Amino acid dipepetide frequency for Candidatus Marinamargulisbacteria bacterium SCGC AAA071-K20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.445AlaAla: 4.445 ± 0.251
0.667AlaCys: 0.667 ± 0.039
2.994AlaAsp: 2.994 ± 0.105
3.265AlaGlu: 3.265 ± 0.098
2.855AlaPhe: 2.855 ± 0.078
3.995AlaGly: 3.995 ± 0.141
1.161AlaHis: 1.161 ± 0.052
5.12AlaIle: 5.12 ± 0.118
4.596AlaLys: 4.596 ± 0.103
6.643AlaLeu: 6.643 ± 0.163
1.466AlaMet: 1.466 ± 0.052
2.651AlaAsn: 2.651 ± 0.092
2.093AlaPro: 2.093 ± 0.082
2.228AlaGln: 2.228 ± 0.086
2.306AlaArg: 2.306 ± 0.072
4.413AlaSer: 4.413 ± 0.114
3.77AlaThr: 3.77 ± 0.117
3.932AlaVal: 3.932 ± 0.123
0.448AlaTrp: 0.448 ± 0.027
2.0AlaTyr: 2.0 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.524CysAla: 0.524 ± 0.031
0.149CysCys: 0.149 ± 0.016
0.539CysAsp: 0.539 ± 0.031
0.534CysGlu: 0.534 ± 0.035
0.551CysPhe: 0.551 ± 0.032
0.73CysGly: 0.73 ± 0.046
0.236CysHis: 0.236 ± 0.025
0.812CysIle: 0.812 ± 0.043
0.722CysLys: 0.722 ± 0.04
1.127CysLeu: 1.127 ± 0.055
0.196CysMet: 0.196 ± 0.017
0.44CysAsn: 0.44 ± 0.031
0.44CysPro: 0.44 ± 0.033
0.29CysGln: 0.29 ± 0.021
0.335CysArg: 0.335 ± 0.023
0.795CysSer: 0.795 ± 0.039
0.469CysThr: 0.469 ± 0.029
0.599CysVal: 0.599 ± 0.036
0.055CysTrp: 0.055 ± 0.009
0.278CysTyr: 0.278 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.238AspAla: 3.238 ± 0.124
0.589AspCys: 0.589 ± 0.034
2.989AspAsp: 2.989 ± 0.083
3.391AspGlu: 3.391 ± 0.097
2.871AspPhe: 2.871 ± 0.076
3.153AspGly: 3.153 ± 0.108
1.109AspHis: 1.109 ± 0.046
5.049AspIle: 5.049 ± 0.097
3.782AspLys: 3.782 ± 0.089
5.796AspLeu: 5.796 ± 0.125
1.155AspMet: 1.155 ± 0.05
2.493AspAsn: 2.493 ± 0.078
2.28AspPro: 2.28 ± 0.072
1.979AspGln: 1.979 ± 0.063
2.011AspArg: 2.011 ± 0.067
3.965AspSer: 3.965 ± 0.098
3.351AspThr: 3.351 ± 0.084
3.519AspVal: 3.519 ± 0.094
0.492AspTrp: 0.492 ± 0.031
2.278AspTyr: 2.278 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.296GluAla: 4.296 ± 0.115
0.522GluCys: 0.522 ± 0.037
3.431GluAsp: 3.431 ± 0.089
4.161GluGlu: 4.161 ± 0.118
2.649GluPhe: 2.649 ± 0.063
3.597GluGly: 3.597 ± 0.082
1.189GluHis: 1.189 ± 0.048
4.962GluIle: 4.962 ± 0.101
5.837GluLys: 5.837 ± 0.129
6.3GluLeu: 6.3 ± 0.126
1.355GluMet: 1.355 ± 0.051
3.662GluAsn: 3.662 ± 0.078
1.618GluPro: 1.618 ± 0.048
2.0GluGln: 2.0 ± 0.061
2.417GluArg: 2.417 ± 0.071
4.394GluSer: 4.394 ± 0.109
3.652GluThr: 3.652 ± 0.085
3.746GluVal: 3.746 ± 0.092
0.494GluTrp: 0.494 ± 0.035
1.712GluTyr: 1.712 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.263PheAla: 2.263 ± 0.073
0.579PheCys: 0.579 ± 0.033
2.865PheAsp: 2.865 ± 0.074
3.13PheGlu: 3.13 ± 0.089
2.592PhePhe: 2.592 ± 0.094
3.124PheGly: 3.124 ± 0.077
0.881PheHis: 0.881 ± 0.047
3.753PheIle: 3.753 ± 0.105
3.978PheLys: 3.978 ± 0.086
5.108PheLeu: 5.108 ± 0.14
1.117PheMet: 1.117 ± 0.049
2.804PheAsn: 2.804 ± 0.079
1.645PhePro: 1.645 ± 0.056
1.508PheGln: 1.508 ± 0.058
1.702PheArg: 1.702 ± 0.052
4.498PheSer: 4.498 ± 0.118
2.672PheThr: 2.672 ± 0.075
2.754PheVal: 2.754 ± 0.079
0.421PheTrp: 0.421 ± 0.027
1.832PheTyr: 1.832 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.249GlyAla: 4.249 ± 0.132
0.73GlyCys: 0.73 ± 0.043
3.309GlyAsp: 3.309 ± 0.111
3.189GlyGlu: 3.189 ± 0.094
3.2GlyPhe: 3.2 ± 0.09
4.26GlyGly: 4.26 ± 0.14
1.42GlyHis: 1.42 ± 0.055
5.005GlyIle: 5.005 ± 0.112
4.449GlyLys: 4.449 ± 0.098
6.446GlyLeu: 6.446 ± 0.123
1.409GlyMet: 1.409 ± 0.057
2.655GlyAsn: 2.655 ± 0.091
1.662GlyPro: 1.662 ± 0.064
1.956GlyGln: 1.956 ± 0.06
2.337GlyArg: 2.337 ± 0.071
4.096GlySer: 4.096 ± 0.107
3.713GlyThr: 3.713 ± 0.098
4.39GlyVal: 4.39 ± 0.102
0.505GlyTrp: 0.505 ± 0.036
2.245GlyTyr: 2.245 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.045HisAla: 1.045 ± 0.042
0.267HisCys: 0.267 ± 0.023
0.768HisAsp: 0.768 ± 0.037
0.829HisGlu: 0.829 ± 0.04
1.277HisPhe: 1.277 ± 0.05
1.062HisGly: 1.062 ± 0.042
0.593HisHis: 0.593 ± 0.038
1.5HisIle: 1.5 ± 0.056
1.393HisLys: 1.393 ± 0.053
2.205HisLeu: 2.205 ± 0.077
0.416HisMet: 0.416 ± 0.032
0.928HisAsn: 0.928 ± 0.046
1.109HisPro: 1.109 ± 0.048
0.801HisGln: 0.801 ± 0.039
0.793HisArg: 0.793 ± 0.043
1.454HisSer: 1.454 ± 0.048
1.218HisThr: 1.218 ± 0.05
1.186HisVal: 1.186 ± 0.046
0.189HisTrp: 0.189 ± 0.021
0.89HisTyr: 0.89 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
4.845IleAla: 4.845 ± 0.125
0.736IleCys: 0.736 ± 0.046
4.796IleAsp: 4.796 ± 0.095
5.436IleGlu: 5.436 ± 0.105
3.223IlePhe: 3.223 ± 0.085
4.933IleGly: 4.933 ± 0.137
1.54IleHis: 1.54 ± 0.062
5.873IleIle: 5.873 ± 0.123
6.69IleLys: 6.69 ± 0.132
7.274IleLeu: 7.274 ± 0.148
1.411IleMet: 1.411 ± 0.058
4.485IleAsn: 4.485 ± 0.089
3.187IlePro: 3.187 ± 0.086
2.781IleGln: 2.781 ± 0.07
2.817IleArg: 2.817 ± 0.076
6.498IleSer: 6.498 ± 0.12
4.731IleThr: 4.731 ± 0.103
4.861IleVal: 4.861 ± 0.108
0.436IleTrp: 0.436 ± 0.033
2.137IleTyr: 2.137 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
4.967LysAla: 4.967 ± 0.132
0.652LysCys: 0.652 ± 0.042
4.939LysAsp: 4.939 ± 0.109
6.387LysGlu: 6.387 ± 0.127
2.672LysPhe: 2.672 ± 0.069
4.493LysGly: 4.493 ± 0.098
1.578LysHis: 1.578 ± 0.054
5.743LysIle: 5.743 ± 0.13
7.682LysLys: 7.682 ± 0.184
7.247LysLeu: 7.247 ± 0.124
1.828LysMet: 1.828 ± 0.063
4.782LysAsn: 4.782 ± 0.122
2.571LysPro: 2.571 ± 0.073
3.292LysGln: 3.292 ± 0.092
3.624LysArg: 3.624 ± 0.084
5.394LysSer: 5.394 ± 0.117
4.964LysThr: 4.964 ± 0.113
4.803LysVal: 4.803 ± 0.087
0.583LysTrp: 0.583 ± 0.035
2.547LysTyr: 2.547 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
6.012LeuAla: 6.012 ± 0.114
0.942LeuCys: 0.942 ± 0.043
5.785LeuAsp: 5.785 ± 0.121
6.831LeuGlu: 6.831 ± 0.137
5.415LeuPhe: 5.415 ± 0.13
6.279LeuGly: 6.279 ± 0.141
1.858LeuHis: 1.858 ± 0.065
7.573LeuIle: 7.573 ± 0.137
8.581LeuLys: 8.581 ± 0.148
10.085LeuLeu: 10.085 ± 0.197
2.101LeuMet: 2.101 ± 0.072
5.859LeuAsn: 5.859 ± 0.123
3.583LeuPro: 3.583 ± 0.083
3.061LeuGln: 3.061 ± 0.104
3.551LeuArg: 3.551 ± 0.089
9.071LeuSer: 9.071 ± 0.158
5.774LeuThr: 5.774 ± 0.125
6.073LeuVal: 6.073 ± 0.104
0.637LeuTrp: 0.637 ± 0.038
3.035LeuTyr: 3.035 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.639MetAla: 1.639 ± 0.06
0.196MetCys: 0.196 ± 0.019
1.174MetAsp: 1.174 ± 0.043
1.014MetGlu: 1.014 ± 0.042
0.902MetPhe: 0.902 ± 0.049
1.546MetGly: 1.546 ± 0.059
0.33MetHis: 0.33 ± 0.022
1.706MetIle: 1.706 ± 0.061
1.708MetLys: 1.708 ± 0.06
1.91MetLeu: 1.91 ± 0.062
0.538MetMet: 0.538 ± 0.037
1.088MetAsn: 1.088 ± 0.054
0.884MetPro: 0.884 ± 0.039
0.579MetGln: 0.579 ± 0.032
0.692MetArg: 0.692 ± 0.031
1.813MetSer: 1.813 ± 0.072
1.378MetThr: 1.378 ± 0.05
1.374MetVal: 1.374 ± 0.051
0.145MetTrp: 0.145 ± 0.016
0.543MetTyr: 0.543 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.924AsnAla: 2.924 ± 0.092
0.547AsnCys: 0.547 ± 0.032
2.529AsnAsp: 2.529 ± 0.079
2.789AsnGlu: 2.789 ± 0.08
2.423AsnPhe: 2.423 ± 0.077
2.954AsnGly: 2.954 ± 0.089
1.006AsnHis: 1.006 ± 0.042
4.27AsnIle: 4.27 ± 0.093
4.485AsnLys: 4.485 ± 0.109
4.954AsnLeu: 4.954 ± 0.111
1.186AsnMet: 1.186 ± 0.053
2.975AsnAsn: 2.975 ± 0.092
2.497AsnPro: 2.497 ± 0.073
1.872AsnGln: 1.872 ± 0.072
2.015AsnArg: 2.015 ± 0.058
3.814AsnSer: 3.814 ± 0.097
3.195AsnThr: 3.195 ± 0.098
2.981AsnVal: 2.981 ± 0.087
0.488AsnTrp: 0.488 ± 0.035
1.967AsnTyr: 1.967 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.912ProAla: 1.912 ± 0.084
0.257ProCys: 0.257 ± 0.024
2.163ProAsp: 2.163 ± 0.062
2.636ProGlu: 2.636 ± 0.074
2.101ProPhe: 2.101 ± 0.064
2.135ProGly: 2.135 ± 0.065
0.753ProHis: 0.753 ± 0.04
2.871ProIle: 2.871 ± 0.079
2.821ProLys: 2.821 ± 0.083
3.627ProLeu: 3.627 ± 0.087
0.648ProMet: 0.648 ± 0.033
1.843ProAsn: 1.843 ± 0.064
1.119ProPro: 1.119 ± 0.048
1.216ProGln: 1.216 ± 0.042
1.09ProArg: 1.09 ± 0.047
2.739ProSer: 2.739 ± 0.078
2.171ProThr: 2.171 ± 0.072
2.474ProVal: 2.474 ± 0.066
0.326ProTrp: 0.326 ± 0.029
1.218ProTyr: 1.218 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.44GlnAla: 2.44 ± 0.076
0.294GlnCys: 0.294 ± 0.027
1.866GlnAsp: 1.866 ± 0.06
2.417GlnGlu: 2.417 ± 0.078
1.858GlnPhe: 1.858 ± 0.065
1.818GlnGly: 1.818 ± 0.06
0.64GlnHis: 0.64 ± 0.034
2.566GlnIle: 2.566 ± 0.071
2.934GlnLys: 2.934 ± 0.08
3.997GlnLeu: 3.997 ± 0.106
0.694GlnMet: 0.694 ± 0.037
1.769GlnAsn: 1.769 ± 0.065
0.846GlnPro: 0.846 ± 0.041
1.271GlnGln: 1.271 ± 0.059
1.231GlnArg: 1.231 ± 0.049
2.539GlnSer: 2.539 ± 0.07
2.051GlnThr: 2.051 ± 0.057
2.186GlnVal: 2.186 ± 0.067
0.257GlnTrp: 0.257 ± 0.022
1.109GlnTyr: 1.109 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.348ArgAla: 2.348 ± 0.089
0.315ArgCys: 0.315 ± 0.026
2.032ArgAsp: 2.032 ± 0.07
2.226ArgGlu: 2.226 ± 0.064
2.051ArgPhe: 2.051 ± 0.065
2.03ArgGly: 2.03 ± 0.07
0.875ArgHis: 0.875 ± 0.041
2.609ArgIle: 2.609 ± 0.076
2.568ArgLys: 2.568 ± 0.08
4.296ArgLeu: 4.296 ± 0.094
0.766ArgMet: 0.766 ± 0.037
1.771ArgAsn: 1.771 ± 0.059
1.416ArgPro: 1.416 ± 0.052
1.38ArgGln: 1.38 ± 0.057
1.533ArgArg: 1.533 ± 0.058
2.569ArgSer: 2.569 ± 0.082
1.975ArgThr: 1.975 ± 0.062
2.558ArgVal: 2.558 ± 0.081
0.288ArgTrp: 0.288 ± 0.025
1.369ArgTyr: 1.369 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.062SerAla: 4.062 ± 0.109
0.677SerCys: 0.677 ± 0.039
4.161SerAsp: 4.161 ± 0.101
4.626SerGlu: 4.626 ± 0.111
4.199SerPhe: 4.199 ± 0.099
4.699SerGly: 4.699 ± 0.12
1.512SerHis: 1.512 ± 0.057
6.246SerIle: 6.246 ± 0.131
6.334SerLys: 6.334 ± 0.125
8.196SerLeu: 8.196 ± 0.129
1.622SerMet: 1.622 ± 0.056
3.717SerAsn: 3.717 ± 0.097
2.745SerPro: 2.745 ± 0.073
2.815SerGln: 2.815 ± 0.081
2.705SerArg: 2.705 ± 0.077
6.048SerSer: 6.048 ± 0.14
4.373SerThr: 4.373 ± 0.091
4.71SerVal: 4.71 ± 0.111
0.568SerTrp: 0.568 ± 0.039
2.467SerTyr: 2.467 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.641ThrAla: 3.641 ± 0.131
0.517ThrCys: 0.517 ± 0.032
3.084ThrAsp: 3.084 ± 0.092
3.136ThrGlu: 3.136 ± 0.08
2.873ThrPhe: 2.873 ± 0.077
3.919ThrGly: 3.919 ± 0.097
1.338ThrHis: 1.338 ± 0.052
4.964ThrIle: 4.964 ± 0.093
4.262ThrLys: 4.262 ± 0.098
6.704ThrLeu: 6.704 ± 0.107
1.035ThrMet: 1.035 ± 0.047
2.709ThrAsn: 2.709 ± 0.079
2.684ThrPro: 2.684 ± 0.069
2.263ThrGln: 2.263 ± 0.073
2.028ThrArg: 2.028 ± 0.066
4.014ThrSer: 4.014 ± 0.088
3.551ThrThr: 3.551 ± 0.112
3.883ThrVal: 3.883 ± 0.112
0.507ThrTrp: 0.507 ± 0.032
1.883ThrTyr: 1.883 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.919ValAla: 3.919 ± 0.106
0.709ValCys: 0.709 ± 0.04
3.776ValAsp: 3.776 ± 0.086
3.753ValGlu: 3.753 ± 0.091
3.086ValPhe: 3.086 ± 0.078
3.953ValGly: 3.953 ± 0.118
1.09ValHis: 1.09 ± 0.047
5.051ValIle: 5.051 ± 0.113
4.74ValLys: 4.74 ± 0.118
6.119ValLeu: 6.119 ± 0.117
1.38ValMet: 1.38 ± 0.055
3.099ValAsn: 3.099 ± 0.084
2.339ValPro: 2.339 ± 0.074
1.864ValGln: 1.864 ± 0.065
2.232ValArg: 2.232 ± 0.064
5.291ValSer: 5.291 ± 0.125
3.599ValThr: 3.599 ± 0.088
4.329ValVal: 4.329 ± 0.104
0.417ValTrp: 0.417 ± 0.033
1.919ValTyr: 1.919 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.551TrpAla: 0.551 ± 0.036
0.084TrpCys: 0.084 ± 0.012
0.517TrpAsp: 0.517 ± 0.036
0.477TrpGlu: 0.477 ± 0.026
0.398TrpPhe: 0.398 ± 0.028
0.536TrpGly: 0.536 ± 0.032
0.162TrpHis: 0.162 ± 0.018
0.583TrpIle: 0.583 ± 0.035
0.532TrpLys: 0.532 ± 0.034
0.749TrpLeu: 0.749 ± 0.048
0.196TrpMet: 0.196 ± 0.019
0.396TrpAsn: 0.396 ± 0.029
0.196TrpPro: 0.196 ± 0.018
0.282TrpGln: 0.282 ± 0.024
0.28TrpArg: 0.28 ± 0.021
0.484TrpSer: 0.484 ± 0.036
0.425TrpThr: 0.425 ± 0.037
0.53TrpVal: 0.53 ± 0.033
0.08TrpTrp: 0.08 ± 0.013
0.227TrpTyr: 0.227 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.729TyrAla: 1.729 ± 0.061
0.395TyrCys: 0.395 ± 0.026
1.771TyrAsp: 1.771 ± 0.057
1.765TyrGlu: 1.765 ± 0.069
2.03TyrPhe: 2.03 ± 0.073
2.011TyrGly: 2.011 ± 0.069
0.65TyrHis: 0.65 ± 0.037
2.434TyrIle: 2.434 ± 0.082
2.657TyrLys: 2.657 ± 0.089
3.322TyrLeu: 3.322 ± 0.082
0.64TyrMet: 0.64 ± 0.035
1.742TyrAsn: 1.742 ± 0.056
1.205TyrPro: 1.205 ± 0.052
1.348TyrGln: 1.348 ± 0.049
1.275TyrArg: 1.275 ± 0.059
2.59TyrSer: 2.59 ± 0.079
1.961TyrThr: 1.961 ± 0.064
1.78TyrVal: 1.78 ± 0.057
0.349TyrTrp: 0.349 ± 0.025
1.336TyrTyr: 1.336 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1682 proteins (524630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski