Amino acid dipepetide frequency for Dichelobacter nodosus (strain VCS1703A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.831AlaAla: 11.831 ± 0.264
0.974AlaCys: 0.974 ± 0.052
5.321AlaAsp: 5.321 ± 0.126
6.673AlaGlu: 6.673 ± 0.177
3.713AlaPhe: 3.713 ± 0.109
6.513AlaGly: 6.513 ± 0.151
2.545AlaHis: 2.545 ± 0.083
5.887AlaIle: 5.887 ± 0.138
4.769AlaLys: 4.769 ± 0.155
11.658AlaLeu: 11.658 ± 0.207
2.502AlaMet: 2.502 ± 0.079
2.838AlaAsn: 2.838 ± 0.081
3.713AlaPro: 3.713 ± 0.119
6.28AlaGln: 6.28 ± 0.19
5.563AlaArg: 5.563 ± 0.142
4.404AlaSer: 4.404 ± 0.124
4.176AlaThr: 4.176 ± 0.113
7.352AlaVal: 7.352 ± 0.13
1.043AlaTrp: 1.043 ± 0.063
2.679AlaTyr: 2.679 ± 0.079
0.002AlaXaa: 0.002 ± 0.003
Cys
1.319CysAla: 1.319 ± 0.056
0.19CysCys: 0.19 ± 0.024
0.652CysAsp: 0.652 ± 0.052
0.557CysGlu: 0.557 ± 0.031
0.501CysPhe: 0.501 ± 0.037
1.07CysGly: 1.07 ± 0.06
0.338CysHis: 0.338 ± 0.032
0.636CysIle: 0.636 ± 0.045
0.254CysLys: 0.254 ± 0.023
1.079CysLeu: 1.079 ± 0.056
0.187CysMet: 0.187 ± 0.023
0.285CysAsn: 0.285 ± 0.025
0.458CysPro: 0.458 ± 0.035
0.573CysGln: 0.573 ± 0.042
0.748CysArg: 0.748 ± 0.04
0.698CysSer: 0.698 ± 0.039
0.53CysThr: 0.53 ± 0.034
0.664CysVal: 0.664 ± 0.038
0.146CysTrp: 0.146 ± 0.021
0.405CysTyr: 0.405 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
5.059AspAla: 5.059 ± 0.13
0.715AspCys: 0.715 ± 0.057
3.296AspAsp: 3.296 ± 0.135
3.963AspGlu: 3.963 ± 0.107
2.883AspPhe: 2.883 ± 0.093
3.766AspGly: 3.766 ± 0.16
1.185AspHis: 1.185 ± 0.057
3.735AspIle: 3.735 ± 0.105
2.751AspLys: 2.751 ± 0.102
5.323AspLeu: 5.323 ± 0.122
1.108AspMet: 1.108 ± 0.058
2.013AspAsn: 2.013 ± 0.098
2.063AspPro: 2.063 ± 0.116
1.67AspGln: 1.67 ± 0.061
2.629AspArg: 2.629 ± 0.085
2.473AspSer: 2.473 ± 0.097
2.286AspThr: 2.286 ± 0.084
3.473AspVal: 3.473 ± 0.1
0.864AspTrp: 0.864 ± 0.049
2.214AspTyr: 2.214 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
5.433GluAla: 5.433 ± 0.164
0.53GluCys: 0.53 ± 0.036
2.572GluAsp: 2.572 ± 0.094
4.078GluGlu: 4.078 ± 0.132
1.878GluPhe: 1.878 ± 0.067
2.891GluGly: 2.891 ± 0.094
1.845GluHis: 1.845 ± 0.079
4.692GluIle: 4.692 ± 0.106
4.99GluLys: 4.99 ± 0.133
5.755GluLeu: 5.755 ± 0.125
1.679GluMet: 1.679 ± 0.069
2.975GluAsn: 2.975 ± 0.11
2.051GluPro: 2.051 ± 0.08
3.903GluGln: 3.903 ± 0.137
4.09GluArg: 4.09 ± 0.115
3.07GluSer: 3.07 ± 0.084
3.416GluThr: 3.416 ± 0.109
3.133GluVal: 3.133 ± 0.097
0.576GluTrp: 0.576 ± 0.038
