Amino acid dipepetide frequency for Apis mellifera associated microvirus 24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.843AlaAla: 3.843 ± 1.103
0.0AlaCys: 0.0 ± 0.0
3.843AlaAsp: 3.843 ± 1.599
8.455AlaGlu: 8.455 ± 0.912
3.075AlaPhe: 3.075 ± 0.991
3.075AlaGly: 3.075 ± 1.423
2.306AlaHis: 2.306 ± 0.743
4.612AlaIle: 4.612 ± 1.85
5.38AlaLys: 5.38 ± 2.915
4.612AlaLeu: 4.612 ± 1.431
1.537AlaMet: 1.537 ± 0.715
3.843AlaAsn: 3.843 ± 1.014
3.843AlaPro: 3.843 ± 1.191
3.843AlaGln: 3.843 ± 1.599
4.612AlaArg: 4.612 ± 1.431
4.612AlaSer: 4.612 ± 2.872
3.843AlaThr: 3.843 ± 1.444
5.38AlaVal: 5.38 ± 2.319
0.0AlaTrp: 0.0 ± 0.0
1.537AlaTyr: 1.537 ± 1.022
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.769CysAsp: 0.769 ± 0.916
0.769CysGlu: 0.769 ± 0.726
0.769CysPhe: 0.769 ± 1.095
1.537CysGly: 1.537 ± 0.617
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.769CysLeu: 0.769 ± 0.726
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.769CysPro: 0.769 ± 0.806
0.0CysGln: 0.0 ± 0.0
1.537CysArg: 1.537 ± 1.452
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
1.537CysTrp: 1.537 ± 0.617
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.918AspAla: 6.918 ± 2.47
1.537AspCys: 1.537 ± 0.865
6.149AspAsp: 6.149 ± 1.076
3.843AspGlu: 3.843 ± 1.489
3.075AspPhe: 3.075 ± 1.525
0.769AspGly: 0.769 ± 0.511
0.0AspHis: 0.0 ± 0.0
1.537AspIle: 1.537 ± 0.865
3.843AspLys: 3.843 ± 1.744
5.38AspLeu: 5.38 ± 1.605
0.0AspMet: 0.0 ± 0.0
3.075AspAsn: 3.075 ± 1.075
3.843AspPro: 3.843 ± 2.621
3.075AspGln: 3.075 ± 1.531
0.0AspArg: 0.0 ± 0.0
3.075AspSer: 3.075 ± 0.727
3.075AspThr: 3.075 ± 1.138
5.38AspVal: 5.38 ± 1.327
0.0AspTrp: 0.0 ± 0.0
5.38AspTyr: 5.38 ± 2.151
0.0AspXaa: 0.0 ± 0.0
Glu
3.843GluAla: 3.843 ± 0.809
0.0GluCys: 0.0 ± 0.0
2.306GluAsp: 2.306 ± 1.469
2.306GluGlu: 2.306 ± 0.723
3.075GluPhe: 3.075 ± 0.727
0.0GluGly: 0.0 ± 0.0
2.306GluHis: 2.306 ± 1.247
6.149GluIle: 6.149 ± 2.136
5.38GluLys: 5.38 ± 2.163
2.306GluLeu: 2.306 ± 1.533
2.306GluMet: 2.306 ± 1.507
0.769GluAsn: 0.769 ± 0.806
0.769GluPro: 0.769 ± 0.99
3.075GluGln: 3.075 ± 1.945
9.224GluArg: 9.224 ± 3.74
4.612GluSer: 4.612 ± 1.683
5.38GluThr: 5.38 ± 0.592
0.0GluVal: 0.0 ± 0.0
0.769GluTrp: 0.769 ± 0.726
3.075GluTyr: 3.075 ± 1.394
0.0GluXaa: 0.0 ± 0.0
Phe
2.306PheAla: 2.306 ± 1.533
0.769PheCys: 0.769 ± 0.511
3.075PheAsp: 3.075 ± 1.343
1.537PheGlu: 1.537 ± 1.048
3.843PhePhe: 3.843 ± 2.555
2.306PheGly: 2.306 ± 0.947
0.769PheHis: 0.769 ± 1.095
2.306PheIle: 2.306 ± 0.869
3.075PheLys: 3.075 ± 2.253
3.075PheLeu: 3.075 ± 1.163
0.0PheMet: 0.0 ± 0.469
5.38PheAsn: 5.38 ± 1.708
0.769PhePro: 0.769 ± 0.627
2.306PheGln: 2.306 ± 0.743
6.149PheArg: 6.149 ± 2.608
5.38PheSer: 5.38 ± 2.285
2.306PheThr: 2.306 ± 0.975
1.537PheVal: 1.537 ± 1.022
0.769PheTrp: 0.769 ± 0.511
0.769PheTyr: 0.769 ± 0.511
0.0PheXaa: 0.0 ± 0.0
Gly
6.149GlyAla: 6.149 ± 2.636
0.0GlyCys: 0.0 ± 0.0
5.38GlyAsp: 5.38 ± 1.795
6.149GlyGlu: 6.149 ± 2.236
0.769GlyPhe: 0.769 ± 0.511
3.075GlyGly: 3.075 ± 1.343
0.0GlyHis: 0.0 ± 0.0
1.537GlyIle: 1.537 ± 0.617
2.306GlyLys: 2.306 ± 0.723
5.38GlyLeu: 5.38 ± 1.041
0.769GlyMet: 0.769 ± 0.806
1.537GlyAsn: 1.537 ± 0.617
2.306GlyPro: 2.306 ± 0.947
1.537GlyGln: 1.537 ± 0.865
1.537GlyArg: 1.537 ± 1.094
3.843GlySer: 3.843 ± 1.798
3.843GlyThr: 3.843 ± 1.899
3.075GlyVal: 3.075 ± 1.343
0.0GlyTrp: 0.0 ± 0.0
3.075GlyTyr: 3.075 ± 1.233
0.0GlyXaa: 0.0 ± 0.0
His
2.306HisAla: 2.306 ± 1.247
0.0HisCys: 0.0 ± 0.0
3.075HisAsp: 3.075 ± 1.163
0.769HisGlu: 0.769 ± 0.726
0.0HisPhe: 0.0 ± 0.0
3.075HisGly: 3.075 ± 1.394
0.769HisHis: 0.769 ± 0.726
0.0HisIle: 0.0 ± 0.0
0.769HisLys: 0.769 ± 0.726
2.306HisLeu: 2.306 ± 0.869
0.0HisMet: 0.0 ± 0.0
0.769HisAsn: 0.769 ± 0.916
3.075HisPro: 3.075 ± 2.264
0.769HisGln: 0.769 ± 0.806
0.769HisArg: 0.769 ± 0.726
0.769HisSer: 0.769 ± 0.511
0.769HisThr: 0.769 ± 0.511
1.537HisVal: 1.537 ± 1.094
1.537HisTrp: 1.537 ± 1.452
0.769HisTyr: 0.769 ± 0.511
0.0HisXaa: 0.0 ± 0.0
Ile
1.537IleAla: 1.537 ± 0.715
0.0IleCys: 0.0 ± 0.0
2.306IleAsp: 2.306 ± 1.247
3.075IleGlu: 3.075 ± 1.284
6.149IlePhe: 6.149 ± 1.831
3.075IleGly: 3.075 ± 0.727
2.306IleHis: 2.306 ± 1.504
1.537IleIle: 1.537 ± 1.022
1.537IleLys: 1.537 ± 1.094
1.537IleLeu: 1.537 ± 0.617
0.0IleMet: 0.0 ± 0.0
4.612IleAsn: 4.612 ± 1.468
4.612IlePro: 4.612 ± 1.431
1.537IleGln: 1.537 ± 1.012
4.612IleArg: 4.612 ± 1.563
2.306IleSer: 2.306 ± 0.869
3.075IleThr: 3.075 ± 0.991
1.537IleVal: 1.537 ± 1.022
2.306IleTrp: 2.306 ± 1.789
3.075IleTyr: 3.075 ± 1.284
0.0IleXaa: 0.0 ± 0.0
Lys
4.612LysAla: 4.612 ± 2.589
0.769LysCys: 0.769 ± 0.726
1.537LysAsp: 1.537 ± 0.865
2.306LysGlu: 2.306 ± 1.613
3.843LysPhe: 3.843 ± 1.753
1.537LysGly: 1.537 ± 0.617
2.306LysHis: 2.306 ± 1.247
3.843LysIle: 3.843 ± 2.218
4.612LysLys: 4.612 ± 3.602
4.612LysLeu: 4.612 ± 2.943
0.769LysMet: 0.769 ± 0.726
3.075LysAsn: 3.075 ± 1.917
2.306LysPro: 2.306 ± 1.707
8.455LysGln: 8.455 ± 5.338
4.612LysArg: 4.612 ± 1.79
4.612LysSer: 4.612 ± 0.944
3.075LysThr: 3.075 ± 1.445
0.769LysVal: 0.769 ± 0.726
0.0LysTrp: 0.0 ± 0.0
1.537LysTyr: 1.537 ± 1.205
0.0LysXaa: 0.0 ± 0.0
Leu
6.149LeuAla: 6.149 ± 3.264
0.0LeuCys: 0.0 ± 0.0
2.306LeuAsp: 2.306 ± 1.311
5.38LeuGlu: 5.38 ± 1.634
2.306LeuPhe: 2.306 ± 1.083
3.843LeuGly: 3.843 ± 1.043
0.0LeuHis: 0.0 ± 0.0
3.075LeuIle: 3.075 ± 1.945
1.537LeuLys: 1.537 ± 1.452
4.612LeuLeu: 4.612 ± 1.138
2.306LeuMet: 2.306 ± 0.703
4.612LeuAsn: 4.612 ± 0.944
6.918LeuPro: 6.918 ± 1.887
5.38LeuGln: 5.38 ± 1.249
4.612LeuArg: 4.612 ± 2.425
3.075LeuSer: 3.075 ± 2.216
6.918LeuThr: 6.918 ± 1.064
6.149LeuVal: 6.149 ± 0.781
0.769LeuTrp: 0.769 ± 0.726
1.537LeuTyr: 1.537 ± 1.255
0.0LeuXaa: 0.0 ± 0.0
Met
2.306MetAla: 2.306 ± 1.436
0.0MetCys: 0.0 ± 0.0
2.306MetAsp: 2.306 ± 0.947
0.769MetGlu: 0.769 ± 0.806
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.769MetHis: 0.769 ± 0.726
1.537MetIle: 1.537 ± 1.048
0.769MetLys: 0.769 ± 0.726
0.769MetLeu: 0.769 ± 0.806
0.769MetMet: 0.769 ± 0.511
1.537MetAsn: 1.537 ± 1.094
0.769MetPro: 0.769 ± 0.916
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.537MetSer: 1.537 ± 0.715
1.537MetThr: 1.537 ± 1.022
1.537MetVal: 1.537 ± 1.012
0.769MetTrp: 0.769 ± 0.511
0.769MetTyr: 0.769 ± 0.511
0.0MetXaa: 0.0 ± 0.0
Asn
2.306AsnAla: 2.306 ± 0.723
0.0AsnCys: 0.0 ± 0.0
0.769AsnAsp: 0.769 ± 1.095
0.769AsnGlu: 0.769 ± 0.806
1.537AsnPhe: 1.537 ± 0.617
1.537AsnGly: 1.537 ± 0.865
0.0AsnHis: 0.0 ± 0.0
1.537AsnIle: 1.537 ± 0.617
3.843AsnLys: 3.843 ± 1.887
6.918AsnLeu: 6.918 ± 1.66
2.306AsnMet: 2.306 ± 0.947
4.612AsnAsn: 4.612 ± 2.272
5.38AsnPro: 5.38 ± 1.899
3.075AsnGln: 3.075 ± 1.566
4.612AsnArg: 4.612 ± 1.431
3.075AsnSer: 3.075 ± 1.075
3.075AsnThr: 3.075 ± 0.991
3.843AsnVal: 3.843 ± 1.239
0.769AsnTrp: 0.769 ± 0.511
2.306AsnTyr: 2.306 ± 1.662
0.0AsnXaa: 0.0 ± 0.0
Pro
4.612ProAla: 4.612 ± 1.05
0.769ProCys: 0.769 ± 0.726
5.38ProAsp: 5.38 ± 1.935
3.075ProGlu: 3.075 ± 2.191
2.306ProPhe: 2.306 ± 0.947
3.843ProGly: 3.843 ± 0.983
2.306ProHis: 2.306 ± 1.247
1.537ProIle: 1.537 ± 0.617
5.38ProLys: 5.38 ± 3.161
3.843ProLeu: 3.843 ± 1.821
1.537ProMet: 1.537 ± 0.617
3.075ProAsn: 3.075 ± 1.286
2.306ProPro: 2.306 ± 1.557
3.843ProGln: 3.843 ± 1.393
4.612ProArg: 4.612 ± 2.261
6.149ProSer: 6.149 ± 2.638
3.075ProThr: 3.075 ± 1.662
2.306ProVal: 2.306 ± 1.085
1.537ProTrp: 1.537 ± 1.094
2.306ProTyr: 2.306 ± 0.869
0.0ProXaa: 0.0 ± 0.0
Gln
2.306GlnAla: 2.306 ± 1.247
0.769GlnCys: 0.769 ± 1.095
4.612GlnAsp: 4.612 ± 1.717
5.38GlnGlu: 5.38 ± 1.418
2.306GlnPhe: 2.306 ± 1.085
2.306GlnGly: 2.306 ± 0.947
2.306GlnHis: 2.306 ± 1.311
2.306GlnIle: 2.306 ± 0.723
5.38GlnLys: 5.38 ± 2.322
3.075GlnLeu: 3.075 ± 1.917
0.769GlnMet: 0.769 ± 0.806
2.306GlnAsn: 2.306 ± 1.085
0.769GlnPro: 0.769 ± 0.806
0.769GlnGln: 0.769 ± 0.511
3.075GlnArg: 3.075 ± 0.991
2.306GlnSer: 2.306 ± 0.975
5.38GlnThr: 5.38 ± 2.825
2.306GlnVal: 2.306 ± 0.743
0.0GlnTrp: 0.0 ± 0.0
0.769GlnTyr: 0.769 ± 0.916
0.0GlnXaa: 0.0 ± 0.0
Arg
5.38ArgAla: 5.38 ± 1.284
0.769ArgCys: 0.769 ± 0.726
3.843ArgAsp: 3.843 ± 1.93
2.306ArgGlu: 2.306 ± 1.436
3.843ArgPhe: 3.843 ± 2.164
3.075ArgGly: 3.075 ± 1.286
0.769ArgHis: 0.769 ± 0.511
3.075ArgIle: 3.075 ± 0.738
1.537ArgLys: 1.537 ± 1.012
8.455ArgLeu: 8.455 ± 1.679
1.537ArgMet: 1.537 ± 1.315
0.769ArgAsn: 0.769 ± 0.916
5.38ArgPro: 5.38 ± 2.569
0.769ArgGln: 0.769 ± 0.511
0.0ArgArg: 0.0 ± 0.0
9.992ArgSer: 9.992 ± 2.83
2.306ArgThr: 2.306 ± 1.247
2.306ArgVal: 2.306 ± 1.979
0.769ArgTrp: 0.769 ± 0.726
6.149ArgTyr: 6.149 ± 2.466
0.0ArgXaa: 0.0 ± 0.0
Ser
6.918SerAla: 6.918 ± 2.447
1.537SerCys: 1.537 ± 1.452
1.537SerAsp: 1.537 ± 1.048
3.843SerGlu: 3.843 ± 1.462
4.612SerPhe: 4.612 ± 2.367
4.612SerGly: 4.612 ± 1.555
1.537SerHis: 1.537 ± 0.617
2.306SerIle: 2.306 ± 0.975
4.612SerLys: 4.612 ± 0.783
6.149SerLeu: 6.149 ± 1.145
0.0SerMet: 0.0 ± 0.0
1.537SerAsn: 1.537 ± 1.612
6.149SerPro: 6.149 ± 1.94
3.075SerGln: 3.075 ± 0.727
4.612SerArg: 4.612 ± 2.17
8.455SerSer: 8.455 ± 3.3
8.455SerThr: 8.455 ± 2.996
2.306SerVal: 2.306 ± 1.083
1.537SerTrp: 1.537 ± 0.715
0.769SerTyr: 0.769 ± 0.806
0.0SerXaa: 0.0 ± 0.0
Thr
3.075ThrAla: 3.075 ± 1.343
0.769ThrCys: 0.769 ± 0.806
6.149ThrAsp: 6.149 ± 2.531
2.306ThrGlu: 2.306 ± 0.869
2.306ThrPhe: 2.306 ± 0.743
6.918ThrGly: 6.918 ± 2.266
1.537ThrHis: 1.537 ± 1.585
8.455ThrIle: 8.455 ± 1.963
3.075ThrLys: 3.075 ± 1.917
5.38ThrLeu: 5.38 ± 1.379
2.306ThrMet: 2.306 ± 0.879
3.843ThrAsn: 3.843 ± 2.055
2.306ThrPro: 2.306 ± 1.282
3.075ThrGln: 3.075 ± 1.531
2.306ThrArg: 2.306 ± 0.947
4.612ThrSer: 4.612 ± 0.645
3.843ThrThr: 3.843 ± 1.753
0.769ThrVal: 0.769 ± 0.806
0.0ThrTrp: 0.0 ± 0.0
3.843ThrTyr: 3.843 ± 1.753
0.0ThrXaa: 0.0 ± 0.0
Val
4.612ValAla: 4.612 ± 1.468
0.0ValCys: 0.0 ± 0.0
0.769ValAsp: 0.769 ± 0.916
3.075ValGlu: 3.075 ± 0.727
1.537ValPhe: 1.537 ± 0.617
4.612ValGly: 4.612 ± 2.225
0.769ValHis: 0.769 ± 0.726
1.537ValIle: 1.537 ± 1.094
3.075ValLys: 3.075 ± 0.727
2.306ValLeu: 2.306 ± 0.743
0.0ValMet: 0.0 ± 0.0
2.306ValAsn: 2.306 ± 1.083
7.686ValPro: 7.686 ± 3.412
2.306ValGln: 2.306 ± 1.469
2.306ValArg: 2.306 ± 1.802
0.769ValSer: 0.769 ± 0.511
5.38ValThr: 5.38 ± 1.418
5.38ValVal: 5.38 ± 2.85
1.537ValTrp: 1.537 ± 1.022
1.537ValTyr: 1.537 ± 1.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.537TrpGlu: 1.537 ± 0.617
2.306TrpPhe: 2.306 ± 1.311
0.0TrpGly: 0.0 ± 0.0
2.306TrpHis: 2.306 ± 1.247
0.769TrpIle: 0.769 ± 0.726
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.537TrpAsn: 1.537 ± 0.617
2.306TrpPro: 2.306 ± 1.085
0.769TrpGln: 0.769 ± 0.726
0.0TrpArg: 0.0 ± 0.0
1.537TrpSer: 1.537 ± 0.865
0.769TrpThr: 0.769 ± 0.806
0.769TrpVal: 0.769 ± 0.726
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.075TyrAla: 3.075 ± 0.727
0.769TyrCys: 0.769 ± 0.726
3.843TyrAsp: 3.843 ± 2.288
0.0TyrGlu: 0.0 ± 0.0
1.537TyrPhe: 1.537 ± 1.022
3.075TyrGly: 3.075 ± 1.163
0.769TyrHis: 0.769 ± 0.726
3.075TyrIle: 3.075 ± 1.286
3.075TyrLys: 3.075 ± 1.075
0.0TyrLeu: 0.0 ± 0.0
0.769TyrMet: 0.769 ± 0.511
3.075TyrAsn: 3.075 ± 0.727
1.537TyrPro: 1.537 ± 1.094
1.537TyrGln: 1.537 ± 1.022
3.843TyrArg: 3.843 ± 1.828
3.843TyrSer: 3.843 ± 1.828
0.769TyrThr: 0.769 ± 0.511
4.612TyrVal: 4.612 ± 1.787
0.0TyrTrp: 0.0 ± 0.0
2.306TyrTyr: 2.306 ± 1.662
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski