Amino acid dipepetide frequency for Vagococcus salmoninarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.449AlaAla: 5.449 ± 0.114
0.5AlaCys: 0.5 ± 0.025
3.931AlaAsp: 3.931 ± 0.069
5.852AlaGlu: 5.852 ± 0.108
3.159AlaPhe: 3.159 ± 0.07
5.279AlaGly: 5.279 ± 0.086
1.094AlaHis: 1.094 ± 0.038
5.504AlaIle: 5.504 ± 0.094
4.892AlaLys: 4.892 ± 0.08
7.361AlaLeu: 7.361 ± 0.096
1.855AlaMet: 1.855 ± 0.051
3.389AlaAsn: 3.389 ± 0.062
2.034AlaPro: 2.034 ± 0.065
2.638AlaGln: 2.638 ± 0.06
2.206AlaArg: 2.206 ± 0.058
4.32AlaSer: 4.32 ± 0.076
4.545AlaThr: 4.545 ± 0.089
4.954AlaVal: 4.954 ± 0.094
0.565AlaTrp: 0.565 ± 0.025
2.493AlaTyr: 2.493 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.317CysAla: 0.317 ± 0.02
0.078CysCys: 0.078 ± 0.01
0.346CysAsp: 0.346 ± 0.02
0.295CysGlu: 0.295 ± 0.018
0.273CysPhe: 0.273 ± 0.017
0.532CysGly: 0.532 ± 0.028
0.181CysHis: 0.181 ± 0.016
0.325CysIle: 0.325 ± 0.02
0.169CysLys: 0.169 ± 0.014
0.77CysLeu: 0.77 ± 0.03
0.112CysMet: 0.112 ± 0.012
0.18CysAsn: 0.18 ± 0.015
0.215CysPro: 0.215 ± 0.016
0.375CysGln: 0.375 ± 0.022
0.218CysArg: 0.218 ± 0.018
0.355CysSer: 0.355 ± 0.019
0.272CysThr: 0.272 ± 0.018
0.337CysVal: 0.337 ± 0.019
0.051CysTrp: 0.051 ± 0.008
0.251CysTyr: 0.251 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
2.628AspAla: 2.628 ± 0.058
0.298AspCys: 0.298 ± 0.019
2.284AspAsp: 2.284 ± 0.055
3.827AspGlu: 3.827 ± 0.078
2.856AspPhe: 2.856 ± 0.053
3.226AspGly: 3.226 ± 0.063
0.869AspHis: 0.869 ± 0.029
3.645AspIle: 3.645 ± 0.068
3.222AspLys: 3.222 ± 0.068
5.579AspLeu: 5.579 ± 0.091
1.258AspMet: 1.258 ± 0.041
2.17AspAsn: 2.17 ± 0.054
1.902AspPro: 1.902 ± 0.049
2.292AspGln: 2.292 ± 0.052
1.565AspArg: 1.565 ± 0.042
2.996AspSer: 2.996 ± 0.071
2.409AspThr: 2.409 ± 0.056
3.646AspVal: 3.646 ± 0.067
0.527AspTrp: 0.527 ± 0.024
2.731AspTyr: 2.731 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.726GluAla: 5.726 ± 0.093
0.259GluCys: 0.259 ± 0.018
3.214GluAsp: 3.214 ± 0.066
6.096GluGlu: 6.096 ± 0.118
2.775GluPhe: 2.775 ± 0.055
4.15GluGly: 4.15 ± 0.067
1.097GluHis: 1.097 ± 0.035
5.903GluIle: 5.903 ± 0.084
5.995GluLys: 5.995 ± 0.087
8.249GluLeu: 8.249 ± 0.112
2.167GluMet: 2.167 ± 0.054
3.496GluAsn: 3.496 ± 0.061
2.033GluPro: 2.033 ± 0.041
2.891GluGln: 2.891 ± 0.066
2.784GluArg: 2.784 ± 0.07
3.875GluSer: 3.875 ± 0.088
4.617GluThr: 4.617 ± 0.092
5.458GluVal: 5.458 ± 0.08
0.589GluTrp: 0.589 ± 0.027
1.928GluTyr: 1.928 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.887PheAla: 2.887 ± 0.057
0.269PheCys: 0.269 ± 0.017
2.427PheAsp: 2.427 ± 0.052
2.813PheGlu: 2.813 ± 0.057
2.254PhePhe: 2.254 ± 0.061
3.159PheGly: 3.159 ± 0.07
0.674PheHis: 0.674 ± 0.026
3.393PheIle: 3.393 ± 0.071
2.806PheLys: 2.806 ± 0.046
4.413PheLeu: 4.413 ± 0.087
1.054PheMet: 1.054 ± 0.036
2.18PheAsn: 2.18 ± 0.048
1.622PhePro: 1.622 ± 0.042
1.595PheGln: 1.595 ± 0.048
1.206PheArg: 1.206 ± 0.044
3.349PheSer: 3.349 ± 0.063
2.677PheThr: 2.677 ± 0.066
3.009PheVal: 3.009 ± 0.063
0.389PheTrp: 0.389 ± 0.022
1.791PheTyr: 1.791 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.671GlyAla: 4.671 ± 0.102
0.485GlyCys: 0.485 ± 0.024
3.147GlyAsp: 3.147 ± 0.063
4.541GlyGlu: 4.541 ± 0.068
3.127GlyPhe: 3.127 ± 0.069
4.645GlyGly: 4.645 ± 0.103
1.182GlyHis: 1.182 ± 0.044
5.78GlyIle: 5.78 ± 0.097
4.723GlyLys: 4.723 ± 0.076
7.037GlyLeu: 7.037 ± 0.105
2.021GlyMet: 2.021 ± 0.059
2.798GlyAsn: 2.798 ± 0.063
1.632GlyPro: 1.632 ± 0.047
2.9GlyGln: 2.9 ± 0.063
2.395GlyArg: 2.395 ± 0.052
4.165GlySer: 4.165 ± 0.068
4.28GlyThr: 4.28 ± 0.085
4.869GlyVal: 4.869 ± 0.082
0.596GlyTrp: 0.596 ± 0.029
2.666GlyTyr: 2.666 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.031
0.148HisCys: 0.148 ± 0.013
0.874HisAsp: 0.874 ± 0.034
1.058HisGlu: 1.058 ± 0.033
0.903HisPhe: 0.903 ± 0.033
1.226HisGly: 1.226 ± 0.044
0.471HisHis: 0.471 ± 0.023
1.027HisIle: 1.027 ± 0.031
0.766HisLys: 0.766 ± 0.027
2.05HisLeu: 2.05 ± 0.055
0.355HisMet: 0.355 ± 0.017
0.653HisAsn: 0.653 ± 0.026
0.838HisPro: 0.838 ± 0.032
1.036HisGln: 1.036 ± 0.033
0.73HisArg: 0.73 ± 0.029
1.086HisSer: 1.086 ± 0.036
0.813HisThr: 0.813 ± 0.034
1.056HisVal: 1.056 ± 0.035
0.159HisTrp: 0.159 ± 0.015
0.81HisTyr: 0.81 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.897IleAla: 5.897 ± 0.094
0.536IleCys: 0.536 ± 0.024
4.261IleAsp: 4.261 ± 0.077
5.151IleGlu: 5.151 ± 0.086
3.253IlePhe: 3.253 ± 0.076
5.588IleGly: 5.588 ± 0.102
1.283IleHis: 1.283 ± 0.037
5.904IleIle: 5.904 ± 0.106
4.908IleLys: 4.908 ± 0.08
6.867IleLeu: 6.867 ± 0.101
1.716IleMet: 1.716 ± 0.05
3.707IleAsn: 3.707 ± 0.06
3.045IlePro: 3.045 ± 0.06
2.786IleGln: 2.786 ± 0.063
2.567IleArg: 2.567 ± 0.064
5.225IleSer: 5.225 ± 0.082
4.7IleThr: 4.7 ± 0.079
5.184IleVal: 5.184 ± 0.093
0.529IleTrp: 0.529 ± 0.024
2.443IleTyr: 2.443 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.117LysAla: 5.117 ± 0.086
0.24LysCys: 0.24 ± 0.018
3.575LysAsp: 3.575 ± 0.065
6.383LysGlu: 6.383 ± 0.098
1.913LysPhe: 1.913 ± 0.046
4.184LysGly: 4.184 ± 0.076
1.022LysHis: 1.022 ± 0.039
5.401LysIle: 5.401 ± 0.086
5.791LysLys: 5.791 ± 0.091
6.036LysLeu: 6.036 ± 0.084
2.258LysMet: 2.258 ± 0.051
3.665LysAsn: 3.665 ± 0.074
2.013LysPro: 2.013 ± 0.049
2.71LysGln: 2.71 ± 0.06
2.544LysArg: 2.544 ± 0.059
3.47LysSer: 3.47 ± 0.061
3.994LysThr: 3.994 ± 0.068
4.711LysVal: 4.711 ± 0.076
0.63LysTrp: 0.63 ± 0.029
2.159LysTyr: 2.159 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
9.26LeuAla: 9.26 ± 0.125
0.535LeuCys: 0.535 ± 0.025
4.84LeuAsp: 4.84 ± 0.076
6.791LeuGlu: 6.791 ± 0.098
4.563LeuPhe: 4.563 ± 0.082
6.907LeuGly: 6.907 ± 0.101
1.439LeuHis: 1.439 ± 0.039
8.067LeuIle: 8.067 ± 0.116
7.068LeuLys: 7.068 ± 0.086
11.077LeuLeu: 11.077 ± 0.163
2.615LeuMet: 2.615 ± 0.057
4.686LeuAsn: 4.686 ± 0.08
4.362LeuPro: 4.362 ± 0.07
3.246LeuGln: 3.246 ± 0.063
3.341LeuArg: 3.341 ± 0.073
7.35LeuSer: 7.35 ± 0.1
7.494LeuThr: 7.494 ± 0.107
7.641LeuVal: 7.641 ± 0.102
0.753LeuTrp: 0.753 ± 0.032
2.919LeuTyr: 2.919 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.261MetAla: 2.261 ± 0.053
0.111MetCys: 0.111 ± 0.011
1.124MetAsp: 1.124 ± 0.037
1.465MetGlu: 1.465 ± 0.041
0.898MetPhe: 0.898 ± 0.037
1.615MetGly: 1.615 ± 0.05
0.292MetHis: 0.292 ± 0.019
2.123MetIle: 2.123 ± 0.051
2.159MetLys: 2.159 ± 0.049
2.489MetLeu: 2.489 ± 0.06
0.822MetMet: 0.822 ± 0.032
1.32MetAsn: 1.32 ± 0.043
0.979MetPro: 0.979 ± 0.035
0.706MetGln: 0.706 ± 0.031
0.867MetArg: 0.867 ± 0.032
1.819MetSer: 1.819 ± 0.045
2.187MetThr: 2.187 ± 0.052
1.619MetVal: 1.619 ± 0.046
0.165MetTrp: 0.165 ± 0.014
0.645MetTyr: 0.645 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.375AsnAla: 2.375 ± 0.06
0.272AsnCys: 0.272 ± 0.018
2.381AsnAsp: 2.381 ± 0.053
2.979AsnGlu: 2.979 ± 0.066
1.979AsnPhe: 1.979 ± 0.05
3.039AsnGly: 3.039 ± 0.07
1.102AsnHis: 1.102 ± 0.036
3.163AsnIle: 3.163 ± 0.061
2.956AsnLys: 2.956 ± 0.072
4.562AsnLeu: 4.562 ± 0.065
1.177AsnMet: 1.177 ± 0.04
2.282AsnAsn: 2.282 ± 0.063
2.042AsnPro: 2.042 ± 0.049
3.118AsnGln: 3.118 ± 0.07
1.821AsnArg: 1.821 ± 0.047
2.719AsnSer: 2.719 ± 0.064
2.149AsnThr: 2.149 ± 0.05
2.87AsnVal: 2.87 ± 0.052
0.497AsnTrp: 0.497 ± 0.026
2.247AsnTyr: 2.247 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.535ProAla: 2.535 ± 0.061
0.157ProCys: 0.157 ± 0.013
1.69ProAsp: 1.69 ± 0.045
3.156ProGlu: 3.156 ± 0.063
1.658ProPhe: 1.658 ± 0.046
2.166ProGly: 2.166 ± 0.056
0.614ProHis: 0.614 ± 0.027
2.572ProIle: 2.572 ± 0.064
2.26ProLys: 2.26 ± 0.053
3.817ProLeu: 3.817 ± 0.07
0.808ProMet: 0.808 ± 0.032
1.684ProAsn: 1.684 ± 0.039
0.774ProPro: 0.774 ± 0.035
1.377ProGln: 1.377 ± 0.041
0.979ProArg: 0.979 ± 0.034
2.099ProSer: 2.099 ± 0.055
2.402ProThr: 2.402 ± 0.052
2.791ProVal: 2.791 ± 0.054
0.285ProTrp: 0.285 ± 0.018
1.278ProTyr: 1.278 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.325GlnAla: 3.325 ± 0.069
0.149GlnCys: 0.149 ± 0.013
1.724GlnAsp: 1.724 ± 0.047
3.644GlnGlu: 3.644 ± 0.074
1.525GlnPhe: 1.525 ± 0.04
3.286GlnGly: 3.286 ± 0.067
0.674GlnHis: 0.674 ± 0.028
2.659GlnIle: 2.659 ± 0.063
3.165GlnLys: 3.165 ± 0.055
4.961GlnLeu: 4.961 ± 0.092
1.045GlnMet: 1.045 ± 0.036
1.546GlnAsn: 1.546 ± 0.04
1.482GlnPro: 1.482 ± 0.042
2.236GlnGln: 2.236 ± 0.067
1.862GlnArg: 1.862 ± 0.057
2.31GlnSer: 2.31 ± 0.055
2.435GlnThr: 2.435 ± 0.051
3.073GlnVal: 3.073 ± 0.064
0.408GlnTrp: 0.408 ± 0.022
1.071GlnTyr: 1.071 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
1.854ArgAla: 1.854 ± 0.048
0.181ArgCys: 0.181 ± 0.015
1.729ArgAsp: 1.729 ± 0.047
2.811ArgGlu: 2.811 ± 0.071
1.6ArgPhe: 1.6 ± 0.04
2.182ArgGly: 2.182 ± 0.051
0.656ArgHis: 0.656 ± 0.029
2.541ArgIle: 2.541 ± 0.052
2.607ArgLys: 2.607 ± 0.055
3.729ArgLeu: 3.729 ± 0.075
0.923ArgMet: 0.923 ± 0.036
1.579ArgAsn: 1.579 ± 0.045
1.193ArgPro: 1.193 ± 0.043
1.954ArgGln: 1.954 ± 0.052
1.599ArgArg: 1.599 ± 0.053
1.962ArgSer: 1.962 ± 0.058
1.706ArgThr: 1.706 ± 0.045
2.293ArgVal: 2.293 ± 0.054
0.311ArgTrp: 0.311 ± 0.019
1.382ArgTyr: 1.382 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.854SerAla: 3.854 ± 0.076
0.332SerCys: 0.332 ± 0.021
3.064SerAsp: 3.064 ± 0.058
4.502SerGlu: 4.502 ± 0.088
3.142SerPhe: 3.142 ± 0.066
4.417SerGly: 4.417 ± 0.071
1.336SerHis: 1.336 ± 0.036
4.21SerIle: 4.21 ± 0.074
3.773SerLys: 3.773 ± 0.068
7.436SerLeu: 7.436 ± 0.096
1.441SerMet: 1.441 ± 0.041
2.686SerAsn: 2.686 ± 0.057
2.137SerPro: 2.137 ± 0.05
3.684SerGln: 3.684 ± 0.073
2.302SerArg: 2.302 ± 0.057
4.119SerSer: 4.119 ± 0.115
3.175SerThr: 3.175 ± 0.083
3.965SerVal: 3.965 ± 0.064
0.629SerTrp: 0.629 ± 0.029
2.519SerTyr: 2.519 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.46ThrAla: 4.46 ± 0.076
0.318ThrCys: 0.318 ± 0.019
3.347ThrAsp: 3.347 ± 0.064
4.428ThrGlu: 4.428 ± 0.075
2.745ThrPhe: 2.745 ± 0.062
4.463ThrGly: 4.463 ± 0.083
1.047ThrHis: 1.047 ± 0.035
4.849ThrIle: 4.849 ± 0.088
3.993ThrLys: 3.993 ± 0.071
6.123ThrLeu: 6.123 ± 0.083
1.371ThrMet: 1.371 ± 0.043
2.871ThrAsn: 2.871 ± 0.059
2.473ThrPro: 2.473 ± 0.059
1.77ThrGln: 1.77 ± 0.05
1.681ThrArg: 1.681 ± 0.044
3.844ThrSer: 3.844 ± 0.083
4.129ThrThr: 4.129 ± 0.086
4.56ThrVal: 4.56 ± 0.081
0.565ThrTrp: 0.565 ± 0.026
2.367ThrTyr: 2.367 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
5.893ValAla: 5.893 ± 0.085
0.471ValCys: 0.471 ± 0.023
3.517ValAsp: 3.517 ± 0.067
4.583ValGlu: 4.583 ± 0.083
2.944ValPhe: 2.944 ± 0.057
4.661ValGly: 4.661 ± 0.08
0.908ValHis: 0.908 ± 0.035
5.909ValIle: 5.909 ± 0.083
4.566ValLys: 4.566 ± 0.079
6.843ValLeu: 6.843 ± 0.086
1.822ValMet: 1.822 ± 0.054
3.053ValAsn: 3.053 ± 0.055
2.682ValPro: 2.682 ± 0.061
1.99ValGln: 1.99 ± 0.054
2.051ValArg: 2.051 ± 0.049
4.908ValSer: 4.908 ± 0.08
5.188ValThr: 5.188 ± 0.083
5.027ValVal: 5.027 ± 0.081
0.464ValTrp: 0.464 ± 0.025
2.242ValTyr: 2.242 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.47TrpAla: 0.47 ± 0.024
0.047TrpCys: 0.047 ± 0.007
0.439TrpAsp: 0.439 ± 0.021
0.59TrpGlu: 0.59 ± 0.025
0.422TrpPhe: 0.422 ± 0.021
0.535TrpGly: 0.535 ± 0.025
0.203TrpHis: 0.203 ± 0.014
0.511TrpIle: 0.511 ± 0.024
0.422TrpLys: 0.422 ± 0.024
1.223TrpLeu: 1.223 ± 0.042
0.196TrpMet: 0.196 ± 0.014
0.368TrpAsn: 0.368 ± 0.024
0.213TrpPro: 0.213 ± 0.017
0.69TrpGln: 0.69 ± 0.029
0.368TrpArg: 0.368 ± 0.019
0.567TrpSer: 0.567 ± 0.026
0.438TrpThr: 0.438 ± 0.024
0.482TrpVal: 0.482 ± 0.025
0.103TrpTrp: 0.103 ± 0.012
0.286TrpTyr: 0.286 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.119TyrAla: 2.119 ± 0.052
0.266TyrCys: 0.266 ± 0.019
2.019TyrAsp: 2.019 ± 0.051
2.335TyrGlu: 2.335 ± 0.06
1.979TyrPhe: 1.979 ± 0.052
2.398TyrGly: 2.398 ± 0.052
0.838TyrHis: 0.838 ± 0.03
2.065TyrIle: 2.065 ± 0.047
1.575TyrLys: 1.575 ± 0.045
4.33TyrLeu: 4.33 ± 0.086
0.649TyrMet: 0.649 ± 0.031
1.417TyrAsn: 1.417 ± 0.04
1.43TyrPro: 1.43 ± 0.045
2.584TyrGln: 2.584 ± 0.055
1.708TyrArg: 1.708 ± 0.049
2.184TyrSer: 2.184 ± 0.052
1.795TyrThr: 1.795 ± 0.047
2.177TyrVal: 2.177 ± 0.041
0.361TyrTrp: 0.361 ± 0.019
1.636TyrTyr: 1.636 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2859 proteins (899546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski