Amino acid dipepetide frequency for Bisgaard taxon 44 str. B96_4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.489AlaAla: 5.489 ± 0.146
0.76AlaCys: 0.76 ± 0.039
4.003AlaAsp: 4.003 ± 0.109
4.398AlaGlu: 4.398 ± 0.135
3.119AlaPhe: 3.119 ± 0.119
5.116AlaGly: 5.116 ± 0.224
1.391AlaHis: 1.391 ± 0.059
4.805AlaIle: 4.805 ± 0.13
6.053AlaLys: 6.053 ± 0.159
8.453AlaLeu: 8.453 ± 0.239
1.252AlaMet: 1.252 ± 0.069
5.993AlaAsn: 5.993 ± 0.491
2.925AlaPro: 2.925 ± 0.115
5.587AlaGln: 5.587 ± 0.184
3.193AlaArg: 3.193 ± 0.092
6.118AlaSer: 6.118 ± 0.261
6.858AlaThr: 6.858 ± 0.813
4.957AlaVal: 4.957 ± 0.124
0.715AlaTrp: 0.715 ± 0.04
2.896AlaTyr: 2.896 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.032
0.103CysCys: 0.103 ± 0.014
0.414CysAsp: 0.414 ± 0.03
0.392CysGlu: 0.392 ± 0.028
0.414CysPhe: 0.414 ± 0.029
0.594CysGly: 0.594 ± 0.031
0.177CysHis: 0.177 ± 0.018
0.483CysIle: 0.483 ± 0.03
0.409CysLys: 0.409 ± 0.034
0.84CysLeu: 0.84 ± 0.053
0.164CysMet: 0.164 ± 0.022
0.407CysAsn: 0.407 ± 0.027
0.324CysPro: 0.324 ± 0.029
0.401CysGln: 0.401 ± 0.028
0.289CysArg: 0.289 ± 0.021
0.557CysSer: 0.557 ± 0.033
0.42CysThr: 0.42 ± 0.03
0.518CysVal: 0.518 ± 0.035
0.058CysTrp: 0.058 ± 0.01
0.313CysTyr: 0.313 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.474AspAla: 3.474 ± 0.096
0.328AspCys: 0.328 ± 0.027
2.176AspAsp: 2.176 ± 0.089
2.399AspGlu: 2.399 ± 0.099
3.03AspPhe: 3.03 ± 0.115
2.495AspGly: 2.495 ± 0.109
0.736AspHis: 0.736 ± 0.046
3.375AspIle: 3.375 ± 0.098
3.351AspLys: 3.351 ± 0.103
6.465AspLeu: 6.465 ± 0.16
0.959AspMet: 0.959 ± 0.079
3.111AspAsn: 3.111 ± 0.102
2.2AspPro: 2.2 ± 0.091
1.998AspGln: 1.998 ± 0.072
1.762AspArg: 1.762 ± 0.074
2.966AspSer: 2.966 ± 0.097
2.473AspThr: 2.473 ± 0.101
3.893AspVal: 3.893 ± 0.162
0.507AspTrp: 0.507 ± 0.037
2.396AspTyr: 2.396 ± 0.106
0.0AspXaa: 0.0 ± 0.0
Glu
4.669GluAla: 4.669 ± 0.119
0.287GluCys: 0.287 ± 0.023
2.71GluAsp: 2.71 ± 0.1
3.801GluGlu: 3.801 ± 0.16
2.762GluPhe: 2.762 ± 0.111
2.688GluGly: 2.688 ± 0.115
1.304GluHis: 1.304 ± 0.069
3.485GluIle: 3.485 ± 0.108
4.069GluLys: 4.069 ± 0.157
6.424GluLeu: 6.424 ± 0.202
0.861GluMet: 0.861 ± 0.045
3.881GluAsn: 3.881 ± 0.185
1.726GluPro: 1.726 ± 0.095
5.178GluGln: 5.178 ± 0.243
2.329GluArg: 2.329 ± 0.086
2.699GluSer: 2.699 ± 0.081
2.426GluThr: 2.426 ± 0.083
4.153GluVal: 4.153 ± 0.1
0.332GluTrp: 0.332 ± 0.023
2.102GluTyr: 2.102 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
4.549PheAla: 4.549 ± 0.176
0.401PheCys: 0.401 ± 0.024
2.111PheAsp: 2.111 ± 0.104
1.922PheGlu: 1.922 ± 0.089
2.062PhePhe: 2.062 ± 0.097
2.558PheGly: 2.558 ± 0.106
0.559PheHis: 0.559 ± 0.038
3.092PheIle: 3.092 ± 0.118
2.648PheLys: 2.648 ± 0.103
3.953PheLeu: 3.953 ± 0.154
0.839PheMet: 0.839 ± 0.049
3.681PheAsn: 3.681 ± 0.196
1.36PhePro: 1.36 ± 0.071
1.037PheGln: 1.037 ± 0.055
1.298PheArg: 1.298 ± 0.065
3.446PheSer: 3.446 ± 0.113
3.574PheThr: 3.574 ± 0.114
3.003PheVal: 3.003 ± 0.101
0.412PheTrp: 0.412 ± 0.033
1.837PheTyr: 1.837 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
4.534GlyAla: 4.534 ± 0.164
0.532GlyCys: 0.532 ± 0.034
3.209GlyAsp: 3.209 ± 0.16
3.139GlyGlu: 3.139 ± 0.09
2.655GlyPhe: 2.655 ± 0.108
3.406GlyGly: 3.406 ± 0.122
1.014GlyHis: 1.014 ± 0.056
3.787GlyIle: 3.787 ± 0.14
4.316GlyLys: 4.316 ± 0.117
5.24GlyLeu: 5.24 ± 0.189
1.083GlyMet: 1.083 ± 0.059
4.3GlyAsn: 4.3 ± 0.438
1.071GlyPro: 1.071 ± 0.062
2.849GlyGln: 2.849 ± 0.072
2.097GlyArg: 2.097 ± 0.081
4.128GlySer: 4.128 ± 0.277
4.477GlyThr: 4.477 ± 0.388
4.579GlyVal: 4.579 ± 0.153
0.48GlyTrp: 0.48 ± 0.035
2.411GlyTyr: 2.411 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.249HisAla: 1.249 ± 0.055
0.178HisCys: 0.178 ± 0.02
0.804HisAsp: 0.804 ± 0.047
0.922HisGlu: 0.922 ± 0.057
0.783HisPhe: 0.783 ± 0.043
1.033HisGly: 1.033 ± 0.048
0.371HisHis: 0.371 ± 0.029
1.011HisIle: 1.011 ± 0.049
1.049HisLys: 1.049 ± 0.054
2.009HisLeu: 2.009 ± 0.087
0.267HisMet: 0.267 ± 0.022
0.88HisAsn: 0.88 ± 0.04
0.79HisPro: 0.79 ± 0.039
0.794HisGln: 0.794 ± 0.048
0.636HisArg: 0.636 ± 0.037
0.842HisSer: 0.842 ± 0.044
0.845HisThr: 0.845 ± 0.037
0.992HisVal: 0.992 ± 0.044
0.164HisTrp: 0.164 ± 0.019
0.662HisTyr: 0.662 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.538IleAla: 5.538 ± 0.132
0.687IleCys: 0.687 ± 0.041
3.629IleAsp: 3.629 ± 0.094
3.502IleGlu: 3.502 ± 0.105
2.8IlePhe: 2.8 ± 0.118
3.967IleGly: 3.967 ± 0.143
0.929IleHis: 0.929 ± 0.044
4.197IleIle: 4.197 ± 0.182
3.662IleLys: 3.662 ± 0.121
5.352IleLeu: 5.352 ± 0.204
0.957IleMet: 0.957 ± 0.05
4.507IleAsn: 4.507 ± 0.204
2.375IlePro: 2.375 ± 0.103
1.906IleGln: 1.906 ± 0.07
2.288IleArg: 2.288 ± 0.086
5.085IleSer: 5.085 ± 0.178
4.554IleThr: 4.554 ± 0.277
4.074IleVal: 4.074 ± 0.125
0.458IleTrp: 0.458 ± 0.03
2.269IleTyr: 2.269 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
5.473LysAla: 5.473 ± 0.202
0.295LysCys: 0.295 ± 0.023
3.591LysAsp: 3.591 ± 0.111
4.624LysGlu: 4.624 ± 0.16
2.487LysPhe: 2.487 ± 0.101
3.229LysGly: 3.229 ± 0.124
1.056LysHis: 1.056 ± 0.05
3.556LysIle: 3.556 ± 0.14
3.12LysLys: 3.12 ± 0.141
5.794LysLeu: 5.794 ± 0.168
1.292LysMet: 1.292 ± 0.063
3.116LysAsn: 3.116 ± 0.097
1.885LysPro: 1.885 ± 0.102
2.846LysGln: 2.846 ± 0.116
2.255LysArg: 2.255 ± 0.103
3.223LysSer: 3.223 ± 0.096
2.975LysThr: 2.975 ± 0.091
5.352LysVal: 5.352 ± 0.137
0.499LysTrp: 0.499 ± 0.043
2.527LysTyr: 2.527 ± 0.096
0.0LysXaa: 0.0 ± 0.0
Leu
9.366LeuAla: 9.366 ± 0.265
0.851LeuCys: 0.851 ± 0.046
5.724LeuAsp: 5.724 ± 0.126
6.937LeuGlu: 6.937 ± 0.216
4.136LeuPhe: 4.136 ± 0.173
6.471LeuGly: 6.471 ± 0.181
1.608LeuHis: 1.608 ± 0.075
6.046LeuIle: 6.046 ± 0.208
5.715LeuLys: 5.715 ± 0.184
8.715LeuLeu: 8.715 ± 0.321
1.5LeuMet: 1.5 ± 0.074
6.695LeuAsn: 6.695 ± 0.234
3.902LeuPro: 3.902 ± 0.144
4.057LeuGln: 4.057 ± 0.164
3.747LeuArg: 3.747 ± 0.132
7.452LeuSer: 7.452 ± 0.161
7.423LeuThr: 7.423 ± 0.374
7.081LeuVal: 7.081 ± 0.158
0.772LeuTrp: 0.772 ± 0.045
3.188LeuTyr: 3.188 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.334MetAla: 1.334 ± 0.069
0.134MetCys: 0.134 ± 0.017
0.617MetAsp: 0.617 ± 0.038
0.722MetGlu: 0.722 ± 0.047
1.262MetPhe: 1.262 ± 0.186
0.943MetGly: 0.943 ± 0.059
0.31MetHis: 0.31 ± 0.027
0.899MetIle: 0.899 ± 0.052
0.884MetLys: 0.884 ± 0.052
1.668MetLeu: 1.668 ± 0.08
0.275MetMet: 0.275 ± 0.023
0.726MetAsn: 0.726 ± 0.046
0.583MetPro: 0.583 ± 0.037
0.966MetGln: 0.966 ± 0.05
0.85MetArg: 0.85 ± 0.048
1.489MetSer: 1.489 ± 0.102
0.949MetThr: 0.949 ± 0.052
1.007MetVal: 1.007 ± 0.054
0.114MetTrp: 0.114 ± 0.014
0.496MetTyr: 0.496 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
5.844AsnAla: 5.844 ± 0.691
0.428AsnCys: 0.428 ± 0.033
2.337AsnAsp: 2.337 ± 0.084
2.591AsnGlu: 2.591 ± 0.075
2.931AsnPhe: 2.931 ± 0.102
3.973AsnGly: 3.973 ± 0.402
0.872AsnHis: 0.872 ± 0.045
5.2AsnIle: 5.2 ± 0.376
3.447AsnLys: 3.447 ± 0.094
8.118AsnLeu: 8.118 ± 0.411
1.164AsnMet: 1.164 ± 0.114
4.237AsnAsn: 4.237 ± 0.29
2.634AsnPro: 2.634 ± 0.106
3.103AsnGln: 3.103 ± 0.105
2.024AsnArg: 2.024 ± 0.072
5.053AsnSer: 5.053 ± 0.359
3.814AsnThr: 3.814 ± 0.287
6.594AsnVal: 6.594 ± 0.852
0.886AsnTrp: 0.886 ± 0.103
2.588AsnTyr: 2.588 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
2.741ProAla: 2.741 ± 0.11
0.227ProCys: 0.227 ± 0.022
1.675ProAsp: 1.675 ± 0.067
3.518ProGlu: 3.518 ± 0.138
1.372ProPhe: 1.372 ± 0.064
1.911ProGly: 1.911 ± 0.082
0.676ProHis: 0.676 ± 0.042
1.9ProIle: 1.9 ± 0.075
1.734ProLys: 1.734 ± 0.086
3.346ProLeu: 3.346 ± 0.123
0.524ProMet: 0.524 ± 0.035
1.972ProAsn: 1.972 ± 0.068
0.897ProPro: 0.897 ± 0.049
1.99ProGln: 1.99 ± 0.083
1.184ProArg: 1.184 ± 0.056
2.165ProSer: 2.165 ± 0.097
2.121ProThr: 2.121 ± 0.084
2.512ProVal: 2.512 ± 0.112
0.33ProTrp: 0.33 ± 0.024
1.393ProTyr: 1.393 ± 0.07
0.0ProXaa: 0.0 ± 0.0
Gln
5.821GlnAla: 5.821 ± 0.206
0.185GlnCys: 0.185 ± 0.02
2.427GlnAsp: 2.427 ± 0.084
4.186GlnGlu: 4.186 ± 0.182
1.513GlnPhe: 1.513 ± 0.068
3.304GlnGly: 3.304 ± 0.107
0.771GlnHis: 0.771 ± 0.042
3.038GlnIle: 3.038 ± 0.108
2.476GlnLys: 2.476 ± 0.112
4.584GlnLeu: 4.584 ± 0.189
0.816GlnMet: 0.816 ± 0.05
2.696GlnAsn: 2.696 ± 0.092
1.303GlnPro: 1.303 ± 0.074
2.666GlnGln: 2.666 ± 0.139
1.882GlnArg: 1.882 ± 0.095
2.274GlnSer: 2.274 ± 0.076
2.65GlnThr: 2.65 ± 0.083
4.227GlnVal: 4.227 ± 0.129
0.377GlnTrp: 0.377 ± 0.031
1.399GlnTyr: 1.399 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
2.809ArgAla: 2.809 ± 0.08
0.286ArgCys: 0.286 ± 0.024
1.911ArgAsp: 1.911 ± 0.071
2.4ArgGlu: 2.4 ± 0.098
1.8ArgPhe: 1.8 ± 0.081
1.955ArgGly: 1.955 ± 0.07
0.641ArgHis: 0.641 ± 0.036
2.569ArgIle: 2.569 ± 0.097
2.35ArgLys: 2.35 ± 0.096
3.823ArgLeu: 3.823 ± 0.145
0.753ArgMet: 0.753 ± 0.047
1.96ArgAsn: 1.96 ± 0.072
1.287ArgPro: 1.287 ± 0.061
1.963ArgGln: 1.963 ± 0.102
1.742ArgArg: 1.742 ± 0.089
2.048ArgSer: 2.048 ± 0.059
1.742ArgThr: 1.742 ± 0.066
2.571ArgVal: 2.571 ± 0.099
0.349ArgTrp: 0.349 ± 0.035
1.475ArgTyr: 1.475 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
4.878SerAla: 4.878 ± 0.312
0.576SerCys: 0.576 ± 0.034
3.094SerAsp: 3.094 ± 0.105
3.392SerGlu: 3.392 ± 0.094
3.532SerPhe: 3.532 ± 0.135
4.232SerGly: 4.232 ± 0.213
1.036SerHis: 1.036 ± 0.047
4.328SerIle: 4.328 ± 0.15
4.014SerLys: 4.014 ± 0.125
7.844SerLeu: 7.844 ± 0.145
1.058SerMet: 1.058 ± 0.07
5.039SerAsn: 5.039 ± 0.432
2.339SerPro: 2.339 ± 0.067
3.526SerGln: 3.526 ± 0.114
2.44SerArg: 2.44 ± 0.084
5.142SerSer: 5.142 ± 0.202
4.114SerThr: 4.114 ± 0.259
4.534SerVal: 4.534 ± 0.305
0.644SerTrp: 0.644 ± 0.04
2.825SerTyr: 2.825 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
6.572ThrAla: 6.572 ± 0.793
0.575ThrCys: 0.575 ± 0.034
3.022ThrAsp: 3.022 ± 0.125
2.479ThrGlu: 2.479 ± 0.073
2.55ThrPhe: 2.55 ± 0.083
4.932ThrGly: 4.932 ± 0.389
0.848ThrHis: 0.848 ± 0.043
3.908ThrIle: 3.908 ± 0.178
3.261ThrLys: 3.261 ± 0.121
6.951ThrLeu: 6.951 ± 0.265
0.684ThrMet: 0.684 ± 0.041
5.642ThrAsn: 5.642 ± 0.63
2.792ThrPro: 2.792 ± 0.095
2.366ThrGln: 2.366 ± 0.073
1.871ThrArg: 1.871 ± 0.064
5.069ThrSer: 5.069 ± 0.315
4.819ThrThr: 4.819 ± 0.419
4.848ThrVal: 4.848 ± 0.481
0.499ThrTrp: 0.499 ± 0.035
2.239ThrTyr: 2.239 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
5.685ValAla: 5.685 ± 0.132
0.655ValCys: 0.655 ± 0.032
4.03ValAsp: 4.03 ± 0.097
4.358ValGlu: 4.358 ± 0.117
2.838ValPhe: 2.838 ± 0.109
3.905ValGly: 3.905 ± 0.109
1.044ValHis: 1.044 ± 0.053
4.335ValIle: 4.335 ± 0.112
4.373ValLys: 4.373 ± 0.121
6.174ValLeu: 6.174 ± 0.192
1.004ValMet: 1.004 ± 0.048
5.982ValAsn: 5.982 ± 0.617
2.255ValPro: 2.255 ± 0.097
2.473ValGln: 2.473 ± 0.085
2.497ValArg: 2.497 ± 0.08
5.958ValSer: 5.958 ± 0.351
7.1ValThr: 7.1 ± 0.777
5.214ValVal: 5.214 ± 0.13
0.452ValTrp: 0.452 ± 0.033
2.553ValTyr: 2.553 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.444TrpAla: 0.444 ± 0.032
0.063TrpCys: 0.063 ± 0.01
0.777TrpAsp: 0.777 ± 0.106
0.445TrpGlu: 0.445 ± 0.029
0.352TrpPhe: 0.352 ± 0.023
0.523TrpGly: 0.523 ± 0.031
0.202TrpHis: 0.202 ± 0.019
0.418TrpIle: 0.418 ± 0.035
0.37TrpLys: 0.37 ± 0.024
1.099TrpLeu: 1.099 ± 0.052
0.171TrpMet: 0.171 ± 0.02
0.649TrpAsn: 0.649 ± 0.092
0.185TrpPro: 0.185 ± 0.019
0.807TrpGln: 0.807 ± 0.06
0.37TrpArg: 0.37 ± 0.027
0.417TrpSer: 0.417 ± 0.033
0.387TrpThr: 0.387 ± 0.029
0.475TrpVal: 0.475 ± 0.026
0.096TrpTrp: 0.096 ± 0.013
0.283TrpTyr: 0.283 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.97TyrAla: 2.97 ± 0.107
0.363TyrCys: 0.363 ± 0.027
1.83TyrAsp: 1.83 ± 0.08
1.758TyrGlu: 1.758 ± 0.085
1.944TyrPhe: 1.944 ± 0.081
2.072TyrGly: 2.072 ± 0.074
0.736TyrHis: 0.736 ± 0.041
2.302TyrIle: 2.302 ± 0.095
1.895TyrLys: 1.895 ± 0.08
4.537TyrLeu: 4.537 ± 0.166
0.605TyrMet: 0.605 ± 0.043
2.366TyrAsn: 2.366 ± 0.083
1.36TyrPro: 1.36 ± 0.069
2.083TyrGln: 2.083 ± 0.088
1.679TyrArg: 1.679 ± 0.083
2.457TyrSer: 2.457 ± 0.086
2.209TyrThr: 2.209 ± 0.087
2.301TyrVal: 2.301 ± 0.086
0.387TyrTrp: 0.387 ± 0.026
1.715TyrTyr: 1.715 ± 0.079
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1522 proteins (633264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski