Amino acid dipepetide frequency for Influenza A virus (A/black-headed gull/Sweden/87533/2009(H16N3))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.245AlaAla: 4.245 ± 0.99
0.708AlaCys: 0.708 ± 0.409
2.594AlaAsp: 2.594 ± 0.475
3.774AlaGlu: 3.774 ± 0.9
1.651AlaPhe: 1.651 ± 0.605
4.481AlaGly: 4.481 ± 1.282
0.708AlaHis: 0.708 ± 0.38
4.009AlaIle: 4.009 ± 0.882
2.358AlaLys: 2.358 ± 0.528
5.896AlaLeu: 5.896 ± 0.966
3.066AlaMet: 3.066 ± 0.776
2.594AlaAsn: 2.594 ± 0.564
2.594AlaPro: 2.594 ± 0.576
1.887AlaGln: 1.887 ± 0.539
3.538AlaArg: 3.538 ± 0.602
5.189AlaSer: 5.189 ± 1.095
4.245AlaThr: 4.245 ± 0.596
3.302AlaVal: 3.302 ± 0.84
1.415AlaTrp: 1.415 ± 0.644
0.943AlaTyr: 0.943 ± 0.357
0.0AlaXaa: 0.0 ± 0.0
Cys
0.943CysAla: 0.943 ± 0.462
0.236CysCys: 0.236 ± 0.19
0.236CysAsp: 0.236 ± 0.227
0.708CysGlu: 0.708 ± 0.325
1.887CysPhe: 1.887 ± 0.937
0.236CysGly: 0.236 ± 0.227
0.708CysHis: 0.708 ± 0.257
0.708CysIle: 0.708 ± 0.425
0.943CysLys: 0.943 ± 0.362
1.415CysLeu: 1.415 ± 0.455
0.708CysMet: 0.708 ± 0.304
1.179CysAsn: 1.179 ± 0.394
0.236CysPro: 0.236 ± 0.227
0.472CysGln: 0.472 ± 0.367
1.179CysArg: 1.179 ± 0.696
1.887CysSer: 1.887 ± 0.914
0.708CysThr: 0.708 ± 0.305
1.415CysVal: 1.415 ± 0.628
0.472CysTrp: 0.472 ± 0.253
0.236CysTyr: 0.236 ± 0.227
0.0CysXaa: 0.0 ± 0.0
Asp
2.594AspAla: 2.594 ± 0.469
1.179AspCys: 1.179 ± 0.424
1.415AspAsp: 1.415 ± 0.413
2.83AspGlu: 2.83 ± 0.533
2.358AspPhe: 2.358 ± 0.876
3.066AspGly: 3.066 ± 1.067
0.708AspHis: 0.708 ± 0.441
1.651AspIle: 1.651 ± 0.483
1.415AspLys: 1.415 ± 0.482
3.774AspLeu: 3.774 ± 0.752
1.651AspMet: 1.651 ± 0.412
3.302AspAsn: 3.302 ± 1.15
4.481AspPro: 4.481 ± 0.803
1.887AspGln: 1.887 ± 0.88
2.594AspArg: 2.594 ± 0.602
3.538AspSer: 3.538 ± 0.798
2.123AspThr: 2.123 ± 0.61
3.538AspVal: 3.538 ± 0.543
0.472AspTrp: 0.472 ± 0.25
1.415AspTyr: 1.415 ± 0.634
0.0AspXaa: 0.0 ± 0.0
Glu
3.066GluAla: 3.066 ± 0.715
0.943GluCys: 0.943 ± 0.57
4.717GluAsp: 4.717 ± 0.628
6.604GluGlu: 6.604 ± 0.916
1.887GluPhe: 1.887 ± 0.587
4.245GluGly: 4.245 ± 1.349
0.708GluHis: 0.708 ± 0.348
5.425GluIle: 5.425 ± 0.793
5.425GluLys: 5.425 ± 1.587
5.189GluLeu: 5.189 ± 0.99
3.302GluMet: 3.302 ± 0.802
4.481GluAsn: 4.481 ± 0.902
3.538GluPro: 3.538 ± 1.227
4.481GluGln: 4.481 ± 1.336
4.481GluArg: 4.481 ± 1.07
6.604GluSer: 6.604 ± 1.3
3.302GluThr: 3.302 ± 0.443
6.132GluVal: 6.132 ± 1.086
1.415GluTrp: 1.415 ± 0.687
1.415GluTyr: 1.415 ± 0.444
0.0GluXaa: 0.0 ± 0.0
Phe
2.358PheAla: 2.358 ± 0.882
0.236PheCys: 0.236 ± 0.227
1.651PheAsp: 1.651 ± 0.552
5.189PheGlu: 5.189 ± 1.075
1.651PhePhe: 1.651 ± 0.56
1.651PheGly: 1.651 ± 0.313
1.179PheHis: 1.179 ± 0.552
1.179PheIle: 1.179 ± 0.407
1.179PheLys: 1.179 ± 0.557
4.009PheLeu: 4.009 ± 0.877
1.179PheMet: 1.179 ± 0.561
2.123PheAsn: 2.123 ± 0.685
1.179PhePro: 1.179 ± 0.453
2.83PheGln: 2.83 ± 0.794
1.651PheArg: 1.651 ± 0.365
3.538PheSer: 3.538 ± 0.564
2.83PheThr: 2.83 ± 0.544
4.009PheVal: 4.009 ± 0.867
0.236PheTrp: 0.236 ± 0.191
0.943PheTyr: 0.943 ± 0.376
0.0PheXaa: 0.0 ± 0.0
Gly
2.594GlyAla: 2.594 ± 0.9
0.472GlyCys: 0.472 ± 0.269
2.83GlyAsp: 2.83 ± 0.462
4.481GlyGlu: 4.481 ± 1.364
3.538GlyPhe: 3.538 ± 0.908
2.83GlyGly: 2.83 ± 0.848
0.708GlyHis: 0.708 ± 0.446
4.009GlyIle: 4.009 ± 0.874
4.009GlyLys: 4.009 ± 0.791
4.009GlyLeu: 4.009 ± 0.992
2.358GlyMet: 2.358 ± 0.51
2.594GlyAsn: 2.594 ± 0.89
3.302GlyPro: 3.302 ± 0.658
2.358GlyGln: 2.358 ± 0.609
5.189GlyArg: 5.189 ± 0.925
3.538GlySer: 3.538 ± 1.066
4.953GlyThr: 4.953 ± 0.8
5.425GlyVal: 5.425 ± 0.465
0.708GlyTrp: 0.708 ± 0.425
1.887GlyTyr: 1.887 ± 0.57
0.0GlyXaa: 0.0 ± 0.0
His
0.472HisAla: 0.472 ± 0.231
0.236HisCys: 0.236 ± 0.201
0.0HisAsp: 0.0 ± 0.0
1.415HisGlu: 1.415 ± 0.449
1.651HisPhe: 1.651 ± 0.367
1.179HisGly: 1.179 ± 0.374
0.0HisHis: 0.0 ± 0.0
2.123HisIle: 2.123 ± 0.998
1.887HisLys: 1.887 ± 0.607
1.887HisLeu: 1.887 ± 0.52
0.236HisMet: 0.236 ± 0.19
0.0HisAsn: 0.0 ± 0.0
0.708HisPro: 0.708 ± 0.349
0.472HisGln: 0.472 ± 0.235
1.651HisArg: 1.651 ± 0.683
1.651HisSer: 1.651 ± 0.58
0.236HisThr: 0.236 ± 0.3
0.708HisVal: 0.708 ± 0.468
0.0HisTrp: 0.0 ± 0.0
0.236HisTyr: 0.236 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
3.538IleAla: 3.538 ± 0.745
1.651IleCys: 1.651 ± 0.572
2.358IleAsp: 2.358 ± 1.05
6.132IleGlu: 6.132 ± 1.999
1.179IlePhe: 1.179 ± 0.38
5.425IleGly: 5.425 ± 1.139
0.708IleHis: 0.708 ± 0.363
3.538IleIle: 3.538 ± 0.963
5.189IleLys: 5.189 ± 0.861
5.425IleLeu: 5.425 ± 1.565
1.887IleMet: 1.887 ± 0.407
3.538IleAsn: 3.538 ± 0.849
2.123IlePro: 2.123 ± 0.705
1.887IleGln: 1.887 ± 0.387
5.896IleArg: 5.896 ± 1.308
2.594IleSer: 2.594 ± 0.591
4.009IleThr: 4.009 ± 0.967
3.774IleVal: 3.774 ± 0.927
0.472IleTrp: 0.472 ± 0.382
2.358IleTyr: 2.358 ± 1.066
0.0IleXaa: 0.0 ± 0.0
Lys
4.481LysAla: 4.481 ± 0.794
0.943LysCys: 0.943 ± 0.532
2.83LysAsp: 2.83 ± 0.53
5.896LysGlu: 5.896 ± 0.96
2.358LysPhe: 2.358 ± 0.698
3.538LysGly: 3.538 ± 0.776
1.415LysHis: 1.415 ± 0.547
3.774LysIle: 3.774 ± 0.78
4.009LysLys: 4.009 ± 1.921
4.481LysLeu: 4.481 ± 1.18
3.302LysMet: 3.302 ± 0.548
1.887LysAsn: 1.887 ± 0.438
0.708LysPro: 0.708 ± 0.428
1.415LysGln: 1.415 ± 0.679
4.953LysArg: 4.953 ± 1.402
3.066LysSer: 3.066 ± 0.764
4.481LysThr: 4.481 ± 1.227
2.594LysVal: 2.594 ± 0.783
1.887LysTrp: 1.887 ± 0.68
1.651LysTyr: 1.651 ± 0.37
0.0LysXaa: 0.0 ± 0.0
Leu
5.425LeuAla: 5.425 ± 0.681
0.472LeuCys: 0.472 ± 0.25
1.415LeuAsp: 1.415 ± 0.615
6.84LeuGlu: 6.84 ± 1.058
2.123LeuPhe: 2.123 ± 0.563
3.774LeuGly: 3.774 ± 0.712
1.179LeuHis: 1.179 ± 0.446
5.896LeuIle: 5.896 ± 0.868
7.783LeuLys: 7.783 ± 1.727
6.368LeuLeu: 6.368 ± 1.346
2.358LeuMet: 2.358 ± 0.512
3.302LeuAsn: 3.302 ± 1.365
4.481LeuPro: 4.481 ± 0.603
3.302LeuGln: 3.302 ± 0.576
5.896LeuArg: 5.896 ± 1.411
4.953LeuSer: 4.953 ± 1.049
5.66LeuThr: 5.66 ± 1.482
4.009LeuVal: 4.009 ± 0.961
1.415LeuTrp: 1.415 ± 0.466
2.83LeuTyr: 2.83 ± 0.992
0.0LeuXaa: 0.0 ± 0.0
Met
4.009MetAla: 4.009 ± 0.759
1.179MetCys: 1.179 ± 0.602
3.538MetAsp: 3.538 ± 0.956
4.953MetGlu: 4.953 ± 1.036
1.179MetPhe: 1.179 ± 0.762
2.123MetGly: 2.123 ± 0.927
0.472MetHis: 0.472 ± 0.278
2.83MetIle: 2.83 ± 0.532
2.594MetLys: 2.594 ± 0.9
1.415MetLeu: 1.415 ± 0.475
1.651MetMet: 1.651 ± 0.612
0.943MetAsn: 0.943 ± 0.535
0.708MetPro: 0.708 ± 0.359
1.415MetGln: 1.415 ± 0.627
2.594MetArg: 2.594 ± 0.699
2.594MetSer: 2.594 ± 0.498
1.415MetThr: 1.415 ± 0.555
3.302MetVal: 3.302 ± 1.196
0.472MetTrp: 0.472 ± 0.301
0.943MetTyr: 0.943 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
3.066AsnAla: 3.066 ± 0.658
0.236AsnCys: 0.236 ± 0.227
3.538AsnAsp: 3.538 ± 0.988
4.953AsnGlu: 4.953 ± 0.801
1.651AsnPhe: 1.651 ± 0.517
3.066AsnGly: 3.066 ± 0.747
0.236AsnHis: 0.236 ± 0.19
2.358AsnIle: 2.358 ± 0.619
3.538AsnLys: 3.538 ± 0.936
3.066AsnLeu: 3.066 ± 0.469
2.123AsnMet: 2.123 ± 0.716
2.83AsnAsn: 2.83 ± 1.498
4.009AsnPro: 4.009 ± 0.65
1.651AsnGln: 1.651 ± 0.511
3.066AsnArg: 3.066 ± 0.678
2.83AsnSer: 2.83 ± 0.504
4.245AsnThr: 4.245 ± 0.719
2.123AsnVal: 2.123 ± 0.611
1.179AsnTrp: 1.179 ± 0.594
0.943AsnTyr: 0.943 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
3.066ProAla: 3.066 ± 0.935
0.708ProCys: 0.708 ± 0.363
1.887ProAsp: 1.887 ± 0.491
2.594ProGlu: 2.594 ± 0.783
2.123ProPhe: 2.123 ± 0.428
2.358ProGly: 2.358 ± 0.423
0.472ProHis: 0.472 ± 0.401
2.83ProIle: 2.83 ± 0.484
2.83ProLys: 2.83 ± 0.661
4.009ProLeu: 4.009 ± 0.912
1.415ProMet: 1.415 ± 0.659
3.538ProAsn: 3.538 ± 0.734
1.179ProPro: 1.179 ± 0.414
0.708ProGln: 0.708 ± 0.272
2.123ProArg: 2.123 ± 0.672
3.302ProSer: 3.302 ± 0.961
1.651ProThr: 1.651 ± 0.546
1.651ProVal: 1.651 ± 0.576
0.708ProTrp: 0.708 ± 0.374
1.179ProTyr: 1.179 ± 0.554
0.0ProXaa: 0.0 ± 0.0
Gln
2.83GlnAla: 2.83 ± 1.049
0.708GlnCys: 0.708 ± 0.363
1.651GlnAsp: 1.651 ± 0.491
2.594GlnGlu: 2.594 ± 0.986
0.472GlnPhe: 0.472 ± 0.318
2.83GlnGly: 2.83 ± 0.834
0.472GlnHis: 0.472 ± 0.331
3.066GlnIle: 3.066 ± 0.539
2.594GlnLys: 2.594 ± 1.1
3.538GlnLeu: 3.538 ± 0.986
2.594GlnMet: 2.594 ± 1.067
2.123GlnAsn: 2.123 ± 0.621
1.179GlnPro: 1.179 ± 0.492
1.415GlnGln: 1.415 ± 0.406
4.245GlnArg: 4.245 ± 1.006
3.302GlnSer: 3.302 ± 0.903
2.358GlnThr: 2.358 ± 0.811
1.415GlnVal: 1.415 ± 0.476
0.708GlnTrp: 0.708 ± 0.413
0.708GlnTyr: 0.708 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
4.245ArgAla: 4.245 ± 0.759
0.943ArgCys: 0.943 ± 0.409
3.302ArgAsp: 3.302 ± 0.759
3.774ArgGlu: 3.774 ± 0.98
3.302ArgPhe: 3.302 ± 0.72
6.368ArgGly: 6.368 ± 1.126
0.708ArgHis: 0.708 ± 0.41
5.425ArgIle: 5.425 ± 1.337
2.123ArgLys: 2.123 ± 0.549
5.425ArgLeu: 5.425 ± 0.707
4.245ArgMet: 4.245 ± 1.526
4.245ArgAsn: 4.245 ± 1.021
2.358ArgPro: 2.358 ± 0.493
3.774ArgGln: 3.774 ± 0.761
6.604ArgArg: 6.604 ± 0.908
4.245ArgSer: 4.245 ± 1.111
6.604ArgThr: 6.604 ± 0.791
2.358ArgVal: 2.358 ± 0.87
0.472ArgTrp: 0.472 ± 0.327
1.415ArgTyr: 1.415 ± 0.537
0.0ArgXaa: 0.0 ± 0.0
Ser
3.538SerAla: 3.538 ± 1.318
1.887SerCys: 1.887 ± 0.849
3.538SerAsp: 3.538 ± 0.826
3.066SerGlu: 3.066 ± 0.74
4.953SerPhe: 4.953 ± 0.993
5.425SerGly: 5.425 ± 0.984
1.887SerHis: 1.887 ± 0.73
4.481SerIle: 4.481 ± 0.807
3.774SerLys: 3.774 ± 0.624
6.132SerLeu: 6.132 ± 1.148
2.594SerMet: 2.594 ± 1.001
3.302SerAsn: 3.302 ± 1.477
2.594SerPro: 2.594 ± 0.589
3.774SerGln: 3.774 ± 0.79
3.066SerArg: 3.066 ± 0.65
7.783SerSer: 7.783 ± 1.379
4.717SerThr: 4.717 ± 0.99
3.302SerVal: 3.302 ± 0.538
1.651SerTrp: 1.651 ± 0.689
1.651SerTyr: 1.651 ± 0.609
0.0SerXaa: 0.0 ± 0.0
Thr
4.481ThrAla: 4.481 ± 0.533
1.179ThrCys: 1.179 ± 0.365
2.123ThrAsp: 2.123 ± 0.502
4.009ThrGlu: 4.009 ± 1.05
2.83ThrPhe: 2.83 ± 0.558
4.481ThrGly: 4.481 ± 0.92
2.594ThrHis: 2.594 ± 0.764
4.481ThrIle: 4.481 ± 0.64
4.481ThrLys: 4.481 ± 0.644
4.009ThrLeu: 4.009 ± 0.842
2.358ThrMet: 2.358 ± 0.509
4.009ThrAsn: 4.009 ± 0.594
2.358ThrPro: 2.358 ± 0.809
3.302ThrGln: 3.302 ± 1.085
4.481ThrArg: 4.481 ± 0.608
2.83ThrSer: 2.83 ± 0.532
3.774ThrThr: 3.774 ± 1.022
3.774ThrVal: 3.774 ± 1.153
0.236ThrTrp: 0.236 ± 0.19
2.123ThrTyr: 2.123 ± 0.789
0.0ThrXaa: 0.0 ± 0.0
Val
3.066ValAla: 3.066 ± 0.816
2.123ValCys: 2.123 ± 0.886
3.774ValAsp: 3.774 ± 0.988
4.481ValGlu: 4.481 ± 0.999
2.123ValPhe: 2.123 ± 0.713
2.358ValGly: 2.358 ± 0.768
1.415ValHis: 1.415 ± 0.554
2.358ValIle: 2.358 ± 0.699
1.887ValLys: 1.887 ± 0.519
7.075ValLeu: 7.075 ± 1.213
1.887ValMet: 1.887 ± 0.651
3.302ValAsn: 3.302 ± 0.612
1.651ValPro: 1.651 ± 0.527
2.358ValGln: 2.358 ± 0.92
4.717ValArg: 4.717 ± 1.281
5.66ValSer: 5.66 ± 0.697
2.83ValThr: 2.83 ± 1.038
2.83ValVal: 2.83 ± 0.732
0.472ValTrp: 0.472 ± 0.291
1.179ValTyr: 1.179 ± 0.355
0.0ValXaa: 0.0 ± 0.0
Trp
0.472TrpAla: 0.472 ± 0.26
0.0TrpCys: 0.0 ± 0.0
0.708TrpAsp: 0.708 ± 0.317
1.651TrpGlu: 1.651 ± 0.582
0.708TrpPhe: 0.708 ± 0.334
0.708TrpGly: 0.708 ± 0.345
0.472TrpHis: 0.472 ± 0.311
1.651TrpIle: 1.651 ± 0.531
0.943TrpLys: 0.943 ± 0.49
1.179TrpLeu: 1.179 ± 0.672
0.708TrpMet: 0.708 ± 0.316
0.708TrpAsn: 0.708 ± 0.358
0.472TrpPro: 0.472 ± 0.269
0.0TrpGln: 0.0 ± 0.0
1.179TrpArg: 1.179 ± 0.573
1.179TrpSer: 1.179 ± 0.682
1.651TrpThr: 1.651 ± 0.621
0.708TrpVal: 0.708 ± 0.31
0.472TrpTrp: 0.472 ± 0.235
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.708TyrAla: 0.708 ± 0.272
0.472TyrCys: 0.472 ± 0.269
1.887TyrAsp: 1.887 ± 0.628
1.415TyrGlu: 1.415 ± 0.498
1.179TyrPhe: 1.179 ± 0.357
1.651TyrGly: 1.651 ± 0.301
0.0TyrHis: 0.0 ± 0.0
1.887TyrIle: 1.887 ± 0.316
0.708TyrLys: 0.708 ± 0.289
1.179TyrLeu: 1.179 ± 0.407
0.472TyrMet: 0.472 ± 0.235
0.943TyrAsn: 0.943 ± 0.296
0.472TyrPro: 0.472 ± 0.379
1.415TyrGln: 1.415 ± 0.456
2.83TyrArg: 2.83 ± 1.091
2.83TyrSer: 2.83 ± 0.516
2.123TyrThr: 2.123 ± 0.637
1.179TyrVal: 1.179 ± 0.556
0.708TyrTrp: 0.708 ± 0.277
0.472TyrTyr: 0.472 ± 0.294
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski