Amino acid dipepetide frequency for Acidiphilium cryptum (strain JF-5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.177AlaAla: 25.177 ± 0.231	1.266AlaCys: 1.266 ± 0.03	7.033AlaAsp: 7.033 ± 0.088	8.486AlaGlu: 8.486 ± 0.108	4.276AlaPhe: 4.276 ± 0.064	13.919AlaGly: 13.919 ± 0.135	2.917AlaHis: 2.917 ± 0.049	7.141AlaIle: 7.141 ± 0.077	3.247AlaLys: 3.247 ± 0.065	16.187AlaLeu: 16.187 ± 0.151	3.937AlaMet: 3.937 ± 0.062	2.73AlaAsn: 2.73 ± 0.054	7.669AlaPro: 7.669 ± 0.1	3.773AlaGln: 3.773 ± 0.064	12.314AlaArg: 12.314 ± 0.148	6.564AlaSer: 6.564 ± 0.085	6.962AlaThr: 6.962 ± 0.187	9.528AlaVal: 9.528 ± 0.103	1.781AlaTrp: 1.781 ± 0.043	2.37AlaTyr: 2.37 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.179CysAla: 1.179 ± 0.031	0.117CysCys: 0.117 ± 0.01	0.521CysAsp: 0.521 ± 0.023	0.386CysGlu: 0.386 ± 0.019	0.325CysPhe: 0.325 ± 0.016	0.999CysGly: 0.999 ± 0.031	0.254CysHis: 0.254 ± 0.015	0.34CysIle: 0.34 ± 0.017	0.147CysLys: 0.147 ± 0.012	0.752CysLeu: 0.752 ± 0.026	0.168CysMet: 0.168 ± 0.011	0.186CysAsn: 0.186 ± 0.012	0.515CysPro: 0.515 ± 0.024	0.23CysGln: 0.23 ± 0.014	0.808CysArg: 0.808 ± 0.027	0.418CysSer: 0.418 ± 0.02	0.43CysThr: 0.43 ± 0.021	0.568CysVal: 0.568 ± 0.024	0.113CysTrp: 0.113 ± 0.01	0.181CysTyr: 0.181 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.357AspAla: 7.357 ± 0.1	0.463AspCys: 0.463 ± 0.018	2.721AspAsp: 2.721 ± 0.061	2.988AspGlu: 2.988 ± 0.056	1.999AspPhe: 1.999 ± 0.043	4.769AspGly: 4.769 ± 0.067	1.292AspHis: 1.292 ± 0.039	2.725AspIle: 2.725 ± 0.057	0.985AspLys: 0.985 ± 0.032	5.655AspLeu: 5.655 ± 0.073	1.114AspMet: 1.114 ± 0.032	1.048AspAsn: 1.048 ± 0.035	3.726AspPro: 3.726 ± 0.058	1.449AspGln: 1.449 ± 0.036	4.479AspArg: 4.479 ± 0.065	1.85AspSer: 1.85 ± 0.044	2.256AspThr: 2.256 ± 0.049	3.386AspVal: 3.386 ± 0.067	0.959AspTrp: 0.959 ± 0.03	1.264AspTyr: 1.264 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.61GluAla: 8.61 ± 0.107	0.334GluCys: 0.334 ± 0.017	2.29GluAsp: 2.29 ± 0.05	2.222GluGlu: 2.222 ± 0.057	1.517GluPhe: 1.517 ± 0.039	3.874GluGly: 3.874 ± 0.057	1.108GluHis: 1.108 ± 0.035	3.22GluIle: 3.22 ± 0.065	1.315GluLys: 1.315 ± 0.042	4.569GluLeu: 4.569 ± 0.07	1.268GluMet: 1.268 ± 0.031	1.17GluAsn: 1.17 ± 0.033	2.571GluPro: 2.571 ± 0.052	1.757GluGln: 1.757 ± 0.044	4.776GluArg: 4.776 ± 0.078	2.082GluSer: 2.082 ± 0.044	3.548GluThr: 3.548 ± 0.061	3.145GluVal: 3.145 ± 0.056	0.559GluTrp: 0.559 ± 0.021	0.79GluTyr: 0.79 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.05PheAla: 5.05 ± 0.077	0.418PheCys: 0.418 ± 0.017	2.283PheAsp: 2.283 ± 0.048	1.726PheGlu: 1.726 ± 0.041	1.175PhePhe: 1.175 ± 0.032	3.848PheGly: 3.848 ± 0.061	0.82PheHis: 0.82 ± 0.025	1.587PheIle: 1.587 ± 0.041	0.578PheLys: 0.578 ± 0.024	3.274PheLeu: 3.274 ± 0.061	0.733PheMet: 0.733 ± 0.024	0.933PheAsn: 0.933 ± 0.035	1.607PhePro: 1.607 ± 0.043	0.798PheGln: 0.798 ± 0.027	2.519PheArg: 2.519 ± 0.045	1.792PheSer: 1.792 ± 0.037	1.931PheThr: 1.931 ± 0.044	2.587PheVal: 2.587 ± 0.049	0.491PheTrp: 0.491 ± 0.021	0.824PheTyr: 0.824 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	12.02GlyAla: 12.02 ± 0.209	0.862GlyCys: 0.862 ± 0.031	3.954GlyAsp: 3.954 ± 0.065	4.323GlyGlu: 4.323 ± 0.071	3.926GlyPhe: 3.926 ± 0.058	8.188GlyGly: 8.188 ± 0.122	2.174GlyHis: 2.174 ± 0.045	5.084GlyIle: 5.084 ± 0.075	2.615GlyLys: 2.615 ± 0.057	9.737GlyLeu: 9.737 ± 0.109	2.452GlyMet: 2.452 ± 0.041	2.112GlyAsn: 2.112 ± 0.049	3.973GlyPro: 3.973 ± 0.059	2.724GlyGln: 2.724 ± 0.049	7.281GlyArg: 7.281 ± 0.093	4.337GlySer: 4.337 ± 0.101	5.009GlyThr: 5.009 ± 0.098	6.193GlyVal: 6.193 ± 0.072	1.45GlyTrp: 1.45 ± 0.039	2.127GlyTyr: 2.127 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	3.004HisAla: 3.004 ± 0.054	0.25HisCys: 0.25 ± 0.014	1.392HisAsp: 1.392 ± 0.035	1.185HisGlu: 1.185 ± 0.033	0.839HisPhe: 0.839 ± 0.027	2.34HisGly: 2.34 ± 0.049	0.715HisHis: 0.715 ± 0.034	0.886HisIle: 0.886 ± 0.028	0.427HisLys: 0.427 ± 0.019	2.283HisLeu: 2.283 ± 0.053	0.487HisMet: 0.487 ± 0.021	0.484HisAsn: 0.484 ± 0.021	1.638HisPro: 1.638 ± 0.04	0.564HisGln: 0.564 ± 0.023	1.781HisArg: 1.781 ± 0.042	0.828HisSer: 0.828 ± 0.026	0.866HisThr: 0.866 ± 0.028	1.755HisVal: 1.755 ± 0.034	0.378HisTrp: 0.378 ± 0.018	0.514HisTyr: 0.514 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.46IleAla: 8.46 ± 0.096	0.453IleCys: 0.453 ± 0.02	3.482IleAsp: 3.482 ± 0.056	3.42IleGlu: 3.42 ± 0.064	1.524IlePhe: 1.524 ± 0.039	5.52IleGly: 5.52 ± 0.065	1.016IleHis: 1.016 ± 0.029	2.022IleIle: 2.022 ± 0.049	0.911IleLys: 0.911 ± 0.031	4.305IleLeu: 4.305 ± 0.066	0.886IleMet: 0.886 ± 0.027	1.243IleAsn: 1.243 ± 0.039	2.399IlePro: 2.399 ± 0.048	0.961IleGln: 0.961 ± 0.033	3.72IleArg: 3.72 ± 0.056	2.656IleSer: 2.656 ± 0.062	2.655IleThr: 2.655 ± 0.06	4.056IleVal: 4.056 ± 0.077	0.566IleTrp: 0.566 ± 0.022	0.933IleTyr: 0.933 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.137LysAla: 3.137 ± 0.07	0.124LysCys: 0.124 ± 0.011	1.068LysAsp: 1.068 ± 0.041	0.868LysGlu: 0.868 ± 0.032	0.744LysPhe: 0.744 ± 0.026	1.835LysGly: 1.835 ± 0.045	0.466LysHis: 0.466 ± 0.021	1.278LysIle: 1.278 ± 0.035	0.736LysLys: 0.736 ± 0.036	2.595LysLeu: 2.595 ± 0.052	0.486LysMet: 0.486 ± 0.022	0.54LysAsn: 0.54 ± 0.025	1.738LysPro: 1.738 ± 0.05	0.729LysGln: 0.729 ± 0.029	1.911LysArg: 1.911 ± 0.042	1.35LysSer: 1.35 ± 0.039	1.436LysThr: 1.436 ± 0.04	1.663LysVal: 1.663 ± 0.042	0.226LysTrp: 0.226 ± 0.014	0.45LysTyr: 0.45 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	17.216LeuAla: 17.216 ± 0.153	0.901LeuCys: 0.901 ± 0.029	6.36LeuAsp: 6.36 ± 0.088	4.424LeuGlu: 4.424 ± 0.072	3.529LeuPhe: 3.529 ± 0.071	9.151LeuGly: 9.151 ± 0.107	2.195LeuHis: 2.195 ± 0.045	4.966LeuIle: 4.966 ± 0.085	2.445LeuLys: 2.445 ± 0.049	10.469LeuLeu: 10.469 ± 0.138	2.054LeuMet: 2.054 ± 0.046	2.325LeuAsn: 2.325 ± 0.044	6.319LeuPro: 6.319 ± 0.081	2.292LeuGln: 2.292 ± 0.044	8.57LeuArg: 8.57 ± 0.093	5.3LeuSer: 5.3 ± 0.078	5.099LeuThr: 5.099 ± 0.078	7.496LeuVal: 7.496 ± 0.088	1.133LeuTrp: 1.133 ± 0.035	1.942LeuTyr: 1.942 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.178MetAla: 3.178 ± 0.047	0.135MetCys: 0.135 ± 0.01	0.976MetAsp: 0.976 ± 0.034	0.942MetGlu: 0.942 ± 0.034	0.691MetPhe: 0.691 ± 0.021	1.578MetGly: 1.578 ± 0.04	0.455MetHis: 0.455 ± 0.019	1.414MetIle: 1.414 ± 0.034	0.801MetLys: 0.801 ± 0.028	2.443MetLeu: 2.443 ± 0.051	0.55MetMet: 0.55 ± 0.024	0.732MetAsn: 0.732 ± 0.025	1.585MetPro: 1.585 ± 0.036	0.743MetGln: 0.743 ± 0.029	1.919MetArg: 1.919 ± 0.042	1.492MetSer: 1.492 ± 0.038	1.795MetThr: 1.795 ± 0.037	1.58MetVal: 1.58 ± 0.039	0.18MetTrp: 0.18 ± 0.012	0.243MetTyr: 0.243 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.049AsnAla: 3.049 ± 0.079	0.209AsnCys: 0.209 ± 0.012	1.153AsnAsp: 1.153 ± 0.031	0.995AsnGlu: 0.995 ± 0.03	0.838AsnPhe: 0.838 ± 0.029	2.132AsnGly: 2.132 ± 0.047	0.499AsnHis: 0.499 ± 0.02	1.179AsnIle: 1.179 ± 0.038	0.471AsnLys: 0.471 ± 0.023	2.352AsnLeu: 2.352 ± 0.043	0.493AsnMet: 0.493 ± 0.024	0.582AsnAsn: 0.582 ± 0.028	1.73AsnPro: 1.73 ± 0.038	0.687AsnGln: 0.687 ± 0.028	1.782AsnArg: 1.782 ± 0.045	1.038AsnSer: 1.038 ± 0.031	1.102AsnThr: 1.102 ± 0.035	1.637AsnVal: 1.637 ± 0.038	0.33AsnTrp: 0.33 ± 0.018	0.568AsnTyr: 0.568 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.625ProAla: 8.625 ± 0.119	0.402ProCys: 0.402 ± 0.019	3.85ProAsp: 3.85 ± 0.065	3.699ProGlu: 3.699 ± 0.055	1.974ProPhe: 1.974 ± 0.038	5.576ProGly: 5.576 ± 0.087	1.335ProHis: 1.335 ± 0.035	2.206ProIle: 2.206 ± 0.047	1.339ProLys: 1.339 ± 0.044	5.058ProLeu: 5.058 ± 0.071	1.232ProMet: 1.232 ± 0.031	1.193ProAsn: 1.193 ± 0.034	3.75ProPro: 3.75 ± 0.096	1.477ProGln: 1.477 ± 0.044	3.929ProArg: 3.929 ± 0.072	2.617ProSer: 2.617 ± 0.048	2.436ProThr: 2.436 ± 0.048	4.604ProVal: 4.604 ± 0.07	0.756ProTrp: 0.756 ± 0.026	1.139ProTyr: 1.139 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.89GlnAla: 3.89 ± 0.068	0.213GlnCys: 0.213 ± 0.013	1.303GlnAsp: 1.303 ± 0.039	1.086GlnGlu: 1.086 ± 0.036	0.951GlnPhe: 0.951 ± 0.029	2.188GlnGly: 2.188 ± 0.037	0.626GlnHis: 0.626 ± 0.026	1.664GlnIle: 1.664 ± 0.036	0.849GlnLys: 0.849 ± 0.029	2.418GlnLeu: 2.418 ± 0.049	0.724GlnMet: 0.724 ± 0.026	0.75GlnAsn: 0.75 ± 0.027	1.564GlnPro: 1.564 ± 0.041	1.019GlnGln: 1.019 ± 0.038	2.214GlnArg: 2.214 ± 0.048	1.462GlnSer: 1.462 ± 0.038	1.525GlnThr: 1.525 ± 0.041	1.96GlnVal: 1.96 ± 0.044	0.292GlnTrp: 0.292 ± 0.016	0.538GlnTyr: 0.538 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	11.217ArgAla: 11.217 ± 0.108	0.662ArgCys: 0.662 ± 0.025	4.308ArgAsp: 4.308 ± 0.063	4.186ArgGlu: 4.186 ± 0.071	3.259ArgPhe: 3.259 ± 0.053	5.836ArgGly: 5.836 ± 0.075	2.401ArgHis: 2.401 ± 0.051	4.564ArgIle: 4.564 ± 0.06	1.928ArgLys: 1.928 ± 0.046	9.633ArgLeu: 9.633 ± 0.125	1.952ArgMet: 1.952 ± 0.043	1.89ArgAsn: 1.89 ± 0.04	4.448ArgPro: 4.448 ± 0.075	2.637ArgGln: 2.637 ± 0.055	8.196ArgArg: 8.196 ± 0.105	3.392ArgSer: 3.392 ± 0.059	3.438ArgThr: 3.438 ± 0.056	4.978ArgVal: 4.978 ± 0.069	1.012ArgTrp: 1.012 ± 0.035	1.655ArgTyr: 1.655 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.041SerAla: 6.041 ± 0.078	0.468SerCys: 0.468 ± 0.02	2.176SerAsp: 2.176 ± 0.048	2.104SerGlu: 2.104 ± 0.047	1.885SerPhe: 1.885 ± 0.045	5.243SerGly: 5.243 ± 0.077	1.014SerHis: 1.014 ± 0.034	2.407SerIle: 2.407 ± 0.067	1.006SerLys: 1.006 ± 0.031	5.14SerLeu: 5.14 ± 0.093	1.143SerMet: 1.143 ± 0.033	1.098SerAsn: 1.098 ± 0.034	2.749SerPro: 2.749 ± 0.054	1.239SerGln: 1.239 ± 0.039	3.492SerArg: 3.492 ± 0.056	2.375SerSer: 2.375 ± 0.062	2.386SerThr: 2.386 ± 0.052	3.56SerVal: 3.56 ± 0.06	0.695SerTrp: 0.695 ± 0.025	1.101SerTyr: 1.101 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.552ThrAla: 6.552 ± 0.078	0.408ThrCys: 0.408 ± 0.018	2.534ThrAsp: 2.534 ± 0.046	2.432ThrGlu: 2.432 ± 0.047	1.615ThrPhe: 1.615 ± 0.035	5.483ThrGly: 5.483 ± 0.196	1.068ThrHis: 1.068 ± 0.03	2.977ThrIle: 2.977 ± 0.066	1.06ThrLys: 1.06 ± 0.037	6.083ThrLeu: 6.083 ± 0.105	1.271ThrMet: 1.271 ± 0.029	1.097ThrAsn: 1.097 ± 0.034	3.343ThrPro: 3.343 ± 0.053	1.144ThrGln: 1.144 ± 0.03	3.564ThrArg: 3.564 ± 0.051	2.394ThrSer: 2.394 ± 0.055	2.776ThrThr: 2.776 ± 0.058	3.966ThrVal: 3.966 ± 0.067	0.592ThrTrp: 0.592 ± 0.027	1.039ThrTyr: 1.039 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.765ValAla: 9.765 ± 0.087	0.601ValCys: 0.601 ± 0.023	3.373ValAsp: 3.373 ± 0.057	3.8ValGlu: 3.8 ± 0.061	2.616ValPhe: 2.616 ± 0.05	5.279ValGly: 5.279 ± 0.068	1.412ValHis: 1.412 ± 0.039	4.094ValIle: 4.094 ± 0.07	1.757ValLys: 1.757 ± 0.048	7.48ValLeu: 7.48 ± 0.083	1.799ValMet: 1.799 ± 0.041	1.864ValAsn: 1.864 ± 0.039	4.083ValPro: 4.083 ± 0.059	1.765ValGln: 1.765 ± 0.044	4.998ValArg: 4.998 ± 0.07	3.768ValSer: 3.768 ± 0.061	4.174ValThr: 4.174 ± 0.07	5.594ValVal: 5.594 ± 0.086	0.876ValTrp: 0.876 ± 0.028	1.25ValTyr: 1.25 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.205TrpAla: 1.205 ± 0.037	0.139TrpCys: 0.139 ± 0.011	0.525TrpAsp: 0.525 ± 0.022	0.484TrpGlu: 0.484 ± 0.023	0.524TrpPhe: 0.524 ± 0.023	0.845TrpGly: 0.845 ± 0.032	0.369TrpHis: 0.369 ± 0.021	0.673TrpIle: 0.673 ± 0.026	0.337TrpLys: 0.337 ± 0.018	1.712TrpLeu: 1.712 ± 0.047	0.309TrpMet: 0.309 ± 0.017	0.372TrpAsn: 0.372 ± 0.018	0.741TrpPro: 0.741 ± 0.027	0.585TrpGln: 0.585 ± 0.024	1.484TrpArg: 1.484 ± 0.039	0.711TrpSer: 0.711 ± 0.024	0.712TrpThr: 0.712 ± 0.025	0.694TrpVal: 0.694 ± 0.025	0.214TrpTrp: 0.214 ± 0.013	0.279TrpTyr: 0.279 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.048	0.21TyrCys: 0.21 ± 0.013	1.185TyrAsp: 1.185 ± 0.032	0.967TyrGlu: 0.967 ± 0.03	0.763TyrPhe: 0.763 ± 0.028	1.938TyrGly: 1.938 ± 0.045	0.483TyrHis: 0.483 ± 0.02	0.758TyrIle: 0.758 ± 0.026	0.428TyrLys: 0.428 ± 0.021	2.04TyrLeu: 2.04 ± 0.044	0.374TyrMet: 0.374 ± 0.018	0.478TyrAsn: 0.478 ± 0.023	1.052TyrPro: 1.052 ± 0.031	0.665TyrGln: 0.665 ± 0.023	1.858TyrArg: 1.858 ± 0.043	0.899TyrSer: 0.899 ± 0.031	0.863TyrThr: 0.863 ± 0.03	1.397TyrVal: 1.397 ± 0.036	0.307TyrTrp: 0.307 ± 0.017	0.518TyrTyr: 0.518 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3521 proteins (1166442 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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