Amino acid dipepetide frequency for Gordonibacter urolithinfaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.514AlaAla: 18.514 ± 0.274	2.488AlaCys: 2.488 ± 0.061	7.495AlaAsp: 7.495 ± 0.113	8.061AlaGlu: 8.061 ± 0.116	5.069AlaPhe: 5.069 ± 0.084	10.999AlaGly: 10.999 ± 0.158	2.162AlaHis: 2.162 ± 0.044	4.984AlaIle: 4.984 ± 0.084	4.178AlaLys: 4.178 ± 0.077	13.288AlaLeu: 13.288 ± 0.175	3.02AlaMet: 3.02 ± 0.058	2.802AlaAsn: 2.802 ± 0.057	5.359AlaPro: 5.359 ± 0.104	3.732AlaGln: 3.732 ± 0.081	8.175AlaArg: 8.175 ± 0.116	6.902AlaSer: 6.902 ± 0.097	5.489AlaThr: 5.489 ± 0.097	10.095AlaVal: 10.095 ± 0.139	1.481AlaTrp: 1.481 ± 0.041	3.259AlaTyr: 3.259 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.992CysAla: 1.992 ± 0.05	0.274CysCys: 0.274 ± 0.017	0.967CysAsp: 0.967 ± 0.034	0.981CysGlu: 0.981 ± 0.035	0.617CysPhe: 0.617 ± 0.031	1.719CysGly: 1.719 ± 0.051	0.384CysHis: 0.384 ± 0.024	0.766CysIle: 0.766 ± 0.03	0.522CysLys: 0.522 ± 0.024	1.356CysLeu: 1.356 ± 0.046	0.42CysMet: 0.42 ± 0.021	0.422CysAsn: 0.422 ± 0.021	0.883CysPro: 0.883 ± 0.036	0.349CysGln: 0.349 ± 0.023	0.895CysArg: 0.895 ± 0.037	0.779CysSer: 0.779 ± 0.03	0.872CysThr: 0.872 ± 0.035	1.297CysVal: 1.297 ± 0.04	0.182CysTrp: 0.182 ± 0.013	0.471CysTyr: 0.471 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	8.187AspAla: 8.187 ± 0.108	0.685AspCys: 0.685 ± 0.03	3.885AspAsp: 3.885 ± 0.082	5.315AspGlu: 5.315 ± 0.084	2.312AspPhe: 2.312 ± 0.053	5.742AspGly: 5.742 ± 0.121	0.926AspHis: 0.926 ± 0.029	2.713AspIle: 2.713 ± 0.065	1.841AspLys: 1.841 ± 0.049	5.553AspLeu: 5.553 ± 0.088	1.379AspMet: 1.379 ± 0.048	1.301AspAsn: 1.301 ± 0.039	3.282AspPro: 3.282 ± 0.064	1.343AspGln: 1.343 ± 0.038	3.338AspArg: 3.338 ± 0.066	2.196AspSer: 2.196 ± 0.053	2.43AspThr: 2.43 ± 0.047	5.104AspVal: 5.104 ± 0.075	0.701AspTrp: 0.701 ± 0.032	1.824AspTyr: 1.824 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	8.478GluAla: 8.478 ± 0.123	0.7GluCys: 0.7 ± 0.027	3.588GluAsp: 3.588 ± 0.068	4.479GluGlu: 4.479 ± 0.097	2.081GluPhe: 2.081 ± 0.043	5.823GluGly: 5.823 ± 0.087	1.466GluHis: 1.466 ± 0.047	2.624GluIle: 2.624 ± 0.064	2.751GluLys: 2.751 ± 0.059	6.397GluLeu: 6.397 ± 0.095	1.532GluMet: 1.532 ± 0.036	1.943GluAsn: 1.943 ± 0.051	3.022GluPro: 3.022 ± 0.065	2.289GluGln: 2.289 ± 0.052	5.668GluArg: 5.668 ± 0.088	2.831GluSer: 2.831 ± 0.057	3.061GluThr: 3.061 ± 0.065	4.378GluVal: 4.378 ± 0.078	0.641GluTrp: 0.641 ± 0.033	1.641GluTyr: 1.641 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	5.043PheAla: 5.043 ± 0.088	0.711PheCys: 0.711 ± 0.032	2.808PheAsp: 2.808 ± 0.054	2.495PheGlu: 2.495 ± 0.055	1.684PhePhe: 1.684 ± 0.052	3.775PheGly: 3.775 ± 0.073	0.567PheHis: 0.567 ± 0.022	1.563PheIle: 1.563 ± 0.045	1.304PheLys: 1.304 ± 0.043	3.444PheLeu: 3.444 ± 0.077	0.989PheMet: 0.989 ± 0.034	1.088PheAsn: 1.088 ± 0.031	1.564PhePro: 1.564 ± 0.044	0.862PheGln: 0.862 ± 0.027	1.627PheArg: 1.627 ± 0.038	2.364PheSer: 2.364 ± 0.061	1.974PheThr: 1.974 ± 0.048	3.347PheVal: 3.347 ± 0.061	0.5PheTrp: 0.5 ± 0.026	1.191PheTyr: 1.191 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.385GlyAla: 10.385 ± 0.141	1.708GlyCys: 1.708 ± 0.052	4.634GlyAsp: 4.634 ± 0.084	5.33GlyGlu: 5.33 ± 0.084	3.759GlyPhe: 3.759 ± 0.072	7.198GlyGly: 7.198 ± 0.12	1.419GlyHis: 1.419 ± 0.04	4.71GlyIle: 4.71 ± 0.076	3.713GlyLys: 3.713 ± 0.085	7.812GlyLeu: 7.812 ± 0.101	2.627GlyMet: 2.627 ± 0.066	2.268GlyAsn: 2.268 ± 0.052	2.804GlyPro: 2.804 ± 0.061	2.252GlyGln: 2.252 ± 0.05	5.453GlyArg: 5.453 ± 0.084	5.06GlySer: 5.06 ± 0.085	4.946GlyThr: 4.946 ± 0.102	6.793GlyVal: 6.793 ± 0.103	1.13GlyTrp: 1.13 ± 0.04	2.698GlyTyr: 2.698 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.146HisAla: 2.146 ± 0.043	0.342HisCys: 0.342 ± 0.019	1.144HisAsp: 1.144 ± 0.034	1.181HisGlu: 1.181 ± 0.035	0.573HisPhe: 0.573 ± 0.026	1.633HisGly: 1.633 ± 0.041	0.38HisHis: 0.38 ± 0.02	0.768HisIle: 0.768 ± 0.027	0.423HisLys: 0.423 ± 0.021	1.62HisLeu: 1.62 ± 0.042	0.367HisMet: 0.367 ± 0.018	0.417HisAsn: 0.417 ± 0.023	1.161HisPro: 1.161 ± 0.033	0.367HisGln: 0.367 ± 0.02	1.092HisArg: 1.092 ± 0.032	0.805HisSer: 0.805 ± 0.028	0.805HisThr: 0.805 ± 0.03	1.505HisVal: 1.505 ± 0.035	0.216HisTrp: 0.216 ± 0.016	0.568HisTyr: 0.568 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.942IleAla: 5.942 ± 0.094	0.692IleCys: 0.692 ± 0.028	3.228IleAsp: 3.228 ± 0.071	3.305IleGlu: 3.305 ± 0.065	1.263IlePhe: 1.263 ± 0.042	4.041IleGly: 4.041 ± 0.078	0.661IleHis: 0.661 ± 0.025	2.001IleIle: 2.001 ± 0.052	1.486IleLys: 1.486 ± 0.049	3.325IleLeu: 3.325 ± 0.078	1.213IleMet: 1.213 ± 0.041	1.184IleAsn: 1.184 ± 0.039	2.152IlePro: 2.152 ± 0.05	0.907IleGln: 0.907 ± 0.032	2.025IleArg: 2.025 ± 0.05	2.201IleSer: 2.201 ± 0.051	2.253IleThr: 2.253 ± 0.052	4.576IleVal: 4.576 ± 0.085	0.429IleTrp: 0.429 ± 0.024	1.013IleTyr: 1.013 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.017LysAla: 4.017 ± 0.082	0.449LysCys: 0.449 ± 0.027	2.072LysAsp: 2.072 ± 0.059	2.179LysGlu: 2.179 ± 0.049	0.913LysPhe: 0.913 ± 0.034	2.81LysGly: 2.81 ± 0.062	0.619LysHis: 0.619 ± 0.026	1.506LysIle: 1.506 ± 0.044	1.933LysLys: 1.933 ± 0.072	3.294LysLeu: 3.294 ± 0.065	0.886LysMet: 0.886 ± 0.034	1.246LysAsn: 1.246 ± 0.039	1.789LysPro: 1.789 ± 0.052	1.215LysGln: 1.215 ± 0.042	2.683LysArg: 2.683 ± 0.055	1.901LysSer: 1.901 ± 0.054	2.077LysThr: 2.077 ± 0.047	2.548LysVal: 2.548 ± 0.062	0.385LysTrp: 0.385 ± 0.019	0.904LysTyr: 0.904 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	13.662LeuAla: 13.662 ± 0.164	1.502LeuCys: 1.502 ± 0.046	5.878LeuAsp: 5.878 ± 0.084	5.701LeuGlu: 5.701 ± 0.075	3.992LeuPhe: 3.992 ± 0.089	7.913LeuGly: 7.913 ± 0.103	1.623LeuHis: 1.623 ± 0.045	3.67LeuIle: 3.67 ± 0.085	3.109LeuLys: 3.109 ± 0.061	8.693LeuLeu: 8.693 ± 0.164	2.484LeuMet: 2.484 ± 0.054	2.147LeuAsn: 2.147 ± 0.046	4.935LeuPro: 4.935 ± 0.08	2.082LeuGln: 2.082 ± 0.052	5.486LeuArg: 5.486 ± 0.09	5.615LeuSer: 5.615 ± 0.087	4.372LeuThr: 4.372 ± 0.07	8.743LeuVal: 8.743 ± 0.119	0.922LeuTrp: 0.922 ± 0.036	2.545LeuTyr: 2.545 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	3.102MetAla: 3.102 ± 0.065	0.341MetCys: 0.341 ± 0.019	1.456MetAsp: 1.456 ± 0.041	1.536MetGlu: 1.536 ± 0.04	0.826MetPhe: 0.826 ± 0.043	2.263MetGly: 2.263 ± 0.05	0.399MetHis: 0.399 ± 0.024	1.035MetIle: 1.035 ± 0.035	1.047MetLys: 1.047 ± 0.035	2.458MetLeu: 2.458 ± 0.054	0.701MetMet: 0.701 ± 0.03	0.835MetAsn: 0.835 ± 0.03	1.339MetPro: 1.339 ± 0.041	0.716MetGln: 0.716 ± 0.029	1.708MetArg: 1.708 ± 0.048	1.498MetSer: 1.498 ± 0.038	1.461MetThr: 1.461 ± 0.042	1.792MetVal: 1.792 ± 0.046	0.246MetTrp: 0.246 ± 0.018	0.548MetTyr: 0.548 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.046AsnAla: 3.046 ± 0.06	0.372AsnCys: 0.372 ± 0.022	1.482AsnAsp: 1.482 ± 0.043	1.561AsnGlu: 1.561 ± 0.044	0.873AsnPhe: 0.873 ± 0.031	2.2AsnGly: 2.2 ± 0.058	0.512AsnHis: 0.512 ± 0.023	1.352AsnIle: 1.352 ± 0.04	0.86AsnLys: 0.86 ± 0.03	2.544AsnLeu: 2.544 ± 0.055	0.689AsnMet: 0.689 ± 0.028	0.742AsnAsn: 0.742 ± 0.032	1.868AsnPro: 1.868 ± 0.046	0.702AsnGln: 0.702 ± 0.03	1.557AsnArg: 1.557 ± 0.04	1.159AsnSer: 1.159 ± 0.044	1.262AsnThr: 1.262 ± 0.041	2.204AsnVal: 2.204 ± 0.05	0.314AsnTrp: 0.314 ± 0.02	0.795AsnTyr: 0.795 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	6.149ProAla: 6.149 ± 0.1	0.636ProCys: 0.636 ± 0.029	3.175ProAsp: 3.175 ± 0.067	3.788ProGlu: 3.788 ± 0.074	1.878ProPhe: 1.878 ± 0.045	3.929ProGly: 3.929 ± 0.07	0.918ProHis: 0.918 ± 0.032	1.705ProIle: 1.705 ± 0.045	1.53ProLys: 1.53 ± 0.042	4.435ProLeu: 4.435 ± 0.07	0.915ProMet: 0.915 ± 0.029	1.193ProAsn: 1.193 ± 0.037	1.68ProPro: 1.68 ± 0.049	1.34ProGln: 1.34 ± 0.038	2.51ProArg: 2.51 ± 0.058	2.842ProSer: 2.842 ± 0.064	2.403ProThr: 2.403 ± 0.061	3.916ProVal: 3.916 ± 0.068	0.571ProTrp: 0.571 ± 0.024	1.504ProTyr: 1.504 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.609GlnAla: 3.609 ± 0.072	0.32GlnCys: 0.32 ± 0.022	1.32GlnAsp: 1.32 ± 0.041	1.654GlnGlu: 1.654 ± 0.042	0.926GlnPhe: 0.926 ± 0.036	2.353GlnGly: 2.353 ± 0.056	0.509GlnHis: 0.509 ± 0.023	1.261GlnIle: 1.261 ± 0.041	1.086GlnLys: 1.086 ± 0.036	2.483GlnLeu: 2.483 ± 0.055	0.768GlnMet: 0.768 ± 0.027	0.818GlnAsn: 0.818 ± 0.033	1.274GlnPro: 1.274 ± 0.04	1.089GlnGln: 1.089 ± 0.041	1.883GlnArg: 1.883 ± 0.053	1.235GlnSer: 1.235 ± 0.036	1.383GlnThr: 1.383 ± 0.036	2.162GlnVal: 2.162 ± 0.055	0.338GlnTrp: 0.338 ± 0.02	0.705GlnTyr: 0.705 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.635ArgAla: 7.635 ± 0.126	0.988ArgCys: 0.988 ± 0.038	3.412ArgAsp: 3.412 ± 0.069	4.484ArgGlu: 4.484 ± 0.079	2.593ArgPhe: 2.593 ± 0.058	4.509ArgGly: 4.509 ± 0.071	1.082ArgHis: 1.082 ± 0.033	3.286ArgIle: 3.286 ± 0.058	2.399ArgLys: 2.399 ± 0.053	5.75ArgLeu: 5.75 ± 0.094	1.892ArgMet: 1.892 ± 0.044	1.597ArgAsn: 1.597 ± 0.044	2.734ArgPro: 2.734 ± 0.058	1.773ArgGln: 1.773 ± 0.047	4.665ArgArg: 4.665 ± 0.1	3.156ArgSer: 3.156 ± 0.059	3.315ArgThr: 3.315 ± 0.059	4.49ArgVal: 4.49 ± 0.077	0.666ArgTrp: 0.666 ± 0.029	1.94ArgTyr: 1.94 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.936SerAla: 5.936 ± 0.104	0.922SerCys: 0.922 ± 0.029	2.837SerAsp: 2.837 ± 0.057	2.914SerGlu: 2.914 ± 0.066	2.561SerPhe: 2.561 ± 0.058	4.793SerGly: 4.793 ± 0.093	0.923SerHis: 0.923 ± 0.033	2.623SerIle: 2.623 ± 0.058	1.847SerLys: 1.847 ± 0.051	5.181SerLeu: 5.181 ± 0.089	1.363SerMet: 1.363 ± 0.043	1.456SerAsn: 1.456 ± 0.046	2.502SerPro: 2.502 ± 0.05	1.54SerGln: 1.54 ± 0.046	2.919SerArg: 2.919 ± 0.054	3.341SerSer: 3.341 ± 0.079	2.787SerThr: 2.787 ± 0.054	4.37SerVal: 4.37 ± 0.084	0.742SerTrp: 0.742 ± 0.028	1.773SerTyr: 1.773 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.463ThrAla: 5.463 ± 0.083	0.884ThrCys: 0.884 ± 0.031	2.789ThrAsp: 2.789 ± 0.067	2.496ThrGlu: 2.496 ± 0.046	2.052ThrPhe: 2.052 ± 0.063	4.916ThrGly: 4.916 ± 0.093	0.898ThrHis: 0.898 ± 0.03	2.35ThrIle: 2.35 ± 0.057	1.597ThrLys: 1.597 ± 0.04	4.778ThrLeu: 4.778 ± 0.08	1.16ThrMet: 1.16 ± 0.034	1.281ThrAsn: 1.281 ± 0.038	2.719ThrPro: 2.719 ± 0.062	1.213ThrGln: 1.213 ± 0.035	2.571ThrArg: 2.571 ± 0.05	2.776ThrSer: 2.776 ± 0.064	2.533ThrThr: 2.533 ± 0.062	4.829ThrVal: 4.829 ± 0.101	0.67ThrTrp: 0.67 ± 0.026	1.546ThrTyr: 1.546 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.967ValAla: 9.967 ± 0.132	1.435ValCys: 1.435 ± 0.044	5.117ValAsp: 5.117 ± 0.084	5.268ValGlu: 5.268 ± 0.089	3.251ValPhe: 3.251 ± 0.076	6.48ValGly: 6.48 ± 0.095	1.318ValHis: 1.318 ± 0.038	3.451ValIle: 3.451 ± 0.066	2.627ValLys: 2.627 ± 0.061	8.444ValLeu: 8.444 ± 0.137	2.069ValMet: 2.069 ± 0.05	2.124ValAsn: 2.124 ± 0.057	4.21ValPro: 4.21 ± 0.071	2.114ValGln: 2.114 ± 0.054	5.336ValArg: 5.336 ± 0.099	4.739ValSer: 4.739 ± 0.084	4.054ValThr: 4.054 ± 0.091	7.434ValVal: 7.434 ± 0.103	0.942ValTrp: 0.942 ± 0.03	2.171ValTyr: 2.171 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.126TrpAla: 1.126 ± 0.035	0.235TrpCys: 0.235 ± 0.018	0.724TrpAsp: 0.724 ± 0.032	0.757TrpGlu: 0.757 ± 0.031	0.504TrpPhe: 0.504 ± 0.027	1.02TrpGly: 1.02 ± 0.04	0.238TrpHis: 0.238 ± 0.017	0.628TrpIle: 0.628 ± 0.026	0.38TrpLys: 0.38 ± 0.02	1.155TrpLeu: 1.155 ± 0.041	0.327TrpMet: 0.327 ± 0.02	0.391TrpAsn: 0.391 ± 0.021	0.422TrpPro: 0.422 ± 0.021	0.422TrpGln: 0.422 ± 0.024	0.746TrpArg: 0.746 ± 0.029	0.635TrpSer: 0.635 ± 0.03	0.537TrpThr: 0.537 ± 0.026	0.813TrpVal: 0.813 ± 0.034	0.215TrpTrp: 0.215 ± 0.017	0.331TrpTyr: 0.331 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.152TyrAla: 3.152 ± 0.06	0.465TyrCys: 0.465 ± 0.022	2.045TyrAsp: 2.045 ± 0.05	1.908TyrGlu: 1.908 ± 0.047	1.174TyrPhe: 1.174 ± 0.036	2.585TyrGly: 2.585 ± 0.056	0.509TyrHis: 0.509 ± 0.025	0.901TyrIle: 0.901 ± 0.036	0.794TyrLys: 0.794 ± 0.03	3.064TyrLeu: 3.064 ± 0.062	0.506TyrMet: 0.506 ± 0.025	0.839TyrAsn: 0.839 ± 0.032	1.318TyrPro: 1.318 ± 0.036	0.87TyrGln: 0.87 ± 0.031	2.023TyrArg: 2.023 ± 0.047	1.297TyrSer: 1.297 ± 0.04	1.506TyrThr: 1.506 ± 0.048	2.156TyrVal: 2.156 ± 0.045	0.314TyrTrp: 0.314 ± 0.022	0.954TyrTyr: 0.954 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2703 proteins (921810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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