Amino acid dipepetide frequency for Tomato mottle virus (isolate Florida) (ToMoV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.406AlaAla: 1.406 ± 0.668
0.703AlaCys: 0.703 ± 0.547
1.406AlaAsp: 1.406 ± 0.566
2.813AlaGlu: 2.813 ± 0.723
0.703AlaPhe: 0.703 ± 0.619
3.516AlaGly: 3.516 ± 1.643
2.813AlaHis: 2.813 ± 0.986
3.516AlaIle: 3.516 ± 1.082
4.219AlaLys: 4.219 ± 1.452
4.923AlaLeu: 4.923 ± 2.088
0.0AlaMet: 0.0 ± 0.0
2.11AlaAsn: 2.11 ± 0.72
3.516AlaPro: 3.516 ± 2.081
2.813AlaGln: 2.813 ± 0.96
4.923AlaArg: 4.923 ± 0.582
9.845AlaSer: 9.845 ± 3.35
2.813AlaThr: 2.813 ± 1.314
1.406AlaVal: 1.406 ± 0.847
0.0AlaTrp: 0.0 ± 0.0
0.703AlaTyr: 0.703 ± 0.765
0.0AlaXaa: 0.0 ± 0.0
Cys
1.406CysAla: 1.406 ± 0.965
0.0CysCys: 0.0 ± 0.0
0.703CysAsp: 0.703 ± 0.619
0.703CysGlu: 0.703 ± 0.547
0.0CysPhe: 0.0 ± 0.0
0.703CysGly: 0.703 ± 0.766
0.0CysHis: 0.0 ± 0.0
1.406CysIle: 1.406 ± 0.769
2.813CysLys: 2.813 ± 0.508
0.703CysLeu: 0.703 ± 0.556
0.703CysMet: 0.703 ± 0.619
1.406CysAsn: 1.406 ± 0.566
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.703CysArg: 0.703 ± 0.591
1.406CysSer: 1.406 ± 0.857
2.11CysThr: 2.11 ± 0.89
1.406CysVal: 1.406 ± 0.769
1.406CysTrp: 1.406 ± 1.112
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.406AspAla: 1.406 ± 0.566
0.0AspCys: 0.0 ± 0.0
2.11AspAsp: 2.11 ± 1.514
3.516AspGlu: 3.516 ± 0.899
2.813AspPhe: 2.813 ± 1.514
2.813AspGly: 2.813 ± 1.492
0.703AspHis: 0.703 ± 0.619
2.813AspIle: 2.813 ± 0.964
2.813AspLys: 2.813 ± 1.132
6.329AspLeu: 6.329 ± 1.355
0.0AspMet: 0.0 ± 0.0
2.11AspAsn: 2.11 ± 0.72
2.11AspPro: 2.11 ± 1.393
0.703AspGln: 0.703 ± 0.765
4.219AspArg: 4.219 ± 1.677
4.923AspSer: 4.923 ± 0.989
4.219AspThr: 4.219 ± 1.412
4.923AspVal: 4.923 ± 0.829
0.703AspTrp: 0.703 ± 0.591
1.406AspTyr: 1.406 ± 0.743
0.0AspXaa: 0.0 ± 0.0
Glu
1.406GluAla: 1.406 ± 0.668
0.703GluCys: 0.703 ± 0.619
0.703GluAsp: 0.703 ± 0.765
2.11GluGlu: 2.11 ± 1.257
1.406GluPhe: 1.406 ± 0.746
4.923GluGly: 4.923 ± 1.632
0.0GluHis: 0.0 ± 0.0
2.11GluIle: 2.11 ± 1.857
0.703GluLys: 0.703 ± 0.556
5.626GluLeu: 5.626 ± 1.374
0.703GluMet: 0.703 ± 0.591
7.736GluAsn: 7.736 ± 1.985
2.813GluPro: 2.813 ± 1.124
2.11GluGln: 2.11 ± 1.068
2.11GluArg: 2.11 ± 0.622
5.626GluSer: 5.626 ± 2.707
0.703GluThr: 0.703 ± 0.591
0.703GluVal: 0.703 ± 0.619
2.813GluTrp: 2.813 ± 1.198
1.406GluTyr: 1.406 ± 1.238
0.0GluXaa: 0.0 ± 0.0
Phe
2.11PheAla: 2.11 ± 0.775
0.703PheCys: 0.703 ± 0.547
2.813PheAsp: 2.813 ± 1.1
1.406PheGlu: 1.406 ± 0.668
1.406PhePhe: 1.406 ± 0.566
1.406PheGly: 1.406 ± 0.746
1.406PheHis: 1.406 ± 0.857
2.11PheIle: 2.11 ± 1.226
4.219PheLys: 4.219 ± 2.035
1.406PheLeu: 1.406 ± 1.183
0.703PheMet: 0.703 ± 0.556
4.219PheAsn: 4.219 ± 0.867
1.406PhePro: 1.406 ± 1.238
2.813PheGln: 2.813 ± 1.326
2.11PheArg: 2.11 ± 0.775
4.923PheSer: 4.923 ± 1.596
2.11PheThr: 2.11 ± 0.816
2.813PheVal: 2.813 ± 1.68
2.11PheTrp: 2.11 ± 1.306
2.813PheTyr: 2.813 ± 1.237
0.0PheXaa: 0.0 ± 0.0
Gly
4.219GlyAla: 4.219 ± 1.364
2.813GlyCys: 2.813 ± 1.507
2.813GlyAsp: 2.813 ± 2.365
4.219GlyGlu: 4.219 ± 1.178
2.11GlyPhe: 2.11 ± 1.163
3.516GlyGly: 3.516 ± 1.082
2.11GlyHis: 2.11 ± 0.816
4.219GlyIle: 4.219 ± 1.309
8.439GlyLys: 8.439 ± 2.11
1.406GlyLeu: 1.406 ± 0.566
0.703GlyMet: 0.703 ± 0.712
2.813GlyAsn: 2.813 ± 1.1
4.923GlyPro: 4.923 ± 0.97
2.813GlyGln: 2.813 ± 0.508
1.406GlyArg: 1.406 ± 1.183
2.813GlySer: 2.813 ± 0.734
4.219GlyThr: 4.219 ± 0.872
2.813GlyVal: 2.813 ± 1.751
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.703HisAla: 0.703 ± 0.547
1.406HisCys: 1.406 ± 0.965
2.813HisAsp: 2.813 ± 1.242
2.11HisGlu: 2.11 ± 0.622
1.406HisPhe: 1.406 ± 0.566
1.406HisGly: 1.406 ± 0.812
0.703HisHis: 0.703 ± 0.766
0.703HisIle: 0.703 ± 0.547
1.406HisLys: 1.406 ± 0.895
4.923HisLeu: 4.923 ± 1.005
0.0HisMet: 0.0 ± 0.0
2.813HisAsn: 2.813 ± 1.236
1.406HisPro: 1.406 ± 0.566
2.11HisGln: 2.11 ± 1.002
3.516HisArg: 3.516 ± 1.802
2.11HisSer: 2.11 ± 1.393
2.11HisThr: 2.11 ± 1.112
4.219HisVal: 4.219 ± 1.252
0.703HisTrp: 0.703 ± 0.591
1.406HisTyr: 1.406 ± 0.566
0.0HisXaa: 0.0 ± 0.0
Ile
0.703IleAla: 0.703 ± 0.591
0.703IleCys: 0.703 ± 0.591
3.516IleAsp: 3.516 ± 1.485
3.516IleGlu: 3.516 ± 1.532
1.406IlePhe: 1.406 ± 1.183
3.516IleGly: 3.516 ± 1.457
2.813IleHis: 2.813 ± 1.257
1.406IleIle: 1.406 ± 0.566
4.923IleLys: 4.923 ± 1.471
2.813IleLeu: 2.813 ± 1.864
0.0IleMet: 0.0 ± 0.0
4.219IleAsn: 4.219 ± 1.415
3.516IlePro: 3.516 ± 1.027
0.703IleGln: 0.703 ± 0.591
6.329IleArg: 6.329 ± 1.964
3.516IleSer: 3.516 ± 1.436
3.516IleThr: 3.516 ± 1.022
4.923IleVal: 4.923 ± 0.995
2.11IleTrp: 2.11 ± 1.271
2.11IleTyr: 2.11 ± 1.172
0.0IleXaa: 0.0 ± 0.0
Lys
6.329LysAla: 6.329 ± 1.796
0.0LysCys: 0.0 ± 0.0
5.626LysAsp: 5.626 ± 1.795
2.11LysGlu: 2.11 ± 1.774
4.219LysPhe: 4.219 ± 1.375
2.813LysGly: 2.813 ± 1.035
1.406LysHis: 1.406 ± 0.566
4.923LysIle: 4.923 ± 1.02
2.11LysLys: 2.11 ± 1.257
4.219LysLeu: 4.219 ± 1.427
1.406LysMet: 1.406 ± 0.685
4.219LysAsn: 4.219 ± 1.692
4.219LysPro: 4.219 ± 1.406
0.703LysGln: 0.703 ± 0.619
7.736LysArg: 7.736 ± 2.738
4.219LysSer: 4.219 ± 0.678
0.703LysThr: 0.703 ± 0.591
4.219LysVal: 4.219 ± 2.667
0.703LysTrp: 0.703 ± 0.619
2.11LysTyr: 2.11 ± 1.137
0.0LysXaa: 0.0 ± 0.0
Leu
2.813LeuAla: 2.813 ± 1.223
0.703LeuCys: 0.703 ± 0.591
4.923LeuAsp: 4.923 ± 1.005
2.11LeuGlu: 2.11 ± 1.502
2.11LeuPhe: 2.11 ± 1.478
7.032LeuGly: 7.032 ± 1.021
4.923LeuHis: 4.923 ± 1.403
1.406LeuIle: 1.406 ± 0.937
7.736LeuLys: 7.736 ± 1.453
2.813LeuLeu: 2.813 ± 1.039
0.703LeuMet: 0.703 ± 0.556
4.219LeuAsn: 4.219 ± 0.976
2.11LeuPro: 2.11 ± 1.602
3.516LeuGln: 3.516 ± 1.178
4.219LeuArg: 4.219 ± 0.846
6.329LeuSer: 6.329 ± 1.956
3.516LeuThr: 3.516 ± 1.051
4.219LeuVal: 4.219 ± 0.666
0.0LeuTrp: 0.0 ± 0.0
3.516LeuTyr: 3.516 ± 1.374
0.0LeuXaa: 0.0 ± 0.0
Met
1.406MetAla: 1.406 ± 1.093
0.703MetCys: 0.703 ± 0.547
3.516MetAsp: 3.516 ± 1.225
0.0MetGlu: 0.0 ± 0.0
1.406MetPhe: 1.406 ± 1.093
0.703MetGly: 0.703 ± 0.619
0.703MetHis: 0.703 ± 0.547
0.0MetIle: 0.0 ± 0.0
0.703MetLys: 0.703 ± 0.619
0.703MetLeu: 0.703 ± 0.556
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.11MetPro: 2.11 ± 0.72
0.703MetGln: 0.703 ± 0.591
0.703MetArg: 0.703 ± 0.766
2.11MetSer: 2.11 ± 1.249
1.406MetThr: 1.406 ± 0.937
1.406MetVal: 1.406 ± 1.112
0.703MetTrp: 0.703 ± 0.591
2.813MetTyr: 2.813 ± 1.237
0.0MetXaa: 0.0 ± 0.0
Asn
4.923AsnAla: 4.923 ± 1.082
2.11AsnCys: 2.11 ± 0.622
2.813AsnAsp: 2.813 ± 1.124
4.219AsnGlu: 4.219 ± 2.119
1.406AsnPhe: 1.406 ± 0.875
2.813AsnGly: 2.813 ± 1.167
5.626AsnHis: 5.626 ± 2.819
4.923AsnIle: 4.923 ± 0.995
1.406AsnLys: 1.406 ± 0.668
3.516AsnLeu: 3.516 ± 1.224
2.813AsnMet: 2.813 ± 1.161
2.11AsnAsn: 2.11 ± 0.856
2.813AsnPro: 2.813 ± 0.723
1.406AsnGln: 1.406 ± 0.746
4.923AsnArg: 4.923 ± 1.339
3.516AsnSer: 3.516 ± 1.596
1.406AsnThr: 1.406 ± 1.183
2.813AsnVal: 2.813 ± 1.01
0.703AsnTrp: 0.703 ± 0.591
3.516AsnTyr: 3.516 ± 1.376
0.0AsnXaa: 0.0 ± 0.0
Pro
1.406ProAla: 1.406 ± 0.746
0.703ProCys: 0.703 ± 0.547
1.406ProAsp: 1.406 ± 1.183
2.813ProGlu: 2.813 ± 1.424
1.406ProPhe: 1.406 ± 0.566
2.11ProGly: 2.11 ± 1.028
2.813ProHis: 2.813 ± 1.775
3.516ProIle: 3.516 ± 3.095
4.219ProLys: 4.219 ± 1.749
3.516ProLeu: 3.516 ± 1.551
1.406ProMet: 1.406 ± 1.093
1.406ProAsn: 1.406 ± 0.746
4.219ProPro: 4.219 ± 2.017
2.11ProGln: 2.11 ± 1.514
2.813ProArg: 2.813 ± 1.778
6.329ProSer: 6.329 ± 2.449
2.11ProThr: 2.11 ± 0.816
4.219ProVal: 4.219 ± 1.787
2.11ProTrp: 2.11 ± 0.571
1.406ProTyr: 1.406 ± 0.769
0.0ProXaa: 0.0 ± 0.0
Gln
3.516GlnAla: 3.516 ± 0.925
2.11GlnCys: 2.11 ± 1.257
0.703GlnAsp: 0.703 ± 0.766
2.813GlnGlu: 2.813 ± 1.685
2.11GlnPhe: 2.11 ± 1.028
1.406GlnGly: 1.406 ± 1.183
0.0GlnHis: 0.0 ± 0.0
2.11GlnIle: 2.11 ± 1.245
2.11GlnLys: 2.11 ± 0.978
4.219GlnLeu: 4.219 ± 2.201
0.0GlnMet: 0.0 ± 0.0
2.11GlnAsn: 2.11 ± 1.257
2.813GlnPro: 2.813 ± 2.241
1.406GlnGln: 1.406 ± 0.566
2.11GlnArg: 2.11 ± 0.791
5.626GlnSer: 5.626 ± 2.242
0.703GlnThr: 0.703 ± 0.619
3.516GlnVal: 3.516 ± 0.573
0.0GlnTrp: 0.0 ± 0.0
2.11GlnTyr: 2.11 ± 0.72
0.0GlnXaa: 0.0 ± 0.0
Arg
4.219ArgAla: 4.219 ± 1.536
1.406ArgCys: 1.406 ± 1.238
2.813ArgAsp: 2.813 ± 1.673
2.11ArgGlu: 2.11 ± 1.226
6.329ArgPhe: 6.329 ± 2.405
5.626ArgGly: 5.626 ± 1.383
2.813ArgHis: 2.813 ± 1.131
3.516ArgIle: 3.516 ± 1.279
3.516ArgLys: 3.516 ± 1.1
2.813ArgLeu: 2.813 ± 1.826
1.406ArgMet: 1.406 ± 0.769
1.406ArgAsn: 1.406 ± 0.689
3.516ArgPro: 3.516 ± 0.853
1.406ArgGln: 1.406 ± 0.965
4.923ArgArg: 4.923 ± 2.392
6.329ArgSer: 6.329 ± 0.949
5.626ArgThr: 5.626 ± 1.728
7.736ArgVal: 7.736 ± 2.078
0.0ArgTrp: 0.0 ± 0.0
2.11ArgTyr: 2.11 ± 0.922
0.0ArgXaa: 0.0 ± 0.0
Ser
5.626SerAla: 5.626 ± 1.891
1.406SerCys: 1.406 ± 0.743
3.516SerAsp: 3.516 ± 0.899
0.703SerGlu: 0.703 ± 0.619
4.219SerPhe: 4.219 ± 0.803
3.516SerGly: 3.516 ± 1.197
3.516SerHis: 3.516 ± 1.796
5.626SerIle: 5.626 ± 2.522
4.219SerLys: 4.219 ± 1.019
4.923SerLeu: 4.923 ± 1.894
4.219SerMet: 4.219 ± 1.411
6.329SerAsn: 6.329 ± 1.161
3.516SerPro: 3.516 ± 2.237
4.219SerGln: 4.219 ± 1.562
7.032SerArg: 7.032 ± 1.542
4.219SerSer: 4.219 ± 1.952
5.626SerThr: 5.626 ± 1.786
4.923SerVal: 4.923 ± 1.066
1.406SerTrp: 1.406 ± 1.238
3.516SerTyr: 3.516 ± 1.942
0.0SerXaa: 0.0 ± 0.0
Thr
4.923ThrAla: 4.923 ± 1.895
0.0ThrCys: 0.0 ± 0.0
2.11ThrAsp: 2.11 ± 1.049
2.11ThrGlu: 2.11 ± 1.284
2.813ThrPhe: 2.813 ± 1.656
5.626ThrGly: 5.626 ± 1.611
3.516ThrHis: 3.516 ± 1.874
2.813ThrIle: 2.813 ± 0.96
0.703ThrLys: 0.703 ± 0.619
3.516ThrLeu: 3.516 ± 1.279
1.406ThrMet: 1.406 ± 0.566
4.219ThrAsn: 4.219 ± 1.029
2.11ThrPro: 2.11 ± 0.72
1.406ThrGln: 1.406 ± 0.857
2.813ThrArg: 2.813 ± 1.479
2.11ThrSer: 2.11 ± 1.172
2.813ThrThr: 2.813 ± 0.955
4.923ThrVal: 4.923 ± 1.921
0.0ThrTrp: 0.0 ± 0.0
0.703ThrTyr: 0.703 ± 0.591
0.0ThrXaa: 0.0 ± 0.0
Val
1.406ValAla: 1.406 ± 0.92
0.703ValCys: 0.703 ± 0.619
4.923ValAsp: 4.923 ± 2.239
4.923ValGlu: 4.923 ± 1.58
3.516ValPhe: 3.516 ± 1.587
1.406ValGly: 1.406 ± 0.769
1.406ValHis: 1.406 ± 1.238
3.516ValIle: 3.516 ± 1.023
4.923ValLys: 4.923 ± 1.441
4.923ValLeu: 4.923 ± 2.341
2.11ValMet: 2.11 ± 1.64
4.219ValAsn: 4.219 ± 1.526
3.516ValPro: 3.516 ± 1.226
6.329ValGln: 6.329 ± 2.512
2.11ValArg: 2.11 ± 1.572
4.219ValSer: 4.219 ± 1.787
1.406ValThr: 1.406 ± 1.093
3.516ValVal: 3.516 ± 1.673
0.703ValTrp: 0.703 ± 0.765
7.032ValTyr: 7.032 ± 2.864
0.0ValXaa: 0.0 ± 0.0
Trp
2.11TrpAla: 2.11 ± 0.978
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.406TrpGlu: 1.406 ± 0.937
0.0TrpPhe: 0.0 ± 0.0
0.703TrpGly: 0.703 ± 0.591
0.0TrpHis: 0.0 ± 0.0
0.703TrpIle: 0.703 ± 0.766
2.11TrpLys: 2.11 ± 0.571
0.703TrpLeu: 0.703 ± 0.547
1.406TrpMet: 1.406 ± 0.689
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.703TrpGln: 0.703 ± 0.591
1.406TrpArg: 1.406 ± 0.92
0.703TrpSer: 0.703 ± 0.556
2.813TrpThr: 2.813 ± 0.723
1.406TrpVal: 1.406 ± 0.668
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.11TyrAla: 2.11 ± 1.068
0.703TyrCys: 0.703 ± 0.556
1.406TyrAsp: 1.406 ± 0.689
0.703TyrGlu: 0.703 ± 0.547
4.219TyrPhe: 4.219 ± 0.933
3.516TyrGly: 3.516 ± 0.853
0.703TyrHis: 0.703 ± 0.765
4.923TyrIle: 4.923 ± 1.339
0.703TyrLys: 0.703 ± 0.591
4.923TyrLeu: 4.923 ± 3.05
1.406TyrMet: 1.406 ± 0.873
2.11TyrAsn: 2.11 ± 0.72
1.406TyrPro: 1.406 ± 0.746
3.516TyrGln: 3.516 ± 0.93
3.516TyrArg: 3.516 ± 2.024
1.406TyrSer: 1.406 ± 0.689
0.703TyrThr: 0.703 ± 0.765
0.703TyrVal: 0.703 ± 0.765
0.0TyrTrp: 0.0 ± 0.0
1.406TyrTyr: 1.406 ± 0.743
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski