Amino acid dipepetide frequency for Grapevine virus K

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.478AlaAla: 2.478 ± 0.806
1.652AlaCys: 1.652 ± 0.909
4.544AlaAsp: 4.544 ± 1.296
4.131AlaGlu: 4.131 ± 1.319
3.717AlaPhe: 3.717 ± 1.455
6.196AlaGly: 6.196 ± 2.237
0.826AlaHis: 0.826 ± 0.455
3.304AlaIle: 3.304 ± 2.717
5.783AlaLys: 5.783 ± 2.467
7.022AlaLeu: 7.022 ± 2.283
1.239AlaMet: 1.239 ± 0.738
2.891AlaAsn: 2.891 ± 1.591
1.239AlaPro: 1.239 ± 0.682
4.131AlaGln: 4.131 ± 2.008
2.478AlaArg: 2.478 ± 2.672
2.891AlaSer: 2.891 ± 1.751
2.065AlaThr: 2.065 ± 1.565
4.544AlaVal: 4.544 ± 1.304
0.413AlaTrp: 0.413 ± 0.914
2.891AlaTyr: 2.891 ± 0.661
0.0AlaXaa: 0.0 ± 0.0
Cys
2.065CysAla: 2.065 ± 0.798
0.413CysCys: 0.413 ± 0.914
1.239CysAsp: 1.239 ± 0.603
2.891CysGlu: 2.891 ± 1.309
0.826CysPhe: 0.826 ± 0.455
2.891CysGly: 2.891 ± 1.296
0.413CysHis: 0.413 ± 0.227
1.239CysIle: 1.239 ± 0.682
1.652CysLys: 1.652 ± 1.351
2.065CysLeu: 2.065 ± 2.283
0.826CysMet: 0.826 ± 0.455
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.413CysGln: 0.413 ± 0.227
1.652CysArg: 1.652 ± 1.494
2.478CysSer: 2.478 ± 1.364
3.717CysThr: 3.717 ± 1.318
1.239CysVal: 1.239 ± 1.311
0.0CysTrp: 0.0 ± 0.0
1.652CysTyr: 1.652 ± 0.909
0.0CysXaa: 0.0 ± 0.0
Asp
4.544AspAla: 4.544 ± 1.304
2.478AspCys: 2.478 ± 2.196
5.783AspAsp: 5.783 ± 1.275
5.783AspGlu: 5.783 ± 2.381
3.717AspPhe: 3.717 ± 0.922
4.131AspGly: 4.131 ± 1.504
2.891AspHis: 2.891 ± 0.687
5.37AspIle: 5.37 ± 1.562
3.717AspLys: 3.717 ± 2.046
6.196AspLeu: 6.196 ± 2.841
1.652AspMet: 1.652 ± 0.909
2.065AspAsn: 2.065 ± 1.199
2.065AspPro: 2.065 ± 1.452
1.239AspGln: 1.239 ± 0.682
4.131AspArg: 4.131 ± 1.821
4.957AspSer: 4.957 ± 0.811
1.652AspThr: 1.652 ± 0.643
3.717AspVal: 3.717 ± 1.455
1.239AspTrp: 1.239 ± 0.682
2.065AspTyr: 2.065 ± 0.693
0.0AspXaa: 0.0 ± 0.0
Glu
5.783GluAla: 5.783 ± 2.228
2.065GluCys: 2.065 ± 1.347
3.717GluAsp: 3.717 ± 1.556
5.783GluGlu: 5.783 ± 2.3
3.304GluPhe: 3.304 ± 1.848
5.783GluGly: 5.783 ± 2.344
0.826GluHis: 0.826 ± 0.455
2.891GluIle: 2.891 ± 0.941
4.957GluLys: 4.957 ± 1.955
7.022GluLeu: 7.022 ± 3.056
2.065GluMet: 2.065 ± 1.821
1.239GluAsn: 1.239 ± 0.738
2.891GluPro: 2.891 ± 2.304
2.478GluGln: 2.478 ± 1.089
5.783GluArg: 5.783 ± 1.436
4.957GluSer: 4.957 ± 1.889
2.891GluThr: 2.891 ± 1.883
7.022GluVal: 7.022 ± 2.237
0.826GluTrp: 0.826 ± 0.455
2.065GluTyr: 2.065 ± 1.347
0.0GluXaa: 0.0 ± 0.0
Phe
3.717PheAla: 3.717 ± 1.534
1.239PheCys: 1.239 ± 0.603
2.891PheAsp: 2.891 ± 1.114
2.065PheGlu: 2.065 ± 0.798
1.239PhePhe: 1.239 ± 0.682
2.478PheGly: 2.478 ± 0.955
0.826PheHis: 0.826 ± 0.618
2.065PheIle: 2.065 ± 0.798
2.891PheLys: 2.891 ± 1.216
2.891PheLeu: 2.891 ± 1.451
0.413PheMet: 0.413 ± 0.227
1.239PheAsn: 1.239 ± 0.738
2.065PhePro: 2.065 ± 1.922
0.413PheGln: 0.413 ± 0.227
4.131PheArg: 4.131 ± 1.688
3.304PheSer: 3.304 ± 0.756
1.652PheThr: 1.652 ± 0.669
2.065PheVal: 2.065 ± 1.566
0.0PheTrp: 0.0 ± 0.0
0.413PheTyr: 0.413 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
3.717GlyAla: 3.717 ± 2.595
1.652GlyCys: 1.652 ± 0.669
5.783GlyAsp: 5.783 ± 2.506
4.544GlyGlu: 4.544 ± 3.125
1.239GlyPhe: 1.239 ± 0.672
2.891GlyGly: 2.891 ± 1.81
1.239GlyHis: 1.239 ± 1.392
2.065GlyIle: 2.065 ± 1.347
5.783GlyLys: 5.783 ± 2.052
5.783GlyLeu: 5.783 ± 3.0
0.826GlyMet: 0.826 ± 0.793
1.239GlyAsn: 1.239 ± 0.738
2.891GlyPro: 2.891 ± 1.751
1.239GlyGln: 1.239 ± 0.672
5.37GlyArg: 5.37 ± 4.364
3.304GlySer: 3.304 ± 1.14
2.891GlyThr: 2.891 ± 0.916
3.717GlyVal: 3.717 ± 1.223
0.826GlyTrp: 0.826 ± 0.455
6.196GlyTyr: 6.196 ± 1.109
0.0GlyXaa: 0.0 ± 0.0
His
2.478HisAla: 2.478 ± 0.806
0.826HisCys: 0.826 ± 0.455
1.239HisAsp: 1.239 ± 0.603
0.413HisGlu: 0.413 ± 0.227
0.413HisPhe: 0.413 ± 0.227
0.413HisGly: 0.413 ± 0.709
0.413HisHis: 0.413 ± 0.227
0.0HisIle: 0.0 ± 0.0
2.891HisLys: 2.891 ± 1.451
2.065HisLeu: 2.065 ± 0.693
1.239HisMet: 1.239 ± 0.603
0.413HisAsn: 0.413 ± 1.573
2.065HisPro: 2.065 ± 0.798
0.413HisGln: 0.413 ± 0.227
1.652HisArg: 1.652 ± 1.235
2.065HisSer: 2.065 ± 0.829
1.239HisThr: 1.239 ± 0.603
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.826HisTyr: 0.826 ± 0.793
0.0HisXaa: 0.0 ± 0.0
Ile
4.131IleAla: 4.131 ± 1.139
1.239IleCys: 1.239 ± 0.682
2.891IleAsp: 2.891 ± 1.451
4.544IleGlu: 4.544 ± 1.187
1.239IlePhe: 1.239 ± 0.682
3.717IleGly: 3.717 ± 0.974
1.239IleHis: 1.239 ± 0.603
0.826IleIle: 0.826 ± 0.793
2.065IleLys: 2.065 ± 0.66
3.304IleLeu: 3.304 ± 1.14
2.065IleMet: 2.065 ± 2.043
2.065IleAsn: 2.065 ± 0.829
1.239IlePro: 1.239 ± 1.619
0.826IleGln: 0.826 ± 0.793
3.304IleArg: 3.304 ± 0.756
3.717IleSer: 3.717 ± 1.076
1.652IleThr: 1.652 ± 0.669
4.131IleVal: 4.131 ± 1.435
0.0IleTrp: 0.0 ± 0.0
0.413IleTyr: 0.413 ± 0.227
0.0IleXaa: 0.0 ± 0.0
Lys
5.783LysAla: 5.783 ± 0.829
3.304LysCys: 3.304 ± 1.568
3.717LysAsp: 3.717 ± 1.455
2.891LysGlu: 2.891 ± 0.661
1.652LysPhe: 1.652 ± 0.909
3.304LysGly: 3.304 ± 0.772
1.239LysHis: 1.239 ± 0.682
4.131LysIle: 4.131 ± 1.339
7.435LysLys: 7.435 ± 2.131
6.609LysLeu: 6.609 ± 2.699
2.065LysMet: 2.065 ± 1.516
5.37LysAsn: 5.37 ± 2.175
2.065LysPro: 2.065 ± 0.829
0.826LysGln: 0.826 ± 0.618
5.37LysArg: 5.37 ± 4.31
5.783LysSer: 5.783 ± 2.052
2.891LysThr: 2.891 ± 0.661
5.37LysVal: 5.37 ± 1.374
0.826LysTrp: 0.826 ± 0.455
1.239LysTyr: 1.239 ± 0.682
0.0LysXaa: 0.0 ± 0.0
Leu
6.196LeuAla: 6.196 ± 1.795
1.652LeuCys: 1.652 ± 0.909
7.848LeuAsp: 7.848 ± 1.934
8.261LeuGlu: 8.261 ± 1.757
6.609LeuPhe: 6.609 ± 1.093
5.37LeuGly: 5.37 ± 3.024
0.0LeuHis: 0.0 ± 0.0
4.544LeuIle: 4.544 ± 1.984
10.739LeuLys: 10.739 ± 4.843
7.022LeuLeu: 7.022 ± 5.811
2.891LeuMet: 2.891 ± 1.15
5.783LeuAsn: 5.783 ± 1.374
3.304LeuPro: 3.304 ± 1.287
2.891LeuGln: 2.891 ± 1.788
6.609LeuArg: 6.609 ± 1.798
7.435LeuSer: 7.435 ± 3.374
3.717LeuThr: 3.717 ± 0.676
4.131LeuVal: 4.131 ± 3.208
1.239LeuTrp: 1.239 ± 0.682
3.717LeuTyr: 3.717 ± 1.028
0.0LeuXaa: 0.0 ± 0.0
Met
3.717MetAla: 3.717 ± 2.215
0.413MetCys: 0.413 ± 0.904
3.304MetAsp: 3.304 ± 1.305
1.239MetGlu: 1.239 ± 0.738
0.413MetPhe: 0.413 ± 0.904
2.891MetGly: 2.891 ± 1.043
1.652MetHis: 1.652 ± 1.569
0.826MetIle: 0.826 ± 0.455
0.826MetLys: 0.826 ± 0.455
2.478MetLeu: 2.478 ± 0.955
0.826MetMet: 0.826 ± 0.455
0.826MetAsn: 0.826 ± 1.468
0.826MetPro: 0.826 ± 0.618
0.826MetGln: 0.826 ± 0.455
2.065MetArg: 2.065 ± 1.137
3.717MetSer: 3.717 ± 2.046
0.826MetThr: 0.826 ± 0.455
1.652MetVal: 1.652 ± 0.643
0.0MetTrp: 0.0 ± 0.0
1.239MetTyr: 1.239 ± 0.738
0.0MetXaa: 0.0 ± 0.0
Asn
2.065AsnAla: 2.065 ± 0.66
1.652AsnCys: 1.652 ± 0.643
0.826AsnAsp: 0.826 ± 0.455
2.891AsnGlu: 2.891 ± 1.591
2.891AsnPhe: 2.891 ± 1.15
2.065AsnGly: 2.065 ± 1.464
0.0AsnHis: 0.0 ± 0.0
1.239AsnIle: 1.239 ± 0.682
2.065AsnLys: 2.065 ± 1.062
2.891AsnLeu: 2.891 ± 1.114
1.239AsnMet: 1.239 ± 0.682
1.239AsnAsn: 1.239 ± 1.708
1.239AsnPro: 1.239 ± 1.392
1.652AsnGln: 1.652 ± 0.768
2.065AsnArg: 2.065 ± 0.829
1.239AsnSer: 1.239 ± 0.682
1.652AsnThr: 1.652 ± 0.669
2.065AsnVal: 2.065 ± 2.149
0.413AsnTrp: 0.413 ± 0.227
2.478AsnTyr: 2.478 ± 1.364
0.0AsnXaa: 0.0 ± 0.0
Pro
1.239ProAla: 1.239 ± 0.682
0.413ProCys: 0.413 ± 0.914
2.478ProAsp: 2.478 ± 1.364
2.065ProGlu: 2.065 ± 1.137
1.239ProPhe: 1.239 ± 0.921
3.304ProGly: 3.304 ± 0.769
1.239ProHis: 1.239 ± 1.052
1.239ProIle: 1.239 ± 0.682
1.652ProLys: 1.652 ± 0.768
4.131ProLeu: 4.131 ± 1.825
0.413ProMet: 0.413 ± 0.227
1.652ProAsn: 1.652 ± 0.909
0.826ProPro: 0.826 ± 0.455
1.652ProGln: 1.652 ± 0.751
1.239ProArg: 1.239 ± 0.603
2.065ProSer: 2.065 ± 2.853
0.826ProThr: 0.826 ± 0.455
3.717ProVal: 3.717 ± 1.424
0.0ProTrp: 0.0 ± 0.0
0.826ProTyr: 0.826 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
1.652GlnAla: 1.652 ± 1.717
1.239GlnCys: 1.239 ± 0.603
3.304GlnAsp: 3.304 ± 1.141
3.304GlnGlu: 3.304 ± 1.502
0.0GlnPhe: 0.0 ± 0.0
1.239GlnGly: 1.239 ± 0.603
0.413GlnHis: 0.413 ± 0.904
2.891GlnIle: 2.891 ± 1.216
0.826GlnLys: 0.826 ± 0.455
4.131GlnLeu: 4.131 ± 1.743
1.239GlnMet: 1.239 ± 0.738
0.0GlnAsn: 0.0 ± 0.0
1.239GlnPro: 1.239 ± 0.682
1.239GlnGln: 1.239 ± 0.682
1.652GlnArg: 1.652 ± 0.751
1.239GlnSer: 1.239 ± 0.738
1.239GlnThr: 1.239 ± 0.682
2.065GlnVal: 2.065 ± 0.66
0.0GlnTrp: 0.0 ± 0.0
0.413GlnTyr: 0.413 ± 0.227
0.0GlnXaa: 0.0 ± 0.0
Arg
4.131ArgAla: 4.131 ± 1.927
1.652ArgCys: 1.652 ± 0.669
4.957ArgAsp: 4.957 ± 2.202
6.196ArgGlu: 6.196 ± 2.759
2.065ArgPhe: 2.065 ± 0.798
4.544ArgGly: 4.544 ± 1.289
1.239ArgHis: 1.239 ± 0.682
1.652ArgIle: 1.652 ± 0.643
3.717ArgLys: 3.717 ± 1.428
10.739ArgLeu: 10.739 ± 3.014
3.717ArgMet: 3.717 ± 1.411
1.652ArgAsn: 1.652 ± 1.587
1.239ArgPro: 1.239 ± 0.682
1.239ArgGln: 1.239 ± 0.921
2.065ArgArg: 2.065 ± 1.394
3.717ArgSer: 3.717 ± 1.805
4.957ArgThr: 4.957 ± 1.993
4.957ArgVal: 4.957 ± 2.154
1.239ArgTrp: 1.239 ± 1.392
1.239ArgTyr: 1.239 ± 0.682
0.0ArgXaa: 0.0 ± 0.0
Ser
3.304SerAla: 3.304 ± 1.781
2.478SerCys: 2.478 ± 0.806
5.783SerAsp: 5.783 ± 2.778
7.435SerGlu: 7.435 ± 2.056
2.065SerPhe: 2.065 ± 1.566
4.131SerGly: 4.131 ± 2.583
2.065SerHis: 2.065 ± 1.137
2.065SerIle: 2.065 ± 0.829
5.37SerLys: 5.37 ± 0.825
7.848SerLeu: 7.848 ± 2.284
1.652SerMet: 1.652 ± 0.88
1.239SerAsn: 1.239 ± 0.738
1.652SerPro: 1.652 ± 0.909
2.478SerGln: 2.478 ± 0.955
6.196SerArg: 6.196 ± 3.496
4.544SerSer: 4.544 ± 1.471
2.478SerThr: 2.478 ± 1.205
5.37SerVal: 5.37 ± 1.143
1.652SerTrp: 1.652 ± 0.643
2.065SerTyr: 2.065 ± 1.347
0.0SerXaa: 0.0 ± 0.0
Thr
0.826ThrAla: 0.826 ± 0.455
1.652ThrCys: 1.652 ± 0.909
0.826ThrAsp: 0.826 ± 0.455
1.652ThrGlu: 1.652 ± 1.185
1.652ThrPhe: 1.652 ± 0.909
0.826ThrGly: 0.826 ± 0.618
1.652ThrHis: 1.652 ± 0.669
4.131ThrIle: 4.131 ± 1.0
2.065ThrLys: 2.065 ± 1.199
7.022ThrLeu: 7.022 ± 2.798
1.239ThrMet: 1.239 ± 0.57
1.239ThrAsn: 1.239 ± 1.311
2.065ThrPro: 2.065 ± 1.394
0.826ThrGln: 0.826 ± 0.618
4.131ThrArg: 4.131 ± 2.02
2.065ThrSer: 2.065 ± 0.829
0.826ThrThr: 0.826 ± 1.419
2.891ThrVal: 2.891 ± 0.941
0.826ThrTrp: 0.826 ± 1.997
2.065ThrTyr: 2.065 ± 1.137
0.0ThrXaa: 0.0 ± 0.0
Val
4.131ValAla: 4.131 ± 1.825
1.239ValCys: 1.239 ± 1.392
5.37ValAsp: 5.37 ± 2.918
5.37ValGlu: 5.37 ± 1.775
2.891ValPhe: 2.891 ± 0.661
3.304ValGly: 3.304 ± 2.701
2.065ValHis: 2.065 ± 1.199
1.652ValIle: 1.652 ± 1.569
4.957ValLys: 4.957 ± 1.925
5.37ValLeu: 5.37 ± 1.709
2.891ValMet: 2.891 ± 0.661
1.652ValAsn: 1.652 ± 0.909
1.239ValPro: 1.239 ± 0.682
3.304ValGln: 3.304 ± 0.756
4.131ValArg: 4.131 ± 1.399
6.196ValSer: 6.196 ± 1.868
2.065ValThr: 2.065 ± 1.566
8.674ValVal: 8.674 ± 0.995
1.239ValTrp: 1.239 ± 0.682
4.131ValTyr: 4.131 ± 1.796
0.0ValXaa: 0.0 ± 0.0
Trp
0.413TrpAla: 0.413 ± 0.227
0.413TrpCys: 0.413 ± 0.227
0.0TrpAsp: 0.0 ± 0.0
1.239TrpGlu: 1.239 ± 0.682
0.0TrpPhe: 0.0 ± 0.0
0.826TrpGly: 0.826 ± 0.769
0.413TrpHis: 0.413 ± 0.227
0.413TrpIle: 0.413 ± 0.227
1.239TrpLys: 1.239 ± 0.682
0.826TrpLeu: 0.826 ± 0.769
0.413TrpMet: 0.413 ± 0.227
0.0TrpAsn: 0.0 ± 0.0
0.413TrpPro: 0.413 ± 0.227
0.0TrpGln: 0.0 ± 0.0
0.413TrpArg: 0.413 ± 0.227
1.652TrpSer: 1.652 ± 0.909
0.413TrpThr: 0.413 ± 0.227
1.652TrpVal: 1.652 ± 3.333
0.0TrpTrp: 0.0 ± 0.0
0.413TrpTyr: 0.413 ± 0.227
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.065TyrAla: 2.065 ± 1.347
0.0TyrCys: 0.0 ± 0.0
2.891TyrAsp: 2.891 ± 0.916
2.065TyrGlu: 2.065 ± 0.829
0.826TyrPhe: 0.826 ± 0.618
2.891TyrGly: 2.891 ± 1.675
0.413TyrHis: 0.413 ± 0.227
2.065TyrIle: 2.065 ± 0.829
1.239TyrLys: 1.239 ± 0.682
4.544TyrLeu: 4.544 ± 1.895
1.239TyrMet: 1.239 ± 0.682
2.065TyrAsn: 2.065 ± 1.137
1.652TyrPro: 1.652 ± 1.538
1.239TyrGln: 1.239 ± 0.603
2.478TyrArg: 2.478 ± 1.381
4.544TyrSer: 4.544 ± 0.698
0.826TyrThr: 0.826 ± 0.455
2.891TyrVal: 2.891 ± 1.591
0.413TyrTrp: 0.413 ± 0.227
0.826TyrTyr: 0.826 ± 0.455
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski