Amino acid dipepetide frequency for Tropilaelaps mercedesae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.64AlaAla: 7.64 ± 0.074	1.437AlaCys: 1.437 ± 0.024	3.86AlaAsp: 3.86 ± 0.029	4.611AlaGlu: 4.611 ± 0.043	2.771AlaPhe: 2.771 ± 0.029	5.16AlaGly: 5.16 ± 0.039	1.863AlaHis: 1.863 ± 0.021	3.633AlaIle: 3.633 ± 0.033	3.884AlaLys: 3.884 ± 0.033	7.167AlaLeu: 7.167 ± 0.05	1.806AlaMet: 1.806 ± 0.021	2.98AlaAsn: 2.98 ± 0.026	4.137AlaPro: 4.137 ± 0.045	3.2AlaGln: 3.2 ± 0.031	4.31AlaArg: 4.31 ± 0.035	6.694AlaSer: 6.694 ± 0.047	4.82AlaThr: 4.82 ± 0.036	5.28AlaVal: 5.28 ± 0.035	0.656AlaTrp: 0.656 ± 0.012	1.789AlaTyr: 1.789 ± 0.023	0.001AlaXaa: 0.001 ± 0.0
Cys	1.47CysAla: 1.47 ± 0.022	0.502CysCys: 0.502 ± 0.012	1.144CysAsp: 1.144 ± 0.021	1.164CysGlu: 1.164 ± 0.019	0.778CysPhe: 0.778 ± 0.014	1.473CysGly: 1.473 ± 0.021	0.577CysHis: 0.577 ± 0.014	0.958CysIle: 0.958 ± 0.018	0.906CysLys: 0.906 ± 0.018	1.929CysLeu: 1.929 ± 0.027	0.418CysMet: 0.418 ± 0.011	0.737CysAsn: 0.737 ± 0.016	1.189CysPro: 1.189 ± 0.022	0.825CysGln: 0.825 ± 0.015	1.408CysArg: 1.408 ± 0.025	1.709CysSer: 1.709 ± 0.022	1.074CysThr: 1.074 ± 0.016	1.525CysVal: 1.525 ± 0.027	0.225CysTrp: 0.225 ± 0.006	0.53CysTyr: 0.53 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.901AspAla: 3.901 ± 0.029	1.005AspCys: 1.005 ± 0.018	3.696AspAsp: 3.696 ± 0.037	4.146AspGlu: 4.146 ± 0.036	2.09AspPhe: 2.09 ± 0.022	3.599AspGly: 3.599 ± 0.034	1.224AspHis: 1.224 ± 0.016	2.762AspIle: 2.762 ± 0.029	2.589AspLys: 2.589 ± 0.028	4.701AspLeu: 4.701 ± 0.036	1.153AspMet: 1.153 ± 0.014	2.044AspAsn: 2.044 ± 0.02	2.556AspPro: 2.556 ± 0.025	1.893AspGln: 1.893 ± 0.021	3.062AspArg: 3.062 ± 0.029	3.979AspSer: 3.979 ± 0.028	2.584AspThr: 2.584 ± 0.024	3.674AspVal: 3.674 ± 0.027	0.595AspTrp: 0.595 ± 0.012	1.468AspTyr: 1.468 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.601GluAla: 4.601 ± 0.041	1.184GluCys: 1.184 ± 0.021	3.663GluAsp: 3.663 ± 0.032	4.851GluGlu: 4.851 ± 0.061	2.133GluPhe: 2.133 ± 0.019	3.335GluGly: 3.335 ± 0.031	1.497GluHis: 1.497 ± 0.018	2.86GluIle: 2.86 ± 0.032	3.8GluLys: 3.8 ± 0.042	5.783GluLeu: 5.783 ± 0.045	1.557GluMet: 1.557 ± 0.018	2.587GluAsn: 2.587 ± 0.025	2.677GluPro: 2.677 ± 0.032	2.799GluGln: 2.799 ± 0.03	4.347GluArg: 4.347 ± 0.04	4.063GluSer: 4.063 ± 0.036	3.26GluThr: 3.26 ± 0.032	3.898GluVal: 3.898 ± 0.037	0.663GluTrp: 0.663 ± 0.012	1.555GluTyr: 1.555 ± 0.019	0.001GluXaa: 0.001 ± 0.0
Phe	2.66PheAla: 2.66 ± 0.024	0.884PheCys: 0.884 ± 0.014	2.109PheAsp: 2.109 ± 0.023	2.189PheGlu: 2.189 ± 0.02	1.503PhePhe: 1.503 ± 0.02	2.52PheGly: 2.52 ± 0.029	0.93PheHis: 0.93 ± 0.012	1.798PheIle: 1.798 ± 0.023	1.684PheLys: 1.684 ± 0.022	3.374PheLeu: 3.374 ± 0.031	0.801PheMet: 0.801 ± 0.013	1.446PheAsn: 1.446 ± 0.019	1.613PhePro: 1.613 ± 0.019	1.357PheGln: 1.357 ± 0.017	2.312PheArg: 2.312 ± 0.025	2.848PheSer: 2.848 ± 0.023	2.0PheThr: 2.0 ± 0.022	2.801PheVal: 2.801 ± 0.026	0.427PheTrp: 0.427 ± 0.009	1.203PheTyr: 1.203 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	4.926GlyAla: 4.926 ± 0.04	1.203GlyCys: 1.203 ± 0.023	3.338GlyAsp: 3.338 ± 0.033	3.421GlyGlu: 3.421 ± 0.034	2.323GlyPhe: 2.323 ± 0.023	6.343GlyGly: 6.343 ± 0.091	1.961GlyHis: 1.961 ± 0.026	2.711GlyIle: 2.711 ± 0.026	3.028GlyLys: 3.028 ± 0.029	5.267GlyLeu: 5.267 ± 0.039	1.278GlyMet: 1.278 ± 0.018	2.429GlyAsn: 2.429 ± 0.022	3.449GlyPro: 3.449 ± 0.054	2.827GlyGln: 2.827 ± 0.03	4.062GlyArg: 4.062 ± 0.042	5.745GlySer: 5.745 ± 0.05	3.501GlyThr: 3.501 ± 0.027	4.267GlyVal: 4.267 ± 0.034	0.706GlyTrp: 0.706 ± 0.017	1.901GlyTyr: 1.901 ± 0.028	0.001GlyXaa: 0.001 ± 0.0
His	1.707HisAla: 1.707 ± 0.017	0.601HisCys: 0.601 ± 0.01	1.175HisAsp: 1.175 ± 0.016	1.406HisGlu: 1.406 ± 0.015	1.068HisPhe: 1.068 ± 0.016	1.771HisGly: 1.771 ± 0.023	1.114HisHis: 1.114 ± 0.024	1.27HisIle: 1.27 ± 0.017	1.203HisLys: 1.203 ± 0.015	2.653HisLeu: 2.653 ± 0.027	0.621HisMet: 0.621 ± 0.011	1.026HisAsn: 1.026 ± 0.016	1.567HisPro: 1.567 ± 0.02	1.331HisGln: 1.331 ± 0.024	1.865HisArg: 1.865 ± 0.021	2.136HisSer: 2.136 ± 0.021	1.461HisThr: 1.461 ± 0.027	1.718HisVal: 1.718 ± 0.019	0.29HisTrp: 0.29 ± 0.008	0.776HisTyr: 0.776 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.494IleAla: 3.494 ± 0.031	1.088IleCys: 1.088 ± 0.017	2.64IleAsp: 2.64 ± 0.024	3.006IleGlu: 3.006 ± 0.039	1.758IlePhe: 1.758 ± 0.021	2.765IleGly: 2.765 ± 0.028	1.215IleHis: 1.215 ± 0.019	2.245IleIle: 2.245 ± 0.027	2.349IleLys: 2.349 ± 0.027	4.193IleLeu: 4.193 ± 0.039	1.005IleMet: 1.005 ± 0.017	1.831IleAsn: 1.831 ± 0.022	2.315IlePro: 2.315 ± 0.024	1.898IleGln: 1.898 ± 0.022	2.903IleArg: 2.903 ± 0.024	3.62IleSer: 3.62 ± 0.03	2.529IleThr: 2.529 ± 0.026	3.316IleVal: 3.316 ± 0.033	0.468IleTrp: 0.468 ± 0.01	1.424IleTyr: 1.424 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.76LysAla: 3.76 ± 0.034	1.017LysCys: 1.017 ± 0.017	2.907LysAsp: 2.907 ± 0.033	3.574LysGlu: 3.574 ± 0.043	1.711LysPhe: 1.711 ± 0.019	2.736LysGly: 2.736 ± 0.028	1.283LysHis: 1.283 ± 0.017	2.542LysIle: 2.542 ± 0.026	3.765LysLys: 3.765 ± 0.05	4.702LysLeu: 4.702 ± 0.034	1.361LysMet: 1.361 ± 0.019	2.135LysAsn: 2.135 ± 0.022	2.574LysPro: 2.574 ± 0.041	2.201LysGln: 2.201 ± 0.022	3.52LysArg: 3.52 ± 0.034	3.467LysSer: 3.467 ± 0.032	2.895LysThr: 2.895 ± 0.025	3.203LysVal: 3.203 ± 0.029	0.521LysTrp: 0.521 ± 0.012	1.431LysTyr: 1.431 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.359LeuAla: 7.359 ± 0.048	2.039LeuCys: 2.039 ± 0.025	4.785LeuAsp: 4.785 ± 0.032	5.775LeuGlu: 5.775 ± 0.053	3.363LeuPhe: 3.363 ± 0.03	5.089LeuGly: 5.089 ± 0.036	2.523LeuHis: 2.523 ± 0.025	3.985LeuIle: 3.985 ± 0.031	4.933LeuLys: 4.933 ± 0.039	9.153LeuLeu: 9.153 ± 0.076	1.992LeuMet: 1.992 ± 0.021	3.612LeuAsn: 3.612 ± 0.027	5.14LeuPro: 5.14 ± 0.038	4.454LeuGln: 4.454 ± 0.038	6.392LeuArg: 6.392 ± 0.047	7.484LeuSer: 7.484 ± 0.051	5.048LeuThr: 5.048 ± 0.032	5.897LeuVal: 5.897 ± 0.045	1.022LeuTrp: 1.022 ± 0.016	2.434LeuTyr: 2.434 ± 0.024	0.002LeuXaa: 0.002 ± 0.001
Met	2.112MetAla: 2.112 ± 0.023	0.488MetCys: 0.488 ± 0.012	1.197MetAsp: 1.197 ± 0.017	1.398MetGlu: 1.398 ± 0.018	0.87MetPhe: 0.87 ± 0.012	1.317MetGly: 1.317 ± 0.02	0.565MetHis: 0.565 ± 0.011	0.915MetIle: 0.915 ± 0.012	1.218MetLys: 1.218 ± 0.017	2.146MetLeu: 2.146 ± 0.021	0.632MetMet: 0.632 ± 0.012	0.861MetAsn: 0.861 ± 0.015	1.179MetPro: 1.179 ± 0.019	0.951MetGln: 0.951 ± 0.017	1.415MetArg: 1.415 ± 0.017	1.848MetSer: 1.848 ± 0.021	1.29MetThr: 1.29 ± 0.015	1.415MetVal: 1.415 ± 0.016	0.233MetTrp: 0.233 ± 0.007	0.611MetTyr: 0.611 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.026	0.809AsnCys: 0.809 ± 0.014	2.067AsnAsp: 2.067 ± 0.023	2.365AsnGlu: 2.365 ± 0.021	1.492AsnPhe: 1.492 ± 0.018	2.938AsnGly: 2.938 ± 0.026	0.991AsnHis: 0.991 ± 0.016	2.047AsnIle: 2.047 ± 0.022	1.965AsnLys: 1.965 ± 0.025	3.413AsnLeu: 3.413 ± 0.028	0.89AsnMet: 0.89 ± 0.014	2.169AsnAsn: 2.169 ± 0.034	2.019AsnPro: 2.019 ± 0.02	1.581AsnGln: 1.581 ± 0.021	2.38AsnArg: 2.38 ± 0.021	3.226AsnSer: 3.226 ± 0.028	1.996AsnThr: 1.996 ± 0.021	2.726AsnVal: 2.726 ± 0.022	0.403AsnTrp: 0.403 ± 0.01	1.121AsnTyr: 1.121 ± 0.017	0.001AsnXaa: 0.001 ± 0.0
Pro	4.397ProAla: 4.397 ± 0.045	0.859ProCys: 0.859 ± 0.015	2.626ProAsp: 2.626 ± 0.023	3.179ProGlu: 3.179 ± 0.031	1.832ProPhe: 1.832 ± 0.023	3.559ProGly: 3.559 ± 0.059	1.44ProHis: 1.44 ± 0.019	2.283ProIle: 2.283 ± 0.025	2.454ProLys: 2.454 ± 0.027	4.866ProLeu: 4.866 ± 0.033	1.147ProMet: 1.147 ± 0.018	1.972ProAsn: 1.972 ± 0.022	4.996ProPro: 4.996 ± 0.072	2.488ProGln: 2.488 ± 0.034	3.088ProArg: 3.088 ± 0.029	5.169ProSer: 5.169 ± 0.048	3.45ProThr: 3.45 ± 0.037	3.843ProVal: 3.843 ± 0.041	0.508ProTrp: 0.508 ± 0.01	1.352ProTyr: 1.352 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	3.232GlnAla: 3.232 ± 0.034	0.847GlnCys: 0.847 ± 0.017	1.885GlnAsp: 1.885 ± 0.022	2.531GlnGlu: 2.531 ± 0.028	1.376GlnPhe: 1.376 ± 0.016	2.444GlnGly: 2.444 ± 0.034	1.382GlnHis: 1.382 ± 0.023	1.927GlnIle: 1.927 ± 0.022	2.218GlnLys: 2.218 ± 0.024	4.638GlnLeu: 4.638 ± 0.04	1.195GlnMet: 1.195 ± 0.016	1.646GlnAsn: 1.646 ± 0.018	2.505GlnPro: 2.505 ± 0.032	4.059GlnGln: 4.059 ± 0.098	3.099GlnArg: 3.099 ± 0.029	2.999GlnSer: 2.999 ± 0.028	2.415GlnThr: 2.415 ± 0.024	2.613GlnVal: 2.613 ± 0.023	0.479GlnTrp: 0.479 ± 0.01	1.038GlnTyr: 1.038 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.285ArgAla: 4.285 ± 0.031	1.451ArgCys: 1.451 ± 0.02	3.189ArgAsp: 3.189 ± 0.026	3.93ArgGlu: 3.93 ± 0.038	2.357ArgPhe: 2.357 ± 0.024	3.627ArgGly: 3.627 ± 0.034	1.831ArgHis: 1.831 ± 0.018	2.889ArgIle: 2.889 ± 0.023	3.672ArgLys: 3.672 ± 0.03	6.107ArgLeu: 6.107 ± 0.046	1.443ArgMet: 1.443 ± 0.019	2.556ArgAsn: 2.556 ± 0.022	3.48ArgPro: 3.48 ± 0.032	2.965ArgGln: 2.965 ± 0.028	5.505ArgArg: 5.505 ± 0.048	5.141ArgSer: 5.141 ± 0.045	3.475ArgThr: 3.475 ± 0.027	3.92ArgVal: 3.92 ± 0.029	0.766ArgTrp: 0.766 ± 0.013	1.747ArgTyr: 1.747 ± 0.02	0.001ArgXaa: 0.001 ± 0.0
Ser	6.533SerAla: 6.533 ± 0.042	1.603SerCys: 1.603 ± 0.023	4.076SerAsp: 4.076 ± 0.036	4.388SerGlu: 4.388 ± 0.04	2.812SerPhe: 2.812 ± 0.024	5.917SerGly: 5.917 ± 0.043	2.038SerHis: 2.038 ± 0.022	3.522SerIle: 3.522 ± 0.032	3.698SerLys: 3.698 ± 0.031	7.31SerLeu: 7.31 ± 0.048	1.739SerMet: 1.739 ± 0.017	3.105SerAsn: 3.105 ± 0.029	5.033SerPro: 5.033 ± 0.062	3.277SerGln: 3.277 ± 0.034	4.947SerArg: 4.947 ± 0.041	9.072SerSer: 9.072 ± 0.074	5.26SerThr: 5.26 ± 0.05	5.209SerVal: 5.209 ± 0.037	0.823SerTrp: 0.823 ± 0.012	1.995SerTyr: 1.995 ± 0.027	0.001SerXaa: 0.001 ± 0.0
Thr	4.776ThrAla: 4.776 ± 0.035	1.159ThrCys: 1.159 ± 0.018	2.721ThrAsp: 2.721 ± 0.028	3.099ThrGlu: 3.099 ± 0.038	2.052ThrPhe: 2.052 ± 0.022	3.817ThrGly: 3.817 ± 0.029	1.471ThrHis: 1.471 ± 0.029	2.697ThrIle: 2.697 ± 0.027	2.705ThrLys: 2.705 ± 0.034	5.244ThrLeu: 5.244 ± 0.036	1.248ThrMet: 1.248 ± 0.018	2.215ThrAsn: 2.215 ± 0.021	3.713ThrPro: 3.713 ± 0.039	2.194ThrGln: 2.194 ± 0.024	3.12ThrArg: 3.12 ± 0.025	5.171ThrSer: 5.171 ± 0.041	4.06ThrThr: 4.06 ± 0.046	3.884ThrVal: 3.884 ± 0.031	0.523ThrTrp: 0.523 ± 0.01	1.404ThrTyr: 1.404 ± 0.022	0.001ThrXaa: 0.001 ± 0.0
Val	5.39ValAla: 5.39 ± 0.04	1.527ValCys: 1.527 ± 0.024	3.649ValAsp: 3.649 ± 0.025	3.995ValGlu: 3.995 ± 0.036	2.568ValPhe: 2.568 ± 0.022	3.884ValGly: 3.884 ± 0.031	1.832ValHis: 1.832 ± 0.021	3.159ValIle: 3.159 ± 0.03	3.351ValLys: 3.351 ± 0.029	6.167ValLeu: 6.167 ± 0.042	1.415ValMet: 1.415 ± 0.017	2.617ValAsn: 2.617 ± 0.023	3.586ValPro: 3.586 ± 0.034	2.676ValGln: 2.676 ± 0.025	4.033ValArg: 4.033 ± 0.031	5.175ValSer: 5.175 ± 0.036	3.996ValThr: 3.996 ± 0.027	4.921ValVal: 4.921 ± 0.038	0.678ValTrp: 0.678 ± 0.015	1.865ValTyr: 1.865 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.664TrpAla: 0.664 ± 0.014	0.244TrpCys: 0.244 ± 0.007	0.542TrpAsp: 0.542 ± 0.012	0.554TrpGlu: 0.554 ± 0.011	0.436TrpPhe: 0.436 ± 0.01	0.524TrpGly: 0.524 ± 0.012	0.268TrpHis: 0.268 ± 0.007	0.515TrpIle: 0.515 ± 0.013	0.604TrpLys: 0.604 ± 0.012	1.099TrpLeu: 1.099 ± 0.017	0.304TrpMet: 0.304 ± 0.008	0.467TrpAsn: 0.467 ± 0.01	0.487TrpPro: 0.487 ± 0.011	0.442TrpGln: 0.442 ± 0.01	0.754TrpArg: 0.754 ± 0.013	0.821TrpSer: 0.821 ± 0.015	0.688TrpThr: 0.688 ± 0.015	0.579TrpVal: 0.579 ± 0.012	0.178TrpTrp: 0.178 ± 0.007	0.309TrpTyr: 0.309 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.84TyrAla: 1.84 ± 0.021	0.593TyrCys: 0.593 ± 0.013	1.45TyrAsp: 1.45 ± 0.017	1.531TyrGlu: 1.531 ± 0.017	1.165TyrPhe: 1.165 ± 0.016	1.867TyrGly: 1.867 ± 0.029	0.756TyrHis: 0.756 ± 0.013	1.346TyrIle: 1.346 ± 0.018	1.28TyrLys: 1.28 ± 0.016	2.57TyrLeu: 2.57 ± 0.024	0.655TyrMet: 0.655 ± 0.011	1.108TyrAsn: 1.108 ± 0.017	1.292TyrPro: 1.292 ± 0.022	1.11TyrGln: 1.11 ± 0.016	1.817TyrArg: 1.817 ± 0.02	1.992TyrSer: 1.992 ± 0.025	1.473TyrThr: 1.473 ± 0.021	1.793TyrVal: 1.793 ± 0.022	0.317TyrTrp: 0.317 ± 0.009	0.901TyrTyr: 0.901 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.135XaaXaa: 0.135 ± 0.062

Statistics based on 14292 proteins (5410289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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