084	4.05ArgSer: 4.05 ± 0.052	3.113ArgThr: 3.113 ± 0.049	4.173ArgVal: 4.173 ± 0.054	0.872ArgTrp: 0.872 ± 0.026	1.739ArgTyr: 1.739 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.584SerAla: 6.584 ± 0.079	0.438SerCys: 0.438 ± 0.02	3.312SerAsp: 3.312 ± 0.05	3.266SerGlu: 3.266 ± 0.051	2.627SerPhe: 2.627 ± 0.038	5.918SerGly: 5.918 ± 0.074	1.186SerHis: 1.186 ± 0.027	3.14SerIle: 3.14 ± 0.046	2.025SerLys: 2.025 ± 0.04	6.033SerLeu: 6.033 ± 0.073	1.55SerMet: 1.55 ± 0.032	1.636SerAsn: 1.636 ± 0.035	2.894SerPro: 2.894 ± 0.041	1.997SerGln: 1.997 ± 0.04	4.019SerArg: 4.019 ± 0.055	3.795SerSer: 3.795 ± 0.064	2.975SerThr: 2.975 ± 0.057	4.334SerVal: 4.334 ± 0.06	0.775SerTrp: 0.775 ± 0.021	1.446SerTyr: 1.446 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.167ThrAla: 6.167 ± 0.082	0.395ThrCys: 0.395 ± 0.021	2.772ThrAsp: 2.772 ± 0.046	2.81ThrGlu: 2.81 ± 0.044	2.041ThrPhe: 2.041 ± 0.042	4.983ThrGly: 4.983 ± 0.063	0.965ThrHis: 0.965 ± 0.025	3.09ThrIle: 3.09 ± 0.052	1.709ThrLys: 1.709 ± 0.04	5.297ThrLeu: 5.297 ± 0.065	1.263ThrMet: 1.263 ± 0.032	1.351ThrAsn: 1.351 ± 0.032	2.813ThrPro: 2.813 ± 0.048	1.452ThrGln: 1.452 ± 0.031	2.992ThrArg: 2.992 ± 0.043	3.145ThrSer: 3.145 ± 0.053	2.807ThrThr: 2.807 ± 0.06	4.347ThrVal: 4.347 ± 0.058	0.662ThrTrp: 0.662 ± 0.026	1.217ThrTyr: 1.217 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.649ValAla: 8.649 ± 0.098	0.577ValCys: 0.577 ± 0.021	4.111ValAsp: 4.111 ± 0.057	4.667ValGlu: 4.667 ± 0.067	2.792ValPhe: 2.792 ± 0.045	5.351ValGly: 5.351 ± 0.075	1.329ValHis: 1.329 ± 0.031	4.207ValIle: 4.207 ± 0.053	2.566ValLys: 2.566 ± 0.042	7.304ValLeu: 7.304 ± 0.08	1.914ValMet: 1.914 ± 0.039	2.005ValAsn: 2.005 ± 0.04	3.551ValPro: 3.551 ± 0.056	2.127ValGln: 2.127 ± 0.041	4.585ValArg: 4.585 ± 0.068	4.731ValSer: 4.731 ± 0.068	4.542ValThr: 4.542 ± 0.055	5.815ValVal: 5.815 ± 0.071	0.813ValTrp: 0.813 ± 0.022	1.517ValTyr: 1.517 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.085TrpAla: 1.085 ± 0.033	0.131TrpCys: 0.131 ± 0.011	0.582TrpAsp: 0.582 ± 0.022	0.574TrpGlu: 0.574 ± 0.02	0.537TrpPhe: 0.537 ± 0.017	0.785TrpGly: 0.785 ± 0.023	0.303TrpHis: 0.303 ± 0.017	0.676TrpIle: 0.676 ± 0.019	0.523TrpLys: 0.523 ± 0.021	1.549TrpLeu: 1.549 ± 0.037	0.354TrpMet: 0.354 ± 0.017	0.446TrpAsn: 0.446 ± 0.02	0.652TrpPro: 0.652 ± 0.024	0.559TrpGln: 0.559 ± 0.021	0.995TrpArg: 0.995 ± 0.028	0.819TrpSer: 0.819 ± 0.027	0.695TrpThr: 0.695 ± 0.025	0.71TrpVal: 0.71 ± 0.025	0.214TrpTrp: 0.214 ± 0.013	0.287TrpTyr: 0.287 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.393TyrAla: 2.393 ± 0.04	0.24TyrCys: 0.24 ± 0.014	1.48TyrAsp: 1.48 ± 0.035	1.252TyrGlu: 1.252 ± 0.035	0.973TyrPhe: 0.973 ± 0.029	2.097TyrGly: 2.097 ± 0.04	0.491TyrHis: 0.491 ± 0.019	0.99TyrIle: 0.99 ± 0.025	0.713TyrLys: 0.713 ± 0.025	2.297TyrLeu: 2.297 ± 0.042	0.483TyrMet: 0.483 ± 0.02	0.622TyrAsn: 0.622 ± 0.021	1.116TyrPro: 1.116 ± 0.031	0.784TyrGln: 0.784 ± 0.024	1.742TyrArg: 1.742 ± 0.032	1.327TyrSer: 1.327 ± 0.031	1.083TyrThr: 1.083 ± 0.029	1.638TyrVal: 1.638 ± 0.03	0.36TyrTrp: 0.36 ± 0.017	0.63TyrTyr: 0.63 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4410 proteins (1370632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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