1.646GluTyr: 1.646 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
4.277PheAla: 4.277 ± 0.111
0.657PheCys: 0.657 ± 0.042
2.495PheAsp: 2.495 ± 0.092
2.061PheGlu: 2.061 ± 0.065
2.329PhePhe: 2.329 ± 0.088
2.699PheGly: 2.699 ± 0.098
1.067PheHis: 1.067 ± 0.044
2.991PheIle: 2.991 ± 0.091
1.547PheLys: 1.547 ± 0.057
4.507PheLeu: 4.507 ± 0.116
1.034PheMet: 1.034 ± 0.053
1.626PheAsn: 1.626 ± 0.071
1.602PhePro: 1.602 ± 0.066
1.379PheGln: 1.379 ± 0.059
1.641PheArg: 1.641 ± 0.072
3.27PheSer: 3.27 ± 0.105
2.101PheThr: 2.101 ± 0.076
2.648PheVal: 2.648 ± 0.092
0.652PheTrp: 0.652 ± 0.044
1.571PheTyr: 1.571 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
5.793GlyAla: 5.793 ± 0.129
0.808GlyCys: 0.808 ± 0.048
3.596GlyAsp: 3.596 ± 0.108
3.776GlyGlu: 3.776 ± 0.098
3.034GlyPhe: 3.034 ± 0.079
4.714GlyGly: 4.714 ± 0.147
1.377GlyHis: 1.377 ± 0.053
4.951GlyIle: 4.951 ± 0.116
4.219GlyLys: 4.219 ± 0.13
6.165GlyLeu: 6.165 ± 0.137
1.725GlyMet: 1.725 ± 0.067
2.396GlyAsn: 2.396 ± 0.09
0.88GlyPro: 0.88 ± 0.049
2.468GlyGln: 2.468 ± 0.074
3.198GlyArg: 3.198 ± 0.091
3.663GlySer: 3.663 ± 0.101
3.236GlyThr: 3.236 ± 0.096
4.558GlyVal: 4.558 ± 0.102
0.753GlyTrp: 0.753 ± 0.045
2.279GlyTyr: 2.279 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
2.236HisAla: 2.236 ± 0.077
0.456HisCys: 0.456 ± 0.037
1.415HisAsp: 1.415 ± 0.06
1.346HisGlu: 1.346 ± 0.058
1.387HisPhe: 1.387 ± 0.057
1.734HisGly: 1.734 ± 0.059
1.077HisHis: 1.077 ± 0.064
1.83HisIle: 1.83 ± 0.068
0.94HisLys: 0.94 ± 0.048
2.814HisLeu: 2.814 ± 0.095
0.429HisMet: 0.429 ± 0.034
0.96HisAsn: 0.96 ± 0.05
1.051HisPro: 1.051 ± 0.053
1.415HisGln: 1.415 ± 0.065
1.415HisArg: 1.415 ± 0.062
1.231HisSer: 1.231 ± 0.059
1.015HisThr: 1.015 ± 0.052
1.267HisVal: 1.267 ± 0.065
0.468HisTrp: 0.468 ± 0.04
1.379HisTyr: 1.379 ± 0.061
0.0HisXaa: 0.0 ± 0.0
Ile
7.918IleAla: 7.918 ± 0.156
0.787IleCys: 0.787 ± 0.04
4.411IleAsp: 4.411 ± 0.107
4.493IleGlu: 4.493 ± 0.127
2.783IlePhe: 2.783 ± 0.093
4.733IleGly: 4.733 ± 0.142
1.605IleHis: 1.605 ± 0.065
4.263IleIle: 4.263 ± 0.127
3.006IleLys: 3.006 ± 0.095
5.954IleLeu: 5.954 ± 0.153
1.317IleMet: 1.317 ± 0.059
2.943IleAsn: 2.943 ± 0.088
2.55IlePro: 2.55 ± 0.078
2.065IleGln: 2.065 ± 0.072
3.421IleArg: 3.421 ± 0.09
4.263IleSer: 4.263 ± 0.115
3.821IleThr: 3.821 ± 0.111
4.654IleVal: 4.654 ± 0.097
0.59IleTrp: 0.59 ± 0.042
2.022IleTyr: 2.022 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
4.601LysAla: 4.601 ± 0.156
0.269LysCys: 0.269 ± 0.025
2.365LysAsp: 2.365 ± 0.115
3.344LysGlu: 3.344 ± 0.131
1.271LysPhe: 1.271 ± 0.057
2.612LysGly: 2.612 ± 0.093
1.007LysHis: 1.007 ± 0.048
4.056LysIle: 4.056 ± 0.086
3.485LysLys: 3.485 ± 0.108
3.975LysLeu: 3.975 ± 0.104
1.622LysMet: 1.622 ± 0.074
2.958LysAsn: 2.958 ± 0.084
2.262LysPro: 2.262 ± 0.098
2.329LysGln: 2.329 ± 0.087
2.958LysArg: 2.958 ± 0.082
2.838LysSer: 2.838 ± 0.076
3.912LysThr: 3.912 ± 0.094
2.816LysVal: 2.816 ± 0.085
0.475LysTrp: 0.475 ± 0.036
1.31LysTyr: 1.31 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
10.574LeuAla: 10.574 ± 0.202
1.291LeuCys: 1.291 ± 0.065
5.301LeuAsp: 5.301 ± 0.132
5.779LeuGlu: 5.779 ± 0.12
4.275LeuPhe: 4.275 ± 0.132
6.446LeuGly: 6.446 ± 0.135
2.485LeuHis: 2.485 ± 0.08
6.659LeuIle: 6.659 ± 0.158
5.229LeuLys: 5.229 ± 0.122
11.02LeuLeu: 11.02 ± 0.252
2.663LeuMet: 2.663 ± 0.092
4.236LeuAsn: 4.236 ± 0.104
5.659LeuPro: 5.659 ± 0.137
4.649LeuGln: 4.649 ± 0.124
5.493LeuArg: 5.493 ± 0.119
7.273LeuSer: 7.273 ± 0.161
6.026LeuThr: 6.026 ± 0.145
5.486LeuVal: 5.486 ± 0.142
1.243LeuTrp: 1.243 ± 0.061
2.569LeuTyr: 2.569 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
2.097MetAla: 2.097 ± 0.067
0.168MetCys: 0.168 ± 0.018
1.019MetAsp: 1.019 ± 0.047
1.163MetGlu: 1.163 ± 0.055
0.657MetPhe: 0.657 ± 0.042
1.451MetGly: 1.451 ± 0.059
0.645MetHis: 0.645 ± 0.039
1.876MetIle: 1.876 ± 0.072
1.339MetLys: 1.339 ± 0.057
2.344MetLeu: 2.344 ± 0.08
0.89MetMet: 0.89 ± 0.052
1.303MetAsn: 1.303 ± 0.063
1.315MetPro: 1.315 ± 0.059
1.406MetGln: 1.406 ± 0.064
1.624MetArg: 1.624 ± 0.071
1.538MetSer: 1.538 ± 0.065
1.538MetThr: 1.538 ± 0.068
1.391MetVal: 1.391 ± 0.06
0.146MetTrp: 0.146 ± 0.019
0.47MetTyr: 0.47 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.951AsnAla: 3.951 ± 0.099
0.441AsnCys: 0.441 ± 0.04
2.221AsnAsp: 2.221 ± 0.088
2.267AsnGlu: 2.267 ± 0.081
1.372AsnPhe: 1.372 ± 0.06
2.775AsnGly: 2.775 ± 0.097
1.19AsnHis: 1.19 ± 0.051
2.646AsnIle: 2.646 ± 0.092
1.706AsnLys: 1.706 ± 0.069
3.267AsnLeu: 3.267 ± 0.099
0.89AsnMet: 0.89 ± 0.043
1.473AsnAsn: 1.473 ± 0.072
2.24AsnPro: 2.24 ± 0.14
1.835AsnGln: 1.835 ± 0.082
2.24AsnArg: 2.24 ± 0.07
1.809AsnSer: 1.809 ± 0.072
1.984AsnThr: 1.984 ± 0.065
2.548AsnVal: 2.548 ± 0.076
0.509AsnTrp: 0.509 ± 0.033
1.363AsnTyr: 1.363 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
3.972ProAla: 3.972 ± 0.131
0.374ProCys: 0.374 ± 0.033
2.61ProAsp: 2.61 ± 0.088
3.673ProGlu: 3.673 ± 0.138
1.893ProPhe: 1.893 ± 0.071
1.19ProGly: 1.19 ± 0.066
1.154ProHis: 1.154 ± 0.053
2.536ProIle: 2.536 ± 0.089
2.008ProLys: 2.008 ± 0.077
4.138ProLeu: 4.138 ± 0.122
0.933ProMet: 0.933 ± 0.049
1.6ProAsn: 1.6 ± 0.061
1.742ProPro: 1.742 ± 0.084
2.252ProGln: 2.252 ± 0.081
1.754ProArg: 1.754 ± 0.069
2.073ProSer: 2.073 ± 0.068
1.866ProThr: 1.866 ± 0.097
2.924ProVal: 2.924 ± 0.104
0.463ProTrp: 0.463 ± 0.037
1.269ProTyr: 1.269 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
4.634GlnAla: 4.634 ± 0.134
0.451GlnCys: 0.451 ± 0.039
1.73GlnAsp: 1.73 ± 0.06
3.133GlnGlu: 3.133 ± 0.112
1.993GlnPhe: 1.993 ± 0.063
2.382GlnGly: 2.382 ± 0.073
1.382GlnHis: 1.382 ± 0.061
3.092GlnIle: 3.092 ± 0.096
3.466GlnLys: 3.466 ± 0.107
5.637GlnLeu: 5.637 ± 0.164
1.259GlnMet: 1.259 ± 0.064
2.296GlnAsn: 2.296 ± 0.087
1.83GlnPro: 1.83 ± 0.075
3.49GlnGln: 3.49 ± 0.165
3.193GlnArg: 3.193 ± 0.116
2.514GlnSer: 2.514 ± 0.069
2.843GlnThr: 2.843 ± 0.091
2.125GlnVal: 2.125 ± 0.069
0.662GlnTrp: 0.662 ± 0.043
1.456GlnTyr: 1.456 ± 0.06
0.0GlnXaa: 0.0 ± 0.0
Arg
5.397ArgAla: 5.397 ± 0.133
0.669ArgCys: 0.669 ± 0.036
2.97ArgAsp: 2.97 ± 0.093
3.284ArgGlu: 3.284 ± 0.102
2.857ArgPhe: 2.857 ± 0.084
3.497ArgGly: 3.497 ± 0.079
1.547ArgHis: 1.547 ± 0.068
3.572ArgIle: 3.572 ± 0.099
2.44ArgLys: 2.44 ± 0.089
6.199ArgLeu: 6.199 ± 0.144
1.214ArgMet: 1.214 ± 0.055
1.845ArgAsn: 1.845 ± 0.065
1.974ArgPro: 1.974 ± 0.085
3.066ArgGln: 3.066 ± 0.103
3.38ArgArg: 3.38 ± 0.102
2.593ArgSer: 2.593 ± 0.082
2.034ArgThr: 2.034 ± 0.072
3.476ArgVal: 3.476 ± 0.098
0.734ArgTrp: 0.734 ± 0.043
2.212ArgTyr: 2.212 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
5.899SerAla: 5.899 ± 0.137
0.64SerCys: 0.64 ± 0.045
3.222SerAsp: 3.222 ± 0.097
3.246SerGlu: 3.246 ± 0.099
2.504SerPhe: 2.504 ± 0.089
4.846SerGly: 4.846 ± 0.106
1.175SerHis: 1.175 ± 0.052
3.274SerIle: 3.274 ± 0.093
2.231SerLys: 2.231 ± 0.068
5.853SerLeu: 5.853 ± 0.119
1.401SerMet: 1.401 ± 0.058
1.861SerAsn: 1.861 ± 0.07
2.085SerPro: 2.085 ± 0.074
2.267SerGln: 2.267 ± 0.068
2.696SerArg: 2.696 ± 0.081
3.224SerSer: 3.224 ± 0.1
2.504SerThr: 2.504 ± 0.086
3.812SerVal: 3.812 ± 0.092
0.638SerTrp: 0.638 ± 0.039
1.684SerTyr: 1.684 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
5.872ThrAla: 5.872 ± 0.144
0.341ThrCys: 0.341 ± 0.031
2.562ThrAsp: 2.562 ± 0.104
2.667ThrGlu: 2.667 ± 0.097
1.967ThrPhe: 1.967 ± 0.066
3.514ThrGly: 3.514 ± 0.091
1.401ThrHis: 1.401 ± 0.06
3.728ThrIle: 3.728 ± 0.112
1.842ThrLys: 1.842 ± 0.08
6.448ThrLeu: 6.448 ± 0.132
1.043ThrMet: 1.043 ± 0.051
1.535ThrAsn: 1.535 ± 0.074
2.737ThrPro: 2.737 ± 0.091
2.449ThrGln: 2.449 ± 0.088
2.42ThrArg: 2.42 ± 0.069
2.188ThrSer: 2.188 ± 0.067
2.691ThrThr: 2.691 ± 0.086
3.704ThrVal: 3.704 ± 0.097
0.489ThrTrp: 0.489 ± 0.04
1.274ThrTyr: 1.274 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
6.033ValAla: 6.033 ± 0.133
0.864ValCys: 0.864 ± 0.045
3.569ValAsp: 3.569 ± 0.104
3.529ValGlu: 3.529 ± 0.119
2.828ValPhe: 2.828 ± 0.094
3.874ValGly: 3.874 ± 0.113
1.399ValHis: 1.399 ± 0.063
4.865ValIle: 4.865 ± 0.113
2.838ValLys: 2.838 ± 0.103
6.786ValLeu: 6.786 ± 0.134
1.799ValMet: 1.799 ± 0.077
2.408ValAsn: 2.408 ± 0.084
2.526ValPro: 2.526 ± 0.087
2.377ValGln: 2.377 ± 0.078
3.361ValArg: 3.361 ± 0.1
3.85ValSer: 3.85 ± 0.101
3.056ValThr: 3.056 ± 0.091
4.411ValVal: 4.411 ± 0.108
0.581ValTrp: 0.581 ± 0.04
1.866ValTyr: 1.866 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.904TrpAla: 0.904 ± 0.052
0.149TrpCys: 0.149 ± 0.022
0.42TrpAsp: 0.42 ± 0.035
0.492TrpGlu: 0.492 ± 0.036
0.521TrpPhe: 0.521 ± 0.033
0.626TrpGly: 0.626 ± 0.039
0.422TrpHis: 0.422 ± 0.036
0.772TrpIle: 0.772 ± 0.043
0.461TrpLys: 0.461 ± 0.034
1.849TrpLeu: 1.849 ± 0.095
0.173TrpMet: 0.173 ± 0.021
0.29TrpAsn: 0.29 ± 0.028
0.17TrpPro: 0.17 ± 0.022
1.36TrpGln: 1.36 ± 0.07
0.813TrpArg: 0.813 ± 0.048
0.559TrpSer: 0.559 ± 0.035
0.501TrpThr: 0.501 ± 0.034
0.638TrpVal: 0.638 ± 0.043
0.151TrpTrp: 0.151 ± 0.02
0.377TrpTyr: 0.377 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.636TyrAla: 2.636 ± 0.077
0.521TyrCys: 0.521 ± 0.039
1.725TyrAsp: 1.725 ± 0.074
1.679TyrGlu: 1.679 ± 0.069
1.509TyrPhe: 1.509 ± 0.06
2.257TyrGly: 2.257 ± 0.064
1.017TyrHis: 1.017 ± 0.05
1.538TyrIle: 1.538 ± 0.066
0.945TyrLys: 0.945 ± 0.043
3.584TyrLeu: 3.584 ± 0.102
0.506TyrMet: 0.506 ± 0.033
0.885TyrAsn: 0.885 ± 0.044
1.514TyrPro: 1.514 ± 0.052
2.334TyrGln: 2.334 ± 0.091
2.322TyrArg: 2.322 ± 0.072
1.533TyrSer: 1.533 ± 0.066
1.336TyrThr: 1.336 ± 0.067
1.739TyrVal: 1.739 ± 0.072
0.465TyrTrp: 0.465 ± 0.038
1.063TyrTyr: 1.063 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.002XaaMet: 0.002 ± 0.003
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1273 proteins (416876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski