Amino acid dipepetide frequency for Dechloromonas sp. HYN0024

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.487AlaAla: 14.487 ± 0.189
1.315AlaCys: 1.315 ± 0.043
6.564AlaAsp: 6.564 ± 0.101
7.319AlaGlu: 7.319 ± 0.092
3.911AlaPhe: 3.911 ± 0.073
9.871AlaGly: 9.871 ± 0.118
2.134AlaHis: 2.134 ± 0.051
6.23AlaIle: 6.23 ± 0.098
4.63AlaLys: 4.63 ± 0.098
12.384AlaLeu: 12.384 ± 0.145
3.341AlaMet: 3.341 ± 0.071
3.48AlaAsn: 3.48 ± 0.076
4.6AlaPro: 4.6 ± 0.099
4.234AlaGln: 4.234 ± 0.075
6.938AlaArg: 6.938 ± 0.111
6.08AlaSer: 6.08 ± 0.092
5.764AlaThr: 5.764 ± 0.121
7.837AlaVal: 7.837 ± 0.119
1.485AlaTrp: 1.485 ± 0.047
2.533AlaTyr: 2.533 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.065CysAla: 1.065 ± 0.036
0.147CysCys: 0.147 ± 0.012
0.613CysAsp: 0.613 ± 0.043
0.535CysGlu: 0.535 ± 0.025
0.377CysPhe: 0.377 ± 0.018
1.019CysGly: 1.019 ± 0.037
0.46CysHis: 0.46 ± 0.084
0.466CysIle: 0.466 ± 0.023
0.321CysLys: 0.321 ± 0.018
1.064CysLeu: 1.064 ± 0.037
0.215CysMet: 0.215 ± 0.017
0.325CysAsn: 0.325 ± 0.018
0.616CysPro: 0.616 ± 0.025
0.364CysGln: 0.364 ± 0.02
0.719CysArg: 0.719 ± 0.027
0.649CysSer: 0.649 ± 0.044
0.505CysThr: 0.505 ± 0.022
0.668CysVal: 0.668 ± 0.028
0.14CysTrp: 0.14 ± 0.012
0.25CysTyr: 0.25 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.115AspAla: 6.115 ± 0.091
0.547AspCys: 0.547 ± 0.023
2.988AspAsp: 2.988 ± 0.059
3.479AspGlu: 3.479 ± 0.073
2.399AspPhe: 2.399 ± 0.055
4.616AspGly: 4.616 ± 0.089
1.16AspHis: 1.16 ± 0.033
3.259AspIle: 3.259 ± 0.062
2.308AspLys: 2.308 ± 0.059
5.552AspLeu: 5.552 ± 0.079
1.351AspMet: 1.351 ± 0.039
1.581AspAsn: 1.581 ± 0.044
2.699AspPro: 2.699 ± 0.062
1.823AspGln: 1.823 ± 0.045
3.185AspArg: 3.185 ± 0.062
2.658AspSer: 2.658 ± 0.058
2.621AspThr: 2.621 ± 0.084
3.64AspVal: 3.64 ± 0.065
0.916AspTrp: 0.916 ± 0.031
1.551AspTyr: 1.551 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.036GluAla: 7.036 ± 0.098
0.476GluCys: 0.476 ± 0.023
2.351GluAsp: 2.351 ± 0.055
3.092GluGlu: 3.092 ± 0.069
2.061GluPhe: 2.061 ± 0.053
3.799GluGly: 3.799 ± 0.074
1.407GluHis: 1.407 ± 0.043
3.776GluIle: 3.776 ± 0.071
3.041GluLys: 3.041 ± 0.068
6.058GluLeu: 6.058 ± 0.091
1.659GluMet: 1.659 ± 0.039
1.829GluAsn: 1.829 ± 0.043
2.243GluPro: 2.243 ± 0.062
2.608GluGln: 2.608 ± 0.059
4.274GluArg: 4.274 ± 0.075
3.04GluSer: 3.04 ± 0.057
3.039GluThr: 3.039 ± 0.058
4.167GluVal: 4.167 ± 0.076
0.787GluTrp: 0.787 ± 0.029
1.169GluTyr: 1.169 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.411PheAla: 4.411 ± 0.073
0.462PheCys: 0.462 ± 0.027
2.5PheAsp: 2.5 ± 0.05
2.072PheGlu: 2.072 ± 0.045
1.515PhePhe: 1.515 ± 0.046
3.359PheGly: 3.359 ± 0.064
0.739PheHis: 0.739 ± 0.032
1.86PheIle: 1.86 ± 0.05
1.379PheLys: 1.379 ± 0.038
3.407PheLeu: 3.407 ± 0.075
0.907PheMet: 0.907 ± 0.033
1.27PheAsn: 1.27 ± 0.041
1.604PhePro: 1.604 ± 0.038
1.072PheGln: 1.072 ± 0.034
2.034PheArg: 2.034 ± 0.046
2.547PheSer: 2.547 ± 0.058
2.013PheThr: 2.013 ± 0.112
2.757PheVal: 2.757 ± 0.058
0.522PheTrp: 0.522 ± 0.021
0.949PheTyr: 0.949 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
7.336GlyAla: 7.336 ± 0.099
1.076GlyCys: 1.076 ± 0.033
4.163GlyAsp: 4.163 ± 0.062
4.938GlyGlu: 4.938 ± 0.083
3.359GlyPhe: 3.359 ± 0.073
6.478GlyGly: 6.478 ± 0.101
1.94GlyHis: 1.94 ± 0.046
4.88GlyIle: 4.88 ± 0.086
4.318GlyLys: 4.318 ± 0.081
8.602GlyLeu: 8.602 ± 0.104
2.523GlyMet: 2.523 ± 0.058
2.561GlyAsn: 2.561 ± 0.082
2.453GlyPro: 2.453 ± 0.05
3.295GlyGln: 3.295 ± 0.06
4.945GlyArg: 4.945 ± 0.084
4.397GlySer: 4.397 ± 0.118
4.019GlyThr: 4.019 ± 0.117
5.808GlyVal: 5.808 ± 0.085
1.32GlyTrp: 1.32 ± 0.043
2.229GlyTyr: 2.229 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.379HisAla: 2.379 ± 0.053
0.276HisCys: 0.276 ± 0.019
1.222HisAsp: 1.222 ± 0.039
1.245HisGlu: 1.245 ± 0.039
0.966HisPhe: 0.966 ± 0.038
1.986HisGly: 1.986 ± 0.054
0.694HisHis: 0.694 ± 0.029
1.098HisIle: 1.098 ± 0.044
0.676HisLys: 0.676 ± 0.034
2.487HisLeu: 2.487 ± 0.049
0.469HisMet: 0.469 ± 0.022
0.644HisAsn: 0.644 ± 0.036
1.368HisPro: 1.368 ± 0.045
0.773HisGln: 0.773 ± 0.027
1.353HisArg: 1.353 ± 0.037
1.09HisSer: 1.09 ± 0.044
0.97HisThr: 0.97 ± 0.046
1.385HisVal: 1.385 ± 0.042
0.352HisTrp: 0.352 ± 0.019
0.65HisTyr: 0.65 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.628IleAla: 6.628 ± 0.082
0.585IleCys: 0.585 ± 0.026
3.709IleAsp: 3.709 ± 0.069
3.725IleGlu: 3.725 ± 0.066
1.885IlePhe: 1.885 ± 0.041
4.845IleGly: 4.845 ± 0.083
1.104IleHis: 1.104 ± 0.036
2.506IleIle: 2.506 ± 0.059
2.193IleLys: 2.193 ± 0.047
4.732IleLeu: 4.732 ± 0.075
1.001IleMet: 1.001 ± 0.035
1.942IleAsn: 1.942 ± 0.049
2.478IlePro: 2.478 ± 0.056
1.597IleGln: 1.597 ± 0.038
3.261IleArg: 3.261 ± 0.061
3.372IleSer: 3.372 ± 0.07
2.889IleThr: 2.889 ± 0.067
4.012IleVal: 4.012 ± 0.064
0.579IleTrp: 0.579 ± 0.023
1.24IleTyr: 1.24 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.788LysAla: 4.788 ± 0.09
0.279LysCys: 0.279 ± 0.021
2.013LysAsp: 2.013 ± 0.048
2.154LysGlu: 2.154 ± 0.052
1.209LysPhe: 1.209 ± 0.036
2.883LysGly: 2.883 ± 0.066
0.886LysHis: 0.886 ± 0.029
2.26LysIle: 2.26 ± 0.047
2.134LysLys: 2.134 ± 0.063
4.389LysLeu: 4.389 ± 0.075
1.217LysMet: 1.217 ± 0.038
1.394LysAsn: 1.394 ± 0.041
2.41LysPro: 2.41 ± 0.056
1.584LysGln: 1.584 ± 0.04
2.519LysArg: 2.519 ± 0.054
2.284LysSer: 2.284 ± 0.047
2.325LysThr: 2.325 ± 0.054
3.101LysVal: 3.101 ± 0.074
0.399LysTrp: 0.399 ± 0.022
0.871LysTyr: 0.871 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
13.998LeuAla: 13.998 ± 0.166
1.073LeuCys: 1.073 ± 0.036
6.04LeuAsp: 6.04 ± 0.091
5.715LeuGlu: 5.715 ± 0.082
3.745LeuPhe: 3.745 ± 0.072
8.459LeuGly: 8.459 ± 0.102
2.178LeuHis: 2.178 ± 0.051
5.683LeuIle: 5.683 ± 0.097
4.363LeuLys: 4.363 ± 0.08
11.332LeuLeu: 11.332 ± 0.166
2.419LeuMet: 2.419 ± 0.051
3.25LeuAsn: 3.25 ± 0.074
5.983LeuPro: 5.983 ± 0.112
3.361LeuGln: 3.361 ± 0.067
6.582LeuArg: 6.582 ± 0.1
6.411LeuSer: 6.411 ± 0.085
5.564LeuThr: 5.564 ± 0.083
7.42LeuVal: 7.42 ± 0.105
1.211LeuTrp: 1.211 ± 0.04
2.019LeuTyr: 2.019 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.148MetAla: 3.148 ± 0.06
0.169MetCys: 0.169 ± 0.013
1.213MetAsp: 1.213 ± 0.04
1.216MetGlu: 1.216 ± 0.039
0.77MetPhe: 0.77 ± 0.029
1.777MetGly: 1.777 ± 0.055
0.539MetHis: 0.539 ± 0.025
1.243MetIle: 1.243 ± 0.037
1.199MetLys: 1.199 ± 0.042
2.733MetLeu: 2.733 ± 0.055
0.652MetMet: 0.652 ± 0.025
0.984MetAsn: 0.984 ± 0.035
1.552MetPro: 1.552 ± 0.043
1.119MetGln: 1.119 ± 0.032
1.646MetArg: 1.646 ± 0.047
1.676MetSer: 1.676 ± 0.051
1.574MetThr: 1.574 ± 0.039
1.788MetVal: 1.788 ± 0.044
0.225MetTrp: 0.225 ± 0.016
0.4MetTyr: 0.4 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.426AsnAla: 3.426 ± 0.082
0.373AsnCys: 0.373 ± 0.022
1.625AsnAsp: 1.625 ± 0.066
1.54AsnGlu: 1.54 ± 0.039
1.163AsnPhe: 1.163 ± 0.036
2.652AsnGly: 2.652 ± 0.085
0.657AsnHis: 0.657 ± 0.036
1.779AsnIle: 1.779 ± 0.052
1.154AsnLys: 1.154 ± 0.031
3.263AsnLeu: 3.263 ± 0.059
0.766AsnMet: 0.766 ± 0.026
1.034AsnAsn: 1.034 ± 0.065
2.128AsnPro: 2.128 ± 0.053
1.109AsnGln: 1.109 ± 0.035
1.941AsnArg: 1.941 ± 0.044
1.597AsnSer: 1.597 ± 0.045
1.541AsnThr: 1.541 ± 0.049
2.127AsnVal: 2.127 ± 0.055
0.497AsnTrp: 0.497 ± 0.022
0.807AsnTyr: 0.807 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
5.763ProAla: 5.763 ± 0.1
0.435ProCys: 0.435 ± 0.019
3.13ProAsp: 3.13 ± 0.054
3.627ProGlu: 3.627 ± 0.065
1.667ProPhe: 1.667 ± 0.044
3.964ProGly: 3.964 ± 0.068
0.962ProHis: 0.962 ± 0.036
2.209ProIle: 2.209 ± 0.053
1.811ProLys: 1.811 ± 0.049
4.907ProLeu: 4.907 ± 0.082
1.204ProMet: 1.204 ± 0.036
1.491ProAsn: 1.491 ± 0.037
2.234ProPro: 2.234 ± 0.064
1.652ProGln: 1.652 ± 0.044
2.312ProArg: 2.312 ± 0.048
2.412ProSer: 2.412 ± 0.058
2.435ProThr: 2.435 ± 0.054
4.133ProVal: 4.133 ± 0.084
0.603ProTrp: 0.603 ± 0.027
1.126ProTyr: 1.126 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.636GlnAla: 4.636 ± 0.084
0.32GlnCys: 0.32 ± 0.037
1.424GlnAsp: 1.424 ± 0.04
1.81GlnGlu: 1.81 ± 0.047
1.311GlnPhe: 1.311 ± 0.039
2.681GlnGly: 2.681 ± 0.056
0.899GlnHis: 0.899 ± 0.029
2.168GlnIle: 2.168 ± 0.045
1.494GlnLys: 1.494 ± 0.038
4.134GlnLeu: 4.134 ± 0.071
1.089GlnMet: 1.089 ± 0.032
1.09GlnAsn: 1.09 ± 0.034
1.987GlnPro: 1.987 ± 0.044
1.668GlnGln: 1.668 ± 0.049
2.696GlnArg: 2.696 ± 0.058
2.005GlnSer: 2.005 ± 0.046
1.851GlnThr: 1.851 ± 0.054
2.678GlnVal: 2.678 ± 0.054
0.488GlnTrp: 0.488 ± 0.022
0.801GlnTyr: 0.801 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.848ArgAla: 5.848 ± 0.084
0.59ArgCys: 0.59 ± 0.026
3.385ArgAsp: 3.385 ± 0.058
3.904ArgGlu: 3.904 ± 0.071
2.74ArgPhe: 2.74 ± 0.064
3.893ArgGly: 3.893 ± 0.065
1.717ArgHis: 1.717 ± 0.048
3.725ArgIle: 3.725 ± 0.068
2.307ArgLys: 2.307 ± 0.044
7.69ArgLeu: 7.69 ± 0.119
1.673ArgMet: 1.673 ± 0.039
1.963ArgAsn: 1.963 ± 0.046
2.798ArgPro: 2.798 ± 0.066
3.208ArgGln: 3.208 ± 0.063
4.266ArgArg: 4.266 ± 0.076
3.043ArgSer: 3.043 ± 0.062
2.676ArgThr: 2.676 ± 0.046
4.125ArgVal: 4.125 ± 0.061
0.884ArgTrp: 0.884 ± 0.032
1.792ArgTyr: 1.792 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.173SerAla: 6.173 ± 0.096
0.586SerCys: 0.586 ± 0.036
2.79SerAsp: 2.79 ± 0.051
3.025SerGlu: 3.025 ± 0.061
2.05SerPhe: 2.05 ± 0.044
5.344SerGly: 5.344 ± 0.095
1.205SerHis: 1.205 ± 0.036
2.868SerIle: 2.868 ± 0.055
1.974SerLys: 1.974 ± 0.049
6.194SerLeu: 6.194 ± 0.079
1.292SerMet: 1.292 ± 0.036
1.577SerAsn: 1.577 ± 0.042
2.779SerPro: 2.779 ± 0.057
2.068SerGln: 2.068 ± 0.042
3.549SerArg: 3.549 ± 0.068
3.182SerSer: 3.182 ± 0.079
2.869SerThr: 2.869 ± 0.086
3.922SerVal: 3.922 ± 0.104
0.671SerTrp: 0.671 ± 0.027
1.294SerTyr: 1.294 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
5.659ThrAla: 5.659 ± 0.159
0.581ThrCys: 0.581 ± 0.068
2.615ThrAsp: 2.615 ± 0.071
2.545ThrGlu: 2.545 ± 0.057
1.944ThrPhe: 1.944 ± 0.09
4.692ThrGly: 4.692 ± 0.091
1.136ThrHis: 1.136 ± 0.04
2.557ThrIle: 2.557 ± 0.055
1.607ThrLys: 1.607 ± 0.037
6.045ThrLeu: 6.045 ± 0.093
1.076ThrMet: 1.076 ± 0.034
1.477ThrAsn: 1.477 ± 0.063
3.142ThrPro: 3.142 ± 0.065
1.802ThrGln: 1.802 ± 0.048
3.023ThrArg: 3.023 ± 0.059
2.585ThrSer: 2.585 ± 0.066
3.028ThrThr: 3.028 ± 0.094
4.135ThrVal: 4.135 ± 0.118
0.62ThrTrp: 0.62 ± 0.027
1.194ThrTyr: 1.194 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.672ValAla: 8.672 ± 0.113
0.776ValCys: 0.776 ± 0.029
4.281ValAsp: 4.281 ± 0.079
4.262ValGlu: 4.262 ± 0.089
2.688ValPhe: 2.688 ± 0.056
5.485ValGly: 5.485 ± 0.107
1.39ValHis: 1.39 ± 0.041
4.07ValIle: 4.07 ± 0.069
2.842ValLys: 2.842 ± 0.062
7.271ValLeu: 7.271 ± 0.106
1.946ValMet: 1.946 ± 0.047
2.159ValAsn: 2.159 ± 0.062
3.261ValPro: 3.261 ± 0.062
2.133ValGln: 2.133 ± 0.053
4.339ValArg: 4.339 ± 0.073
4.398ValSer: 4.398 ± 0.081
3.914ValThr: 3.914 ± 0.105
5.873ValVal: 5.873 ± 0.085
0.829ValTrp: 0.829 ± 0.03
1.523ValTyr: 1.523 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.105TrpAla: 1.105 ± 0.035
0.158TrpCys: 0.158 ± 0.012
0.511TrpAsp: 0.511 ± 0.021
0.599TrpGlu: 0.599 ± 0.025
0.527TrpPhe: 0.527 ± 0.026
0.808TrpGly: 0.808 ± 0.03
0.343TrpHis: 0.343 ± 0.02
0.657TrpIle: 0.657 ± 0.025
0.551TrpLys: 0.551 ± 0.025
2.03TrpLeu: 2.03 ± 0.055
0.348TrpMet: 0.348 ± 0.021
0.447TrpAsn: 0.447 ± 0.024
0.576TrpPro: 0.576 ± 0.025
0.754TrpGln: 0.754 ± 0.03
0.977TrpArg: 0.977 ± 0.035
0.725TrpSer: 0.725 ± 0.029
0.576TrpThr: 0.576 ± 0.024
0.912TrpVal: 0.912 ± 0.029
0.225TrpTrp: 0.225 ± 0.017
0.267TrpTyr: 0.267 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.463TyrAla: 2.463 ± 0.055
0.294TyrCys: 0.294 ± 0.019
1.31TyrAsp: 1.31 ± 0.038
1.108TyrGlu: 1.108 ± 0.034
1.091TyrPhe: 1.091 ± 0.034
2.031TyrGly: 2.031 ± 0.043
0.532TyrHis: 0.532 ± 0.025
0.985TyrIle: 0.985 ± 0.033
0.798TyrLys: 0.798 ± 0.034
2.534TyrLeu: 2.534 ± 0.056
0.475TyrMet: 0.475 ± 0.027
0.683TyrAsn: 0.683 ± 0.028
1.168TyrPro: 1.168 ± 0.035
1.006TyrGln: 1.006 ± 0.034
1.666TyrArg: 1.666 ± 0.045
1.261TyrSer: 1.261 ± 0.04
1.29TyrThr: 1.29 ± 0.065
1.625TyrVal: 1.625 ± 0.045
0.343TyrTrp: 0.343 ± 0.019
0.608TyrTyr: 0.608 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3011 proteins (978272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski