Amino acid dipepetide frequency for Rhodococcus triatomae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.611AlaAla: 19.611 ± 0.198
0.877AlaCys: 0.877 ± 0.027
8.557AlaAsp: 8.557 ± 0.085
8.166AlaGlu: 8.166 ± 0.098
3.418AlaPhe: 3.418 ± 0.053
12.351AlaGly: 12.351 ± 0.101
2.607AlaHis: 2.607 ± 0.049
4.522AlaIle: 4.522 ± 0.067
2.33AlaLys: 2.33 ± 0.053
13.663AlaLeu: 13.663 ± 0.122
2.388AlaMet: 2.388 ± 0.045
1.986AlaAsn: 1.986 ± 0.036
6.633AlaPro: 6.633 ± 0.087
3.586AlaGln: 3.586 ± 0.051
9.619AlaArg: 9.619 ± 0.098
6.213AlaSer: 6.213 ± 0.061
7.35AlaThr: 7.35 ± 0.078
12.742AlaVal: 12.742 ± 0.125
1.549AlaTrp: 1.549 ± 0.03
2.234AlaTyr: 2.234 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.936CysAla: 0.936 ± 0.031
0.079CysCys: 0.079 ± 0.007
0.421CysAsp: 0.421 ± 0.018
0.379CysGlu: 0.379 ± 0.017
0.187CysPhe: 0.187 ± 0.012
0.871CysGly: 0.871 ± 0.03
0.152CysHis: 0.152 ± 0.01
0.219CysIle: 0.219 ± 0.012
0.076CysLys: 0.076 ± 0.007
0.55CysLeu: 0.55 ± 0.02
0.1CysMet: 0.1 ± 0.008
0.123CysAsn: 0.123 ± 0.01
0.413CysPro: 0.413 ± 0.017
0.138CysGln: 0.138 ± 0.01
0.52CysArg: 0.52 ± 0.02
0.462CysSer: 0.462 ± 0.021
0.438CysThr: 0.438 ± 0.019
0.546CysVal: 0.546 ± 0.02
0.083CysTrp: 0.083 ± 0.008
0.12CysTyr: 0.12 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
8.269AspAla: 8.269 ± 0.088
0.366AspCys: 0.366 ± 0.016
4.224AspAsp: 4.224 ± 0.058
4.484AspGlu: 4.484 ± 0.062
1.664AspPhe: 1.664 ± 0.04
6.382AspGly: 6.382 ± 0.077
1.485AspHis: 1.485 ± 0.033
2.294AspIle: 2.294 ± 0.039
0.987AspLys: 0.987 ± 0.025
6.661AspLeu: 6.661 ± 0.081
0.849AspMet: 0.849 ± 0.024
0.966AspAsn: 0.966 ± 0.026
4.767AspPro: 4.767 ± 0.067
1.52AspGln: 1.52 ± 0.035
5.301AspArg: 5.301 ± 0.073
3.219AspSer: 3.219 ± 0.048
3.712AspThr: 3.712 ± 0.06
5.84AspVal: 5.84 ± 0.076
0.869AspTrp: 0.869 ± 0.028
1.254AspTyr: 1.254 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.517GluAla: 6.517 ± 0.092
0.341GluCys: 0.341 ± 0.016
2.985GluAsp: 2.985 ± 0.052
2.959GluGlu: 2.959 ± 0.047
1.885GluPhe: 1.885 ± 0.038
3.929GluGly: 3.929 ± 0.06
1.639GluHis: 1.639 ± 0.031
2.832GluIle: 2.832 ± 0.054
1.41GluLys: 1.41 ± 0.034
6.63GluLeu: 6.63 ± 0.075
1.053GluMet: 1.053 ± 0.028
1.277GluAsn: 1.277 ± 0.032
3.221GluPro: 3.221 ± 0.056
2.312GluGln: 2.312 ± 0.039
5.125GluArg: 5.125 ± 0.073
3.418GluSer: 3.418 ± 0.046
2.806GluThr: 2.806 ± 0.043
4.864GluVal: 4.864 ± 0.066
0.86GluTrp: 0.86 ± 0.026
1.27GluTyr: 1.27 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.126PheAla: 4.126 ± 0.054
0.237PheCys: 0.237 ± 0.015
2.444PheAsp: 2.444 ± 0.046
1.703PheGlu: 1.703 ± 0.037
0.949PhePhe: 0.949 ± 0.032
3.442PheGly: 3.442 ± 0.059
0.599PheHis: 0.599 ± 0.02
0.704PheIle: 0.704 ± 0.024
0.363PheLys: 0.363 ± 0.016
2.64PheLeu: 2.64 ± 0.048
0.384PheMet: 0.384 ± 0.018
0.477PheAsn: 0.477 ± 0.019
1.422PhePro: 1.422 ± 0.032
0.639PheGln: 0.639 ± 0.022
1.797PheArg: 1.797 ± 0.037
1.569PheSer: 1.569 ± 0.033
2.073PheThr: 2.073 ± 0.039
2.944PheVal: 2.944 ± 0.048
0.413PheTrp: 0.413 ± 0.017
0.608PheTyr: 0.608 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
11.066GlyAla: 11.066 ± 0.094
0.723GlyCys: 0.723 ± 0.029
5.375GlyAsp: 5.375 ± 0.066
5.015GlyGlu: 5.015 ± 0.063
3.105GlyPhe: 3.105 ± 0.052
8.237GlyGly: 8.237 ± 0.107
2.026GlyHis: 2.026 ± 0.047
4.304GlyIle: 4.304 ± 0.056
2.056GlyLys: 2.056 ± 0.041
8.868GlyLeu: 8.868 ± 0.088
1.996GlyMet: 1.996 ± 0.04
1.775GlyAsn: 1.775 ± 0.037
4.694GlyPro: 4.694 ± 0.066
2.367GlyGln: 2.367 ± 0.048
7.085GlyArg: 7.085 ± 0.078
5.668GlySer: 5.668 ± 0.072
6.102GlyThr: 6.102 ± 0.057
8.034GlyVal: 8.034 ± 0.081
1.581GlyTrp: 1.581 ± 0.042
2.319GlyTyr: 2.319 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.421HisAla: 2.421 ± 0.045
0.181HisCys: 0.181 ± 0.011
1.339HisAsp: 1.339 ± 0.029
1.16HisGlu: 1.16 ± 0.035
0.605HisPhe: 0.605 ± 0.019
2.167HisGly: 2.167 ± 0.045
0.677HisHis: 0.677 ± 0.027
0.649HisIle: 0.649 ± 0.021
0.259HisLys: 0.259 ± 0.013
2.15HisLeu: 2.15 ± 0.04
0.334HisMet: 0.334 ± 0.016
0.356HisAsn: 0.356 ± 0.016
1.688HisPro: 1.688 ± 0.034
0.526HisGln: 0.526 ± 0.022
2.017HisArg: 2.017 ± 0.04
1.112HisSer: 1.112 ± 0.028
1.231HisThr: 1.231 ± 0.032
1.76HisVal: 1.76 ± 0.033
0.35HisTrp: 0.35 ± 0.016
0.457HisTyr: 0.457 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.745IleAla: 5.745 ± 0.078
0.267IleCys: 0.267 ± 0.014
3.13IleAsp: 3.13 ± 0.057
2.52IleGlu: 2.52 ± 0.041
0.913IlePhe: 0.913 ± 0.03
4.358IleGly: 4.358 ± 0.061
0.695IleHis: 0.695 ± 0.023
1.029IleIle: 1.029 ± 0.035
0.581IleLys: 0.581 ± 0.022
3.251IleLeu: 3.251 ± 0.054
0.513IleMet: 0.513 ± 0.02
0.724IleAsn: 0.724 ± 0.025
2.191IlePro: 2.191 ± 0.039
0.727IleGln: 0.727 ± 0.027
2.582IleArg: 2.582 ± 0.041
2.022IleSer: 2.022 ± 0.034
2.365IleThr: 2.365 ± 0.037
3.785IleVal: 3.785 ± 0.06
0.399IleTrp: 0.399 ± 0.018
0.662IleTyr: 0.662 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.22LysAla: 2.22 ± 0.049
0.084LysCys: 0.084 ± 0.009
0.965LysAsp: 0.965 ± 0.028
0.874LysGlu: 0.874 ± 0.029
0.515LysPhe: 0.515 ± 0.02
1.366LysGly: 1.366 ± 0.038
0.339LysHis: 0.339 ± 0.015
0.94LysIle: 0.94 ± 0.026
0.602LysLys: 0.602 ± 0.031
1.684LysLeu: 1.684 ± 0.034
0.37LysMet: 0.37 ± 0.016
0.451LysAsn: 0.451 ± 0.019
0.99LysPro: 0.99 ± 0.03
0.53LysGln: 0.53 ± 0.021
1.187LysArg: 1.187 ± 0.035
1.037LysSer: 1.037 ± 0.028
1.101LysThr: 1.101 ± 0.032
1.6LysVal: 1.6 ± 0.041
0.266LysTrp: 0.266 ± 0.013
0.432LysTyr: 0.432 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.344LeuAla: 14.344 ± 0.125
0.711LeuCys: 0.711 ± 0.023
7.343LeuAsp: 7.343 ± 0.09
5.074LeuGlu: 5.074 ± 0.058
2.823LeuPhe: 2.823 ± 0.049
9.396LeuGly: 9.396 ± 0.09
2.007LeuHis: 2.007 ± 0.044
3.338LeuIle: 3.338 ± 0.053
1.288LeuLys: 1.288 ± 0.039
9.754LeuLeu: 9.754 ± 0.116
1.526LeuMet: 1.526 ± 0.03
1.462LeuAsn: 1.462 ± 0.033
5.853LeuPro: 5.853 ± 0.059
2.105LeuGln: 2.105 ± 0.04
7.745LeuArg: 7.745 ± 0.08
5.602LeuSer: 5.602 ± 0.064
6.307LeuThr: 6.307 ± 0.069
9.847LeuVal: 9.847 ± 0.091
1.213LeuTrp: 1.213 ± 0.033
1.615LeuTyr: 1.615 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.039
0.146MetCys: 0.146 ± 0.009
0.824MetAsp: 0.824 ± 0.027
0.627MetGlu: 0.627 ± 0.018
0.583MetPhe: 0.583 ± 0.02
1.316MetGly: 1.316 ± 0.032
0.356MetHis: 0.356 ± 0.018
0.824MetIle: 0.824 ± 0.024
0.374MetLys: 0.374 ± 0.018
1.843MetLeu: 1.843 ± 0.036
0.334MetMet: 0.334 ± 0.017
0.455MetAsn: 0.455 ± 0.019
0.997MetPro: 0.997 ± 0.028
0.462MetGln: 0.462 ± 0.017
1.405MetArg: 1.405 ± 0.034
1.565MetSer: 1.565 ± 0.031
1.662MetThr: 1.662 ± 0.03
1.46MetVal: 1.46 ± 0.032
0.259MetTrp: 0.259 ± 0.014
0.329MetTyr: 0.329 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.095AsnAla: 2.095 ± 0.039
0.127AsnCys: 0.127 ± 0.01
0.913AsnAsp: 0.913 ± 0.028
0.894AsnGlu: 0.894 ± 0.026
0.546AsnPhe: 0.546 ± 0.021
1.666AsnGly: 1.666 ± 0.041
0.377AsnHis: 0.377 ± 0.016
0.772AsnIle: 0.772 ± 0.023
0.331AsnLys: 0.331 ± 0.016
1.807AsnLeu: 1.807 ± 0.036
0.316AsnMet: 0.316 ± 0.016
0.371AsnAsn: 0.371 ± 0.02
1.401AsnPro: 1.401 ± 0.031
0.486AsnGln: 0.486 ± 0.017
1.281AsnArg: 1.281 ± 0.029
0.974AsnSer: 0.974 ± 0.029
1.174AsnThr: 1.174 ± 0.033
1.492AsnVal: 1.492 ± 0.031
0.309AsnTrp: 0.309 ± 0.016
0.452AsnTyr: 0.452 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.317ProAla: 7.317 ± 0.088
0.265ProCys: 0.265 ± 0.014
4.767ProAsp: 4.767 ± 0.06
4.29ProGlu: 4.29 ± 0.067
1.589ProPhe: 1.589 ± 0.035
5.95ProGly: 5.95 ± 0.075
1.193ProHis: 1.193 ± 0.028
1.946ProIle: 1.946 ± 0.032
0.997ProLys: 0.997 ± 0.031
4.797ProLeu: 4.797 ± 0.06
1.007ProMet: 1.007 ± 0.029
0.992ProAsn: 0.992 ± 0.03
3.206ProPro: 3.206 ± 0.071
1.478ProGln: 1.478 ± 0.033
3.756ProArg: 3.756 ± 0.058
3.25ProSer: 3.25 ± 0.05
3.551ProThr: 3.551 ± 0.048
5.464ProVal: 5.464 ± 0.074
0.8ProTrp: 0.8 ± 0.023
1.091ProTyr: 1.091 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.075GlnAla: 3.075 ± 0.049
0.164GlnCys: 0.164 ± 0.011
1.174GlnAsp: 1.174 ± 0.031
1.129GlnGlu: 1.129 ± 0.027
0.865GlnPhe: 0.865 ± 0.026
1.907GlnGly: 1.907 ± 0.039
0.526GlnHis: 0.526 ± 0.019
1.345GlnIle: 1.345 ± 0.036
0.535GlnLys: 0.535 ± 0.018
2.911GlnLeu: 2.911 ± 0.051
0.537GlnMet: 0.537 ± 0.018
0.494GlnAsn: 0.494 ± 0.018
1.432GlnPro: 1.432 ± 0.037
1.08GlnGln: 1.08 ± 0.032
2.212GlnArg: 2.212 ± 0.044
1.342GlnSer: 1.342 ± 0.031
1.307GlnThr: 1.307 ± 0.029
2.51GlnVal: 2.51 ± 0.044
0.5GlnTrp: 0.5 ± 0.018
0.587GlnTyr: 0.587 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.144ArgAla: 9.144 ± 0.106
0.498ArgCys: 0.498 ± 0.018
4.598ArgAsp: 4.598 ± 0.06
4.652ArgGlu: 4.652 ± 0.061
2.461ArgPhe: 2.461 ± 0.035
5.691ArgGly: 5.691 ± 0.062
1.801ArgHis: 1.801 ± 0.037
3.761ArgIle: 3.761 ± 0.055
1.508ArgLys: 1.508 ± 0.033
7.318ArgLeu: 7.318 ± 0.085
1.824ArgMet: 1.824 ± 0.035
1.443ArgAsn: 1.443 ± 0.033
4.19ArgPro: 4.19 ± 0.061
1.943ArgGln: 1.943 ± 0.039
7.209ArgArg: 7.209 ± 0.104
4.53ArgSer: 4.53 ± 0.062
5.026ArgThr: 5.026 ± 0.059
6.151ArgVal: 6.151 ± 0.073
1.327ArgTrp: 1.327 ± 0.032
1.893ArgTyr: 1.893 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
7.205SerAla: 7.205 ± 0.063
0.369SerCys: 0.369 ± 0.017
3.283SerAsp: 3.283 ± 0.045
2.891SerGlu: 2.891 ± 0.046
1.668SerPhe: 1.668 ± 0.034
6.29SerGly: 6.29 ± 0.072
0.988SerHis: 0.988 ± 0.024
2.139SerIle: 2.139 ± 0.035
0.91SerLys: 0.91 ± 0.028
5.079SerLeu: 5.079 ± 0.068
1.268SerMet: 1.268 ± 0.028
0.984SerAsn: 0.984 ± 0.024
3.25SerPro: 3.25 ± 0.048
1.233SerGln: 1.233 ± 0.031
4.074SerArg: 4.074 ± 0.053
3.284SerSer: 3.284 ± 0.051
3.638SerThr: 3.638 ± 0.054
5.111SerVal: 5.111 ± 0.055
0.917SerTrp: 0.917 ± 0.027
1.156SerTyr: 1.156 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
8.082ThrAla: 8.082 ± 0.078
0.376ThrCys: 0.376 ± 0.016
4.074ThrAsp: 4.074 ± 0.062
3.547ThrGlu: 3.547 ± 0.051
1.795ThrPhe: 1.795 ± 0.039
6.313ThrGly: 6.313 ± 0.071
1.234ThrHis: 1.234 ± 0.034
2.241ThrIle: 2.241 ± 0.04
0.988ThrLys: 0.988 ± 0.029
5.943ThrLeu: 5.943 ± 0.063
1.029ThrMet: 1.029 ± 0.026
1.004ThrAsn: 1.004 ± 0.027
3.995ThrPro: 3.995 ± 0.053
1.265ThrGln: 1.265 ± 0.032
4.245ThrArg: 4.245 ± 0.059
3.346ThrSer: 3.346 ± 0.047
4.069ThrThr: 4.069 ± 0.07
6.542ThrVal: 6.542 ± 0.07
0.841ThrTrp: 0.841 ± 0.026
1.215ThrTyr: 1.215 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
12.353ValAla: 12.353 ± 0.099
0.687ValCys: 0.687 ± 0.022
6.627ValAsp: 6.627 ± 0.076
5.178ValGlu: 5.178 ± 0.061
2.742ValPhe: 2.742 ± 0.051
7.766ValGly: 7.766 ± 0.083
2.022ValHis: 2.022 ± 0.04
3.263ValIle: 3.263 ± 0.049
1.373ValLys: 1.373 ± 0.036
10.031ValLeu: 10.031 ± 0.106
1.417ValMet: 1.417 ± 0.039
1.69ValAsn: 1.69 ± 0.033
5.469ValPro: 5.469 ± 0.073
2.127ValGln: 2.127 ± 0.038
6.849ValArg: 6.849 ± 0.079
5.006ValSer: 5.006 ± 0.062
6.191ValThr: 6.191 ± 0.072
9.953ValVal: 9.953 ± 0.099
1.135ValTrp: 1.135 ± 0.029
1.563ValTyr: 1.563 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.542TrpAla: 1.542 ± 0.034
0.141TrpCys: 0.141 ± 0.01
0.779TrpAsp: 0.779 ± 0.025
0.712TrpGlu: 0.712 ± 0.021
0.52TrpPhe: 0.52 ± 0.02
0.999TrpGly: 0.999 ± 0.027
0.314TrpHis: 0.314 ± 0.017
0.722TrpIle: 0.722 ± 0.022
0.301TrpLys: 0.301 ± 0.013
1.52TrpLeu: 1.52 ± 0.029
0.363TrpMet: 0.363 ± 0.015
0.384TrpAsn: 0.384 ± 0.016
0.685TrpPro: 0.685 ± 0.02
0.546TrpGln: 0.546 ± 0.019
1.148TrpArg: 1.148 ± 0.03
0.946TrpSer: 0.946 ± 0.025
0.931TrpThr: 0.931 ± 0.029
1.132TrpVal: 1.132 ± 0.033
0.327TrpTrp: 0.327 ± 0.016
0.304TrpTyr: 0.304 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.26TyrAla: 2.26 ± 0.039
0.173TyrCys: 0.173 ± 0.012
1.288TyrAsp: 1.288 ± 0.029
1.082TyrGlu: 1.082 ± 0.028
0.7TyrPhe: 0.7 ± 0.025
1.999TyrGly: 1.999 ± 0.038
0.4TyrHis: 0.4 ± 0.016
0.615TyrIle: 0.615 ± 0.025
0.281TyrLys: 0.281 ± 0.015
2.251TyrLeu: 2.251 ± 0.045
0.29TyrMet: 0.29 ± 0.014
0.368TyrAsn: 0.368 ± 0.014
1.208TyrPro: 1.208 ± 0.034
0.562TyrGln: 0.562 ± 0.023
1.811TyrArg: 1.811 ± 0.043
1.175TyrSer: 1.175 ± 0.03
1.113TyrThr: 1.113 ± 0.03
1.668TyrVal: 1.668 ± 0.032
0.317TyrTrp: 0.317 ± 0.015
0.425TyrTyr: 0.425 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4426 proteins (1436612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski