Amino acid dipepetide frequency for Pyrococcus abyssi virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.247AlaAla: 2.247 ± 0.568
0.173AlaCys: 0.173 ± 0.19
3.111AlaAsp: 3.111 ± 0.785
5.185AlaGlu: 5.185 ± 1.095
3.284AlaPhe: 3.284 ± 0.601
3.629AlaGly: 3.629 ± 0.589
1.037AlaHis: 1.037 ± 0.476
5.185AlaIle: 5.185 ± 0.921
4.148AlaLys: 4.148 ± 0.925
8.296AlaLeu: 8.296 ± 1.647
1.728AlaMet: 1.728 ± 0.854
1.728AlaAsn: 1.728 ± 0.387
3.111AlaPro: 3.111 ± 0.915
1.901AlaGln: 1.901 ± 0.66
3.975AlaArg: 3.975 ± 0.87
5.531AlaSer: 5.531 ± 0.973
4.666AlaThr: 4.666 ± 0.589
5.358AlaVal: 5.358 ± 1.119
0.864AlaTrp: 0.864 ± 0.283
2.42AlaTyr: 2.42 ± 0.659
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.173CysAsp: 0.173 ± 0.152
0.173CysGlu: 0.173 ± 0.152
0.0CysPhe: 0.0 ± 0.0
0.346CysGly: 0.346 ± 0.273
0.173CysHis: 0.173 ± 0.165
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.173CysMet: 0.173 ± 0.176
0.173CysAsn: 0.173 ± 0.152
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.346CysArg: 0.346 ± 0.284
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.457AspAla: 3.457 ± 1.091
0.0AspCys: 0.0 ± 0.0
3.802AspAsp: 3.802 ± 1.13
3.284AspGlu: 3.284 ± 1.065
3.802AspPhe: 3.802 ± 0.767
2.765AspGly: 2.765 ± 1.196
0.691AspHis: 0.691 ± 0.486
6.395AspIle: 6.395 ± 1.89
3.975AspLys: 3.975 ± 0.698
5.876AspLeu: 5.876 ± 1.021
0.864AspMet: 0.864 ± 0.312
2.42AspAsn: 2.42 ± 0.794
2.592AspPro: 2.592 ± 0.703
1.383AspGln: 1.383 ± 0.509
1.728AspArg: 1.728 ± 0.46
3.457AspSer: 3.457 ± 0.972
2.765AspThr: 2.765 ± 0.82
3.975AspVal: 3.975 ± 0.612
1.21AspTrp: 1.21 ± 0.57
3.111AspTyr: 3.111 ± 0.713
0.0AspXaa: 0.0 ± 0.0
Glu
4.494GluAla: 4.494 ± 1.228
0.0GluCys: 0.0 ± 0.0
5.358GluAsp: 5.358 ± 1.021
5.531GluGlu: 5.531 ± 1.473
3.629GluPhe: 3.629 ± 0.907
3.284GluGly: 3.284 ± 0.742
0.518GluHis: 0.518 ± 0.282
5.531GluIle: 5.531 ± 0.975
5.358GluLys: 5.358 ± 1.286
7.95GluLeu: 7.95 ± 1.805
1.383GluMet: 1.383 ± 0.497
2.42GluAsn: 2.42 ± 0.657
1.728GluPro: 1.728 ± 0.561
2.247GluGln: 2.247 ± 0.678
4.494GluArg: 4.494 ± 0.857
3.111GluSer: 3.111 ± 0.676
3.111GluThr: 3.111 ± 0.655
3.284GluVal: 3.284 ± 0.73
1.037GluTrp: 1.037 ± 0.344
2.765GluTyr: 2.765 ± 0.723
0.0GluXaa: 0.0 ± 0.0
Phe
3.111PheAla: 3.111 ± 0.762
0.173PheCys: 0.173 ± 0.152
2.42PheAsp: 2.42 ± 0.531
2.765PheGlu: 2.765 ± 0.645
2.42PhePhe: 2.42 ± 0.731
3.629PheGly: 3.629 ± 0.849
0.518PheHis: 0.518 ± 0.283
2.938PheIle: 2.938 ± 0.843
3.457PheLys: 3.457 ± 0.79
6.568PheLeu: 6.568 ± 1.265
1.901PheMet: 1.901 ± 0.672
2.247PheAsn: 2.247 ± 0.489
2.074PhePro: 2.074 ± 0.452
0.864PheGln: 0.864 ± 0.429
2.42PheArg: 2.42 ± 0.471
2.592PheSer: 2.592 ± 0.574
1.901PheThr: 1.901 ± 0.591
3.284PheVal: 3.284 ± 0.927
1.383PheTrp: 1.383 ± 0.425
2.765PheTyr: 2.765 ± 0.713
0.0PheXaa: 0.0 ± 0.0
Gly
4.148GlyAla: 4.148 ± 0.749
0.346GlyCys: 0.346 ± 0.238
2.592GlyAsp: 2.592 ± 0.731
3.457GlyGlu: 3.457 ± 0.617
2.938GlyPhe: 2.938 ± 0.704
3.802GlyGly: 3.802 ± 0.777
0.518GlyHis: 0.518 ± 0.221
4.321GlyIle: 4.321 ± 1.039
6.568GlyLys: 6.568 ± 1.452
7.432GlyLeu: 7.432 ± 0.864
2.247GlyMet: 2.247 ± 0.836
2.42GlyAsn: 2.42 ± 0.902
2.42GlyPro: 2.42 ± 0.81
1.037GlyGln: 1.037 ± 0.361
3.284GlyArg: 3.284 ± 0.968
3.284GlySer: 3.284 ± 0.806
2.938GlyThr: 2.938 ± 0.678
4.839GlyVal: 4.839 ± 0.914
1.555GlyTrp: 1.555 ± 0.599
2.765GlyTyr: 2.765 ± 0.642
0.0GlyXaa: 0.0 ± 0.0
His
0.173HisAla: 0.173 ± 0.202
0.0HisCys: 0.0 ± 0.0
1.037HisAsp: 1.037 ± 0.474
0.518HisGlu: 0.518 ± 0.257
0.864HisPhe: 0.864 ± 0.454
0.691HisGly: 0.691 ± 0.344
0.0HisHis: 0.0 ± 0.0
1.037HisIle: 1.037 ± 0.403
0.518HisLys: 0.518 ± 0.322
1.037HisLeu: 1.037 ± 0.351
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.691HisPro: 0.691 ± 0.324
0.518HisGln: 0.518 ± 0.247
0.691HisArg: 0.691 ± 0.423
0.346HisSer: 0.346 ± 0.264
0.173HisThr: 0.173 ± 0.134
0.346HisVal: 0.346 ± 0.241
0.691HisTrp: 0.691 ± 0.436
0.691HisTyr: 0.691 ± 0.43
0.0HisXaa: 0.0 ± 0.0
Ile
5.358IleAla: 5.358 ± 0.78
0.173IleCys: 0.173 ± 0.176
4.494IleAsp: 4.494 ± 1.054
3.975IleGlu: 3.975 ± 0.931
3.629IlePhe: 3.629 ± 0.969
3.111IleGly: 3.111 ± 0.67
0.864IleHis: 0.864 ± 0.397
5.358IleIle: 5.358 ± 0.669
3.629IleLys: 3.629 ± 0.711
9.333IleLeu: 9.333 ± 1.452
1.383IleMet: 1.383 ± 0.516
2.765IleAsn: 2.765 ± 0.601
2.592IlePro: 2.592 ± 0.587
2.765IleGln: 2.765 ± 0.695
3.284IleArg: 3.284 ± 0.712
5.012IleSer: 5.012 ± 0.885
2.938IleThr: 2.938 ± 0.635
6.222IleVal: 6.222 ± 1.121
0.864IleTrp: 0.864 ± 0.402
4.494IleTyr: 4.494 ± 1.438
0.0IleXaa: 0.0 ± 0.0
Lys
5.703LysAla: 5.703 ± 1.153
0.173LysCys: 0.173 ± 0.165
4.666LysAsp: 4.666 ± 0.938
6.913LysGlu: 6.913 ± 1.711
2.42LysPhe: 2.42 ± 0.437
3.457LysGly: 3.457 ± 0.654
0.691LysHis: 0.691 ± 0.37
5.703LysIle: 5.703 ± 1.065
8.469LysLys: 8.469 ± 2.086
6.568LysLeu: 6.568 ± 1.197
1.383LysMet: 1.383 ± 0.384
1.555LysAsn: 1.555 ± 0.492
2.765LysPro: 2.765 ± 0.866
1.037LysGln: 1.037 ± 0.366
4.148LysArg: 4.148 ± 1.036
3.629LysSer: 3.629 ± 0.582
4.148LysThr: 4.148 ± 1.454
4.494LysVal: 4.494 ± 1.262
1.037LysTrp: 1.037 ± 0.405
2.938LysTyr: 2.938 ± 0.631
0.0LysXaa: 0.0 ± 0.0
Leu
7.605LeuAla: 7.605 ± 1.013
0.173LeuCys: 0.173 ± 0.172
7.259LeuAsp: 7.259 ± 1.438
7.432LeuGlu: 7.432 ± 1.569
5.703LeuPhe: 5.703 ± 1.079
9.679LeuGly: 9.679 ± 1.123
1.037LeuHis: 1.037 ± 0.277
5.703LeuIle: 5.703 ± 1.469
8.469LeuLys: 8.469 ± 1.935
10.024LeuLeu: 10.024 ± 1.792
3.284LeuMet: 3.284 ± 0.803
4.148LeuAsn: 4.148 ± 0.737
2.592LeuPro: 2.592 ± 0.808
2.938LeuGln: 2.938 ± 0.61
5.012LeuArg: 5.012 ± 1.115
6.74LeuSer: 6.74 ± 1.108
5.012LeuThr: 5.012 ± 1.28
10.716LeuVal: 10.716 ± 1.392
1.901LeuTrp: 1.901 ± 0.638
4.494LeuTyr: 4.494 ± 0.888
0.0LeuXaa: 0.0 ± 0.0
Met
2.074MetAla: 2.074 ± 0.636
0.0MetCys: 0.0 ± 0.0
1.383MetAsp: 1.383 ± 0.421
0.864MetGlu: 0.864 ± 0.368
2.074MetPhe: 2.074 ± 0.765
2.247MetGly: 2.247 ± 0.666
0.0MetHis: 0.0 ± 0.0
1.901MetIle: 1.901 ± 0.51
0.864MetLys: 0.864 ± 0.411
2.938MetLeu: 2.938 ± 0.673
1.21MetMet: 1.21 ± 0.557
0.691MetAsn: 0.691 ± 0.325
1.037MetPro: 1.037 ± 0.647
1.383MetGln: 1.383 ± 0.495
1.383MetArg: 1.383 ± 0.584
1.21MetSer: 1.21 ± 0.382
1.21MetThr: 1.21 ± 0.482
1.901MetVal: 1.901 ± 0.594
0.173MetTrp: 0.173 ± 0.179
0.346MetTyr: 0.346 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
2.938AsnAla: 2.938 ± 0.806
0.0AsnCys: 0.0 ± 0.0
1.555AsnAsp: 1.555 ± 0.506
3.111AsnGlu: 3.111 ± 0.554
1.555AsnPhe: 1.555 ± 0.51
2.42AsnGly: 2.42 ± 0.659
0.173AsnHis: 0.173 ± 0.152
3.111AsnIle: 3.111 ± 0.834
2.074AsnLys: 2.074 ± 0.592
4.148AsnLeu: 4.148 ± 0.548
0.864AsnMet: 0.864 ± 0.238
1.21AsnAsn: 1.21 ± 0.381
2.592AsnPro: 2.592 ± 0.641
1.21AsnGln: 1.21 ± 0.403
1.383AsnArg: 1.383 ± 0.495
2.592AsnSer: 2.592 ± 0.816
1.901AsnThr: 1.901 ± 0.556
3.111AsnVal: 3.111 ± 0.605
0.518AsnTrp: 0.518 ± 0.279
1.728AsnTyr: 1.728 ± 0.648
0.0AsnXaa: 0.0 ± 0.0
Pro
1.21ProAla: 1.21 ± 0.447
0.0ProCys: 0.0 ± 0.0
2.592ProAsp: 2.592 ± 0.804
2.592ProGlu: 2.592 ± 0.685
0.691ProPhe: 0.691 ± 0.431
3.284ProGly: 3.284 ± 0.701
0.173ProHis: 0.173 ± 0.188
2.42ProIle: 2.42 ± 0.851
2.592ProLys: 2.592 ± 1.392
5.185ProLeu: 5.185 ± 0.824
0.346ProMet: 0.346 ± 0.299
2.42ProAsn: 2.42 ± 0.672
2.42ProPro: 2.42 ± 0.827
1.383ProGln: 1.383 ± 0.608
1.728ProArg: 1.728 ± 0.64
2.592ProSer: 2.592 ± 0.739
1.901ProThr: 1.901 ± 0.347
3.111ProVal: 3.111 ± 0.474
0.518ProTrp: 0.518 ± 0.296
1.037ProTyr: 1.037 ± 0.495
0.0ProXaa: 0.0 ± 0.0
Gln
2.592GlnAla: 2.592 ± 0.691
0.0GlnCys: 0.0 ± 0.0
2.247GlnAsp: 2.247 ± 0.571
1.728GlnGlu: 1.728 ± 0.614
0.691GlnPhe: 0.691 ± 0.409
1.21GlnGly: 1.21 ± 0.467
0.691GlnHis: 0.691 ± 0.442
2.074GlnIle: 2.074 ± 0.603
2.42GlnLys: 2.42 ± 0.725
3.284GlnLeu: 3.284 ± 0.654
0.864GlnMet: 0.864 ± 0.366
1.728GlnAsn: 1.728 ± 0.448
1.21GlnPro: 1.21 ± 0.409
0.864GlnGln: 0.864 ± 0.4
1.728GlnArg: 1.728 ± 0.457
0.864GlnSer: 0.864 ± 0.435
1.728GlnThr: 1.728 ± 0.575
2.074GlnVal: 2.074 ± 0.701
0.346GlnTrp: 0.346 ± 0.225
1.555GlnTyr: 1.555 ± 0.61
0.0GlnXaa: 0.0 ± 0.0
Arg
3.802ArgAla: 3.802 ± 0.574
0.0ArgCys: 0.0 ± 0.0
2.592ArgAsp: 2.592 ± 1.0
4.494ArgGlu: 4.494 ± 1.706
3.111ArgPhe: 3.111 ± 0.585
3.111ArgGly: 3.111 ± 0.66
0.346ArgHis: 0.346 ± 0.215
3.111ArgIle: 3.111 ± 0.786
3.802ArgLys: 3.802 ± 1.133
4.148ArgLeu: 4.148 ± 0.896
1.555ArgMet: 1.555 ± 0.597
1.901ArgAsn: 1.901 ± 0.667
2.42ArgPro: 2.42 ± 0.629
1.383ArgGln: 1.383 ± 0.562
3.802ArgArg: 3.802 ± 0.999
1.383ArgSer: 1.383 ± 0.363
3.111ArgThr: 3.111 ± 0.812
5.012ArgVal: 5.012 ± 1.107
1.21ArgTrp: 1.21 ± 0.337
1.21ArgTyr: 1.21 ± 0.467
0.0ArgXaa: 0.0 ± 0.0
Ser
4.148SerAla: 4.148 ± 0.88
0.173SerCys: 0.173 ± 0.152
3.629SerAsp: 3.629 ± 0.974
3.802SerGlu: 3.802 ± 0.976
3.284SerPhe: 3.284 ± 0.982
4.666SerGly: 4.666 ± 0.903
0.691SerHis: 0.691 ± 0.315
5.012SerIle: 5.012 ± 0.756
2.247SerLys: 2.247 ± 0.508
5.185SerLeu: 5.185 ± 0.49
1.555SerMet: 1.555 ± 0.456
1.901SerAsn: 1.901 ± 0.642
1.383SerPro: 1.383 ± 0.435
2.247SerGln: 2.247 ± 0.674
1.728SerArg: 1.728 ± 0.492
4.321SerSer: 4.321 ± 0.982
2.938SerThr: 2.938 ± 0.77
3.975SerVal: 3.975 ± 0.8
1.037SerTrp: 1.037 ± 0.388
3.802SerTyr: 3.802 ± 0.799
0.0SerXaa: 0.0 ± 0.0
Thr
4.148ThrAla: 4.148 ± 0.769
0.0ThrCys: 0.0 ± 0.0
2.074ThrAsp: 2.074 ± 0.62
1.555ThrGlu: 1.555 ± 0.392
2.247ThrPhe: 2.247 ± 0.562
5.012ThrGly: 5.012 ± 0.912
0.346ThrHis: 0.346 ± 0.262
2.938ThrIle: 2.938 ± 0.667
3.457ThrLys: 3.457 ± 0.86
6.568ThrLeu: 6.568 ± 1.083
0.346ThrMet: 0.346 ± 0.242
1.728ThrAsn: 1.728 ± 0.642
2.074ThrPro: 2.074 ± 0.575
1.037ThrGln: 1.037 ± 0.537
3.975ThrArg: 3.975 ± 1.01
3.975ThrSer: 3.975 ± 1.016
3.284ThrThr: 3.284 ± 0.664
3.802ThrVal: 3.802 ± 0.698
1.037ThrTrp: 1.037 ± 0.482
1.728ThrTyr: 1.728 ± 0.503
0.0ThrXaa: 0.0 ± 0.0
Val
4.839ValAla: 4.839 ± 1.068
0.0ValCys: 0.0 ± 0.0
3.629ValAsp: 3.629 ± 1.021
6.049ValGlu: 6.049 ± 1.304
3.975ValPhe: 3.975 ± 1.288
3.284ValGly: 3.284 ± 0.598
0.518ValHis: 0.518 ± 0.403
5.185ValIle: 5.185 ± 0.878
5.185ValLys: 5.185 ± 0.88
8.296ValLeu: 8.296 ± 1.218
2.074ValMet: 2.074 ± 0.736
3.802ValAsn: 3.802 ± 0.746
2.938ValPro: 2.938 ± 0.636
3.629ValGln: 3.629 ± 0.529
3.457ValArg: 3.457 ± 0.837
3.629ValSer: 3.629 ± 0.512
4.666ValThr: 4.666 ± 0.863
5.358ValVal: 5.358 ± 1.079
1.21ValTrp: 1.21 ± 0.519
3.111ValTyr: 3.111 ± 0.714
0.0ValXaa: 0.0 ± 0.0
Trp
1.901TrpAla: 1.901 ± 0.642
0.0TrpCys: 0.0 ± 0.0
0.864TrpAsp: 0.864 ± 0.295
1.383TrpGlu: 1.383 ± 0.444
0.518TrpPhe: 0.518 ± 0.259
1.037TrpGly: 1.037 ± 0.393
0.518TrpHis: 0.518 ± 0.304
1.555TrpIle: 1.555 ± 0.617
1.037TrpLys: 1.037 ± 0.473
2.765TrpLeu: 2.765 ± 0.654
0.173TrpMet: 0.173 ± 0.188
1.21TrpAsn: 1.21 ± 0.447
0.518TrpPro: 0.518 ± 0.277
0.346TrpGln: 0.346 ± 0.264
0.346TrpArg: 0.346 ± 0.234
0.346TrpSer: 0.346 ± 0.199
0.691TrpThr: 0.691 ± 0.364
0.864TrpVal: 0.864 ± 0.316
0.0TrpTrp: 0.0 ± 0.0
1.21TrpTyr: 1.21 ± 0.369
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.629TyrAla: 3.629 ± 0.896
0.173TyrCys: 0.173 ± 0.152
2.074TyrAsp: 2.074 ± 0.608
2.42TyrGlu: 2.42 ± 0.625
2.592TyrPhe: 2.592 ± 0.526
2.247TyrGly: 2.247 ± 0.837
0.518TyrHis: 0.518 ± 0.313
2.765TyrIle: 2.765 ± 0.757
3.629TyrLys: 3.629 ± 0.751
4.494TyrLeu: 4.494 ± 0.881
1.383TyrMet: 1.383 ± 0.329
1.728TyrAsn: 1.728 ± 0.801
1.037TyrPro: 1.037 ± 0.423
1.728TyrGln: 1.728 ± 0.554
2.592TyrArg: 2.592 ± 0.651
3.111TyrSer: 3.111 ± 0.609
2.247TyrThr: 2.247 ± 0.616
3.111TyrVal: 3.111 ± 0.827
0.691TyrTrp: 0.691 ± 0.284
3.629TyrTyr: 3.629 ± 1.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (5787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski