Amino acid dipepetide frequency for Candidatus Vampirococcus archaeovorus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.437AlaAla: 9.437 ± 0.338
1.304AlaCys: 1.304 ± 0.089
4.384AlaAsp: 4.384 ± 0.125
4.803AlaGlu: 4.803 ± 0.154
3.912AlaPhe: 3.912 ± 0.084
7.253AlaGly: 7.253 ± 0.191
1.616AlaHis: 1.616 ± 0.058
5.208AlaIle: 5.208 ± 0.11
5.033AlaLys: 5.033 ± 0.101
8.669AlaLeu: 8.669 ± 0.159
2.235AlaMet: 2.235 ± 0.059
2.257AlaAsn: 2.257 ± 0.103
2.896AlaPro: 2.896 ± 0.098
3.363AlaGln: 3.363 ± 0.157
5.358AlaArg: 5.358 ± 0.11
5.268AlaSer: 5.268 ± 0.162
3.653AlaThr: 3.653 ± 0.132
7.121AlaVal: 7.121 ± 0.133
0.907AlaTrp: 0.907 ± 0.055
2.68AlaTyr: 2.68 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
1.073CysAla: 1.073 ± 0.062
0.239CysCys: 0.239 ± 0.021
0.707CysAsp: 0.707 ± 0.053
0.656CysGlu: 0.656 ± 0.046
0.633CysPhe: 0.633 ± 0.046
1.359CysGly: 1.359 ± 0.071
0.288CysHis: 0.288 ± 0.025
0.672CysIle: 0.672 ± 0.045
0.486CysLys: 0.486 ± 0.038
1.416CysLeu: 1.416 ± 0.085
0.261CysMet: 0.261 ± 0.021
0.34CysAsn: 0.34 ± 0.026
0.69CysPro: 0.69 ± 0.049
0.357CysGln: 0.357 ± 0.027
0.969CysArg: 0.969 ± 0.067
0.687CysSer: 0.687 ± 0.049
0.36CysThr: 0.36 ± 0.029
0.958CysVal: 0.958 ± 0.07
0.12CysTrp: 0.12 ± 0.015
0.367CysTyr: 0.367 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.822AspAla: 4.822 ± 0.13
0.594AspCys: 0.594 ± 0.042
2.438AspAsp: 2.438 ± 0.076
3.494AspGlu: 3.494 ± 0.088
2.839AspPhe: 2.839 ± 0.079
3.588AspGly: 3.588 ± 0.081
0.939AspHis: 0.939 ± 0.049
4.478AspIle: 4.478 ± 0.094
3.516AspLys: 3.516 ± 0.097
5.426AspLeu: 5.426 ± 0.103
1.306AspMet: 1.306 ± 0.049
1.6AspAsn: 1.6 ± 0.057
2.465AspPro: 2.465 ± 0.06
1.196AspGln: 1.196 ± 0.049
3.084AspArg: 3.084 ± 0.082
2.347AspSer: 2.347 ± 0.076
2.254AspThr: 2.254 ± 0.072
4.297AspVal: 4.297 ± 0.097
0.56AspTrp: 0.56 ± 0.038
2.13AspTyr: 2.13 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.082GluAla: 6.082 ± 0.14
0.47GluCys: 0.47 ± 0.04
3.36GluAsp: 3.36 ± 0.089
4.829GluGlu: 4.829 ± 0.114
2.489GluPhe: 2.489 ± 0.077
4.406GluGly: 4.406 ± 0.106
1.15GluHis: 1.15 ± 0.046
4.746GluIle: 4.746 ± 0.1
5.319GluLys: 5.319 ± 0.155
5.587GluLeu: 5.587 ± 0.121
1.695GluMet: 1.695 ± 0.053
2.338GluAsn: 2.338 ± 0.06
1.826GluPro: 1.826 ± 0.064
1.756GluGln: 1.756 ± 0.082
3.819GluArg: 3.819 ± 0.097
2.888GluSer: 2.888 ± 0.07
3.282GluThr: 3.282 ± 0.097
4.25GluVal: 4.25 ± 0.127
0.511GluTrp: 0.511 ± 0.029
1.826GluTyr: 1.826 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.404PheAla: 3.404 ± 0.091
0.856PheCys: 0.856 ± 0.05
2.849PheAsp: 2.849 ± 0.078
2.55PheGlu: 2.55 ± 0.07
2.714PhePhe: 2.714 ± 0.108
3.58PheGly: 3.58 ± 0.093
0.876PheHis: 0.876 ± 0.051
2.891PheIle: 2.891 ± 0.089
2.477PheLys: 2.477 ± 0.091
5.302PheLeu: 5.302 ± 0.187
1.078PheMet: 1.078 ± 0.047
1.48PheAsn: 1.48 ± 0.061
1.609PhePro: 1.609 ± 0.069
1.184PheGln: 1.184 ± 0.054
2.448PheArg: 2.448 ± 0.059
3.499PheSer: 3.499 ± 0.102
1.947PheThr: 1.947 ± 0.069
3.594PheVal: 3.594 ± 0.084
0.575PheTrp: 0.575 ± 0.042
1.641PheTyr: 1.641 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
5.928GlyAla: 5.928 ± 0.14
1.095GlyCys: 1.095 ± 0.067
3.46GlyAsp: 3.46 ± 0.084
4.192GlyGlu: 4.192 ± 0.092
3.624GlyPhe: 3.624 ± 0.079
5.257GlyGly: 5.257 ± 0.131
1.533GlyHis: 1.533 ± 0.057
5.497GlyIle: 5.497 ± 0.129
4.512GlyLys: 4.512 ± 0.108
7.671GlyLeu: 7.671 ± 0.143
1.959GlyMet: 1.959 ± 0.065
2.117GlyAsn: 2.117 ± 0.08
2.26GlyPro: 2.26 ± 0.061
2.331GlyGln: 2.331 ± 0.08
5.307GlyArg: 5.307 ± 0.147
4.184GlySer: 4.184 ± 0.101
3.659GlyThr: 3.659 ± 0.121
5.796GlyVal: 5.796 ± 0.102
0.902GlyTrp: 0.902 ± 0.047
2.66GlyTyr: 2.66 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.55HisAla: 1.55 ± 0.044
0.286HisCys: 0.286 ± 0.03
0.912HisAsp: 0.912 ± 0.036
1.112HisGlu: 1.112 ± 0.044
0.932HisPhe: 0.932 ± 0.043
1.369HisGly: 1.369 ± 0.045
0.536HisHis: 0.536 ± 0.032
1.365HisIle: 1.365 ± 0.053
1.135HisLys: 1.135 ± 0.053
1.959HisLeu: 1.959 ± 0.062
0.458HisMet: 0.458 ± 0.027
0.623HisAsn: 0.623 ± 0.03
1.135HisPro: 1.135 ± 0.053
0.634HisGln: 0.634 ± 0.035
1.13HisArg: 1.13 ± 0.051
0.924HisSer: 0.924 ± 0.039
0.809HisThr: 0.809 ± 0.034
1.298HisVal: 1.298 ± 0.047
0.213HisTrp: 0.213 ± 0.021
0.648HisTyr: 0.648 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.883IleAla: 5.883 ± 0.123
0.826IleCys: 0.826 ± 0.052
3.891IleAsp: 3.891 ± 0.088
4.154IleGlu: 4.154 ± 0.106
3.259IlePhe: 3.259 ± 0.109
4.785IleGly: 4.785 ± 0.113
1.321IleHis: 1.321 ± 0.053
3.891IleIle: 3.891 ± 0.146
4.483IleLys: 4.483 ± 0.134
6.786IleLeu: 6.786 ± 0.188
1.323IleMet: 1.323 ± 0.059
2.238IleAsn: 2.238 ± 0.067
2.874IlePro: 2.874 ± 0.074
1.81IleGln: 1.81 ± 0.071
4.016IleArg: 4.016 ± 0.097
4.231IleSer: 4.231 ± 0.097
2.957IleThr: 2.957 ± 0.095
5.125IleVal: 5.125 ± 0.153
0.56IleTrp: 0.56 ± 0.03
2.123IleTyr: 2.123 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.306LysAla: 5.306 ± 0.1
0.513LysCys: 0.513 ± 0.046
4.363LysAsp: 4.363 ± 0.096
5.592LysGlu: 5.592 ± 0.197
2.081LysPhe: 2.081 ± 0.077
4.595LysGly: 4.595 ± 0.109
1.156LysHis: 1.156 ± 0.048
5.361LysIle: 5.361 ± 0.183
6.434LysLys: 6.434 ± 0.308
5.027LysLeu: 5.027 ± 0.139
1.809LysMet: 1.809 ± 0.083
2.979LysAsn: 2.979 ± 0.101
2.237LysPro: 2.237 ± 0.061
1.915LysGln: 1.915 ± 0.065
3.516LysArg: 3.516 ± 0.145
3.284LysSer: 3.284 ± 0.106
3.952LysThr: 3.952 ± 0.084
4.14LysVal: 4.14 ± 0.122
0.46LysTrp: 0.46 ± 0.031
1.732LysTyr: 1.732 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
8.904LeuAla: 8.904 ± 0.154
1.227LeuCys: 1.227 ± 0.08
5.126LeuAsp: 5.126 ± 0.107
6.58LeuGlu: 6.58 ± 0.113
4.319LeuPhe: 4.319 ± 0.129
7.326LeuGly: 7.326 ± 0.111
1.633LeuHis: 1.633 ± 0.058
5.749LeuIle: 5.749 ± 0.145
7.852LeuLys: 7.852 ± 0.21
9.287LeuLeu: 9.287 ± 0.199
2.286LeuMet: 2.286 ± 0.069
3.362LeuAsn: 3.362 ± 0.078
4.099LeuPro: 4.099 ± 0.089
2.641LeuGln: 2.641 ± 0.093
5.996LeuArg: 5.996 ± 0.122
6.879LeuSer: 6.879 ± 0.123
4.813LeuThr: 4.813 ± 0.107
7.052LeuVal: 7.052 ± 0.123
1.0LeuTrp: 1.0 ± 0.044
2.797LeuTyr: 2.797 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.338MetAla: 2.338 ± 0.065
0.218MetCys: 0.218 ± 0.023
1.33MetAsp: 1.33 ± 0.043
1.479MetGlu: 1.479 ± 0.052
0.939MetPhe: 0.939 ± 0.038
1.837MetGly: 1.837 ± 0.076
0.442MetHis: 0.442 ± 0.029
1.579MetIle: 1.579 ± 0.058
1.939MetLys: 1.939 ± 0.092
2.093MetLeu: 2.093 ± 0.064
0.694MetMet: 0.694 ± 0.038
0.988MetAsn: 0.988 ± 0.042
1.244MetPro: 1.244 ± 0.049
0.707MetGln: 0.707 ± 0.046
1.589MetArg: 1.589 ± 0.05
1.381MetSer: 1.381 ± 0.057
1.421MetThr: 1.421 ± 0.053
1.641MetVal: 1.641 ± 0.059
0.166MetTrp: 0.166 ± 0.018
0.508MetTyr: 0.508 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.754AsnAla: 2.754 ± 0.079
0.321AsnCys: 0.321 ± 0.03
1.621AsnAsp: 1.621 ± 0.059
1.766AsnGlu: 1.766 ± 0.06
1.54AsnPhe: 1.54 ± 0.051
2.22AsnGly: 2.22 ± 0.131
0.536AsnHis: 0.536 ± 0.035
2.746AsnIle: 2.746 ± 0.076
2.204AsnLys: 2.204 ± 0.082
3.171AsnLeu: 3.171 ± 0.082
0.771AsnMet: 0.771 ± 0.037
1.293AsnAsn: 1.293 ± 0.06
1.817AsnPro: 1.817 ± 0.056
0.905AsnGln: 0.905 ± 0.047
1.8AsnArg: 1.8 ± 0.062
1.524AsnSer: 1.524 ± 0.061
1.629AsnThr: 1.629 ± 0.067
2.495AsnVal: 2.495 ± 0.088
0.387AsnTrp: 0.387 ± 0.03
1.061AsnTyr: 1.061 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.791ProAla: 3.791 ± 0.173
0.474ProCys: 0.474 ± 0.032
2.243ProAsp: 2.243 ± 0.068
2.849ProGlu: 2.849 ± 0.078
2.052ProPhe: 2.052 ± 0.055
2.922ProGly: 2.922 ± 0.071
0.824ProHis: 0.824 ± 0.041
1.925ProIle: 1.925 ± 0.056
2.179ProLys: 2.179 ± 0.076
3.856ProLeu: 3.856 ± 0.104
0.871ProMet: 0.871 ± 0.037
1.024ProAsn: 1.024 ± 0.054
1.391ProPro: 1.391 ± 0.07
1.902ProGln: 1.902 ± 0.087
2.093ProArg: 2.093 ± 0.062
2.377ProSer: 2.377 ± 0.089
1.651ProThr: 1.651 ± 0.059
3.509ProVal: 3.509 ± 0.089
0.475ProTrp: 0.475 ± 0.032
1.313ProTyr: 1.313 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.237GlnAla: 3.237 ± 0.195
0.261GlnCys: 0.261 ± 0.021
1.827GlnAsp: 1.827 ± 0.059
2.729GlnGlu: 2.729 ± 0.083
0.946GlnPhe: 0.946 ± 0.039
2.294GlnGly: 2.294 ± 0.1
0.53GlnHis: 0.53 ± 0.028
2.056GlnIle: 2.056 ± 0.056
2.705GlnLys: 2.705 ± 0.077
2.414GlnLeu: 2.414 ± 0.063
0.964GlnMet: 0.964 ± 0.042
1.095GlnAsn: 1.095 ± 0.054
1.088GlnPro: 1.088 ± 0.057
1.002GlnGln: 1.002 ± 0.087
1.809GlnArg: 1.809 ± 0.089
1.355GlnSer: 1.355 ± 0.05
1.636GlnThr: 1.636 ± 0.078
2.218GlnVal: 2.218 ± 0.072
0.294GlnTrp: 0.294 ± 0.025
0.88GlnTyr: 0.88 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
4.468ArgAla: 4.468 ± 0.12
0.768ArgCys: 0.768 ± 0.061
3.198ArgAsp: 3.198 ± 0.1
3.732ArgGlu: 3.732 ± 0.089
2.856ArgPhe: 2.856 ± 0.067
3.869ArgGly: 3.869 ± 0.091
1.502ArgHis: 1.502 ± 0.049
4.494ArgIle: 4.494 ± 0.104
3.89ArgLys: 3.89 ± 0.129
6.828ArgLeu: 6.828 ± 0.132
1.724ArgMet: 1.724 ± 0.062
1.939ArgAsn: 1.939 ± 0.07
2.558ArgPro: 2.558 ± 0.072
2.736ArgGln: 2.736 ± 0.088
4.947ArgArg: 4.947 ± 0.138
3.138ArgSer: 3.138 ± 0.073
2.653ArgThr: 2.653 ± 0.085
4.02ArgVal: 4.02 ± 0.086
0.621ArgTrp: 0.621 ± 0.038
1.976ArgTyr: 1.976 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.685SerAla: 4.685 ± 0.134
0.89SerCys: 0.89 ± 0.053
2.847SerAsp: 2.847 ± 0.101
2.939SerGlu: 2.939 ± 0.075
3.179SerPhe: 3.179 ± 0.081
5.209SerGly: 5.209 ± 0.11
1.037SerHis: 1.037 ± 0.043
3.426SerIle: 3.426 ± 0.094
2.93SerLys: 2.93 ± 0.097
6.529SerLeu: 6.529 ± 0.107
1.425SerMet: 1.425 ± 0.048
1.535SerAsn: 1.535 ± 0.071
2.394SerPro: 2.394 ± 0.181
1.91SerGln: 1.91 ± 0.08
4.077SerArg: 4.077 ± 0.094
4.143SerSer: 4.143 ± 0.238
2.287SerThr: 2.287 ± 0.098
4.209SerVal: 4.209 ± 0.088
0.79SerTrp: 0.79 ± 0.047
1.913SerTyr: 1.913 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.209ThrAla: 4.209 ± 0.148
0.513ThrCys: 0.513 ± 0.039
2.538ThrAsp: 2.538 ± 0.084
2.441ThrGlu: 2.441 ± 0.083
2.045ThrPhe: 2.045 ± 0.072
4.196ThrGly: 4.196 ± 0.099
0.953ThrHis: 0.953 ± 0.036
3.189ThrIle: 3.189 ± 0.098
2.653ThrLys: 2.653 ± 0.076
4.62ThrLeu: 4.62 ± 0.113
1.059ThrMet: 1.059 ± 0.047
1.491ThrAsn: 1.491 ± 0.066
2.387ThrPro: 2.387 ± 0.066
1.726ThrGln: 1.726 ± 0.093
2.458ThrArg: 2.458 ± 0.073
2.754ThrSer: 2.754 ± 0.114
2.678ThrThr: 2.678 ± 0.097
3.577ThrVal: 3.577 ± 0.089
0.48ThrTrp: 0.48 ± 0.06
1.56ThrTyr: 1.56 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
6.174ValAla: 6.174 ± 0.141
1.149ValCys: 1.149 ± 0.069
3.857ValAsp: 3.857 ± 0.09
4.263ValGlu: 4.263 ± 0.088
4.0ValPhe: 4.0 ± 0.111
4.732ValGly: 4.732 ± 0.093
1.225ValHis: 1.225 ± 0.047
4.932ValIle: 4.932 ± 0.155
4.235ValLys: 4.235 ± 0.114
7.679ValLeu: 7.679 ± 0.134
1.753ValMet: 1.753 ± 0.062
2.482ValAsn: 2.482 ± 0.076
2.951ValPro: 2.951 ± 0.086
1.726ValGln: 1.726 ± 0.057
4.697ValArg: 4.697 ± 0.113
5.223ValSer: 5.223 ± 0.114
3.881ValThr: 3.881 ± 0.111
6.422ValVal: 6.422 ± 0.138
0.792ValTrp: 0.792 ± 0.04
2.386ValTyr: 2.386 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.756TrpAla: 0.756 ± 0.061
0.12TrpCys: 0.12 ± 0.015
0.587TrpAsp: 0.587 ± 0.033
0.616TrpGlu: 0.616 ± 0.04
0.486TrpPhe: 0.486 ± 0.032
0.758TrpGly: 0.758 ± 0.046
0.233TrpHis: 0.233 ± 0.021
0.609TrpIle: 0.609 ± 0.032
0.695TrpLys: 0.695 ± 0.038
1.054TrpLeu: 1.054 ± 0.047
0.291TrpMet: 0.291 ± 0.024
0.381TrpAsn: 0.381 ± 0.03
0.389TrpPro: 0.389 ± 0.027
0.477TrpGln: 0.477 ± 0.039
0.645TrpArg: 0.645 ± 0.036
0.562TrpSer: 0.562 ± 0.044
0.511TrpThr: 0.511 ± 0.054
0.726TrpVal: 0.726 ± 0.04
0.149TrpTrp: 0.149 ± 0.014
0.289TrpTyr: 0.289 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.556TyrAla: 2.556 ± 0.074
0.514TyrCys: 0.514 ± 0.036
1.834TyrAsp: 1.834 ± 0.082
1.853TyrGlu: 1.853 ± 0.066
1.712TyrPhe: 1.712 ± 0.049
2.391TyrGly: 2.391 ± 0.059
0.7TyrHis: 0.7 ± 0.035
1.724TyrIle: 1.724 ± 0.067
1.773TyrLys: 1.773 ± 0.07
3.553TyrLeu: 3.553 ± 0.076
0.567TyrMet: 0.567 ± 0.034
1.003TyrAsn: 1.003 ± 0.053
1.411TyrPro: 1.411 ± 0.051
1.059TyrGln: 1.059 ± 0.045
2.159TyrArg: 2.159 ± 0.071
1.707TyrSer: 1.707 ± 0.068
1.492TyrThr: 1.492 ± 0.058
2.11TyrVal: 2.11 ± 0.076
0.371TyrTrp: 0.371 ± 0.028
1.232TyrTyr: 1.232 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1851 proteins (591068 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski