Amino acid dipepetide frequency for Alcanivorax sp. N3-2A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.373AlaAla: 13.373 ± 0.137
1.112AlaCys: 1.112 ± 0.035
6.382AlaAsp: 6.382 ± 0.099
6.434AlaGlu: 6.434 ± 0.08
3.741AlaPhe: 3.741 ± 0.066
10.641AlaGly: 10.641 ± 0.123
2.253AlaHis: 2.253 ± 0.046
4.685AlaIle: 4.685 ± 0.063
2.706AlaLys: 2.706 ± 0.064
14.77AlaLeu: 14.77 ± 0.155
3.066AlaMet: 3.066 ± 0.054
2.697AlaAsn: 2.697 ± 0.054
5.197AlaPro: 5.197 ± 0.083
3.856AlaGln: 3.856 ± 0.058
8.902AlaArg: 8.902 ± 0.114
5.885AlaSer: 5.885 ± 0.079
5.198AlaThr: 5.198 ± 0.085
8.156AlaVal: 8.156 ± 0.098
1.645AlaTrp: 1.645 ± 0.043
2.229AlaTyr: 2.229 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.995CysAla: 0.995 ± 0.028
0.119CysCys: 0.119 ± 0.009
0.556CysAsp: 0.556 ± 0.023
0.516CysGlu: 0.516 ± 0.021
0.336CysPhe: 0.336 ± 0.018
0.922CysGly: 0.922 ± 0.029
0.292CysHis: 0.292 ± 0.018
0.296CysIle: 0.296 ± 0.015
0.208CysLys: 0.208 ± 0.012
0.98CysLeu: 0.98 ± 0.03
0.168CysMet: 0.168 ± 0.014
0.216CysAsn: 0.216 ± 0.015
0.522CysPro: 0.522 ± 0.026
0.428CysGln: 0.428 ± 0.02
0.672CysArg: 0.672 ± 0.027
0.458CysSer: 0.458 ± 0.022
0.397CysThr: 0.397 ± 0.018
0.636CysVal: 0.636 ± 0.023
0.13CysTrp: 0.13 ± 0.009
0.264CysTyr: 0.264 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.505AspAla: 6.505 ± 0.097
0.481AspCys: 0.481 ± 0.02
3.79AspAsp: 3.79 ± 0.074
3.496AspGlu: 3.496 ± 0.064
2.054AspPhe: 2.054 ± 0.044
5.14AspGly: 5.14 ± 0.092
1.472AspHis: 1.472 ± 0.035
2.574AspIle: 2.574 ± 0.054
1.716AspLys: 1.716 ± 0.047
6.174AspLeu: 6.174 ± 0.095
1.282AspMet: 1.282 ± 0.037
1.908AspAsn: 1.908 ± 0.047
3.108AspPro: 3.108 ± 0.049
2.96AspGln: 2.96 ± 0.046
3.857AspArg: 3.857 ± 0.049
2.883AspSer: 2.883 ± 0.051
3.15AspThr: 3.15 ± 0.051
3.843AspVal: 3.843 ± 0.061
1.012AspTrp: 1.012 ± 0.032
1.919AspTyr: 1.919 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.332GluAla: 6.332 ± 0.084
0.42GluCys: 0.42 ± 0.017
2.807GluAsp: 2.807 ± 0.054
3.239GluGlu: 3.239 ± 0.071
1.692GluPhe: 1.692 ± 0.038
4.13GluGly: 4.13 ± 0.059
1.658GluHis: 1.658 ± 0.04
2.774GluIle: 2.774 ± 0.053
2.262GluLys: 2.262 ± 0.052
6.077GluLeu: 6.077 ± 0.082
1.464GluMet: 1.464 ± 0.042
1.694GluAsn: 1.694 ± 0.04
2.74GluPro: 2.74 ± 0.055
3.803GluGln: 3.803 ± 0.072
5.391GluArg: 5.391 ± 0.081
2.827GluSer: 2.827 ± 0.054
2.815GluThr: 2.815 ± 0.046
3.936GluVal: 3.936 ± 0.067
0.691GluTrp: 0.691 ± 0.024
1.314GluTyr: 1.314 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.731PheAla: 3.731 ± 0.063
0.399PheCys: 0.399 ± 0.018
2.435PheAsp: 2.435 ± 0.042
2.059PheGlu: 2.059 ± 0.041
1.453PhePhe: 1.453 ± 0.059
3.223PheGly: 3.223 ± 0.065
0.893PheHis: 0.893 ± 0.027
1.556PheIle: 1.556 ± 0.04
1.01PheLys: 1.01 ± 0.032
3.368PheLeu: 3.368 ± 0.063
0.822PheMet: 0.822 ± 0.026
1.215PheAsn: 1.215 ± 0.036
1.533PhePro: 1.533 ± 0.035
1.403PheGln: 1.403 ± 0.032
2.048PheArg: 2.048 ± 0.037
2.28PheSer: 2.28 ± 0.047
1.907PheThr: 1.907 ± 0.043
2.427PheVal: 2.427 ± 0.051
0.57PheTrp: 0.57 ± 0.025
1.021PheTyr: 1.021 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.809GlyAla: 8.809 ± 0.094
0.886GlyCys: 0.886 ± 0.03
5.278GlyAsp: 5.278 ± 0.112
5.812GlyGlu: 5.812 ± 0.067
3.328GlyPhe: 3.328 ± 0.054
7.41GlyGly: 7.41 ± 0.115
2.058GlyHis: 2.058 ± 0.038
3.916GlyIle: 3.916 ± 0.06
2.831GlyLys: 2.831 ± 0.061
9.427GlyLeu: 9.427 ± 0.104
2.22GlyMet: 2.22 ± 0.054
2.364GlyAsn: 2.364 ± 0.053
3.076GlyPro: 3.076 ± 0.046
3.371GlyGln: 3.371 ± 0.05
5.517GlyArg: 5.517 ± 0.07
4.194GlySer: 4.194 ± 0.074
3.916GlyThr: 3.916 ± 0.06
6.514GlyVal: 6.514 ± 0.086
1.43GlyTrp: 1.43 ± 0.034
2.544GlyTyr: 2.544 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.293HisAla: 2.293 ± 0.043
0.344HisCys: 0.344 ± 0.016
1.29HisAsp: 1.29 ± 0.032
1.06HisGlu: 1.06 ± 0.03
1.048HisPhe: 1.048 ± 0.026
2.357HisGly: 2.357 ± 0.052
0.757HisHis: 0.757 ± 0.027
0.926HisIle: 0.926 ± 0.03
0.539HisLys: 0.539 ± 0.02
2.525HisLeu: 2.525 ± 0.047
0.47HisMet: 0.47 ± 0.018
0.61HisAsn: 0.61 ± 0.025
1.513HisPro: 1.513 ± 0.037
1.056HisGln: 1.056 ± 0.029
1.901HisArg: 1.901 ± 0.038
1.159HisSer: 1.159 ± 0.032
1.055HisThr: 1.055 ± 0.027
1.23HisVal: 1.23 ± 0.033
0.533HisTrp: 0.533 ± 0.024
0.762HisTyr: 0.762 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.214IleAla: 5.214 ± 0.073
0.416IleCys: 0.416 ± 0.018
3.079IleAsp: 3.079 ± 0.051
2.947IleGlu: 2.947 ± 0.05
1.311IlePhe: 1.311 ± 0.04
4.063IleGly: 4.063 ± 0.071
0.999IleHis: 0.999 ± 0.032
1.951IleIle: 1.951 ± 0.052
1.548IleLys: 1.548 ± 0.04
3.812IleLeu: 3.812 ± 0.061
0.888IleMet: 0.888 ± 0.029
1.752IleAsn: 1.752 ± 0.038
1.956IlePro: 1.956 ± 0.04
1.497IleGln: 1.497 ± 0.032
2.915IleArg: 2.915 ± 0.052
2.539IleSer: 2.539 ± 0.052
2.685IleThr: 2.685 ± 0.053
2.964IleVal: 2.964 ± 0.055
0.531IleTrp: 0.531 ± 0.019
1.093IleTyr: 1.093 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.377LysAla: 3.377 ± 0.066
0.161LysCys: 0.161 ± 0.013
1.571LysAsp: 1.571 ± 0.042
1.794LysGlu: 1.794 ± 0.052
0.708LysPhe: 0.708 ± 0.029
2.324LysGly: 2.324 ± 0.055
0.634LysHis: 0.634 ± 0.023
1.334LysIle: 1.334 ± 0.04
1.447LysLys: 1.447 ± 0.05
2.839LysLeu: 2.839 ± 0.057
0.719LysMet: 0.719 ± 0.03
0.873LysAsn: 0.873 ± 0.028
1.698LysPro: 1.698 ± 0.045
1.314LysGln: 1.314 ± 0.033
2.25LysArg: 2.25 ± 0.044
1.483LysSer: 1.483 ± 0.037
1.545LysThr: 1.545 ± 0.035
2.362LysVal: 2.362 ± 0.054
0.29LysTrp: 0.29 ± 0.016
0.637LysTyr: 0.637 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.162LeuAla: 14.162 ± 0.123
1.165LeuCys: 1.165 ± 0.03
6.928LeuAsp: 6.928 ± 0.093
6.521LeuGlu: 6.521 ± 0.084
3.994LeuPhe: 3.994 ± 0.067
9.111LeuGly: 9.111 ± 0.105
2.32LeuHis: 2.32 ± 0.039
5.303LeuIle: 5.303 ± 0.076
3.558LeuLys: 3.558 ± 0.063
11.986LeuLeu: 11.986 ± 0.139
2.704LeuMet: 2.704 ± 0.049
3.422LeuAsn: 3.422 ± 0.06
5.996LeuPro: 5.996 ± 0.079
3.458LeuGln: 3.458 ± 0.059
7.69LeuArg: 7.69 ± 0.085
6.629LeuSer: 6.629 ± 0.082
5.746LeuThr: 5.746 ± 0.083
8.199LeuVal: 8.199 ± 0.098
1.438LeuTrp: 1.438 ± 0.043
2.649LeuTyr: 2.649 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.98MetAla: 2.98 ± 0.052
0.142MetCys: 0.142 ± 0.01
1.279MetAsp: 1.279 ± 0.037
1.254MetGlu: 1.254 ± 0.035
0.688MetPhe: 0.688 ± 0.024
1.763MetGly: 1.763 ± 0.044
0.453MetHis: 0.453 ± 0.021
1.19MetIle: 1.19 ± 0.032
0.942MetLys: 0.942 ± 0.03
2.661MetLeu: 2.661 ± 0.051
0.69MetMet: 0.69 ± 0.028
0.854MetAsn: 0.854 ± 0.026
1.259MetPro: 1.259 ± 0.031
0.839MetGln: 0.839 ± 0.028
1.573MetArg: 1.573 ± 0.043
1.588MetSer: 1.588 ± 0.036
1.482MetThr: 1.482 ± 0.037
1.822MetVal: 1.822 ± 0.038
0.189MetTrp: 0.189 ± 0.012
0.375MetTyr: 0.375 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.06
0.222AsnCys: 0.222 ± 0.015
1.76AsnAsp: 1.76 ± 0.042
1.422AsnGlu: 1.422 ± 0.036
0.874AsnPhe: 0.874 ± 0.031
2.732AsnGly: 2.732 ± 0.063
0.637AsnHis: 0.637 ± 0.021
1.332AsnIle: 1.332 ± 0.031
0.805AsnLys: 0.805 ± 0.03
3.071AsnLeu: 3.071 ± 0.054
0.576AsnMet: 0.576 ± 0.022
0.935AsnAsn: 0.935 ± 0.029
1.835AsnPro: 1.835 ± 0.042
1.209AsnGln: 1.209 ± 0.033
2.028AsnArg: 2.028 ± 0.046
1.351AsnSer: 1.351 ± 0.035
1.459AsnThr: 1.459 ± 0.036
1.843AsnVal: 1.843 ± 0.038
0.422AsnTrp: 0.422 ± 0.021
0.715AsnTyr: 0.715 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.156ProAla: 6.156 ± 0.089
0.351ProCys: 0.351 ± 0.017
3.421ProAsp: 3.421 ± 0.059
3.614ProGlu: 3.614 ± 0.06
1.791ProPhe: 1.791 ± 0.035
4.638ProGly: 4.638 ± 0.068
1.029ProHis: 1.029 ± 0.031
1.78ProIle: 1.78 ± 0.039
1.276ProLys: 1.276 ± 0.037
5.592ProLeu: 5.592 ± 0.074
1.278ProMet: 1.278 ± 0.034
1.16ProAsn: 1.16 ± 0.032
2.529ProPro: 2.529 ± 0.082
1.626ProGln: 1.626 ± 0.04
3.106ProArg: 3.106 ± 0.052
2.363ProSer: 2.363 ± 0.044
2.085ProThr: 2.085 ± 0.036
4.223ProVal: 4.223 ± 0.068
0.841ProTrp: 0.841 ± 0.029
1.153ProTyr: 1.153 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.326GlnAla: 5.326 ± 0.074
0.329GlnCys: 0.329 ± 0.016
1.949GlnAsp: 1.949 ± 0.043
2.007GlnGlu: 2.007 ± 0.052
1.139GlnPhe: 1.139 ± 0.032
3.428GlnGly: 3.428 ± 0.059
0.991GlnHis: 0.991 ± 0.029
1.662GlnIle: 1.662 ± 0.043
1.063GlnLys: 1.063 ± 0.032
3.972GlnLeu: 3.972 ± 0.051
0.908GlnMet: 0.908 ± 0.026
0.963GlnAsn: 0.963 ± 0.031
2.188GlnPro: 2.188 ± 0.043
2.156GlnGln: 2.156 ± 0.055
3.843GlnArg: 3.843 ± 0.071
2.036GlnSer: 2.036 ± 0.04
1.7GlnThr: 1.7 ± 0.04
3.217GlnVal: 3.217 ± 0.056
0.754GlnTrp: 0.754 ± 0.028
0.889GlnTyr: 0.889 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.592ArgAla: 7.592 ± 0.092
0.637ArgCys: 0.637 ± 0.025
4.509ArgAsp: 4.509 ± 0.069
4.633ArgGlu: 4.633 ± 0.072
3.271ArgPhe: 3.271 ± 0.05
4.758ArgGly: 4.758 ± 0.067
2.213ArgHis: 2.213 ± 0.051
3.377ArgIle: 3.377 ± 0.057
1.994ArgLys: 1.994 ± 0.044
9.107ArgLeu: 9.107 ± 0.125
1.71ArgMet: 1.71 ± 0.039
1.836ArgAsn: 1.836 ± 0.042
3.391ArgPro: 3.391 ± 0.053
3.531ArgGln: 3.531 ± 0.057
6.185ArgArg: 6.185 ± 0.099
3.069ArgSer: 3.069 ± 0.052
2.949ArgThr: 2.949 ± 0.044
5.318ArgVal: 5.318 ± 0.074
1.262ArgTrp: 1.262 ± 0.038
2.197ArgTyr: 2.197 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.846SerAla: 5.846 ± 0.082
0.4SerCys: 0.4 ± 0.019
3.118SerAsp: 3.118 ± 0.052
3.042SerGlu: 3.042 ± 0.054
1.796SerPhe: 1.796 ± 0.04
5.304SerGly: 5.304 ± 0.083
1.188SerHis: 1.188 ± 0.032
2.143SerIle: 2.143 ± 0.048
1.418SerLys: 1.418 ± 0.039
5.959SerLeu: 5.959 ± 0.085
1.327SerMet: 1.327 ± 0.039
1.433SerAsn: 1.433 ± 0.041
2.582SerPro: 2.582 ± 0.048
1.94SerGln: 1.94 ± 0.037
3.651SerArg: 3.651 ± 0.056
2.816SerSer: 2.816 ± 0.061
2.383SerThr: 2.383 ± 0.048
3.977SerVal: 3.977 ± 0.055
0.697SerTrp: 0.697 ± 0.025
1.285SerTyr: 1.285 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.034ThrAla: 5.034 ± 0.093
0.415ThrCys: 0.415 ± 0.019
2.787ThrAsp: 2.787 ± 0.056
2.378ThrGlu: 2.378 ± 0.046
1.762ThrPhe: 1.762 ± 0.039
4.68ThrGly: 4.68 ± 0.081
1.015ThrHis: 1.015 ± 0.03
1.836ThrIle: 1.836 ± 0.04
0.905ThrLys: 0.905 ± 0.031
7.227ThrLeu: 7.227 ± 0.104
0.944ThrMet: 0.944 ± 0.028
1.094ThrAsn: 1.094 ± 0.032
3.107ThrPro: 3.107 ± 0.055
1.429ThrGln: 1.429 ± 0.035
3.291ThrArg: 3.291 ± 0.047
2.408ThrSer: 2.408 ± 0.06
2.36ThrThr: 2.36 ± 0.058
4.424ThrVal: 4.424 ± 0.065
0.655ThrTrp: 0.655 ± 0.023
1.026ThrTyr: 1.026 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.507ValAla: 8.507 ± 0.088
0.69ValCys: 0.69 ± 0.028
4.367ValAsp: 4.367 ± 0.066
4.207ValGlu: 4.207 ± 0.07
2.713ValPhe: 2.713 ± 0.052
5.155ValGly: 5.155 ± 0.071
1.548ValHis: 1.548 ± 0.035
3.981ValIle: 3.981 ± 0.068
2.116ValLys: 2.116 ± 0.049
8.163ValLeu: 8.163 ± 0.111
1.914ValMet: 1.914 ± 0.044
2.299ValAsn: 2.299 ± 0.046
3.692ValPro: 3.692 ± 0.059
2.309ValGln: 2.309 ± 0.05
5.038ValArg: 5.038 ± 0.063
4.211ValSer: 4.211 ± 0.067
4.135ValThr: 4.135 ± 0.08
5.853ValVal: 5.853 ± 0.092
0.895ValTrp: 0.895 ± 0.026
1.632ValTyr: 1.632 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.205TrpAla: 1.205 ± 0.033
0.16TrpCys: 0.16 ± 0.011
0.616TrpAsp: 0.616 ± 0.025
0.571TrpGlu: 0.571 ± 0.022
0.598TrpPhe: 0.598 ± 0.023
0.956TrpGly: 0.956 ± 0.027
0.411TrpHis: 0.411 ± 0.018
0.642TrpIle: 0.642 ± 0.025
0.403TrpLys: 0.403 ± 0.02
2.294TrpLeu: 2.294 ± 0.058
0.375TrpMet: 0.375 ± 0.017
0.415TrpAsn: 0.415 ± 0.019
0.761TrpPro: 0.761 ± 0.029
0.844TrpGln: 0.844 ± 0.027
1.45TrpArg: 1.45 ± 0.036
0.811TrpSer: 0.811 ± 0.028
0.575TrpThr: 0.575 ± 0.025
0.922TrpVal: 0.922 ± 0.031
0.241TrpTrp: 0.241 ± 0.015
0.35TrpTyr: 0.35 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.042
0.264TyrCys: 0.264 ± 0.015
1.401TyrAsp: 1.401 ± 0.04
1.059TyrGlu: 1.059 ± 0.029
1.055TyrPhe: 1.055 ± 0.034
2.165TyrGly: 2.165 ± 0.05
0.608TyrHis: 0.608 ± 0.023
0.904TyrIle: 0.904 ± 0.027
0.615TyrLys: 0.615 ± 0.022
2.975TyrLeu: 2.975 ± 0.053
0.497TyrMet: 0.497 ± 0.023
0.695TyrAsn: 0.695 ± 0.023
1.33TyrPro: 1.33 ± 0.03
1.491TyrGln: 1.491 ± 0.037
2.23TyrArg: 2.23 ± 0.04
1.317TyrSer: 1.317 ± 0.034
1.237TyrThr: 1.237 ± 0.036
1.561TyrVal: 1.561 ± 0.036
0.373TyrTrp: 0.373 ± 0.019
0.695TyrTyr: 0.695 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3757 proteins (1225219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski