Amino acid dipepetide frequency for Aquimarina brevivitae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.593AlaAla: 4.593 ± 0.084
0.539AlaCys: 0.539 ± 0.025
3.447AlaAsp: 3.447 ± 0.069
4.133AlaGlu: 4.133 ± 0.074
3.116AlaPhe: 3.116 ± 0.057
4.012AlaGly: 4.012 ± 0.074
1.105AlaHis: 1.105 ± 0.032
5.751AlaIle: 5.751 ± 0.075
4.938AlaLys: 4.938 ± 0.089
6.33AlaLeu: 6.33 ± 0.081
1.541AlaMet: 1.541 ± 0.041
3.602AlaAsn: 3.602 ± 0.059
2.035AlaPro: 2.035 ± 0.049
2.657AlaGln: 2.657 ± 0.049
1.961AlaArg: 1.961 ± 0.044
4.176AlaSer: 4.176 ± 0.067
4.143AlaThr: 4.143 ± 0.09
4.113AlaVal: 4.113 ± 0.065
0.601AlaTrp: 0.601 ± 0.025
2.656AlaTyr: 2.656 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.429CysAla: 0.429 ± 0.022
0.121CysCys: 0.121 ± 0.012
0.391CysAsp: 0.391 ± 0.018
0.393CysGlu: 0.393 ± 0.02
0.41CysPhe: 0.41 ± 0.02
0.57CysGly: 0.57 ± 0.024
0.161CysHis: 0.161 ± 0.013
0.63CysIle: 0.63 ± 0.024
0.478CysLys: 0.478 ± 0.021
0.612CysLeu: 0.612 ± 0.025
0.149CysMet: 0.149 ± 0.01
0.416CysAsn: 0.416 ± 0.02
0.318CysPro: 0.318 ± 0.023
0.253CysGln: 0.253 ± 0.013
0.214CysArg: 0.214 ± 0.013
0.6CysSer: 0.6 ± 0.029
0.513CysThr: 0.513 ± 0.029
0.429CysVal: 0.429 ± 0.023
0.076CysTrp: 0.076 ± 0.008
0.345CysTyr: 0.345 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.619AspAla: 3.619 ± 0.068
0.42AspCys: 0.42 ± 0.022
3.035AspAsp: 3.035 ± 0.058
3.632AspGlu: 3.632 ± 0.058
3.46AspPhe: 3.46 ± 0.062
3.644AspGly: 3.644 ± 0.082
1.009AspHis: 1.009 ± 0.034
4.504AspIle: 4.504 ± 0.066
4.174AspLys: 4.174 ± 0.072
5.357AspLeu: 5.357 ± 0.075
1.04AspMet: 1.04 ± 0.031
3.291AspAsn: 3.291 ± 0.062
2.285AspPro: 2.285 ± 0.052
2.332AspGln: 2.332 ± 0.049
2.074AspArg: 2.074 ± 0.043
3.231AspSer: 3.231 ± 0.062
3.28AspThr: 3.28 ± 0.055
3.357AspVal: 3.357 ± 0.065
0.812AspTrp: 0.812 ± 0.029
2.806AspTyr: 2.806 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.617GluAla: 4.617 ± 0.074
0.327GluCys: 0.327 ± 0.018
3.921GluAsp: 3.921 ± 0.063
5.555GluGlu: 5.555 ± 0.091
2.933GluPhe: 2.933 ± 0.053
3.759GluGly: 3.759 ± 0.066
1.113GluHis: 1.113 ± 0.032
5.227GluIle: 5.227 ± 0.07
5.413GluLys: 5.413 ± 0.084
6.582GluLeu: 6.582 ± 0.091
1.353GluMet: 1.353 ± 0.034
4.089GluAsn: 4.089 ± 0.065
1.613GluPro: 1.613 ± 0.043
2.626GluGln: 2.626 ± 0.051
2.517GluArg: 2.517 ± 0.048
3.202GluSer: 3.202 ± 0.054
3.481GluThr: 3.481 ± 0.052
4.562GluVal: 4.562 ± 0.061
0.546GluTrp: 0.546 ± 0.022
2.46GluTyr: 2.46 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.941PheAla: 2.941 ± 0.058
0.416PheCys: 0.416 ± 0.018
3.3PheAsp: 3.3 ± 0.056
3.425PheGlu: 3.425 ± 0.046
2.65PhePhe: 2.65 ± 0.065
3.354PheGly: 3.354 ± 0.063
0.726PheHis: 0.726 ± 0.024
3.923PheIle: 3.923 ± 0.067
3.482PheLys: 3.482 ± 0.065
4.408PheLeu: 4.408 ± 0.082
1.026PheMet: 1.026 ± 0.031
2.997PheAsn: 2.997 ± 0.062
1.53PhePro: 1.53 ± 0.044
1.444PheGln: 1.444 ± 0.036
1.673PheArg: 1.673 ± 0.036
3.806PheSer: 3.806 ± 0.069
3.342PheThr: 3.342 ± 0.058
2.834PheVal: 2.834 ± 0.049
0.558PheTrp: 0.558 ± 0.023
2.235PheTyr: 2.235 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.207GlyAla: 4.207 ± 0.07
0.617GlyCys: 0.617 ± 0.035
3.443GlyAsp: 3.443 ± 0.059
3.496GlyGlu: 3.496 ± 0.062
3.528GlyPhe: 3.528 ± 0.061
4.536GlyGly: 4.536 ± 0.1
1.014GlyHis: 1.014 ± 0.034
5.253GlyIle: 5.253 ± 0.066
4.506GlyLys: 4.506 ± 0.069
5.597GlyLeu: 5.597 ± 0.078
1.416GlyMet: 1.416 ± 0.037
3.633GlyAsn: 3.633 ± 0.083
1.406GlyPro: 1.406 ± 0.045
1.978GlyGln: 1.978 ± 0.046
2.049GlyArg: 2.049 ± 0.043
4.08GlySer: 4.08 ± 0.086
4.205GlyThr: 4.205 ± 0.102
4.345GlyVal: 4.345 ± 0.064
0.758GlyTrp: 0.758 ± 0.029
2.911GlyTyr: 2.911 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
0.82HisAla: 0.82 ± 0.029
0.189HisCys: 0.189 ± 0.012
0.74HisAsp: 0.74 ± 0.026
0.773HisGlu: 0.773 ± 0.025
1.067HisPhe: 1.067 ± 0.034
0.974HisGly: 0.974 ± 0.032
0.479HisHis: 0.479 ± 0.022
1.415HisIle: 1.415 ± 0.033
1.315HisLys: 1.315 ± 0.034
1.742HisLeu: 1.742 ± 0.037
0.344HisMet: 0.344 ± 0.017
0.978HisAsn: 0.978 ± 0.028
0.87HisPro: 0.87 ± 0.03
0.941HisGln: 0.941 ± 0.027
0.706HisArg: 0.706 ± 0.025
0.978HisSer: 0.978 ± 0.028
1.046HisThr: 1.046 ± 0.029
0.792HisVal: 0.792 ± 0.026
0.216HisTrp: 0.216 ± 0.015
0.86HisTyr: 0.86 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.041IleAla: 6.041 ± 0.084
0.586IleCys: 0.586 ± 0.024
4.993IleAsp: 4.993 ± 0.073
5.504IleGlu: 5.504 ± 0.079
3.48IlePhe: 3.48 ± 0.066
5.054IleGly: 5.054 ± 0.072
1.344IleHis: 1.344 ± 0.037
5.88IleIle: 5.88 ± 0.093
5.721IleLys: 5.721 ± 0.087
6.927IleLeu: 6.927 ± 0.095
1.204IleMet: 1.204 ± 0.032
4.574IleAsn: 4.574 ± 0.073
3.295IlePro: 3.295 ± 0.05
2.761IleGln: 2.761 ± 0.047
2.683IleArg: 2.683 ± 0.047
5.232IleSer: 5.232 ± 0.076
5.348IleThr: 5.348 ± 0.083
4.774IleVal: 4.774 ± 0.075
0.696IleTrp: 0.696 ± 0.027
2.812IleTyr: 2.812 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.961LysAla: 4.961 ± 0.081
0.323LysCys: 0.323 ± 0.017
4.499LysAsp: 4.499 ± 0.066
6.507LysGlu: 6.507 ± 0.107
2.591LysPhe: 2.591 ± 0.051
4.312LysGly: 4.312 ± 0.075
1.283LysHis: 1.283 ± 0.033
5.788LysIle: 5.788 ± 0.085
6.797LysLys: 6.797 ± 0.107
6.554LysLeu: 6.554 ± 0.096
1.699LysMet: 1.699 ± 0.047
4.894LysAsn: 4.894 ± 0.084
2.329LysPro: 2.329 ± 0.05
2.796LysGln: 2.796 ± 0.052
2.873LysArg: 2.873 ± 0.05
4.359LysSer: 4.359 ± 0.079
4.243LysThr: 4.243 ± 0.078
4.606LysVal: 4.606 ± 0.072
0.674LysTrp: 0.674 ± 0.027
2.84LysTyr: 2.84 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.054LeuAla: 6.054 ± 0.091
0.726LeuCys: 0.726 ± 0.022
5.122LeuAsp: 5.122 ± 0.066
5.803LeuGlu: 5.803 ± 0.075
4.775LeuPhe: 4.775 ± 0.084
5.783LeuGly: 5.783 ± 0.068
1.664LeuHis: 1.664 ± 0.044
7.135LeuIle: 7.135 ± 0.104
7.272LeuLys: 7.272 ± 0.106
9.229LeuLeu: 9.229 ± 0.124
1.919LeuMet: 1.919 ± 0.044
5.297LeuAsn: 5.297 ± 0.066
3.502LeuPro: 3.502 ± 0.052
3.981LeuGln: 3.981 ± 0.062
3.373LeuArg: 3.373 ± 0.056
6.875LeuSer: 6.875 ± 0.085
5.458LeuThr: 5.458 ± 0.067
5.584LeuVal: 5.584 ± 0.074
0.857LeuTrp: 0.857 ± 0.03
3.328LeuTyr: 3.328 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.44MetAla: 1.44 ± 0.034
0.141MetCys: 0.141 ± 0.013
1.15MetAsp: 1.15 ± 0.031
1.327MetGlu: 1.327 ± 0.04
0.686MetPhe: 0.686 ± 0.026
1.275MetGly: 1.275 ± 0.034
0.359MetHis: 0.359 ± 0.017
1.495MetIle: 1.495 ± 0.041
1.943MetLys: 1.943 ± 0.037
1.826MetLeu: 1.826 ± 0.04
0.518MetMet: 0.518 ± 0.021
1.206MetAsn: 1.206 ± 0.032
0.759MetPro: 0.759 ± 0.024
0.822MetGln: 0.822 ± 0.029
0.762MetArg: 0.762 ± 0.026
1.188MetSer: 1.188 ± 0.034
1.072MetThr: 1.072 ± 0.032
1.286MetVal: 1.286 ± 0.031
0.144MetTrp: 0.144 ± 0.012
0.7MetTyr: 0.7 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 0.062
0.476AsnCys: 0.476 ± 0.022
3.206AsnAsp: 3.206 ± 0.056
3.699AsnGlu: 3.699 ± 0.07
2.914AsnPhe: 2.914 ± 0.061
3.844AsnGly: 3.844 ± 0.08
1.038AsnHis: 1.038 ± 0.036
4.387AsnIle: 4.387 ± 0.063
3.93AsnLys: 3.93 ± 0.07
5.223AsnLeu: 5.223 ± 0.074
1.097AsnMet: 1.097 ± 0.029
3.561AsnAsn: 3.561 ± 0.068
2.744AsnPro: 2.744 ± 0.06
2.356AsnGln: 2.356 ± 0.049
2.193AsnArg: 2.193 ± 0.047
3.59AsnSer: 3.59 ± 0.064
3.975AsnThr: 3.975 ± 0.069
3.332AsnVal: 3.332 ± 0.062
0.752AsnTrp: 0.752 ± 0.03
2.836AsnTyr: 2.836 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
1.937ProAla: 1.937 ± 0.048
0.221ProCys: 0.221 ± 0.016
2.271ProAsp: 2.271 ± 0.047
2.755ProGlu: 2.755 ± 0.059
1.8ProPhe: 1.8 ± 0.038
2.137ProGly: 2.137 ± 0.052
0.539ProHis: 0.539 ± 0.022
2.676ProIle: 2.676 ± 0.055
2.56ProLys: 2.56 ± 0.055
3.022ProLeu: 3.022 ± 0.053
0.67ProMet: 0.67 ± 0.027
2.216ProAsn: 2.216 ± 0.052
0.99ProPro: 0.99 ± 0.043
1.277ProGln: 1.277 ± 0.037
0.955ProArg: 0.955 ± 0.029
2.153ProSer: 2.153 ± 0.055
2.045ProThr: 2.045 ± 0.049
2.464ProVal: 2.464 ± 0.057
0.317ProTrp: 0.317 ± 0.019
1.528ProTyr: 1.528 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.19GlnAla: 2.19 ± 0.046
0.208GlnCys: 0.208 ± 0.015
1.926GlnAsp: 1.926 ± 0.041
2.765GlnGlu: 2.765 ± 0.047
1.789GlnPhe: 1.789 ± 0.038
2.099GlnGly: 2.099 ± 0.04
0.734GlnHis: 0.734 ± 0.027
2.734GlnIle: 2.734 ± 0.051
3.165GlnLys: 3.165 ± 0.055
4.081GlnLeu: 4.081 ± 0.06
0.788GlnMet: 0.788 ± 0.024
2.256GlnAsn: 2.256 ± 0.051
1.282GlnPro: 1.282 ± 0.038
2.073GlnGln: 2.073 ± 0.056
1.474GlnArg: 1.474 ± 0.039
2.17GlnSer: 2.17 ± 0.053
1.938GlnThr: 1.938 ± 0.048
2.132GlnVal: 2.132 ± 0.046
0.461GlnTrp: 0.461 ± 0.022
1.586GlnTyr: 1.586 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.267ArgAla: 2.267 ± 0.039
0.232ArgCys: 0.232 ± 0.016
1.855ArgAsp: 1.855 ± 0.05
2.013ArgGlu: 2.013 ± 0.046
2.002ArgPhe: 2.002 ± 0.043
1.962ArgGly: 1.962 ± 0.043
0.565ArgHis: 0.565 ± 0.026
2.971ArgIle: 2.971 ± 0.045
2.738ArgLys: 2.738 ± 0.055
3.374ArgLeu: 3.374 ± 0.051
0.88ArgMet: 0.88 ± 0.027
2.147ArgAsn: 2.147 ± 0.047
1.087ArgPro: 1.087 ± 0.03
1.14ArgGln: 1.14 ± 0.033
1.389ArgArg: 1.389 ± 0.043
2.042ArgSer: 2.042 ± 0.049
1.923ArgThr: 1.923 ± 0.039
2.206ArgVal: 2.206 ± 0.046
0.401ArgTrp: 0.401 ± 0.019
1.725ArgTyr: 1.725 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.739SerAla: 3.739 ± 0.057
0.685SerCys: 0.685 ± 0.026
3.52SerAsp: 3.52 ± 0.052
3.637SerGlu: 3.637 ± 0.06
3.724SerPhe: 3.724 ± 0.067
4.592SerGly: 4.592 ± 0.087
0.953SerHis: 0.953 ± 0.029
5.184SerIle: 5.184 ± 0.076
4.575SerLys: 4.575 ± 0.067
6.128SerLeu: 6.128 ± 0.079
1.136SerMet: 1.136 ± 0.032
3.626SerAsn: 3.626 ± 0.063
2.04SerPro: 2.04 ± 0.044
2.042SerGln: 2.042 ± 0.051
2.036SerArg: 2.036 ± 0.051
4.228SerSer: 4.228 ± 0.068
3.827SerThr: 3.827 ± 0.064
3.779SerVal: 3.779 ± 0.052
0.767SerTrp: 0.767 ± 0.024
3.014SerTyr: 3.014 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.244ThrAla: 4.244 ± 0.079
0.347ThrCys: 0.347 ± 0.022
3.632ThrAsp: 3.632 ± 0.074
3.675ThrGlu: 3.675 ± 0.063
3.009ThrPhe: 3.009 ± 0.057
4.133ThrGly: 4.133 ± 0.095
1.041ThrHis: 1.041 ± 0.032
5.403ThrIle: 5.403 ± 0.082
4.017ThrLys: 4.017 ± 0.073
5.817ThrLeu: 5.817 ± 0.074
0.995ThrMet: 0.995 ± 0.029
3.447ThrAsn: 3.447 ± 0.067
2.593ThrPro: 2.593 ± 0.062
1.97ThrGln: 1.97 ± 0.044
1.744ThrArg: 1.744 ± 0.04
3.94ThrSer: 3.94 ± 0.065
4.145ThrThr: 4.145 ± 0.088
4.118ThrVal: 4.118 ± 0.108
0.535ThrTrp: 0.535 ± 0.027
2.707ThrTyr: 2.707 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
4.375ValAla: 4.375 ± 0.067
0.477ValCys: 0.477 ± 0.023
3.69ValAsp: 3.69 ± 0.06
3.74ValGlu: 3.74 ± 0.056
3.261ValPhe: 3.261 ± 0.057
3.673ValGly: 3.673 ± 0.061
1.001ValHis: 1.001 ± 0.024
4.963ValIle: 4.963 ± 0.065
4.11ValLys: 4.11 ± 0.066
6.063ValLeu: 6.063 ± 0.092
1.303ValMet: 1.303 ± 0.033
3.474ValAsn: 3.474 ± 0.053
2.121ValPro: 2.121 ± 0.054
2.061ValGln: 2.061 ± 0.048
2.049ValArg: 2.049 ± 0.046
4.181ValSer: 4.181 ± 0.062
4.106ValThr: 4.106 ± 0.109
4.352ValVal: 4.352 ± 0.072
0.57ValTrp: 0.57 ± 0.026
2.486ValTyr: 2.486 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.577TrpAla: 0.577 ± 0.023
0.099TrpCys: 0.099 ± 0.01
0.615TrpAsp: 0.615 ± 0.029
0.603TrpGlu: 0.603 ± 0.024
0.546TrpPhe: 0.546 ± 0.025
0.579TrpGly: 0.579 ± 0.024
0.201TrpHis: 0.201 ± 0.011
0.778TrpIle: 0.778 ± 0.028
0.803TrpLys: 0.803 ± 0.031
0.964TrpLeu: 0.964 ± 0.033
0.29TrpMet: 0.29 ± 0.016
0.705TrpAsn: 0.705 ± 0.026
0.225TrpPro: 0.225 ± 0.017
0.439TrpGln: 0.439 ± 0.018
0.389TrpArg: 0.389 ± 0.016
0.678TrpSer: 0.678 ± 0.031
0.576TrpThr: 0.576 ± 0.026
0.65TrpVal: 0.65 ± 0.024
0.151TrpTrp: 0.151 ± 0.013
0.505TrpTyr: 0.505 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.632TyrAla: 2.632 ± 0.046
0.357TyrCys: 0.357 ± 0.016
2.609TyrAsp: 2.609 ± 0.057
2.462TyrGlu: 2.462 ± 0.053
2.33TyrPhe: 2.33 ± 0.045
2.685TyrGly: 2.685 ± 0.057
0.916TyrHis: 0.916 ± 0.031
2.812TyrIle: 2.812 ± 0.051
2.993TyrLys: 2.993 ± 0.058
3.903TyrLeu: 3.903 ± 0.062
0.728TyrMet: 0.728 ± 0.028
2.505TyrAsn: 2.505 ± 0.053
1.509TyrPro: 1.509 ± 0.034
1.905TyrGln: 1.905 ± 0.053
1.805TyrArg: 1.805 ± 0.043
2.522TyrSer: 2.522 ± 0.049
2.845TyrThr: 2.845 ± 0.076
2.342TyrVal: 2.342 ± 0.05
0.482TyrTrp: 0.482 ± 0.021
2.079TyrTyr: 2.079 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3416 proteins (1162327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski