Amino acid dipepetide frequency for Blackberry leaf mottle associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.333AlaAla: 2.333 ± 0.999
0.778AlaCys: 0.778 ± 0.496
3.37AlaAsp: 3.37 ± 0.544
1.814AlaGlu: 1.814 ± 0.434
2.333AlaPhe: 2.333 ± 0.44
2.074AlaGly: 2.074 ± 2.217
1.037AlaHis: 1.037 ± 0.369
5.184AlaIle: 5.184 ± 1.226
2.851AlaLys: 2.851 ± 0.62
4.406AlaLeu: 4.406 ± 1.187
1.296AlaMet: 1.296 ± 1.196
3.37AlaAsn: 3.37 ± 0.882
0.518AlaPro: 0.518 ± 0.485
1.296AlaGln: 1.296 ± 1.01
1.037AlaArg: 1.037 ± 0.453
2.592AlaSer: 2.592 ± 1.435
2.592AlaThr: 2.592 ± 1.406
2.333AlaVal: 2.333 ± 0.95
0.0AlaTrp: 0.0 ± 0.0
2.074AlaTyr: 2.074 ± 0.51
0.0AlaXaa: 0.0 ± 0.0
Cys
1.037CysAla: 1.037 ± 0.666
0.0CysCys: 0.0 ± 0.0
0.518CysAsp: 0.518 ± 0.291
1.555CysGlu: 1.555 ± 0.785
1.555CysPhe: 1.555 ± 0.835
0.778CysGly: 0.778 ± 0.294
0.518CysHis: 0.518 ± 0.262
1.296CysIle: 1.296 ± 0.342
1.037CysLys: 1.037 ± 0.523
1.814CysLeu: 1.814 ± 0.453
0.778CysMet: 0.778 ± 0.436
0.778CysAsn: 0.778 ± 0.446
1.037CysPro: 1.037 ± 0.523
1.037CysGln: 1.037 ± 0.849
0.259CysArg: 0.259 ± 0.145
1.555CysSer: 1.555 ± 0.785
1.037CysThr: 1.037 ± 0.369
0.259CysVal: 0.259 ± 0.145
0.0CysTrp: 0.0 ± 0.0
0.259CysTyr: 0.259 ± 0.305
0.0CysXaa: 0.0 ± 0.0
Asp
2.851AspAla: 2.851 ± 0.918
1.296AspCys: 1.296 ± 0.569
4.925AspAsp: 4.925 ± 1.396
5.962AspGlu: 5.962 ± 2.023
2.333AspPhe: 2.333 ± 1.128
1.555AspGly: 1.555 ± 0.375
1.037AspHis: 1.037 ± 0.402
5.962AspIle: 5.962 ± 0.748
2.333AspLys: 2.333 ± 0.876
6.998AspLeu: 6.998 ± 1.801
1.555AspMet: 1.555 ± 0.587
3.629AspAsn: 3.629 ± 0.643
3.37AspPro: 3.37 ± 0.496
2.074AspGln: 2.074 ± 0.626
3.11AspArg: 3.11 ± 0.537
4.666AspSer: 4.666 ± 0.863
3.888AspThr: 3.888 ± 1.364
5.702AspVal: 5.702 ± 1.208
0.259AspTrp: 0.259 ± 0.559
4.666AspTyr: 4.666 ± 0.866
0.0AspXaa: 0.0 ± 0.0
Glu
2.592GluAla: 2.592 ± 1.269
1.296GluCys: 1.296 ± 0.569
2.851GluAsp: 2.851 ± 0.4
3.11GluGlu: 3.11 ± 0.457
3.629GluPhe: 3.629 ± 0.751
1.555GluGly: 1.555 ± 0.723
0.518GluHis: 0.518 ± 0.262
6.221GluIle: 6.221 ± 1.191
5.443GluLys: 5.443 ± 2.45
6.739GluLeu: 6.739 ± 2.671
2.074GluMet: 2.074 ± 0.638
1.814GluAsn: 1.814 ± 0.691
1.037GluPro: 1.037 ± 0.382
1.296GluGln: 1.296 ± 0.48
1.814GluArg: 1.814 ± 0.661
4.666GluSer: 4.666 ± 1.494
3.11GluThr: 3.11 ± 0.711
3.629GluVal: 3.629 ± 1.744
0.518GluTrp: 0.518 ± 0.291
2.592GluTyr: 2.592 ± 0.437
0.0GluXaa: 0.0 ± 0.0
Phe
1.037PheAla: 1.037 ± 0.315
0.778PheCys: 0.778 ± 0.294
2.074PheAsp: 2.074 ± 1.308
1.814PheGlu: 1.814 ± 0.505
1.555PhePhe: 1.555 ± 0.375
2.333PheGly: 2.333 ± 0.863
2.074PheHis: 2.074 ± 0.789
3.629PheIle: 3.629 ± 1.122
2.851PheLys: 2.851 ± 0.65
4.147PheLeu: 4.147 ± 0.827
1.296PheMet: 1.296 ± 0.33
3.37PheAsn: 3.37 ± 0.544
1.037PhePro: 1.037 ± 0.402
1.814PheGln: 1.814 ± 1.502
1.814PheArg: 1.814 ± 0.416
3.629PheSer: 3.629 ± 0.845
2.333PheThr: 2.333 ± 0.797
2.074PheVal: 2.074 ± 0.395
0.0PheTrp: 0.0 ± 0.0
3.11PheTyr: 3.11 ± 0.953
0.0PheXaa: 0.0 ± 0.0
Gly
1.296GlyAla: 1.296 ± 1.091
1.037GlyCys: 1.037 ± 0.849
2.851GlyAsp: 2.851 ± 1.053
1.296GlyGlu: 1.296 ± 0.466
3.11GlyPhe: 3.11 ± 0.647
0.259GlyGly: 0.259 ± 0.457
2.333GlyHis: 2.333 ± 0.48
2.592GlyIle: 2.592 ± 1.026
2.851GlyLys: 2.851 ± 1.352
2.074GlyLeu: 2.074 ± 0.357
1.555GlyMet: 1.555 ± 0.375
3.888GlyAsn: 3.888 ± 0.372
0.518GlyPro: 0.518 ± 0.262
0.259GlyGln: 0.259 ± 0.305
1.814GlyArg: 1.814 ± 0.445
1.555GlySer: 1.555 ± 1.146
2.333GlyThr: 2.333 ± 1.358
1.296GlyVal: 1.296 ± 0.513
0.0GlyTrp: 0.0 ± 0.0
1.296GlyTyr: 1.296 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
1.296HisAla: 1.296 ± 1.022
0.518HisCys: 0.518 ± 0.291
2.074HisAsp: 2.074 ± 0.506
1.814HisGlu: 1.814 ± 0.469
0.518HisPhe: 0.518 ± 0.262
1.814HisGly: 1.814 ± 0.766
1.814HisHis: 1.814 ± 0.703
1.814HisIle: 1.814 ± 0.703
2.333HisLys: 2.333 ± 0.876
2.592HisLeu: 2.592 ± 0.453
0.259HisMet: 0.259 ± 0.305
1.555HisAsn: 1.555 ± 0.401
1.296HisPro: 1.296 ± 0.726
0.518HisGln: 0.518 ± 0.836
0.778HisArg: 0.778 ± 0.294
1.555HisSer: 1.555 ± 0.375
1.037HisThr: 1.037 ± 0.453
1.296HisVal: 1.296 ± 0.524
0.259HisTrp: 0.259 ± 0.356
0.518HisTyr: 0.518 ± 0.291
0.0HisXaa: 0.0 ± 0.0
Ile
2.851IleAla: 2.851 ± 0.957
1.555IleCys: 1.555 ± 0.872
6.48IleAsp: 6.48 ± 2.083
6.221IleGlu: 6.221 ± 1.626
3.888IlePhe: 3.888 ± 1.255
2.851IleGly: 2.851 ± 0.962
3.11IleHis: 3.11 ± 0.439
5.702IleIle: 5.702 ± 0.764
5.962IleLys: 5.962 ± 1.901
7.258IleLeu: 7.258 ± 1.537
2.074IleMet: 2.074 ± 0.405
8.294IleAsn: 8.294 ± 1.67
2.592IlePro: 2.592 ± 0.995
2.333IleGln: 2.333 ± 0.44
3.37IleArg: 3.37 ± 1.014
7.258IleSer: 7.258 ± 1.442
3.888IleThr: 3.888 ± 1.16
5.184IleVal: 5.184 ± 1.382
0.518IleTrp: 0.518 ± 0.61
3.888IleTyr: 3.888 ± 1.519
0.0IleXaa: 0.0 ± 0.0
Lys
4.666LysAla: 4.666 ± 0.72
0.259LysCys: 0.259 ± 0.145
6.998LysAsp: 6.998 ± 1.239
5.184LysGlu: 5.184 ± 0.738
3.37LysPhe: 3.37 ± 0.496
2.592LysGly: 2.592 ± 1.1
1.555LysHis: 1.555 ± 0.481
7.258LysIle: 7.258 ± 2.467
6.739LysLys: 6.739 ± 0.977
7.258LysLeu: 7.258 ± 0.767
1.296LysMet: 1.296 ± 0.466
5.702LysAsn: 5.702 ± 1.663
3.37LysPro: 3.37 ± 0.742
1.555LysGln: 1.555 ± 0.587
2.074LysArg: 2.074 ± 0.631
4.666LysSer: 4.666 ± 0.791
5.443LysThr: 5.443 ± 1.749
3.888LysVal: 3.888 ± 0.249
0.518LysTrp: 0.518 ± 0.291
5.184LysTyr: 5.184 ± 0.814
0.0LysXaa: 0.0 ± 0.0
Leu
4.925LeuAla: 4.925 ± 1.497
2.074LeuCys: 2.074 ± 0.764
4.666LeuAsp: 4.666 ± 1.665
5.962LeuGlu: 5.962 ± 1.394
3.888LeuPhe: 3.888 ± 1.125
1.814LeuGly: 1.814 ± 0.666
1.555LeuHis: 1.555 ± 0.358
8.035LeuIle: 8.035 ± 2.377
9.85LeuLys: 9.85 ± 0.764
9.59LeuLeu: 9.59 ± 1.501
2.074LeuMet: 2.074 ± 0.863
6.48LeuAsn: 6.48 ± 1.795
3.37LeuPro: 3.37 ± 1.067
3.629LeuGln: 3.629 ± 1.018
3.11LeuArg: 3.11 ± 1.217
5.702LeuSer: 5.702 ± 1.063
8.294LeuThr: 8.294 ± 1.404
6.998LeuVal: 6.998 ± 2.255
0.0LeuTrp: 0.0 ± 0.0
4.925LeuTyr: 4.925 ± 0.681
0.0LeuXaa: 0.0 ± 0.0
Met
2.074MetAla: 2.074 ± 0.998
0.518MetCys: 0.518 ± 0.262
1.814MetAsp: 1.814 ± 1.271
2.074MetGlu: 2.074 ± 0.473
0.259MetPhe: 0.259 ± 0.457
1.037MetGly: 1.037 ± 0.514
0.778MetHis: 0.778 ± 0.333
3.37MetIle: 3.37 ± 0.868
2.074MetLys: 2.074 ± 1.322
3.888MetLeu: 3.888 ± 1.002
0.518MetMet: 0.518 ± 0.651
1.037MetAsn: 1.037 ± 0.514
1.814MetPro: 1.814 ± 0.469
0.518MetGln: 0.518 ± 0.291
1.037MetArg: 1.037 ± 0.402
2.074MetSer: 2.074 ± 0.706
1.555MetThr: 1.555 ± 0.467
2.074MetVal: 2.074 ± 0.899
0.0MetTrp: 0.0 ± 0.0
1.037MetTyr: 1.037 ± 0.499
0.0MetXaa: 0.0 ± 0.0
Asn
2.074AsnAla: 2.074 ± 0.9
0.259AsnCys: 0.259 ± 0.145
3.11AsnAsp: 3.11 ± 0.776
2.592AsnGlu: 2.592 ± 0.453
3.11AsnPhe: 3.11 ± 0.897
3.11AsnGly: 3.11 ± 0.86
1.296AsnHis: 1.296 ± 0.513
7.776AsnIle: 7.776 ± 0.422
7.258AsnLys: 7.258 ± 1.284
7.776AsnLeu: 7.776 ± 1.622
2.592AsnMet: 2.592 ± 0.959
4.147AsnAsn: 4.147 ± 1.012
2.592AsnPro: 2.592 ± 0.708
1.555AsnGln: 1.555 ± 0.494
2.074AsnArg: 2.074 ± 0.808
5.443AsnSer: 5.443 ± 1.263
2.851AsnThr: 2.851 ± 0.832
5.962AsnVal: 5.962 ± 1.635
0.259AsnTrp: 0.259 ± 0.145
2.851AsnTyr: 2.851 ± 0.806
0.0AsnXaa: 0.0 ± 0.0
Pro
1.555ProAla: 1.555 ± 0.992
0.259ProCys: 0.259 ± 0.145
4.147ProAsp: 4.147 ± 0.992
3.11ProGlu: 3.11 ± 1.046
1.296ProPhe: 1.296 ± 0.466
2.333ProGly: 2.333 ± 1.644
0.259ProHis: 0.259 ± 0.145
3.11ProIle: 3.11 ± 0.984
3.11ProLys: 3.11 ± 0.67
1.814ProLeu: 1.814 ± 0.765
1.555ProMet: 1.555 ± 0.41
2.333ProAsn: 2.333 ± 0.719
1.037ProPro: 1.037 ± 1.109
0.259ProGln: 0.259 ± 0.145
2.074ProArg: 2.074 ± 0.624
1.037ProSer: 1.037 ± 0.406
2.074ProThr: 2.074 ± 0.357
1.296ProVal: 1.296 ± 0.562
0.0ProTrp: 0.0 ± 0.0
2.074ProTyr: 2.074 ± 0.508
0.0ProXaa: 0.0 ± 0.0
Gln
0.518GlnAla: 0.518 ± 0.291
0.259GlnCys: 0.259 ± 0.145
0.778GlnAsp: 0.778 ± 0.436
1.037GlnGlu: 1.037 ± 0.315
0.778GlnPhe: 0.778 ± 0.333
0.518GlnGly: 0.518 ± 0.313
1.555GlnHis: 1.555 ± 0.808
1.037GlnIle: 1.037 ± 0.382
3.629GlnLys: 3.629 ± 0.77
2.851GlnLeu: 2.851 ± 1.529
1.555GlnMet: 1.555 ± 0.886
2.333GlnAsn: 2.333 ± 0.985
1.296GlnPro: 1.296 ± 0.862
0.518GlnGln: 0.518 ± 0.455
1.555GlnArg: 1.555 ± 0.635
1.555GlnSer: 1.555 ± 0.401
2.074GlnThr: 2.074 ± 1.465
2.333GlnVal: 2.333 ± 0.963
0.518GlnTrp: 0.518 ± 0.455
1.037GlnTyr: 1.037 ± 0.581
0.0GlnXaa: 0.0 ± 0.0
Arg
1.037ArgAla: 1.037 ± 1.025
1.037ArgCys: 1.037 ± 1.022
3.11ArgAsp: 3.11 ± 0.559
2.074ArgGlu: 2.074 ± 0.939
2.592ArgPhe: 2.592 ± 1.176
0.778ArgGly: 0.778 ± 0.445
1.037ArgHis: 1.037 ± 0.408
3.37ArgIle: 3.37 ± 1.015
0.778ArgLys: 0.778 ± 0.333
5.184ArgLeu: 5.184 ± 1.418
0.778ArgMet: 0.778 ± 0.654
2.333ArgAsn: 2.333 ± 0.697
0.518ArgPro: 0.518 ± 0.262
1.555ArgGln: 1.555 ± 0.737
1.037ArgArg: 1.037 ± 0.406
2.851ArgSer: 2.851 ± 2.048
2.074ArgThr: 2.074 ± 0.51
1.037ArgVal: 1.037 ± 0.59
0.0ArgTrp: 0.0 ± 0.0
4.666ArgTyr: 4.666 ± 1.665
0.0ArgXaa: 0.0 ± 0.0
Ser
2.592SerAla: 2.592 ± 1.809
1.814SerCys: 1.814 ± 1.121
6.998SerAsp: 6.998 ± 0.887
3.11SerGlu: 3.11 ± 1.119
2.074SerPhe: 2.074 ± 0.762
3.37SerGly: 3.37 ± 0.824
2.074SerHis: 2.074 ± 0.825
6.221SerIle: 6.221 ± 1.599
4.406SerLys: 4.406 ± 0.621
6.998SerLeu: 6.998 ± 0.555
1.555SerMet: 1.555 ± 0.488
4.147SerAsn: 4.147 ± 1.588
1.814SerPro: 1.814 ± 0.375
2.074SerGln: 2.074 ± 0.861
3.11SerArg: 3.11 ± 0.679
5.184SerSer: 5.184 ± 1.199
5.184SerThr: 5.184 ± 0.237
3.37SerVal: 3.37 ± 0.848
0.259SerTrp: 0.259 ± 0.356
4.666SerTyr: 4.666 ± 0.993
0.0SerXaa: 0.0 ± 0.0
Thr
4.147ThrAla: 4.147 ± 0.693
0.778ThrCys: 0.778 ± 0.915
5.184ThrAsp: 5.184 ± 0.998
2.851ThrGlu: 2.851 ± 0.674
2.851ThrPhe: 2.851 ± 0.727
1.814ThrGly: 1.814 ± 0.375
1.037ThrHis: 1.037 ± 0.382
4.925ThrIle: 4.925 ± 1.066
5.184ThrLys: 5.184 ± 1.237
4.666ThrLeu: 4.666 ± 1.237
1.555ThrMet: 1.555 ± 0.401
2.851ThrAsn: 2.851 ± 1.081
2.851ThrPro: 2.851 ± 0.334
0.778ThrGln: 0.778 ± 0.687
2.851ThrArg: 2.851 ± 0.496
6.48ThrSer: 6.48 ± 1.881
3.629ThrThr: 3.629 ± 1.593
3.888ThrVal: 3.888 ± 1.687
0.0ThrTrp: 0.0 ± 0.0
2.592ThrTyr: 2.592 ± 1.453
0.0ThrXaa: 0.0 ± 0.0
Val
2.592ValAla: 2.592 ± 0.735
1.555ValCys: 1.555 ± 0.587
3.11ValAsp: 3.11 ± 0.625
2.851ValGlu: 2.851 ± 0.817
1.555ValPhe: 1.555 ± 0.358
1.555ValGly: 1.555 ± 1.631
1.555ValHis: 1.555 ± 0.626
3.629ValIle: 3.629 ± 1.101
4.406ValLys: 4.406 ± 0.886
4.925ValLeu: 4.925 ± 0.869
2.074ValMet: 2.074 ± 0.911
5.184ValAsn: 5.184 ± 0.449
2.333ValPro: 2.333 ± 2.007
2.851ValGln: 2.851 ± 0.886
2.851ValArg: 2.851 ± 0.78
3.888ValSer: 3.888 ± 0.973
3.888ValThr: 3.888 ± 1.61
3.629ValVal: 3.629 ± 0.931
0.778ValTrp: 0.778 ± 0.363
4.406ValTyr: 4.406 ± 1.141
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.259TrpCys: 0.259 ± 0.145
0.518TrpAsp: 0.518 ± 0.313
0.0TrpGlu: 0.0 ± 0.0
0.259TrpPhe: 0.259 ± 0.145
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.518TrpLys: 0.518 ± 0.455
0.778TrpLeu: 0.778 ± 0.294
0.518TrpMet: 0.518 ± 0.485
0.259TrpAsn: 0.259 ± 0.356
0.259TrpPro: 0.259 ± 0.145
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.518TrpSer: 0.518 ± 0.262
0.518TrpThr: 0.518 ± 0.608
0.259TrpVal: 0.259 ± 0.356
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.814TyrAla: 1.814 ± 0.765
0.778TyrCys: 0.778 ± 0.446
2.592TyrAsp: 2.592 ± 0.975
2.074TyrGlu: 2.074 ± 0.861
1.814TyrPhe: 1.814 ± 0.703
2.074TyrGly: 2.074 ± 0.626
0.518TyrHis: 0.518 ± 0.549
4.147TyrIle: 4.147 ± 1.179
5.962TyrLys: 5.962 ± 1.88
5.184TyrLeu: 5.184 ± 0.874
2.333TyrMet: 2.333 ± 0.92
5.184TyrAsn: 5.184 ± 1.679
2.074TyrPro: 2.074 ± 0.808
2.074TyrGln: 2.074 ± 0.506
2.074TyrArg: 2.074 ± 0.808
4.147TyrSer: 4.147 ± 1.483
3.11TyrThr: 3.11 ± 0.947
3.11TyrVal: 3.11 ± 1.094
0.778TyrTrp: 0.778 ± 0.446
3.888TyrTyr: 3.888 ± 0.553
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski