Amino acid dipepetide frequency for Pseudomonas phage YMC/01/01/P52_PAE_BP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.954AlaAla: 14.954 ± 1.793
1.502AlaCys: 1.502 ± 0.304
6.145AlaAsp: 6.145 ± 0.735
7.921AlaGlu: 7.921 ± 0.697
2.117AlaPhe: 2.117 ± 0.361
8.126AlaGly: 8.126 ± 0.864
2.253AlaHis: 2.253 ± 0.382
6.145AlaIle: 6.145 ± 0.578
4.78AlaLys: 4.78 ± 0.6
9.286AlaLeu: 9.286 ± 1.002
3.687AlaMet: 3.687 ± 0.479
3.619AlaAsn: 3.619 ± 0.684
3.96AlaPro: 3.96 ± 0.707
5.463AlaGln: 5.463 ± 0.845
6.897AlaArg: 6.897 ± 0.851
6.214AlaSer: 6.214 ± 0.681
6.623AlaThr: 6.623 ± 1.059
6.828AlaVal: 6.828 ± 0.788
2.526AlaTrp: 2.526 ± 0.36
3.073AlaTyr: 3.073 ± 0.504
0.0AlaXaa: 0.0 ± 0.0
Cys
0.956CysAla: 0.956 ± 0.252
0.205CysCys: 0.205 ± 0.121
0.888CysAsp: 0.888 ± 0.232
0.341CysGlu: 0.341 ± 0.133
0.137CysPhe: 0.137 ± 0.092
1.502CysGly: 1.502 ± 0.312
0.068CysHis: 0.068 ± 0.06
0.341CysIle: 0.341 ± 0.172
0.546CysLys: 0.546 ± 0.185
1.229CysLeu: 1.229 ± 0.236
0.205CysMet: 0.205 ± 0.119
0.478CysAsn: 0.478 ± 0.182
0.751CysPro: 0.751 ± 0.212
0.546CysGln: 0.546 ± 0.173
0.615CysArg: 0.615 ± 0.177
0.546CysSer: 0.546 ± 0.202
0.751CysThr: 0.751 ± 0.183
0.137CysVal: 0.137 ± 0.09
0.273CysTrp: 0.273 ± 0.116
0.137CysTyr: 0.137 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
6.214AspAla: 6.214 ± 0.548
0.683AspCys: 0.683 ± 0.212
3.278AspAsp: 3.278 ± 0.497
4.097AspGlu: 4.097 ± 0.577
2.185AspPhe: 2.185 ± 0.392
5.531AspGly: 5.531 ± 0.642
1.024AspHis: 1.024 ± 0.262
2.868AspIle: 2.868 ± 0.328
2.253AspLys: 2.253 ± 0.378
5.804AspLeu: 5.804 ± 0.619
1.434AspMet: 1.434 ± 0.351
1.571AspAsn: 1.571 ± 0.268
3.209AspPro: 3.209 ± 0.321
3.687AspGln: 3.687 ± 0.53
4.165AspArg: 4.165 ± 0.574
3.141AspSer: 3.141 ± 0.481
2.731AspThr: 2.731 ± 0.438
4.985AspVal: 4.985 ± 0.69
1.024AspTrp: 1.024 ± 0.221
1.434AspTyr: 1.434 ± 0.334
0.0AspXaa: 0.0 ± 0.0
Glu
6.76GluAla: 6.76 ± 0.928
0.683GluCys: 0.683 ± 0.193
3.004GluAsp: 3.004 ± 0.411
3.824GluGlu: 3.824 ± 0.459
2.526GluPhe: 2.526 ± 0.468
3.96GluGly: 3.96 ± 0.471
1.502GluHis: 1.502 ± 0.295
4.302GluIle: 4.302 ± 0.601
2.458GluLys: 2.458 ± 0.513
5.804GluLeu: 5.804 ± 0.591
1.502GluMet: 1.502 ± 0.305
2.253GluAsn: 2.253 ± 0.426
3.073GluPro: 3.073 ± 0.468
3.004GluGln: 3.004 ± 0.46
5.736GluArg: 5.736 ± 0.703
3.619GluSer: 3.619 ± 0.522
2.936GluThr: 2.936 ± 0.33
4.234GluVal: 4.234 ± 0.471
0.956GluTrp: 0.956 ± 0.271
1.775GluTyr: 1.775 ± 0.278
0.0GluXaa: 0.0 ± 0.0
Phe
2.868PheAla: 2.868 ± 0.423
0.068PheCys: 0.068 ± 0.063
2.8PheAsp: 2.8 ± 0.385
1.912PheGlu: 1.912 ± 0.381
0.683PhePhe: 0.683 ± 0.241
2.526PheGly: 2.526 ± 0.431
0.615PheHis: 0.615 ± 0.22
1.571PheIle: 1.571 ± 0.253
1.229PheLys: 1.229 ± 0.267
2.526PheLeu: 2.526 ± 0.391
0.683PheMet: 0.683 ± 0.249
1.229PheAsn: 1.229 ± 0.309
0.888PhePro: 0.888 ± 0.22
0.956PheGln: 0.956 ± 0.236
1.161PheArg: 1.161 ± 0.25
1.912PheSer: 1.912 ± 0.45
1.571PheThr: 1.571 ± 0.332
1.707PheVal: 1.707 ± 0.394
0.341PheTrp: 0.341 ± 0.133
0.751PheTyr: 0.751 ± 0.235
0.0PheXaa: 0.0 ± 0.0
Gly
7.921GlyAla: 7.921 ± 1.052
1.297GlyCys: 1.297 ± 0.319
4.302GlyAsp: 4.302 ± 0.59
4.78GlyGlu: 4.78 ± 0.583
2.117GlyPhe: 2.117 ± 0.467
6.692GlyGly: 6.692 ± 0.768
1.775GlyHis: 1.775 ± 0.278
3.551GlyIle: 3.551 ± 0.397
3.687GlyLys: 3.687 ± 0.424
8.399GlyLeu: 8.399 ± 0.606
2.595GlyMet: 2.595 ± 0.4
2.868GlyAsn: 2.868 ± 0.716
2.663GlyPro: 2.663 ± 0.462
3.96GlyGln: 3.96 ± 0.492
5.258GlyArg: 5.258 ± 0.553
3.687GlySer: 3.687 ± 0.717
4.302GlyThr: 4.302 ± 0.555
5.599GlyVal: 5.599 ± 0.672
1.229GlyTrp: 1.229 ± 0.265
3.073GlyTyr: 3.073 ± 0.431
0.0GlyXaa: 0.0 ± 0.0
His
2.458HisAla: 2.458 ± 0.52
0.478HisCys: 0.478 ± 0.151
1.366HisAsp: 1.366 ± 0.294
1.297HisGlu: 1.297 ± 0.315
0.615HisPhe: 0.615 ± 0.182
1.912HisGly: 1.912 ± 0.351
0.819HisHis: 0.819 ± 0.306
0.615HisIle: 0.615 ± 0.187
0.478HisLys: 0.478 ± 0.169
1.912HisLeu: 1.912 ± 0.373
0.478HisMet: 0.478 ± 0.158
0.615HisAsn: 0.615 ± 0.193
1.366HisPro: 1.366 ± 0.295
1.024HisGln: 1.024 ± 0.318
1.502HisArg: 1.502 ± 0.336
0.683HisSer: 0.683 ± 0.184
1.093HisThr: 1.093 ± 0.28
1.229HisVal: 1.229 ± 0.315
0.137HisTrp: 0.137 ± 0.091
0.273HisTyr: 0.273 ± 0.129
0.0HisXaa: 0.0 ± 0.0
Ile
5.736IleAla: 5.736 ± 0.564
0.478IleCys: 0.478 ± 0.175
4.234IleAsp: 4.234 ± 0.556
3.482IleGlu: 3.482 ± 0.449
1.161IlePhe: 1.161 ± 0.326
3.687IleGly: 3.687 ± 0.504
0.888IleHis: 0.888 ± 0.272
2.39IleIle: 2.39 ± 0.425
2.595IleLys: 2.595 ± 0.459
3.687IleLeu: 3.687 ± 0.479
0.956IleMet: 0.956 ± 0.226
2.048IleAsn: 2.048 ± 0.365
2.595IlePro: 2.595 ± 0.443
1.639IleGln: 1.639 ± 0.367
3.073IleArg: 3.073 ± 0.529
3.004IleSer: 3.004 ± 0.472
3.209IleThr: 3.209 ± 0.424
3.687IleVal: 3.687 ± 0.423
0.888IleTrp: 0.888 ± 0.222
1.434IleTyr: 1.434 ± 0.35
0.0IleXaa: 0.0 ± 0.0
Lys
4.165LysAla: 4.165 ± 0.564
0.341LysCys: 0.341 ± 0.138
1.912LysAsp: 1.912 ± 0.28
2.663LysGlu: 2.663 ± 0.53
0.956LysPhe: 0.956 ± 0.212
3.482LysGly: 3.482 ± 0.406
0.888LysHis: 0.888 ± 0.237
1.571LysIle: 1.571 ± 0.341
1.639LysLys: 1.639 ± 0.344
4.097LysLeu: 4.097 ± 0.533
0.546LysMet: 0.546 ± 0.195
1.229LysAsn: 1.229 ± 0.329
2.663LysPro: 2.663 ± 0.423
1.434LysGln: 1.434 ± 0.247
3.551LysArg: 3.551 ± 0.408
1.775LysSer: 1.775 ± 0.306
2.663LysThr: 2.663 ± 0.45
3.346LysVal: 3.346 ± 0.546
0.615LysTrp: 0.615 ± 0.179
1.229LysTyr: 1.229 ± 0.273
0.0LysXaa: 0.0 ± 0.0
Leu
9.15LeuAla: 9.15 ± 1.08
0.819LeuCys: 0.819 ± 0.217
6.282LeuAsp: 6.282 ± 0.681
4.848LeuGlu: 4.848 ± 0.518
2.253LeuPhe: 2.253 ± 0.372
6.828LeuGly: 6.828 ± 0.739
1.571LeuHis: 1.571 ± 0.33
4.37LeuIle: 4.37 ± 0.574
3.346LeuLys: 3.346 ± 0.393
7.238LeuLeu: 7.238 ± 0.66
1.775LeuMet: 1.775 ± 0.292
3.687LeuAsn: 3.687 ± 0.576
3.687LeuPro: 3.687 ± 0.462
3.756LeuGln: 3.756 ± 0.463
6.487LeuArg: 6.487 ± 0.634
5.599LeuSer: 5.599 ± 0.552
5.394LeuThr: 5.394 ± 0.583
5.736LeuVal: 5.736 ± 0.712
0.751LeuTrp: 0.751 ± 0.233
2.526LeuTyr: 2.526 ± 0.328
0.0LeuXaa: 0.0 ± 0.0
Met
3.414MetAla: 3.414 ± 0.47
0.205MetCys: 0.205 ± 0.103
1.434MetAsp: 1.434 ± 0.291
1.571MetGlu: 1.571 ± 0.354
0.888MetPhe: 0.888 ± 0.235
1.434MetGly: 1.434 ± 0.361
0.341MetHis: 0.341 ± 0.121
1.297MetIle: 1.297 ± 0.299
1.571MetLys: 1.571 ± 0.317
2.048MetLeu: 2.048 ± 0.304
0.273MetMet: 0.273 ± 0.136
1.093MetAsn: 1.093 ± 0.249
1.229MetPro: 1.229 ± 0.274
0.751MetGln: 0.751 ± 0.264
1.844MetArg: 1.844 ± 0.329
1.775MetSer: 1.775 ± 0.372
2.253MetThr: 2.253 ± 0.344
1.434MetVal: 1.434 ± 0.347
0.341MetTrp: 0.341 ± 0.123
0.478MetTyr: 0.478 ± 0.189
0.0MetXaa: 0.0 ± 0.0
Asn
3.278AsnAla: 3.278 ± 0.531
0.478AsnCys: 0.478 ± 0.177
2.185AsnAsp: 2.185 ± 0.425
2.048AsnGlu: 2.048 ± 0.449
1.093AsnPhe: 1.093 ± 0.244
4.234AsnGly: 4.234 ± 0.612
1.024AsnHis: 1.024 ± 0.258
1.229AsnIle: 1.229 ± 0.296
1.434AsnLys: 1.434 ± 0.394
3.073AsnLeu: 3.073 ± 0.533
0.341AsnMet: 0.341 ± 0.145
1.093AsnAsn: 1.093 ± 0.32
1.707AsnPro: 1.707 ± 0.382
1.093AsnGln: 1.093 ± 0.266
2.185AsnArg: 2.185 ± 0.4
2.8AsnSer: 2.8 ± 0.471
1.707AsnThr: 1.707 ± 0.354
1.775AsnVal: 1.775 ± 0.499
0.546AsnTrp: 0.546 ± 0.195
1.093AsnTyr: 1.093 ± 0.261
0.0AsnXaa: 0.0 ± 0.0
Pro
5.599ProAla: 5.599 ± 0.589
0.41ProCys: 0.41 ± 0.14
3.414ProAsp: 3.414 ± 0.453
3.482ProGlu: 3.482 ± 0.422
1.229ProPhe: 1.229 ± 0.299
3.756ProGly: 3.756 ± 0.462
0.615ProHis: 0.615 ± 0.184
1.912ProIle: 1.912 ± 0.359
1.639ProLys: 1.639 ± 0.214
4.712ProLeu: 4.712 ± 0.628
1.229ProMet: 1.229 ± 0.27
1.775ProAsn: 1.775 ± 0.312
1.707ProPro: 1.707 ± 0.284
1.502ProGln: 1.502 ± 0.281
2.731ProArg: 2.731 ± 0.41
3.004ProSer: 3.004 ± 0.402
3.209ProThr: 3.209 ± 0.534
3.073ProVal: 3.073 ± 0.495
0.751ProTrp: 0.751 ± 0.255
1.229ProTyr: 1.229 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
5.804GlnAla: 5.804 ± 1.295
0.546GlnCys: 0.546 ± 0.191
1.775GlnAsp: 1.775 ± 0.361
2.322GlnGlu: 2.322 ± 0.327
1.093GlnPhe: 1.093 ± 0.256
2.253GlnGly: 2.253 ± 0.3
0.683GlnHis: 0.683 ± 0.189
2.458GlnIle: 2.458 ± 0.409
1.297GlnLys: 1.297 ± 0.285
3.004GlnLeu: 3.004 ± 0.528
1.571GlnMet: 1.571 ± 0.316
1.093GlnAsn: 1.093 ± 0.309
2.8GlnPro: 2.8 ± 0.542
3.414GlnGln: 3.414 ± 0.698
3.756GlnArg: 3.756 ± 0.526
1.775GlnSer: 1.775 ± 0.265
2.185GlnThr: 2.185 ± 0.377
3.482GlnVal: 3.482 ± 0.506
0.478GlnTrp: 0.478 ± 0.155
1.639GlnTyr: 1.639 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
8.33ArgAla: 8.33 ± 0.699
0.751ArgCys: 0.751 ± 0.202
4.37ArgAsp: 4.37 ± 0.571
4.643ArgGlu: 4.643 ± 0.647
2.39ArgPhe: 2.39 ± 0.318
4.78ArgGly: 4.78 ± 0.533
2.117ArgHis: 2.117 ± 0.312
4.438ArgIle: 4.438 ± 0.595
2.526ArgLys: 2.526 ± 0.41
6.487ArgLeu: 6.487 ± 0.667
2.048ArgMet: 2.048 ± 0.338
2.322ArgAsn: 2.322 ± 0.346
3.619ArgPro: 3.619 ± 0.559
2.595ArgGln: 2.595 ± 0.383
5.463ArgArg: 5.463 ± 0.69
3.141ArgSer: 3.141 ± 0.465
2.731ArgThr: 2.731 ± 0.415
4.507ArgVal: 4.507 ± 0.472
1.366ArgTrp: 1.366 ± 0.271
2.117ArgTyr: 2.117 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
5.667SerAla: 5.667 ± 0.7
0.478SerCys: 0.478 ± 0.211
3.073SerAsp: 3.073 ± 0.432
3.96SerGlu: 3.96 ± 0.665
1.844SerPhe: 1.844 ± 0.387
5.394SerGly: 5.394 ± 0.816
0.956SerHis: 0.956 ± 0.259
3.346SerIle: 3.346 ± 0.434
2.117SerLys: 2.117 ± 0.399
4.438SerLeu: 4.438 ± 0.45
2.253SerMet: 2.253 ± 0.361
1.707SerAsn: 1.707 ± 0.395
3.687SerPro: 3.687 ± 0.626
2.731SerGln: 2.731 ± 0.383
3.278SerArg: 3.278 ± 0.418
3.346SerSer: 3.346 ± 0.642
2.663SerThr: 2.663 ± 0.533
3.619SerVal: 3.619 ± 0.503
0.956SerTrp: 0.956 ± 0.32
1.229SerTyr: 1.229 ± 0.277
0.0SerXaa: 0.0 ± 0.0
Thr
7.101ThrAla: 7.101 ± 0.832
0.41ThrCys: 0.41 ± 0.142
3.619ThrAsp: 3.619 ± 0.476
3.619ThrGlu: 3.619 ± 0.408
1.707ThrPhe: 1.707 ± 0.441
4.916ThrGly: 4.916 ± 0.64
0.751ThrHis: 0.751 ± 0.211
3.141ThrIle: 3.141 ± 0.573
2.253ThrLys: 2.253 ± 0.402
3.824ThrLeu: 3.824 ± 0.445
1.571ThrMet: 1.571 ± 0.354
1.434ThrAsn: 1.434 ± 0.265
2.595ThrPro: 2.595 ± 0.322
1.844ThrGln: 1.844 ± 0.267
3.619ThrArg: 3.619 ± 0.589
2.936ThrSer: 2.936 ± 0.543
2.663ThrThr: 2.663 ± 0.409
5.258ThrVal: 5.258 ± 0.973
0.956ThrTrp: 0.956 ± 0.195
1.707ThrTyr: 1.707 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
7.511ValAla: 7.511 ± 0.816
0.341ValCys: 0.341 ± 0.147
4.37ValAsp: 4.37 ± 0.53
4.643ValGlu: 4.643 ± 0.541
1.844ValPhe: 1.844 ± 0.313
5.394ValGly: 5.394 ± 0.663
1.434ValHis: 1.434 ± 0.295
3.414ValIle: 3.414 ± 0.44
3.687ValLys: 3.687 ± 0.495
4.848ValLeu: 4.848 ± 0.585
1.434ValMet: 1.434 ± 0.3
2.868ValAsn: 2.868 ± 0.407
3.209ValPro: 3.209 ± 0.52
2.526ValGln: 2.526 ± 0.446
4.712ValArg: 4.712 ± 0.673
4.438ValSer: 4.438 ± 0.666
4.848ValThr: 4.848 ± 0.828
4.985ValVal: 4.985 ± 0.808
0.956ValTrp: 0.956 ± 0.229
1.434ValTyr: 1.434 ± 0.318
0.0ValXaa: 0.0 ± 0.0
Trp
1.639TrpAla: 1.639 ± 0.318
0.068TrpCys: 0.068 ± 0.064
1.161TrpAsp: 1.161 ± 0.247
0.888TrpGlu: 0.888 ± 0.231
0.615TrpPhe: 0.615 ± 0.22
0.751TrpGly: 0.751 ± 0.197
0.41TrpHis: 0.41 ± 0.252
0.888TrpIle: 0.888 ± 0.268
0.683TrpLys: 0.683 ± 0.213
1.366TrpLeu: 1.366 ± 0.266
0.41TrpMet: 0.41 ± 0.154
0.546TrpAsn: 0.546 ± 0.183
0.751TrpPro: 0.751 ± 0.234
0.341TrpGln: 0.341 ± 0.192
1.366TrpArg: 1.366 ± 0.284
1.434TrpSer: 1.434 ± 0.342
0.615TrpThr: 0.615 ± 0.199
1.434TrpVal: 1.434 ± 0.365
0.205TrpTrp: 0.205 ± 0.16
0.341TrpTyr: 0.341 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.595TyrAla: 2.595 ± 0.47
0.41TyrCys: 0.41 ± 0.193
1.707TyrAsp: 1.707 ± 0.344
1.571TyrGlu: 1.571 ± 0.322
0.546TyrPhe: 0.546 ± 0.166
2.595TyrGly: 2.595 ± 0.303
0.615TyrHis: 0.615 ± 0.203
1.024TyrIle: 1.024 ± 0.236
0.546TyrLys: 0.546 ± 0.189
2.322TyrLeu: 2.322 ± 0.388
0.615TyrMet: 0.615 ± 0.197
0.888TyrAsn: 0.888 ± 0.265
0.819TyrPro: 0.819 ± 0.199
1.161TyrGln: 1.161 ± 0.257
3.346TyrArg: 3.346 ± 0.46
1.98TyrSer: 1.98 ± 0.388
1.775TyrThr: 1.775 ± 0.315
1.844TyrVal: 1.844 ± 0.491
0.615TyrTrp: 0.615 ± 0.193
0.478TyrTyr: 0.478 ± 0.156
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (14646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski