Amino acid dipepetide frequency for Arthrobacter subterraneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.048AlaAla: 19.048 ± 0.184	0.779AlaCys: 0.779 ± 0.03	7.054AlaAsp: 7.054 ± 0.094	8.296AlaGlu: 8.296 ± 0.104	3.688AlaPhe: 3.688 ± 0.06	12.412AlaGly: 12.412 ± 0.107	2.32AlaHis: 2.32 ± 0.052	4.769AlaIle: 4.769 ± 0.08	2.705AlaLys: 2.705 ± 0.057	12.95AlaLeu: 12.95 ± 0.129	2.649AlaMet: 2.649 ± 0.049	2.539AlaAsn: 2.539 ± 0.049	5.95AlaPro: 5.95 ± 0.098	3.901AlaGln: 3.901 ± 0.073	8.233AlaArg: 8.233 ± 0.097	6.769AlaSer: 6.769 ± 0.09	6.229AlaThr: 6.229 ± 0.079	11.383AlaVal: 11.383 ± 0.115	1.602AlaTrp: 1.602 ± 0.042	2.267AlaTyr: 2.267 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.731CysAla: 0.731 ± 0.027	0.065CysCys: 0.065 ± 0.008	0.351CysAsp: 0.351 ± 0.019	0.343CysGlu: 0.343 ± 0.018	0.19CysPhe: 0.19 ± 0.014	0.705CysGly: 0.705 ± 0.024	0.14CysHis: 0.14 ± 0.012	0.262CysIle: 0.262 ± 0.015	0.107CysLys: 0.107 ± 0.01	0.584CysLeu: 0.584 ± 0.024	0.1CysMet: 0.1 ± 0.009	0.132CysAsn: 0.132 ± 0.011	0.365CysPro: 0.365 ± 0.018	0.179CysGln: 0.179 ± 0.013	0.442CysArg: 0.442 ± 0.022	0.399CysSer: 0.399 ± 0.02	0.417CysThr: 0.417 ± 0.018	0.441CysVal: 0.441 ± 0.02	0.08CysTrp: 0.08 ± 0.009	0.129CysTyr: 0.129 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.18AspAla: 7.18 ± 0.085	0.322AspCys: 0.322 ± 0.019	3.492AspAsp: 3.492 ± 0.062	3.614AspGlu: 3.614 ± 0.056	1.783AspPhe: 1.783 ± 0.035	5.826AspGly: 5.826 ± 0.084	1.243AspHis: 1.243 ± 0.035	2.378AspIle: 2.378 ± 0.045	1.064AspLys: 1.064 ± 0.036	5.835AspLeu: 5.835 ± 0.072	0.909AspMet: 0.909 ± 0.028	1.146AspAsn: 1.146 ± 0.032	3.853AspPro: 3.853 ± 0.059	1.699AspGln: 1.699 ± 0.039	4.001AspArg: 4.001 ± 0.057	3.054AspSer: 3.054 ± 0.056	2.901AspThr: 2.901 ± 0.052	4.912AspVal: 4.912 ± 0.067	0.883AspTrp: 0.883 ± 0.028	1.281AspTyr: 1.281 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.29GluAla: 7.29 ± 0.095	0.315GluCys: 0.315 ± 0.019	3.403GluAsp: 3.403 ± 0.05	4.095GluGlu: 4.095 ± 0.07	1.764GluPhe: 1.764 ± 0.043	4.467GluGly: 4.467 ± 0.068	1.549GluHis: 1.549 ± 0.038	2.679GluIle: 2.679 ± 0.047	1.743GluLys: 1.743 ± 0.048	6.827GluLeu: 6.827 ± 0.081	0.982GluMet: 0.982 ± 0.032	1.666GluAsn: 1.666 ± 0.039	3.255GluPro: 3.255 ± 0.055	2.555GluGln: 2.555 ± 0.049	4.731GluArg: 4.731 ± 0.073	3.235GluSer: 3.235 ± 0.052	3.218GluThr: 3.218 ± 0.061	4.635GluVal: 4.635 ± 0.066	0.805GluTrp: 0.805 ± 0.027	1.229GluTyr: 1.229 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.843PheAla: 3.843 ± 0.056	0.243PheCys: 0.243 ± 0.015	2.164PheAsp: 2.164 ± 0.047	1.819PheGlu: 1.819 ± 0.045	1.123PhePhe: 1.123 ± 0.034	3.272PheGly: 3.272 ± 0.056	0.599PheHis: 0.599 ± 0.023	1.378PheIle: 1.378 ± 0.038	0.636PheLys: 0.636 ± 0.025	3.111PheLeu: 3.111 ± 0.056	0.543PheMet: 0.543 ± 0.024	0.935PheAsn: 0.935 ± 0.033	1.527PhePro: 1.527 ± 0.033	0.796PheGln: 0.796 ± 0.03	1.89PheArg: 1.89 ± 0.037	2.021PheSer: 2.021 ± 0.042	2.195PheThr: 2.195 ± 0.043	2.415PheVal: 2.415 ± 0.048	0.485PheTrp: 0.485 ± 0.021	0.692PheTyr: 0.692 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.135GlyAla: 10.135 ± 0.108	0.641GlyCys: 0.641 ± 0.025	4.441GlyAsp: 4.441 ± 0.075	5.011GlyGlu: 5.011 ± 0.071	3.224GlyPhe: 3.224 ± 0.049	7.735GlyGly: 7.735 ± 0.102	1.929GlyHis: 1.929 ± 0.044	4.676GlyIle: 4.676 ± 0.068	2.524GlyLys: 2.524 ± 0.05	8.895GlyLeu: 8.895 ± 0.095	2.065GlyMet: 2.065 ± 0.045	2.352GlyAsn: 2.352 ± 0.053	4.006GlyPro: 4.006 ± 0.06	2.768GlyGln: 2.768 ± 0.051	6.103GlyArg: 6.103 ± 0.081	5.96GlySer: 5.96 ± 0.079	5.945GlyThr: 5.945 ± 0.085	7.385GlyVal: 7.385 ± 0.089	1.598GlyTrp: 1.598 ± 0.044	2.324GlyTyr: 2.324 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.3HisAla: 2.3 ± 0.05	0.177HisCys: 0.177 ± 0.013	1.177HisAsp: 1.177 ± 0.032	1.144HisGlu: 1.144 ± 0.03	0.64HisPhe: 0.64 ± 0.025	2.038HisGly: 2.038 ± 0.054	0.656HisHis: 0.656 ± 0.025	0.898HisIle: 0.898 ± 0.029	0.388HisLys: 0.388 ± 0.021	2.214HisLeu: 2.214 ± 0.041	0.353HisMet: 0.353 ± 0.015	0.495HisAsn: 0.495 ± 0.021	1.509HisPro: 1.509 ± 0.039	0.649HisGln: 0.649 ± 0.027	1.741HisArg: 1.741 ± 0.04	1.233HisSer: 1.233 ± 0.031	1.194HisThr: 1.194 ± 0.034	1.533HisVal: 1.533 ± 0.033	0.296HisTrp: 0.296 ± 0.018	0.494HisTyr: 0.494 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.701IleAla: 5.701 ± 0.073	0.314IleCys: 0.314 ± 0.018	2.896IleAsp: 2.896 ± 0.053	2.713IleGlu: 2.713 ± 0.054	1.348IlePhe: 1.348 ± 0.043	4.225IleGly: 4.225 ± 0.07	0.865IleHis: 0.865 ± 0.027	1.977IleIle: 1.977 ± 0.052	0.939IleLys: 0.939 ± 0.027	4.2IleLeu: 4.2 ± 0.072	0.756IleMet: 0.756 ± 0.028	1.221IleAsn: 1.221 ± 0.03	2.434IlePro: 2.434 ± 0.042	1.058IleGln: 1.058 ± 0.034	2.82IleArg: 2.82 ± 0.052	2.674IleSer: 2.674 ± 0.052	2.892IleThr: 2.892 ± 0.053	3.535IleVal: 3.535 ± 0.065	0.486IleTrp: 0.486 ± 0.019	0.843IleTyr: 0.843 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.882LysAla: 2.882 ± 0.059	0.094LysCys: 0.094 ± 0.009	1.357LysAsp: 1.357 ± 0.034	1.297LysGlu: 1.297 ± 0.038	0.658LysPhe: 0.658 ± 0.026	1.734LysGly: 1.734 ± 0.039	0.53LysHis: 0.53 ± 0.025	1.052LysIle: 1.052 ± 0.034	0.794LysLys: 0.794 ± 0.034	2.27LysLeu: 2.27 ± 0.047	0.494LysMet: 0.494 ± 0.02	0.667LysAsn: 0.667 ± 0.028	1.484LysPro: 1.484 ± 0.04	0.744LysGln: 0.744 ± 0.029	1.652LysArg: 1.652 ± 0.04	1.345LysSer: 1.345 ± 0.031	1.383LysThr: 1.383 ± 0.035	1.91LysVal: 1.91 ± 0.049	0.273LysTrp: 0.273 ± 0.017	0.561LysTyr: 0.561 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.754LeuAla: 13.754 ± 0.137	0.634LeuCys: 0.634 ± 0.02	6.159LeuAsp: 6.159 ± 0.078	5.818LeuGlu: 5.818 ± 0.077	2.976LeuPhe: 2.976 ± 0.056	8.994LeuGly: 8.994 ± 0.103	2.115LeuHis: 2.115 ± 0.043	4.613LeuIle: 4.613 ± 0.076	2.291LeuLys: 2.291 ± 0.043	10.752LeuLeu: 10.752 ± 0.136	1.952LeuMet: 1.952 ± 0.044	2.457LeuAsn: 2.457 ± 0.053	5.683LeuPro: 5.683 ± 0.072	3.045LeuGln: 3.045 ± 0.055	7.239LeuArg: 7.239 ± 0.09	6.324LeuSer: 6.324 ± 0.071	6.573LeuThr: 6.573 ± 0.079	8.594LeuVal: 8.594 ± 0.101	1.32LeuTrp: 1.32 ± 0.033	1.819LeuTyr: 1.819 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.442MetAla: 2.442 ± 0.049	0.11MetCys: 0.11 ± 0.009	0.976MetAsp: 0.976 ± 0.025	0.943MetGlu: 0.943 ± 0.027	0.565MetPhe: 0.565 ± 0.022	1.588MetGly: 1.588 ± 0.045	0.377MetHis: 0.377 ± 0.02	0.934MetIle: 0.934 ± 0.034	0.584MetLys: 0.584 ± 0.024	1.954MetLeu: 1.954 ± 0.042	0.378MetMet: 0.378 ± 0.02	0.609MetAsn: 0.609 ± 0.027	1.11MetPro: 1.11 ± 0.028	0.539MetGln: 0.539 ± 0.022	1.169MetArg: 1.169 ± 0.033	1.499MetSer: 1.499 ± 0.033	1.571MetThr: 1.571 ± 0.037	1.609MetVal: 1.609 ± 0.042	0.215MetTrp: 0.215 ± 0.013	0.34MetTyr: 0.34 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.799AsnAla: 2.799 ± 0.051	0.16AsnCys: 0.16 ± 0.013	1.346AsnAsp: 1.346 ± 0.038	1.303AsnGlu: 1.303 ± 0.034	0.818AsnPhe: 0.818 ± 0.03	2.41AsnGly: 2.41 ± 0.055	0.56AsnHis: 0.56 ± 0.023	1.073AsnIle: 1.073 ± 0.032	0.565AsnLys: 0.565 ± 0.023	2.42AsnLeu: 2.42 ± 0.045	0.456AsnMet: 0.456 ± 0.019	0.663AsnAsn: 0.663 ± 0.027	1.922AsnPro: 1.922 ± 0.041	0.815AsnGln: 0.815 ± 0.029	1.709AsnArg: 1.709 ± 0.04	1.39AsnSer: 1.39 ± 0.036	1.325AsnThr: 1.325 ± 0.037	1.912AsnVal: 1.912 ± 0.043	0.373AsnTrp: 0.373 ± 0.017	0.594AsnTyr: 0.594 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.489ProAla: 7.489 ± 0.095	0.256ProCys: 0.256 ± 0.014	3.726ProAsp: 3.726 ± 0.059	4.23ProGlu: 4.23 ± 0.062	1.693ProPhe: 1.693 ± 0.033	5.377ProGly: 5.377 ± 0.077	1.154ProHis: 1.154 ± 0.035	1.824ProIle: 1.824 ± 0.04	1.137ProLys: 1.137 ± 0.037	4.95ProLeu: 4.95 ± 0.069	0.942ProMet: 0.942 ± 0.029	1.139ProAsn: 1.139 ± 0.036	2.491ProPro: 2.491 ± 0.065	1.644ProGln: 1.644 ± 0.039	3.019ProArg: 3.019 ± 0.046	3.452ProSer: 3.452 ± 0.063	3.038ProThr: 3.038 ± 0.047	5.058ProVal: 5.058 ± 0.071	0.78ProTrp: 0.78 ± 0.028	1.038ProTyr: 1.038 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.818GlnAla: 3.818 ± 0.057	0.153GlnCys: 0.153 ± 0.012	1.555GlnAsp: 1.555 ± 0.037	1.873GlnGlu: 1.873 ± 0.042	0.932GlnPhe: 0.932 ± 0.026	2.279GlnGly: 2.279 ± 0.045	0.731GlnHis: 0.731 ± 0.029	1.39GlnIle: 1.39 ± 0.032	0.801GlnLys: 0.801 ± 0.028	3.611GlnLeu: 3.611 ± 0.05	0.626GlnMet: 0.626 ± 0.024	0.7GlnAsn: 0.7 ± 0.024	1.814GlnPro: 1.814 ± 0.048	1.384GlnGln: 1.384 ± 0.036	2.503GlnArg: 2.503 ± 0.049	1.649GlnSer: 1.649 ± 0.042	1.555GlnThr: 1.555 ± 0.036	2.499GlnVal: 2.499 ± 0.047	0.557GlnTrp: 0.557 ± 0.027	0.676GlnTyr: 0.676 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.368ArgAla: 7.368 ± 0.089	0.409ArgCys: 0.409 ± 0.018	3.684ArgAsp: 3.684 ± 0.059	4.313ArgGlu: 4.313 ± 0.072	2.393ArgPhe: 2.393 ± 0.052	4.844ArgGly: 4.844 ± 0.067	1.544ArgHis: 1.544 ± 0.035	3.499ArgIle: 3.499 ± 0.059	1.98ArgLys: 1.98 ± 0.051	7.177ArgLeu: 7.177 ± 0.09	1.62ArgMet: 1.62 ± 0.039	1.892ArgAsn: 1.892 ± 0.04	3.496ArgPro: 3.496 ± 0.059	2.365ArgGln: 2.365 ± 0.042	6.243ArgArg: 6.243 ± 0.092	4.342ArgSer: 4.342 ± 0.07	4.383ArgThr: 4.383 ± 0.07	5.108ArgVal: 5.108 ± 0.062	1.132ArgTrp: 1.132 ± 0.025	1.602ArgTyr: 1.602 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.448SerAla: 7.448 ± 0.083	0.333SerCys: 0.333 ± 0.018	3.122SerAsp: 3.122 ± 0.059	3.252SerGlu: 3.252 ± 0.053	2.05SerPhe: 2.05 ± 0.045	6.165SerGly: 6.165 ± 0.072	1.152SerHis: 1.152 ± 0.029	2.489SerIle: 2.489 ± 0.049	1.219SerLys: 1.219 ± 0.03	5.882SerLeu: 5.882 ± 0.071	1.371SerMet: 1.371 ± 0.034	1.478SerAsn: 1.478 ± 0.037	3.264SerPro: 3.264 ± 0.062	1.705SerGln: 1.705 ± 0.038	4.05SerArg: 4.05 ± 0.065	3.927SerSer: 3.927 ± 0.068	3.774SerThr: 3.774 ± 0.054	4.96SerVal: 4.96 ± 0.07	0.952SerTrp: 0.952 ± 0.032	1.321SerTyr: 1.321 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.754ThrAla: 7.754 ± 0.086	0.334ThrCys: 0.334 ± 0.018	3.35ThrAsp: 3.35 ± 0.053	3.351ThrGlu: 3.351 ± 0.053	1.901ThrPhe: 1.901 ± 0.045	5.973ThrGly: 5.973 ± 0.073	1.173ThrHis: 1.173 ± 0.036	2.597ThrIle: 2.597 ± 0.048	1.154ThrLys: 1.154 ± 0.033	5.88ThrLeu: 5.88 ± 0.09	1.077ThrMet: 1.077 ± 0.032	1.353ThrAsn: 1.353 ± 0.037	3.66ThrPro: 3.66 ± 0.059	1.583ThrGln: 1.583 ± 0.035	3.62ThrArg: 3.62 ± 0.049	3.403ThrSer: 3.403 ± 0.055	3.523ThrThr: 3.523 ± 0.062	5.717ThrVal: 5.717 ± 0.073	0.754ThrTrp: 0.754 ± 0.03	1.302ThrTyr: 1.302 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.731ValAla: 9.731 ± 0.114	0.545ValCys: 0.545 ± 0.019	5.062ValAsp: 5.062 ± 0.062	5.045ValGlu: 5.045 ± 0.072	2.673ValPhe: 2.673 ± 0.064	6.661ValGly: 6.661 ± 0.083	1.778ValHis: 1.778 ± 0.044	3.981ValIle: 3.981 ± 0.065	1.755ValLys: 1.755 ± 0.043	9.638ValLeu: 9.638 ± 0.116	1.614ValMet: 1.614 ± 0.031	2.133ValAsn: 2.133 ± 0.05	4.869ValPro: 4.869 ± 0.069	2.46ValGln: 2.46 ± 0.049	5.524ValArg: 5.524 ± 0.079	5.063ValSer: 5.063 ± 0.072	5.331ValThr: 5.331 ± 0.075	7.917ValVal: 7.917 ± 0.094	0.99ValTrp: 0.99 ± 0.031	1.522ValTyr: 1.522 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.478TrpAla: 1.478 ± 0.034	0.103TrpCys: 0.103 ± 0.01	0.771TrpAsp: 0.771 ± 0.029	0.745TrpGlu: 0.745 ± 0.025	0.516TrpPhe: 0.516 ± 0.021	0.984TrpGly: 0.984 ± 0.03	0.352TrpHis: 0.352 ± 0.017	0.693TrpIle: 0.693 ± 0.026	0.39TrpLys: 0.39 ± 0.019	1.73TrpLeu: 1.73 ± 0.04	0.337TrpMet: 0.337 ± 0.017	0.495TrpAsn: 0.495 ± 0.021	0.613TrpPro: 0.613 ± 0.025	0.559TrpGln: 0.559 ± 0.026	1.046TrpArg: 1.046 ± 0.034	0.855TrpSer: 0.855 ± 0.03	0.839TrpThr: 0.839 ± 0.027	1.118TrpVal: 1.118 ± 0.029	0.296TrpTrp: 0.296 ± 0.016	0.278TrpTyr: 0.278 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.352TyrAla: 2.352 ± 0.043	0.177TyrCys: 0.177 ± 0.012	1.29TyrAsp: 1.29 ± 0.035	1.236TyrGlu: 1.236 ± 0.034	0.752TyrPhe: 0.752 ± 0.023	2.027TyrGly: 2.027 ± 0.04	0.361TyrHis: 0.361 ± 0.018	0.734TyrIle: 0.734 ± 0.029	0.406TyrLys: 0.406 ± 0.017	2.23TyrLeu: 2.23 ± 0.046	0.286TyrMet: 0.286 ± 0.015	0.545TyrAsn: 0.545 ± 0.024	1.13TyrPro: 1.13 ± 0.035	0.656TyrGln: 0.656 ± 0.024	1.658TyrArg: 1.658 ± 0.04	1.323TyrSer: 1.323 ± 0.032	1.176TyrThr: 1.176 ± 0.031	1.652TyrVal: 1.652 ± 0.038	0.321TyrTrp: 0.321 ± 0.018	0.517TyrTyr: 0.517 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3624 proteins (1160108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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