Amino acid dipepetide frequency for Human respiratory syncytial virus A (strain A2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.836AlaAla: 1.836 ± 1.079
0.408AlaCys: 0.408 ± 0.429
1.02AlaAsp: 1.02 ± 0.399
2.447AlaGlu: 2.447 ± 0.758
1.224AlaPhe: 1.224 ± 0.379
3.467AlaGly: 3.467 ± 1.212
0.204AlaHis: 0.204 ± 0.129
4.487AlaIle: 4.487 ± 0.967
3.059AlaLys: 3.059 ± 0.369
3.671AlaLeu: 3.671 ± 0.716
1.632AlaMet: 1.632 ± 0.592
3.263AlaAsn: 3.263 ± 0.683
0.816AlaPro: 0.816 ± 0.3
1.632AlaGln: 1.632 ± 0.461
1.428AlaArg: 1.428 ± 1.104
3.467AlaSer: 3.467 ± 1.022
1.836AlaThr: 1.836 ± 0.501
2.651AlaVal: 2.651 ± 1.032
0.0AlaTrp: 0.0 ± 0.0
1.428AlaTyr: 1.428 ± 0.61
0.0AlaXaa: 0.0 ± 0.0
Cys
0.204CysAla: 0.204 ± 0.314
0.0CysCys: 0.0 ± 0.0
1.224CysAsp: 1.224 ± 0.5
1.224CysGlu: 1.224 ± 0.738
0.408CysPhe: 0.408 ± 0.167
0.612CysGly: 0.612 ± 0.424
0.612CysHis: 0.612 ± 0.286
2.04CysIle: 2.04 ± 0.736
1.632CysLys: 1.632 ± 0.647
1.632CysLeu: 1.632 ± 0.439
0.408CysMet: 0.408 ± 0.257
1.428CysAsn: 1.428 ± 0.563
0.612CysPro: 0.612 ± 0.302
0.204CysGln: 0.204 ± 0.129
0.204CysArg: 0.204 ± 0.278
2.855CysSer: 2.855 ± 0.68
0.612CysThr: 0.612 ± 0.33
0.816CysVal: 0.816 ± 0.313
0.612CysTrp: 0.612 ± 0.472
0.612CysTyr: 0.612 ± 0.251
0.0CysXaa: 0.0 ± 0.0
Asp
3.059AspAla: 3.059 ± 0.611
1.02AspCys: 1.02 ± 0.295
1.836AspAsp: 1.836 ± 0.713
2.855AspGlu: 2.855 ± 0.665
1.224AspPhe: 1.224 ± 0.394
0.408AspGly: 0.408 ± 0.421
1.02AspHis: 1.02 ± 0.462
4.691AspIle: 4.691 ± 0.963
3.263AspLys: 3.263 ± 1.08
5.711AspLeu: 5.711 ± 1.537
1.02AspMet: 1.02 ± 0.384
4.691AspAsn: 4.691 ± 1.24
2.04AspPro: 2.04 ± 0.566
1.428AspGln: 1.428 ± 0.436
1.836AspArg: 1.836 ± 0.561
1.836AspSer: 1.836 ± 0.634
3.467AspThr: 3.467 ± 1.456
2.04AspVal: 2.04 ± 0.889
0.408AspTrp: 0.408 ± 0.257
1.428AspTyr: 1.428 ± 0.699
0.0AspXaa: 0.0 ± 0.0
Glu
1.224GluAla: 1.224 ± 0.609
1.02GluCys: 1.02 ± 0.517
2.04GluAsp: 2.04 ± 0.873
3.059GluGlu: 3.059 ± 1.518
3.059GluPhe: 3.059 ± 0.758
2.855GluGly: 2.855 ± 0.382
0.408GluHis: 0.408 ± 0.257
3.875GluIle: 3.875 ± 0.751
3.875GluLys: 3.875 ± 1.399
7.75GluLeu: 7.75 ± 1.111
2.04GluMet: 2.04 ± 0.929
2.04GluAsn: 2.04 ± 0.586
1.224GluPro: 1.224 ± 0.367
1.224GluGln: 1.224 ± 0.502
1.836GluArg: 1.836 ± 0.626
3.263GluSer: 3.263 ± 1.309
2.651GluThr: 2.651 ± 0.858
3.671GluVal: 3.671 ± 1.001
0.408GluTrp: 0.408 ± 0.255
2.651GluTyr: 2.651 ± 0.887
0.0GluXaa: 0.0 ± 0.0
Phe
1.224PheAla: 1.224 ± 0.328
0.408PheCys: 0.408 ± 0.373
1.224PheAsp: 1.224 ± 0.509
2.04PheGlu: 2.04 ± 1.063
0.816PhePhe: 0.816 ± 0.336
0.816PheGly: 0.816 ± 0.341
2.244PheHis: 2.244 ± 0.729
3.059PheIle: 3.059 ± 0.641
1.224PheLys: 1.224 ± 0.651
3.671PheLeu: 3.671 ± 1.084
1.224PheMet: 1.224 ± 0.411
3.467PheAsn: 3.467 ± 1.024
2.244PhePro: 2.244 ± 0.459
1.02PheGln: 1.02 ± 0.35
1.428PheArg: 1.428 ± 0.9
3.263PheSer: 3.263 ± 0.645
2.244PheThr: 2.244 ± 0.69
1.632PheVal: 1.632 ± 0.376
0.204PheTrp: 0.204 ± 0.232
2.447PheTyr: 2.447 ± 0.775
0.0PheXaa: 0.0 ± 0.0
Gly
1.428GlyAla: 1.428 ± 0.606
0.816GlyCys: 0.816 ± 0.336
2.244GlyAsp: 2.244 ± 1.016
2.447GlyGlu: 2.447 ± 0.61
2.04GlyPhe: 2.04 ± 0.527
1.224GlyGly: 1.224 ± 0.479
1.224GlyHis: 1.224 ± 0.443
3.467GlyIle: 3.467 ± 0.639
2.447GlyLys: 2.447 ± 0.555
3.467GlyLeu: 3.467 ± 0.913
1.224GlyMet: 1.224 ± 0.699
2.244GlyAsn: 2.244 ± 0.802
1.224GlyPro: 1.224 ± 0.511
0.816GlyGln: 0.816 ± 0.24
0.816GlyArg: 0.816 ± 0.341
3.467GlySer: 3.467 ± 0.535
1.224GlyThr: 1.224 ± 0.3
3.263GlyVal: 3.263 ± 1.201
0.612GlyTrp: 0.612 ± 0.33
1.02GlyTyr: 1.02 ± 0.3
0.0GlyXaa: 0.0 ± 0.0
His
1.428HisAla: 1.428 ± 0.594
0.612HisCys: 0.612 ± 0.523
1.02HisAsp: 1.02 ± 0.617
0.612HisGlu: 0.612 ± 0.431
1.632HisPhe: 1.632 ± 0.959
0.816HisGly: 0.816 ± 0.4
0.204HisHis: 0.204 ± 0.129
1.836HisIle: 1.836 ± 0.788
2.855HisLys: 2.855 ± 0.647
2.244HisLeu: 2.244 ± 0.503
1.632HisMet: 1.632 ± 0.705
2.04HisAsn: 2.04 ± 0.466
1.224HisPro: 1.224 ± 0.568
0.612HisGln: 0.612 ± 0.328
0.612HisArg: 0.612 ± 0.251
1.428HisSer: 1.428 ± 0.54
1.224HisThr: 1.224 ± 0.604
1.428HisVal: 1.428 ± 0.559
0.816HisTrp: 0.816 ± 0.404
0.204HisTyr: 0.204 ± 0.129
0.0HisXaa: 0.0 ± 0.0
Ile
3.875IleAla: 3.875 ± 0.862
1.836IleCys: 1.836 ± 0.759
5.303IleAsp: 5.303 ± 1.651
4.283IleGlu: 4.283 ± 0.95
2.447IlePhe: 2.447 ± 0.503
2.447IleGly: 2.447 ± 0.568
2.244IleHis: 2.244 ± 0.818
10.402IleIle: 10.402 ± 1.836
7.546IleLys: 7.546 ± 1.018
9.79IleLeu: 9.79 ± 2.229
2.651IleMet: 2.651 ± 0.707
6.935IleAsn: 6.935 ± 0.652
2.04IlePro: 2.04 ± 0.719
1.836IleGln: 1.836 ± 0.478
2.447IleArg: 2.447 ± 0.727
7.546IleSer: 7.546 ± 1.417
10.606IleThr: 10.606 ± 1.584
3.875IleVal: 3.875 ± 0.932
0.612IleTrp: 0.612 ± 0.386
1.428IleTyr: 1.428 ± 0.853
0.0IleXaa: 0.0 ± 0.0
Lys
3.467LysAla: 3.467 ± 0.723
1.02LysCys: 1.02 ± 0.383
5.099LysAsp: 5.099 ± 0.915
4.079LysGlu: 4.079 ± 0.886
3.875LysPhe: 3.875 ± 1.008
3.467LysGly: 3.467 ± 0.817
2.04LysHis: 2.04 ± 0.648
4.691LysIle: 4.691 ± 0.868
6.527LysLys: 6.527 ± 0.991
10.606LysLeu: 10.606 ± 1.819
0.612LysMet: 0.612 ± 0.394
5.711LysAsn: 5.711 ± 0.866
4.895LysPro: 4.895 ± 3.132
2.855LysGln: 2.855 ± 0.705
2.244LysArg: 2.244 ± 0.597
6.323LysSer: 6.323 ± 0.774
5.711LysThr: 5.711 ± 1.491
3.671LysVal: 3.671 ± 0.537
0.204LysTrp: 0.204 ± 0.129
3.467LysTyr: 3.467 ± 1.033
0.0LysXaa: 0.0 ± 0.0
Leu
4.079LeuAla: 4.079 ± 0.775
2.447LeuCys: 2.447 ± 0.494
3.671LeuAsp: 3.671 ± 0.625
5.711LeuGlu: 5.711 ± 1.234
2.855LeuPhe: 2.855 ± 0.986
4.283LeuGly: 4.283 ± 1.067
3.059LeuHis: 3.059 ± 0.865
8.566LeuIle: 8.566 ± 1.984
9.586LeuLys: 9.586 ± 2.621
11.014LeuLeu: 11.014 ± 1.147
2.447LeuMet: 2.447 ± 0.52
8.566LeuAsn: 8.566 ± 1.501
3.875LeuPro: 3.875 ± 0.723
2.244LeuGln: 2.244 ± 0.623
3.671LeuArg: 3.671 ± 0.817
10.606LeuSer: 10.606 ± 2.098
9.994LeuThr: 9.994 ± 1.209
2.651LeuVal: 2.651 ± 1.015
0.612LeuTrp: 0.612 ± 0.275
5.303LeuTyr: 5.303 ± 1.483
0.0LeuXaa: 0.0 ± 0.0
Met
0.612MetAla: 0.612 ± 0.603
0.204MetCys: 0.204 ± 0.129
1.224MetAsp: 1.224 ± 0.331
2.447MetGlu: 2.447 ± 0.697
1.02MetPhe: 1.02 ± 0.512
1.02MetGly: 1.02 ± 0.471
0.0MetHis: 0.0 ± 0.0
3.467MetIle: 3.467 ± 1.245
1.428MetLys: 1.428 ± 0.506
3.263MetLeu: 3.263 ± 0.999
0.408MetMet: 0.408 ± 0.24
1.632MetAsn: 1.632 ± 0.403
1.836MetPro: 1.836 ± 0.756
1.02MetGln: 1.02 ± 0.453
0.612MetArg: 0.612 ± 0.279
2.04MetSer: 2.04 ± 0.58
1.224MetThr: 1.224 ± 0.439
0.612MetVal: 0.612 ± 0.386
0.0MetTrp: 0.0 ± 0.0
0.612MetTyr: 0.612 ± 0.533
0.0MetXaa: 0.0 ± 0.0
Asn
3.263AsnAla: 3.263 ± 0.947
1.224AsnCys: 1.224 ± 0.625
4.691AsnAsp: 4.691 ± 1.317
3.059AsnGlu: 3.059 ± 0.893
2.244AsnPhe: 2.244 ± 0.415
3.467AsnGly: 3.467 ± 0.935
3.059AsnHis: 3.059 ± 0.713
7.342AsnIle: 7.342 ± 1.222
7.954AsnLys: 7.954 ± 0.981
5.099AsnLeu: 5.099 ± 2.142
0.408AsnMet: 0.408 ± 0.349
7.138AsnAsn: 7.138 ± 1.266
5.507AsnPro: 5.507 ± 2.283
3.263AsnGln: 3.263 ± 1.029
3.059AsnArg: 3.059 ± 0.801
3.875AsnSer: 3.875 ± 0.685
6.119AsnThr: 6.119 ± 1.9
4.079AsnVal: 4.079 ± 0.907
0.408AsnTrp: 0.408 ± 0.3
3.875AsnTyr: 3.875 ± 0.789
0.0AsnXaa: 0.0 ± 0.0
Pro
1.632ProAla: 1.632 ± 0.694
1.428ProCys: 1.428 ± 0.622
1.02ProAsp: 1.02 ± 0.384
1.224ProGlu: 1.224 ± 0.387
0.612ProPhe: 0.612 ± 0.317
1.02ProGly: 1.02 ± 0.725
1.02ProHis: 1.02 ± 0.524
2.855ProIle: 2.855 ± 0.702
3.263ProLys: 3.263 ± 0.998
2.04ProLeu: 2.04 ± 0.506
1.632ProMet: 1.632 ± 0.903
3.671ProAsn: 3.671 ± 1.016
2.04ProPro: 2.04 ± 0.637
2.04ProGln: 2.04 ± 0.978
1.428ProArg: 1.428 ± 0.618
5.303ProSer: 5.303 ± 3.118
6.527ProThr: 6.527 ± 3.451
1.02ProVal: 1.02 ± 0.354
1.02ProTrp: 1.02 ± 0.457
1.02ProTyr: 1.02 ± 0.425
0.0ProXaa: 0.0 ± 0.0
Gln
1.632GlnAla: 1.632 ± 0.422
0.204GlnCys: 0.204 ± 0.273
1.836GlnAsp: 1.836 ± 0.49
1.02GlnGlu: 1.02 ± 0.428
1.632GlnPhe: 1.632 ± 0.637
0.0GlnGly: 0.0 ± 0.0
1.02GlnHis: 1.02 ± 0.508
3.059GlnIle: 3.059 ± 1.043
2.244GlnLys: 2.244 ± 0.608
3.059GlnLeu: 3.059 ± 0.958
1.02GlnMet: 1.02 ± 0.84
3.059GlnAsn: 3.059 ± 0.823
1.224GlnPro: 1.224 ± 0.738
0.408GlnGln: 0.408 ± 0.373
1.428GlnArg: 1.428 ± 0.743
4.283GlnSer: 4.283 ± 1.04
1.836GlnThr: 1.836 ± 0.781
1.632GlnVal: 1.632 ± 0.463
0.0GlnTrp: 0.0 ± 0.0
1.02GlnTyr: 1.02 ± 0.512
0.0GlnXaa: 0.0 ± 0.0
Arg
1.428ArgAla: 1.428 ± 0.511
0.612ArgCys: 0.612 ± 0.379
2.244ArgAsp: 2.244 ± 0.657
1.632ArgGlu: 1.632 ± 0.37
1.224ArgPhe: 1.224 ± 0.379
1.836ArgGly: 1.836 ± 0.532
0.408ArgHis: 0.408 ± 0.207
2.651ArgIle: 2.651 ± 0.827
1.836ArgLys: 1.836 ± 0.485
3.263ArgLeu: 3.263 ± 0.855
0.408ArgMet: 0.408 ± 0.257
1.632ArgAsn: 1.632 ± 0.446
0.408ArgPro: 0.408 ± 0.253
2.651ArgGln: 2.651 ± 0.645
1.428ArgArg: 1.428 ± 0.411
2.244ArgSer: 2.244 ± 0.801
2.244ArgThr: 2.244 ± 0.531
2.447ArgVal: 2.447 ± 0.528
0.816ArgTrp: 0.816 ± 0.341
1.224ArgTyr: 1.224 ± 0.568
0.0ArgXaa: 0.0 ± 0.0
Ser
3.059SerAla: 3.059 ± 0.718
0.816SerCys: 0.816 ± 0.424
3.671SerAsp: 3.671 ± 0.986
4.487SerGlu: 4.487 ± 1.036
1.632SerPhe: 1.632 ± 0.445
2.855SerGly: 2.855 ± 0.614
1.224SerHis: 1.224 ± 0.406
7.342SerIle: 7.342 ± 1.045
7.75SerLys: 7.75 ± 1.034
11.014SerLeu: 11.014 ± 1.955
2.04SerMet: 2.04 ± 0.655
7.138SerAsn: 7.138 ± 1.68
3.059SerPro: 3.059 ± 1.21
3.263SerGln: 3.263 ± 2.103
2.651SerArg: 2.651 ± 0.751
4.895SerSer: 4.895 ± 0.777
7.546SerThr: 7.546 ± 2.418
4.283SerVal: 4.283 ± 0.938
0.612SerTrp: 0.612 ± 0.386
2.855SerTyr: 2.855 ± 0.698
0.0SerXaa: 0.0 ± 0.0
Thr
3.263ThrAla: 3.263 ± 0.71
1.428ThrCys: 1.428 ± 0.602
2.651ThrAsp: 2.651 ± 0.53
4.283ThrGlu: 4.283 ± 0.421
2.651ThrPhe: 2.651 ± 1.207
1.836ThrGly: 1.836 ± 0.439
1.632ThrHis: 1.632 ± 0.707
7.342ThrIle: 7.342 ± 1.368
6.935ThrLys: 6.935 ± 2.894
7.546ThrLeu: 7.546 ± 1.387
2.244ThrMet: 2.244 ± 0.972
5.711ThrAsn: 5.711 ± 1.101
4.283ThrPro: 4.283 ± 2.077
2.855ThrGln: 2.855 ± 1.0
1.428ThrArg: 1.428 ± 0.466
8.77ThrSer: 8.77 ± 2.619
13.053ThrThr: 13.053 ± 6.766
2.855ThrVal: 2.855 ± 0.604
0.612ThrTrp: 0.612 ± 0.294
4.487ThrTyr: 4.487 ± 1.411
0.0ThrXaa: 0.0 ± 0.0
Val
1.428ValAla: 1.428 ± 0.582
1.224ValCys: 1.224 ± 0.771
1.836ValAsp: 1.836 ± 0.541
1.632ValGlu: 1.632 ± 0.688
3.263ValPhe: 3.263 ± 0.515
1.836ValGly: 1.836 ± 0.494
0.816ValHis: 0.816 ± 0.318
4.079ValIle: 4.079 ± 1.075
3.671ValLys: 3.671 ± 0.755
5.303ValLeu: 5.303 ± 1.063
0.408ValMet: 0.408 ± 0.37
4.487ValAsn: 4.487 ± 0.9
1.02ValPro: 1.02 ± 0.852
1.836ValGln: 1.836 ± 0.537
1.632ValArg: 1.632 ± 0.499
4.487ValSer: 4.487 ± 1.74
4.079ValThr: 4.079 ± 1.174
3.263ValVal: 3.263 ± 0.702
0.204ValTrp: 0.204 ± 0.129
2.04ValTyr: 2.04 ± 0.861
0.0ValXaa: 0.0 ± 0.0
Trp
0.408TrpAla: 0.408 ± 0.394
0.204TrpCys: 0.204 ± 0.129
0.204TrpAsp: 0.204 ± 0.265
0.204TrpGlu: 0.204 ± 0.238
0.816TrpPhe: 0.816 ± 0.355
0.408TrpGly: 0.408 ± 0.207
0.204TrpHis: 0.204 ± 0.129
0.816TrpIle: 0.816 ± 0.514
1.02TrpLys: 1.02 ± 0.396
0.816TrpLeu: 0.816 ± 0.514
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.612TrpPro: 0.612 ± 0.361
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.816TrpSer: 0.816 ± 0.514
0.612TrpThr: 0.612 ± 0.319
0.816TrpVal: 0.816 ± 0.414
0.0TrpTrp: 0.0 ± 0.0
0.408TrpTyr: 0.408 ± 0.373
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.428TyrAla: 1.428 ± 0.707
1.02TyrCys: 1.02 ± 0.383
1.224TyrAsp: 1.224 ± 0.782
1.428TyrGlu: 1.428 ± 0.478
1.224TyrPhe: 1.224 ± 0.455
2.04TyrGly: 2.04 ± 0.494
1.836TyrHis: 1.836 ± 0.788
4.079TyrIle: 4.079 ± 1.157
2.651TyrLys: 2.651 ± 0.641
4.283TyrLeu: 4.283 ± 1.263
1.02TyrMet: 1.02 ± 0.342
4.283TyrAsn: 4.283 ± 1.45
1.632TyrPro: 1.632 ± 0.511
0.408TyrGln: 0.408 ± 0.332
2.447TyrArg: 2.447 ± 1.135
1.428TyrSer: 1.428 ± 0.438
3.059TyrThr: 3.059 ± 0.62
1.836TyrVal: 1.836 ± 0.749
0.204TyrTrp: 0.204 ± 0.129
1.224TyrTyr: 1.224 ± 0.436
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (4904 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski