Amino acid dipepetide frequency for Piptocephalis cylindrospora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.339AlaAla: 6.339 ± 0.102	1.073AlaCys: 1.073 ± 0.027	3.494AlaAsp: 3.494 ± 0.043	4.376AlaGlu: 4.376 ± 0.061	2.947AlaPhe: 2.947 ± 0.05	5.026AlaGly: 5.026 ± 0.062	2.136AlaHis: 2.136 ± 0.038	3.881AlaIle: 3.881 ± 0.058	3.702AlaLys: 3.702 ± 0.061	8.915AlaLeu: 8.915 ± 0.09	2.095AlaMet: 2.095 ± 0.039	2.094AlaAsn: 2.094 ± 0.036	4.447AlaPro: 4.447 ± 0.074	3.278AlaGln: 3.278 ± 0.043	4.924AlaArg: 4.924 ± 0.072	7.452AlaSer: 7.452 ± 0.085	4.369AlaThr: 4.369 ± 0.06	4.368AlaVal: 4.368 ± 0.057	1.192AlaTrp: 1.192 ± 0.031	2.221AlaTyr: 2.221 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.873CysAla: 0.873 ± 0.024	0.179CysCys: 0.179 ± 0.012	0.536CysAsp: 0.536 ± 0.022	0.551CysGlu: 0.551 ± 0.021	0.44CysPhe: 0.44 ± 0.018	0.925CysGly: 0.925 ± 0.027	0.344CysHis: 0.344 ± 0.015	0.734CysIle: 0.734 ± 0.022	0.447CysLys: 0.447 ± 0.015	1.448CysLeu: 1.448 ± 0.033	0.303CysMet: 0.303 ± 0.014	0.296CysAsn: 0.296 ± 0.016	0.831CysPro: 0.831 ± 0.029	0.457CysGln: 0.457 ± 0.017	0.834CysArg: 0.834 ± 0.023	0.858CysSer: 0.858 ± 0.023	0.716CysThr: 0.716 ± 0.022	0.802CysVal: 0.802 ± 0.023	0.151CysTrp: 0.151 ± 0.009	0.331CysTyr: 0.331 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.188AspAla: 4.188 ± 0.061	0.496AspCys: 0.496 ± 0.019	3.306AspAsp: 3.306 ± 0.075	4.401AspGlu: 4.401 ± 0.075	1.644AspPhe: 1.644 ± 0.032	4.284AspGly: 4.284 ± 0.061	1.406AspHis: 1.406 ± 0.035	2.608AspIle: 2.608 ± 0.045	2.061AspLys: 2.061 ± 0.036	5.291AspLeu: 5.291 ± 0.065	1.361AspMet: 1.361 ± 0.03	1.309AspAsn: 1.309 ± 0.033	3.838AspPro: 3.838 ± 0.055	2.249AspGln: 2.249 ± 0.045	3.657AspArg: 3.657 ± 0.05	3.303AspSer: 3.303 ± 0.05	2.917AspThr: 2.917 ± 0.052	3.45AspVal: 3.45 ± 0.047	0.823AspTrp: 0.823 ± 0.021	1.307AspTyr: 1.307 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.178GluAla: 6.178 ± 0.084	0.72GluCys: 0.72 ± 0.025	5.134GluAsp: 5.134 ± 0.08	9.723GluGlu: 9.723 ± 0.212	1.462GluPhe: 1.462 ± 0.03	6.13GluGly: 6.13 ± 0.095	1.277GluHis: 1.277 ± 0.03	2.414GluIle: 2.414 ± 0.04	3.692GluLys: 3.692 ± 0.065	4.616GluLeu: 4.616 ± 0.075	1.94GluMet: 1.94 ± 0.036	1.636GluAsn: 1.636 ± 0.034	2.196GluPro: 2.196 ± 0.04	2.037GluGln: 2.037 ± 0.043	4.781GluArg: 4.781 ± 0.083	3.927GluSer: 3.927 ± 0.058	3.188GluThr: 3.188 ± 0.062	4.322GluVal: 4.322 ± 0.063	0.95GluTrp: 0.95 ± 0.025	1.435GluTyr: 1.435 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	2.185PheAla: 2.185 ± 0.04	0.434PheCys: 0.434 ± 0.017	1.653PheAsp: 1.653 ± 0.032	1.406PheGlu: 1.406 ± 0.031	1.35PhePhe: 1.35 ± 0.037	2.281PheGly: 2.281 ± 0.055	1.038PheHis: 1.038 ± 0.027	1.666PheIle: 1.666 ± 0.04	1.076PheLys: 1.076 ± 0.03	3.907PheLeu: 3.907 ± 0.057	0.677PheMet: 0.677 ± 0.02	0.908PheAsn: 0.908 ± 0.022	2.211PhePro: 2.211 ± 0.039	1.251PheGln: 1.251 ± 0.027	1.949PheArg: 1.949 ± 0.036	2.883PheSer: 2.883 ± 0.06	1.994PheThr: 1.994 ± 0.038	1.759PheVal: 1.759 ± 0.04	0.457PheTrp: 0.457 ± 0.015	0.969PheTyr: 0.969 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	5.222GlyAla: 5.222 ± 0.072	0.912GlyCys: 0.912 ± 0.027	3.921GlyAsp: 3.921 ± 0.056	5.149GlyGlu: 5.149 ± 0.082	2.296GlyPhe: 2.296 ± 0.037	7.261GlyGly: 7.261 ± 0.133	1.996GlyHis: 1.996 ± 0.04	3.605GlyIle: 3.605 ± 0.057	4.511GlyLys: 4.511 ± 0.058	6.452GlyLeu: 6.452 ± 0.075	2.205GlyMet: 2.205 ± 0.043	2.219GlyAsn: 2.219 ± 0.05	3.792GlyPro: 3.792 ± 0.059	2.879GlyGln: 2.879 ± 0.054	5.191GlyArg: 5.191 ± 0.069	6.43GlySer: 6.43 ± 0.088	4.011GlyThr: 4.011 ± 0.053	4.498GlyVal: 4.498 ± 0.058	1.339GlyTrp: 1.339 ± 0.033	2.103GlyTyr: 2.103 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.978HisAla: 1.978 ± 0.039	0.334HisCys: 0.334 ± 0.014	1.148HisAsp: 1.148 ± 0.028	1.183HisGlu: 1.183 ± 0.031	0.989HisPhe: 0.989 ± 0.024	1.94HisGly: 1.94 ± 0.039	1.102HisHis: 1.102 ± 0.033	1.288HisIle: 1.288 ± 0.031	0.732HisLys: 0.732 ± 0.024	3.159HisLeu: 3.159 ± 0.049	0.501HisMet: 0.501 ± 0.017	0.578HisAsn: 0.578 ± 0.021	2.382HisPro: 2.382 ± 0.047	1.115HisGln: 1.115 ± 0.03	1.987HisArg: 1.987 ± 0.034	2.037HisSer: 2.037 ± 0.036	1.472HisThr: 1.472 ± 0.035	1.578HisVal: 1.578 ± 0.032	0.398HisTrp: 0.398 ± 0.018	0.754HisTyr: 0.754 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.09IleAla: 3.09 ± 0.051	0.544IleCys: 0.544 ± 0.021	2.097IleAsp: 2.097 ± 0.044	2.182IleGlu: 2.182 ± 0.044	1.712IlePhe: 1.712 ± 0.042	2.884IleGly: 2.884 ± 0.051	1.649IleHis: 1.649 ± 0.031	2.422IleIle: 2.422 ± 0.048	1.936IleLys: 1.936 ± 0.041	5.917IleLeu: 5.917 ± 0.072	0.982IleMet: 0.982 ± 0.025	1.268IleAsn: 1.268 ± 0.025	3.45IlePro: 3.45 ± 0.051	2.193IleGln: 2.193 ± 0.044	3.482IleArg: 3.482 ± 0.047	3.766IleSer: 3.766 ± 0.047	2.553IleThr: 2.553 ± 0.046	2.58IleVal: 2.58 ± 0.042	0.637IleTrp: 0.637 ± 0.019	1.304IleTyr: 1.304 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.502LysAla: 4.502 ± 0.065	0.502LysCys: 0.502 ± 0.02	3.177LysAsp: 3.177 ± 0.048	4.327LysGlu: 4.327 ± 0.08	0.96LysPhe: 0.96 ± 0.027	3.784LysGly: 3.784 ± 0.06	0.972LysHis: 0.972 ± 0.026	1.728LysIle: 1.728 ± 0.035	3.048LysLys: 3.048 ± 0.069	3.044LysLeu: 3.044 ± 0.054	1.071LysMet: 1.071 ± 0.027	1.334LysAsn: 1.334 ± 0.028	1.908LysPro: 1.908 ± 0.035	1.361LysGln: 1.361 ± 0.031	3.263LysArg: 3.263 ± 0.052	3.016LysSer: 3.016 ± 0.054	2.355LysThr: 2.355 ± 0.042	2.996LysVal: 2.996 ± 0.048	0.509LysTrp: 0.509 ± 0.017	1.161LysTyr: 1.161 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	8.217LeuAla: 8.217 ± 0.088	1.302LeuCys: 1.302 ± 0.028	5.454LeuAsp: 5.454 ± 0.066	6.107LeuGlu: 6.107 ± 0.087	3.3LeuPhe: 3.3 ± 0.058	6.999LeuGly: 6.999 ± 0.077	2.677LeuHis: 2.677 ± 0.043	4.368LeuIle: 4.368 ± 0.065	3.722LeuLys: 3.722 ± 0.057	10.807LeuLeu: 10.807 ± 0.136	1.998LeuMet: 1.998 ± 0.04	2.601LeuAsn: 2.601 ± 0.043	6.273LeuPro: 6.273 ± 0.065	3.848LeuGln: 3.848 ± 0.057	6.612LeuArg: 6.612 ± 0.09	8.388LeuSer: 8.388 ± 0.079	5.739LeuThr: 5.739 ± 0.064	5.973LeuVal: 5.973 ± 0.076	1.275LeuTrp: 1.275 ± 0.032	2.659LeuTyr: 2.659 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.36MetAla: 2.36 ± 0.042	0.308MetCys: 0.308 ± 0.015	1.906MetAsp: 1.906 ± 0.036	1.943MetGlu: 1.943 ± 0.039	0.55MetPhe: 0.55 ± 0.019	1.987MetGly: 1.987 ± 0.038	0.567MetHis: 0.567 ± 0.019	1.049MetIle: 1.049 ± 0.027	0.932MetLys: 0.932 ± 0.028	1.866MetLeu: 1.866 ± 0.039	0.693MetMet: 0.693 ± 0.022	0.802MetAsn: 0.802 ± 0.024	1.131MetPro: 1.131 ± 0.031	0.762MetGln: 0.762 ± 0.023	1.477MetArg: 1.477 ± 0.032	2.067MetSer: 2.067 ± 0.035	1.527MetThr: 1.527 ± 0.025	1.612MetVal: 1.612 ± 0.034	0.267MetTrp: 0.267 ± 0.012	0.625MetTyr: 0.625 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.248AsnAla: 2.248 ± 0.038	0.296AsnCys: 0.296 ± 0.015	1.484AsnAsp: 1.484 ± 0.038	1.551AsnGlu: 1.551 ± 0.036	0.908AsnPhe: 0.908 ± 0.03	2.234AsnGly: 2.234 ± 0.053	0.761AsnHis: 0.761 ± 0.022	1.386AsnIle: 1.386 ± 0.031	1.047AsnLys: 1.047 ± 0.027	2.587AsnLeu: 2.587 ± 0.042	0.612AsnMet: 0.612 ± 0.02	0.814AsnAsn: 0.814 ± 0.03	2.098AsnPro: 2.098 ± 0.037	1.101AsnGln: 1.101 ± 0.03	1.647AsnArg: 1.647 ± 0.03	1.877AsnSer: 1.877 ± 0.034	1.491AsnThr: 1.491 ± 0.034	1.72AsnVal: 1.72 ± 0.035	0.373AsnTrp: 0.373 ± 0.017	0.725AsnTyr: 0.725 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.132ProAla: 4.132 ± 0.059	0.587ProCys: 0.587 ± 0.022	2.803ProAsp: 2.803 ± 0.044	3.603ProGlu: 3.603 ± 0.061	2.045ProPhe: 2.045 ± 0.038	4.338ProGly: 4.338 ± 0.065	1.571ProHis: 1.571 ± 0.039	2.92ProIle: 2.92 ± 0.044	2.553ProLys: 2.553 ± 0.041	5.483ProLeu: 5.483 ± 0.064	1.354ProMet: 1.354 ± 0.035	1.636ProAsn: 1.636 ± 0.034	5.337ProPro: 5.337 ± 0.135	2.029ProGln: 2.029 ± 0.04	3.324ProArg: 3.324 ± 0.052	7.757ProSer: 7.757 ± 0.129	4.098ProThr: 4.098 ± 0.066	3.366ProVal: 3.366 ± 0.05	0.809ProTrp: 0.809 ± 0.024	1.586ProTyr: 1.586 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.718GlnAla: 3.718 ± 0.053	0.536GlnCys: 0.536 ± 0.02	2.34GlnAsp: 2.34 ± 0.043	3.047GlnGlu: 3.047 ± 0.057	0.937GlnPhe: 0.937 ± 0.025	3.581GlnGly: 3.581 ± 0.061	0.893GlnHis: 0.893 ± 0.026	1.541GlnIle: 1.541 ± 0.029	1.478GlnLys: 1.478 ± 0.033	3.197GlnLeu: 3.197 ± 0.05	0.889GlnMet: 0.889 ± 0.026	0.947GlnAsn: 0.947 ± 0.027	1.732GlnPro: 1.732 ± 0.035	1.601GlnGln: 1.601 ± 0.059	2.562GlnArg: 2.562 ± 0.045	2.628GlnSer: 2.628 ± 0.045	1.816GlnThr: 1.816 ± 0.039	2.717GlnVal: 2.717 ± 0.042	0.678GlnTrp: 0.678 ± 0.022	1.057GlnTyr: 1.057 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.163ArgAla: 5.163 ± 0.071	0.789ArgCys: 0.789 ± 0.023	3.353ArgAsp: 3.353 ± 0.048	4.787ArgGlu: 4.787 ± 0.075	2.074ArgPhe: 2.074 ± 0.037	4.5ArgGly: 4.5 ± 0.079	1.76ArgHis: 1.76 ± 0.032	3.36ArgIle: 3.36 ± 0.042	3.511ArgLys: 3.511 ± 0.053	6.486ArgLeu: 6.486 ± 0.071	1.825ArgMet: 1.825 ± 0.037	1.69ArgAsn: 1.69 ± 0.034	3.485ArgPro: 3.485 ± 0.05	2.648ArgGln: 2.648 ± 0.044	5.799ArgArg: 5.799 ± 0.077	5.184ArgSer: 5.184 ± 0.07	3.437ArgThr: 3.437 ± 0.047	4.446ArgVal: 4.446 ± 0.059	1.099ArgTrp: 1.099 ± 0.031	1.789ArgTyr: 1.789 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.971SerAla: 5.971 ± 0.083	0.802SerCys: 0.802 ± 0.021	3.513SerAsp: 3.513 ± 0.051	3.781SerGlu: 3.781 ± 0.055	2.977SerPhe: 2.977 ± 0.045	6.26SerGly: 6.26 ± 0.074	2.194SerHis: 2.194 ± 0.041	4.168SerIle: 4.168 ± 0.055	3.645SerLys: 3.645 ± 0.057	9.012SerLeu: 9.012 ± 0.076	2.02SerMet: 2.02 ± 0.038	2.263SerAsn: 2.263 ± 0.047	6.615SerPro: 6.615 ± 0.12	2.999SerGln: 2.999 ± 0.047	5.148SerArg: 5.148 ± 0.067	12.185SerSer: 12.185 ± 0.246	5.919SerThr: 5.919 ± 0.086	4.428SerVal: 4.428 ± 0.057	1.102SerTrp: 1.102 ± 0.029	2.0SerTyr: 2.0 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.229ThrAla: 4.229 ± 0.056	0.691ThrCys: 0.691 ± 0.021	2.58ThrAsp: 2.58 ± 0.04	3.034ThrGlu: 3.034 ± 0.049	2.065ThrPhe: 2.065 ± 0.044	4.247ThrGly: 4.247 ± 0.058	1.534ThrHis: 1.534 ± 0.03	2.67ThrIle: 2.67 ± 0.044	2.257ThrLys: 2.257 ± 0.042	6.236ThrLeu: 6.236 ± 0.066	1.271ThrMet: 1.271 ± 0.028	1.472ThrAsn: 1.472 ± 0.03	4.141ThrPro: 4.141 ± 0.073	2.12ThrGln: 2.12 ± 0.037	3.474ThrArg: 3.474 ± 0.048	5.64ThrSer: 5.64 ± 0.086	3.854ThrThr: 3.854 ± 0.086	3.257ThrVal: 3.257 ± 0.051	0.793ThrTrp: 0.793 ± 0.02	1.51ThrTyr: 1.51 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	4.559ValAla: 4.559 ± 0.065	0.893ValCys: 0.893 ± 0.024	3.71ValAsp: 3.71 ± 0.053	4.315ValGlu: 4.315 ± 0.067	1.897ValPhe: 1.897 ± 0.033	4.187ValGly: 4.187 ± 0.065	1.649ValHis: 1.649 ± 0.033	2.9ValIle: 2.9 ± 0.052	2.87ValLys: 2.87 ± 0.052	5.77ValLeu: 5.77 ± 0.069	1.52ValMet: 1.52 ± 0.034	1.87ValAsn: 1.87 ± 0.039	3.314ValPro: 3.314 ± 0.046	2.472ValGln: 2.472 ± 0.044	4.161ValArg: 4.161 ± 0.059	4.569ValSer: 4.569 ± 0.061	3.246ValThr: 3.246 ± 0.059	3.97ValVal: 3.97 ± 0.06	0.934ValTrp: 0.934 ± 0.029	1.633ValTyr: 1.633 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.109TrpAla: 1.109 ± 0.028	0.228TrpCys: 0.228 ± 0.011	0.898TrpAsp: 0.898 ± 0.027	0.926TrpGlu: 0.926 ± 0.026	0.443TrpPhe: 0.443 ± 0.018	0.951TrpGly: 0.951 ± 0.026	0.296TrpHis: 0.296 ± 0.013	0.774TrpIle: 0.774 ± 0.025	0.881TrpLys: 0.881 ± 0.027	1.235TrpLeu: 1.235 ± 0.028	0.516TrpMet: 0.516 ± 0.019	0.48TrpAsn: 0.48 ± 0.019	0.515TrpPro: 0.515 ± 0.019	0.389TrpGln: 0.389 ± 0.015	1.069TrpArg: 1.069 ± 0.03	1.188TrpSer: 1.188 ± 0.03	0.83TrpThr: 0.83 ± 0.027	1.033TrpVal: 1.033 ± 0.025	0.309TrpTrp: 0.309 ± 0.014	0.418TrpTyr: 0.418 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.067TyrAla: 2.067 ± 0.042	0.43TyrCys: 0.43 ± 0.017	1.391TyrAsp: 1.391 ± 0.032	1.366TyrGlu: 1.366 ± 0.032	1.059TyrPhe: 1.059 ± 0.027	2.194TyrGly: 2.194 ± 0.042	0.833TyrHis: 0.833 ± 0.025	1.166TyrIle: 1.166 ± 0.031	0.916TyrLys: 0.916 ± 0.028	2.89TyrLeu: 2.89 ± 0.055	0.598TyrMet: 0.598 ± 0.019	0.74TyrAsn: 0.74 ± 0.025	1.635TyrPro: 1.635 ± 0.041	1.104TyrGln: 1.104 ± 0.03	1.844TyrArg: 1.844 ± 0.04	1.846TyrSer: 1.846 ± 0.036	1.544TyrThr: 1.544 ± 0.035	1.565TyrVal: 1.565 ± 0.036	0.395TyrTrp: 0.395 ± 0.015	0.883TyrTyr: 0.883 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4271 proteins (1596308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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