Amino acid dipepetide frequency for Sulfitobacter indolifex HEL-45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.139AlaAla: 16.139 ± 0.167	1.14AlaCys: 1.14 ± 0.03	6.861AlaAsp: 6.861 ± 0.083	8.57AlaGlu: 8.57 ± 0.121	4.228AlaPhe: 4.228 ± 0.061	10.04AlaGly: 10.04 ± 0.113	2.358AlaHis: 2.358 ± 0.049	5.723AlaIle: 5.723 ± 0.071	4.075AlaLys: 4.075 ± 0.059	13.927AlaLeu: 13.927 ± 0.136	3.797AlaMet: 3.797 ± 0.061	2.702AlaAsn: 2.702 ± 0.053	5.759AlaPro: 5.759 ± 0.073	4.936AlaGln: 4.936 ± 0.066	8.309AlaArg: 8.309 ± 0.111	5.508AlaSer: 5.508 ± 0.07	5.982AlaThr: 5.982 ± 0.08	8.328AlaVal: 8.328 ± 0.102	1.391AlaTrp: 1.391 ± 0.035	2.469AlaTyr: 2.469 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.033	0.117CysCys: 0.117 ± 0.01	0.664CysAsp: 0.664 ± 0.023	0.451CysGlu: 0.451 ± 0.019	0.318CysPhe: 0.318 ± 0.017	0.919CysGly: 0.919 ± 0.029	0.3CysHis: 0.3 ± 0.017	0.453CysIle: 0.453 ± 0.019	0.236CysLys: 0.236 ± 0.013	0.832CysLeu: 0.832 ± 0.023	0.182CysMet: 0.182 ± 0.012	0.252CysAsn: 0.252 ± 0.014	0.497CysPro: 0.497 ± 0.021	0.216CysGln: 0.216 ± 0.012	0.521CysArg: 0.521 ± 0.021	0.437CysSer: 0.437 ± 0.019	0.476CysThr: 0.476 ± 0.02	0.613CysVal: 0.613 ± 0.021	0.119CysTrp: 0.119 ± 0.008	0.193CysTyr: 0.193 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.492AspAla: 7.492 ± 0.083	0.548AspCys: 0.548 ± 0.022	3.593AspAsp: 3.593 ± 0.074	3.515AspGlu: 3.515 ± 0.057	2.225AspPhe: 2.225 ± 0.044	5.344AspGly: 5.344 ± 0.085	1.406AspHis: 1.406 ± 0.037	3.224AspIle: 3.224 ± 0.057	1.795AspLys: 1.795 ± 0.039	6.393AspLeu: 6.393 ± 0.078	1.774AspMet: 1.774 ± 0.041	1.476AspAsn: 1.476 ± 0.036	3.437AspPro: 3.437 ± 0.05	1.955AspGln: 1.955 ± 0.047	4.152AspArg: 4.152 ± 0.067	2.312AspSer: 2.312 ± 0.042	3.084AspThr: 3.084 ± 0.051	4.497AspVal: 4.497 ± 0.065	1.16AspTrp: 1.16 ± 0.033	1.568AspTyr: 1.568 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.079GluAla: 8.079 ± 0.089	0.367GluCys: 0.367 ± 0.018	3.47GluAsp: 3.47 ± 0.052	3.641GluGlu: 3.641 ± 0.067	1.853GluPhe: 1.853 ± 0.038	5.067GluGly: 5.067 ± 0.068	1.157GluHis: 1.157 ± 0.03	3.572GluIle: 3.572 ± 0.051	2.307GluLys: 2.307 ± 0.049	5.266GluLeu: 5.266 ± 0.079	1.962GluMet: 1.962 ± 0.039	1.926GluAsn: 1.926 ± 0.043	2.432GluPro: 2.432 ± 0.054	2.075GluGln: 2.075 ± 0.046	4.053GluArg: 4.053 ± 0.067	2.225GluSer: 2.225 ± 0.035	3.977GluThr: 3.977 ± 0.051	4.649GluVal: 4.649 ± 0.065	0.71GluTrp: 0.71 ± 0.026	1.083GluTyr: 1.083 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.512PheAla: 4.512 ± 0.065	0.409PheCys: 0.409 ± 0.017	2.954PheAsp: 2.954 ± 0.053	2.281PheGlu: 2.281 ± 0.049	1.418PhePhe: 1.418 ± 0.038	3.67PheGly: 3.67 ± 0.055	0.753PheHis: 0.753 ± 0.026	1.703PheIle: 1.703 ± 0.041	1.024PheLys: 1.024 ± 0.029	3.298PheLeu: 3.298 ± 0.061	0.889PheMet: 0.889 ± 0.032	1.089PheAsn: 1.089 ± 0.034	1.47PhePro: 1.47 ± 0.035	1.036PheGln: 1.036 ± 0.028	1.959PheArg: 1.959 ± 0.043	2.087PheSer: 2.087 ± 0.039	2.18PheThr: 2.18 ± 0.041	2.698PheVal: 2.698 ± 0.044	0.579PheTrp: 0.579 ± 0.023	0.918PheTyr: 0.918 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.677GlyAla: 9.677 ± 0.106	0.844GlyCys: 0.844 ± 0.031	4.785GlyAsp: 4.785 ± 0.08	4.695GlyGlu: 4.695 ± 0.067	3.632GlyPhe: 3.632 ± 0.06	7.265GlyGly: 7.265 ± 0.113	1.983GlyHis: 1.983 ± 0.04	4.416GlyIle: 4.416 ± 0.066	3.28GlyLys: 3.28 ± 0.055	8.98GlyLeu: 8.98 ± 0.11	2.715GlyMet: 2.715 ± 0.048	2.147GlyAsn: 2.147 ± 0.046	3.533GlyPro: 3.533 ± 0.059	3.19GlyGln: 3.19 ± 0.052	5.316GlyArg: 5.316 ± 0.064	4.329GlySer: 4.329 ± 0.069	4.542GlyThr: 4.542 ± 0.055	6.319GlyVal: 6.319 ± 0.073	1.413GlyTrp: 1.413 ± 0.032	2.274GlyTyr: 2.274 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.338HisAla: 2.338 ± 0.047	0.243HisCys: 0.243 ± 0.015	1.337HisAsp: 1.337 ± 0.037	1.085HisGlu: 1.085 ± 0.026	0.863HisPhe: 0.863 ± 0.023	1.974HisGly: 1.974 ± 0.043	0.566HisHis: 0.566 ± 0.025	1.006HisIle: 1.006 ± 0.027	0.53HisLys: 0.53 ± 0.022	2.202HisLeu: 2.202 ± 0.054	0.558HisMet: 0.558 ± 0.022	0.502HisAsn: 0.502 ± 0.023	1.384HisPro: 1.384 ± 0.04	0.607HisGln: 0.607 ± 0.023	1.294HisArg: 1.294 ± 0.037	0.986HisSer: 0.986 ± 0.031	0.845HisThr: 0.845 ± 0.025	1.492HisVal: 1.492 ± 0.035	0.335HisTrp: 0.335 ± 0.017	0.558HisTyr: 0.558 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.99IleAla: 6.99 ± 0.074	0.678IleCys: 0.678 ± 0.024	3.645IleAsp: 3.645 ± 0.059	3.56IleGlu: 3.56 ± 0.057	1.858IlePhe: 1.858 ± 0.049	4.779IleGly: 4.779 ± 0.059	0.905IleHis: 0.905 ± 0.027	2.501IleIle: 2.501 ± 0.046	1.596IleLys: 1.596 ± 0.036	4.658IleLeu: 4.658 ± 0.078	1.17IleMet: 1.17 ± 0.031	1.525IleAsn: 1.525 ± 0.034	2.259IlePro: 2.259 ± 0.049	1.206IleGln: 1.206 ± 0.031	2.978IleArg: 2.978 ± 0.05	3.043IleSer: 3.043 ± 0.058	3.23IleThr: 3.23 ± 0.052	3.719IleVal: 3.719 ± 0.065	0.734IleTrp: 0.734 ± 0.029	1.201IleTyr: 1.201 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.914LysAla: 3.914 ± 0.063	0.196LysCys: 0.196 ± 0.011	1.917LysAsp: 1.917 ± 0.037	1.668LysGlu: 1.668 ± 0.039	1.025LysPhe: 1.025 ± 0.031	2.844LysGly: 2.844 ± 0.062	0.656LysHis: 0.656 ± 0.026	1.753LysIle: 1.753 ± 0.038	1.251LysLys: 1.251 ± 0.04	3.161LysLeu: 3.161 ± 0.059	0.973LysMet: 0.973 ± 0.03	0.881LysAsn: 0.881 ± 0.031	1.856LysPro: 1.856 ± 0.042	0.992LysGln: 0.992 ± 0.031	2.413LysArg: 2.413 ± 0.044	1.9LysSer: 1.9 ± 0.049	2.054LysThr: 2.054 ± 0.045	2.487LysVal: 2.487 ± 0.054	0.387LysTrp: 0.387 ± 0.018	0.643LysTyr: 0.643 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.615LeuAla: 12.615 ± 0.132	0.916LeuCys: 0.916 ± 0.028	5.844LeuAsp: 5.844 ± 0.071	5.405LeuGlu: 5.405 ± 0.07	3.445LeuPhe: 3.445 ± 0.072	8.249LeuGly: 8.249 ± 0.088	1.994LeuHis: 1.994 ± 0.04	5.443LeuIle: 5.443 ± 0.067	3.281LeuLys: 3.281 ± 0.058	9.261LeuLeu: 9.261 ± 0.123	2.83LeuMet: 2.83 ± 0.048	2.874LeuAsn: 2.874 ± 0.046	5.666LeuPro: 5.666 ± 0.073	3.0LeuGln: 3.0 ± 0.054	7.163LeuArg: 7.163 ± 0.089	6.751LeuSer: 6.751 ± 0.082	6.073LeuThr: 6.073 ± 0.076	6.641LeuVal: 6.641 ± 0.092	1.301LeuTrp: 1.301 ± 0.034	1.952LeuTyr: 1.952 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.528MetAla: 3.528 ± 0.06	0.197MetCys: 0.197 ± 0.014	1.468MetAsp: 1.468 ± 0.034	1.419MetGlu: 1.419 ± 0.042	0.894MetPhe: 0.894 ± 0.027	2.374MetGly: 2.374 ± 0.052	0.466MetHis: 0.466 ± 0.019	1.686MetIle: 1.686 ± 0.034	1.15MetLys: 1.15 ± 0.031	2.723MetLeu: 2.723 ± 0.047	0.871MetMet: 0.871 ± 0.029	0.882MetAsn: 0.882 ± 0.029	1.631MetPro: 1.631 ± 0.038	1.136MetGln: 1.136 ± 0.031	1.991MetArg: 1.991 ± 0.046	1.849MetSer: 1.849 ± 0.037	2.198MetThr: 2.198 ± 0.044	1.908MetVal: 1.908 ± 0.037	0.248MetTrp: 0.248 ± 0.016	0.361MetTyr: 0.361 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.426AsnAla: 3.426 ± 0.057	0.28AsnCys: 0.28 ± 0.014	1.624AsnAsp: 1.624 ± 0.044	1.335AsnGlu: 1.335 ± 0.032	1.066AsnPhe: 1.066 ± 0.033	2.392AsnGly: 2.392 ± 0.047	0.526AsnHis: 0.526 ± 0.022	1.493AsnIle: 1.493 ± 0.031	0.75AsnLys: 0.75 ± 0.03	2.67AsnLeu: 2.67 ± 0.049	0.737AsnMet: 0.737 ± 0.026	0.784AsnAsn: 0.784 ± 0.026	1.828AsnPro: 1.828 ± 0.042	0.776AsnGln: 0.776 ± 0.023	1.774AsnArg: 1.774 ± 0.039	1.254AsnSer: 1.254 ± 0.034	1.423AsnThr: 1.423 ± 0.036	1.853AsnVal: 1.853 ± 0.038	0.456AsnTrp: 0.456 ± 0.018	0.643AsnTyr: 0.643 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.349ProAla: 5.349 ± 0.073	0.365ProCys: 0.365 ± 0.018	3.681ProAsp: 3.681 ± 0.056	4.12ProGlu: 4.12 ± 0.06	1.904ProPhe: 1.904 ± 0.045	4.228ProGly: 4.228 ± 0.06	1.071ProHis: 1.071 ± 0.035	2.292ProIle: 2.292 ± 0.041	1.761ProLys: 1.761 ± 0.041	4.709ProLeu: 4.709 ± 0.068	1.321ProMet: 1.321 ± 0.034	1.397ProAsn: 1.397 ± 0.035	2.181ProPro: 2.181 ± 0.051	1.872ProGln: 1.872 ± 0.041	2.781ProArg: 2.781 ± 0.054	2.52ProSer: 2.52 ± 0.039	2.42ProThr: 2.42 ± 0.045	3.968ProVal: 3.968 ± 0.066	0.614ProTrp: 0.614 ± 0.023	1.154ProTyr: 1.154 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.144GlnAla: 4.144 ± 0.062	0.224GlnCys: 0.224 ± 0.015	1.846GlnAsp: 1.846 ± 0.039	1.72GlnGlu: 1.72 ± 0.04	1.126GlnPhe: 1.126 ± 0.035	2.687GlnGly: 2.687 ± 0.049	0.683GlnHis: 0.683 ± 0.023	2.183GlnIle: 2.183 ± 0.046	1.122GlnLys: 1.122 ± 0.03	3.092GlnLeu: 3.092 ± 0.05	1.27GlnMet: 1.27 ± 0.032	0.98GlnAsn: 0.98 ± 0.027	1.641GlnPro: 1.641 ± 0.036	1.233GlnGln: 1.233 ± 0.037	2.302GlnArg: 2.302 ± 0.049	1.923GlnSer: 1.923 ± 0.045	2.029GlnThr: 2.029 ± 0.043	2.483GlnVal: 2.483 ± 0.048	0.405GlnTrp: 0.405 ± 0.02	0.597GlnTyr: 0.597 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.018ArgAla: 8.018 ± 0.1	0.455ArgCys: 0.455 ± 0.019	4.232ArgAsp: 4.232 ± 0.06	3.87ArgGlu: 3.87 ± 0.067	2.557ArgPhe: 2.557 ± 0.043	4.569ArgGly: 4.569 ± 0.058	1.483ArgHis: 1.483 ± 0.036	3.611ArgIle: 3.611 ± 0.057	2.307ArgLys: 2.307 ± 0.046	6.814ArgLeu: 6.814 ± 0.078	1.941ArgMet: 1.941 ± 0.042	1.772ArgAsn: 1.772 ± 0.042	2.991ArgPro: 2.991 ± 0.055	2.358ArgGln: 2.358 ± 0.046	4.712ArgArg: 4.712 ± 0.075	3.256ArgSer: 3.256 ± 0.057	2.801ArgThr: 2.801 ± 0.049	4.477ArgVal: 4.477 ± 0.065	0.872ArgTrp: 0.872 ± 0.028	1.568ArgTyr: 1.568 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.918SerAla: 5.918 ± 0.068	0.435SerCys: 0.435 ± 0.019	3.526SerAsp: 3.526 ± 0.052	3.02SerGlu: 3.02 ± 0.053	2.258SerPhe: 2.258 ± 0.048	5.323SerGly: 5.323 ± 0.085	1.12SerHis: 1.12 ± 0.034	2.563SerIle: 2.563 ± 0.047	1.62SerLys: 1.62 ± 0.039	5.123SerLeu: 5.123 ± 0.076	1.428SerMet: 1.428 ± 0.034	1.46SerAsn: 1.46 ± 0.035	2.444SerPro: 2.444 ± 0.053	1.598SerGln: 1.598 ± 0.033	3.095SerArg: 3.095 ± 0.057	2.656SerSer: 2.656 ± 0.061	2.607SerThr: 2.607 ± 0.047	3.781SerVal: 3.781 ± 0.055	0.635SerTrp: 0.635 ± 0.024	1.377SerTyr: 1.377 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.467ThrAla: 6.467 ± 0.087	0.483ThrCys: 0.483 ± 0.02	3.104ThrAsp: 3.104 ± 0.053	3.035ThrGlu: 3.035 ± 0.051	2.049ThrPhe: 2.049 ± 0.043	5.161ThrGly: 5.161 ± 0.066	1.118ThrHis: 1.118 ± 0.032	2.729ThrIle: 2.729 ± 0.049	1.612ThrLys: 1.612 ± 0.04	6.231ThrLeu: 6.231 ± 0.074	1.366ThrMet: 1.366 ± 0.036	1.39ThrAsn: 1.39 ± 0.04	3.581ThrPro: 3.581 ± 0.055	1.777ThrGln: 1.777 ± 0.041	3.418ThrArg: 3.418 ± 0.061	2.885ThrSer: 2.885 ± 0.053	3.021ThrThr: 3.021 ± 0.057	4.094ThrVal: 4.094 ± 0.062	0.674ThrTrp: 0.674 ± 0.024	1.289ThrTyr: 1.289 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.629ValAla: 8.629 ± 0.1	0.617ValCys: 0.617 ± 0.023	4.015ValAsp: 4.015 ± 0.067	4.608ValGlu: 4.608 ± 0.066	2.704ValPhe: 2.704 ± 0.057	5.335ValGly: 5.335 ± 0.067	1.28ValHis: 1.28 ± 0.034	4.235ValIle: 4.235 ± 0.07	2.229ValLys: 2.229 ± 0.047	7.476ValLeu: 7.476 ± 0.088	2.29ValMet: 2.29 ± 0.043	2.048ValAsn: 2.048 ± 0.038	3.425ValPro: 3.425 ± 0.052	2.344ValGln: 2.344 ± 0.049	3.902ValArg: 3.902 ± 0.061	4.136ValSer: 4.136 ± 0.069	4.7ValThr: 4.7 ± 0.062	5.476ValVal: 5.476 ± 0.07	0.894ValTrp: 0.894 ± 0.029	1.513ValTyr: 1.513 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.349TrpAla: 1.349 ± 0.038	0.156TrpCys: 0.156 ± 0.012	0.738TrpAsp: 0.738 ± 0.027	0.612TrpGlu: 0.612 ± 0.023	0.569TrpPhe: 0.569 ± 0.021	1.013TrpGly: 1.013 ± 0.034	0.333TrpHis: 0.333 ± 0.017	0.664TrpIle: 0.664 ± 0.025	0.432TrpLys: 0.432 ± 0.02	1.591TrpLeu: 1.591 ± 0.034	0.404TrpMet: 0.404 ± 0.019	0.382TrpAsn: 0.382 ± 0.017	0.644TrpPro: 0.644 ± 0.024	0.66TrpGln: 0.66 ± 0.021	1.052TrpArg: 1.052 ± 0.034	0.776TrpSer: 0.776 ± 0.027	0.726TrpThr: 0.726 ± 0.025	0.904TrpVal: 0.904 ± 0.026	0.216TrpTrp: 0.216 ± 0.014	0.266TrpTyr: 0.266 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.553TyrAla: 2.553 ± 0.05	0.233TyrCys: 0.233 ± 0.014	1.648TyrAsp: 1.648 ± 0.04	1.261TyrGlu: 1.261 ± 0.037	0.935TyrPhe: 0.935 ± 0.026	2.099TyrGly: 2.099 ± 0.038	0.545TyrHis: 0.545 ± 0.02	0.984TyrIle: 0.984 ± 0.025	0.612TyrLys: 0.612 ± 0.022	2.298TyrLeu: 2.298 ± 0.04	0.502TyrMet: 0.502 ± 0.019	0.622TyrAsn: 0.622 ± 0.026	1.049TyrPro: 1.049 ± 0.03	0.724TyrGln: 0.724 ± 0.023	1.48TyrArg: 1.48 ± 0.038	1.153TyrSer: 1.153 ± 0.032	1.118TyrThr: 1.118 ± 0.033	1.465TyrVal: 1.465 ± 0.037	0.345TyrTrp: 0.345 ± 0.018	0.585TyrTyr: 0.585 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4147 proteins (1216087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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