Amino acid dipepetide frequency for Salmo salar (Atlantic salmon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.727AlaAla: 5.727 ± 0.021	1.185AlaCys: 1.185 ± 0.007	2.976AlaAsp: 2.976 ± 0.009	4.578AlaGlu: 4.578 ± 0.019	2.051AlaPhe: 2.051 ± 0.008	4.466AlaGly: 4.466 ± 0.023	1.445AlaHis: 1.445 ± 0.006	2.534AlaIle: 2.534 ± 0.008	3.396AlaLys: 3.396 ± 0.015	6.134AlaLeu: 6.134 ± 0.016	1.67AlaMet: 1.67 ± 0.006	2.168AlaAsn: 2.168 ± 0.009	3.847AlaPro: 3.847 ± 0.017	3.13AlaGln: 3.13 ± 0.013	3.126AlaArg: 3.126 ± 0.01	5.517AlaSer: 5.517 ± 0.016	3.739AlaThr: 3.739 ± 0.014	4.546AlaVal: 4.546 ± 0.011	0.605AlaTrp: 0.605 ± 0.004	1.375AlaTyr: 1.375 ± 0.005	0.0AlaXaa: 0.0 ± 0.0
Cys	1.016CysAla: 1.016 ± 0.005	0.561CysCys: 0.561 ± 0.005	1.11CysAsp: 1.11 ± 0.008	1.235CysGlu: 1.235 ± 0.009	0.74CysPhe: 0.74 ± 0.005	1.508CysGly: 1.508 ± 0.011	0.624CysHis: 0.624 ± 0.006	0.862CysIle: 0.862 ± 0.005	1.057CysLys: 1.057 ± 0.006	1.912CysLeu: 1.912 ± 0.009	0.441CysMet: 0.441 ± 0.003	0.772CysAsn: 0.772 ± 0.005	1.237CysPro: 1.237 ± 0.009	0.991CysGln: 0.991 ± 0.007	1.141CysArg: 1.141 ± 0.006	2.056CysSer: 2.056 ± 0.01	1.105CysThr: 1.105 ± 0.007	1.38CysVal: 1.38 ± 0.007	0.24CysTrp: 0.24 ± 0.003	0.557CysTyr: 0.557 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.74AspAla: 2.74 ± 0.01	1.135AspCys: 1.135 ± 0.007	3.092AspAsp: 3.092 ± 0.014	3.697AspGlu: 3.697 ± 0.018	1.869AspPhe: 1.869 ± 0.008	3.708AspGly: 3.708 ± 0.017	1.252AspHis: 1.252 ± 0.006	2.666AspIle: 2.666 ± 0.011	2.732AspLys: 2.732 ± 0.009	4.857AspLeu: 4.857 ± 0.014	1.439AspMet: 1.439 ± 0.009	1.998AspAsn: 1.998 ± 0.007	3.064AspPro: 3.064 ± 0.01	2.158AspGln: 2.158 ± 0.008	2.914AspArg: 2.914 ± 0.011	4.676AspSer: 4.676 ± 0.013	2.906AspThr: 2.906 ± 0.01	3.108AspVal: 3.108 ± 0.009	0.63AspTrp: 0.63 ± 0.004	1.507AspTyr: 1.507 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	4.808GluAla: 4.808 ± 0.015	1.176GluCys: 1.176 ± 0.007	4.587GluAsp: 4.587 ± 0.015	8.629GluGlu: 8.629 ± 0.039	1.777GluPhe: 1.777 ± 0.007	4.785GluGly: 4.785 ± 0.018	1.458GluHis: 1.458 ± 0.007	2.729GluIle: 2.729 ± 0.015	4.881GluLys: 4.881 ± 0.024	6.062GluLeu: 6.062 ± 0.02	1.832GluMet: 1.832 ± 0.008	2.612GluAsn: 2.612 ± 0.011	3.139GluPro: 3.139 ± 0.018	3.188GluGln: 3.188 ± 0.014	4.807GluArg: 4.807 ± 0.019	4.45GluSer: 4.45 ± 0.011	3.689GluThr: 3.689 ± 0.018	4.645GluVal: 4.645 ± 0.017	0.648GluTrp: 0.648 ± 0.004	1.538GluTyr: 1.538 ± 0.011	0.001GluXaa: 0.001 ± 0.0
Phe	1.633PheAla: 1.633 ± 0.006	0.767PheCys: 0.767 ± 0.005	1.573PheAsp: 1.573 ± 0.007	1.702PheGlu: 1.702 ± 0.007	1.247PhePhe: 1.247 ± 0.007	1.958PheGly: 1.958 ± 0.009	0.928PheHis: 0.928 ± 0.005	1.586PheIle: 1.586 ± 0.007	1.63PheLys: 1.63 ± 0.008	3.234PheLeu: 3.234 ± 0.015	0.728PheMet: 0.728 ± 0.004	1.348PheAsn: 1.348 ± 0.007	1.689PhePro: 1.689 ± 0.009	1.516PheGln: 1.516 ± 0.006	1.719PheArg: 1.719 ± 0.012	3.064PheSer: 3.064 ± 0.011	2.06PheThr: 2.06 ± 0.008	1.841PheVal: 1.841 ± 0.007	0.382PheTrp: 0.382 ± 0.003	0.99PheTyr: 0.99 ± 0.005	0.0PheXaa: 0.0 ± 0.0
Gly	4.225GlyAla: 4.225 ± 0.022	1.222GlyCys: 1.222 ± 0.008	3.497GlyAsp: 3.497 ± 0.01	4.696GlyGlu: 4.696 ± 0.018	2.211GlyPhe: 2.211 ± 0.011	6.468GlyGly: 6.468 ± 0.035	1.788GlyHis: 1.788 ± 0.007	2.361GlyIle: 2.361 ± 0.008	3.738GlyLys: 3.738 ± 0.014	5.656GlyLeu: 5.656 ± 0.018	1.67GlyMet: 1.67 ± 0.009	2.491GlyAsn: 2.491 ± 0.008	3.948GlyPro: 3.948 ± 0.027	3.177GlyGln: 3.177 ± 0.012	3.811GlyArg: 3.811 ± 0.012	6.194GlySer: 6.194 ± 0.016	3.605GlyThr: 3.605 ± 0.012	4.14GlyVal: 4.14 ± 0.017	0.764GlyTrp: 0.764 ± 0.006	1.936GlyTyr: 1.936 ± 0.013	0.001GlyXaa: 0.001 ± 0.0
His	1.315HisAla: 1.315 ± 0.006	0.772HisCys: 0.772 ± 0.005	1.032HisAsp: 1.032 ± 0.009	1.182HisGlu: 1.182 ± 0.006	0.929HisPhe: 0.929 ± 0.005	1.6HisGly: 1.6 ± 0.007	1.244HisHis: 1.244 ± 0.01	1.247HisIle: 1.247 ± 0.005	1.265HisLys: 1.265 ± 0.005	2.644HisLeu: 2.644 ± 0.01	0.696HisMet: 0.696 ± 0.005	1.059HisAsn: 1.059 ± 0.006	1.764HisPro: 1.764 ± 0.01	1.5HisGln: 1.5 ± 0.011	1.686HisArg: 1.686 ± 0.008	2.717HisSer: 2.717 ± 0.012	1.891HisThr: 1.891 ± 0.011	1.413HisVal: 1.413 ± 0.006	0.296HisTrp: 0.296 ± 0.003	0.856HisTyr: 0.856 ± 0.005	0.0HisXaa: 0.0 ± 0.0
Ile	2.313IleAla: 2.313 ± 0.009	0.884IleCys: 0.884 ± 0.006	2.043IleAsp: 2.043 ± 0.009	2.407IleGlu: 2.407 ± 0.016	1.444IlePhe: 1.444 ± 0.006	2.15IleGly: 2.15 ± 0.009	1.259IleHis: 1.259 ± 0.006	2.115IleIle: 2.115 ± 0.012	2.392IleLys: 2.392 ± 0.014	3.825IleLeu: 3.825 ± 0.012	1.059IleMet: 1.059 ± 0.012	1.794IleAsn: 1.794 ± 0.007	2.472IlePro: 2.472 ± 0.008	2.152IleGln: 2.152 ± 0.008	2.275IleArg: 2.275 ± 0.006	3.486IleSer: 3.486 ± 0.01	2.78IleThr: 2.78 ± 0.019	2.368IleVal: 2.368 ± 0.011	0.397IleTrp: 0.397 ± 0.004	1.16IleTyr: 1.16 ± 0.005	0.0IleXaa: 0.0 ± 0.0
Lys	3.764LysAla: 3.764 ± 0.014	0.957LysCys: 0.957 ± 0.006	3.271LysAsp: 3.271 ± 0.014	4.863LysGlu: 4.863 ± 0.021	1.398LysPhe: 1.398 ± 0.007	3.424LysGly: 3.424 ± 0.014	1.374LysHis: 1.374 ± 0.007	2.231LysIle: 2.231 ± 0.012	4.253LysLys: 4.253 ± 0.019	4.649LysLeu: 4.649 ± 0.014	1.49LysMet: 1.49 ± 0.007	2.069LysAsn: 2.069 ± 0.008	3.22LysPro: 3.22 ± 0.023	2.545LysGln: 2.545 ± 0.01	3.474LysArg: 3.474 ± 0.011	3.811LysSer: 3.811 ± 0.013	3.193LysThr: 3.193 ± 0.01	3.501LysVal: 3.501 ± 0.018	0.548LysTrp: 0.548 ± 0.005	1.377LysTyr: 1.377 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	5.82LeuAla: 5.82 ± 0.019	1.979LeuCys: 1.979 ± 0.009	4.728LeuAsp: 4.728 ± 0.011	6.577LeuGlu: 6.577 ± 0.018	2.891LeuPhe: 2.891 ± 0.013	5.228LeuGly: 5.228 ± 0.018	2.676LeuHis: 2.676 ± 0.011	3.31LeuIle: 3.31 ± 0.01	5.361LeuLys: 5.361 ± 0.016	9.148LeuLeu: 9.148 ± 0.033	1.974LeuMet: 1.974 ± 0.009	3.404LeuAsn: 3.404 ± 0.011	5.436LeuPro: 5.436 ± 0.018	5.455LeuGln: 5.455 ± 0.023	5.495LeuArg: 5.495 ± 0.016	8.213LeuSer: 8.213 ± 0.02	5.198LeuThr: 5.198 ± 0.014	5.072LeuVal: 5.072 ± 0.013	0.916LeuTrp: 0.916 ± 0.005	2.372LeuTyr: 2.372 ± 0.01	0.001LeuXaa: 0.001 ± 0.0
Met	1.979MetAla: 1.979 ± 0.007	0.46MetCys: 0.46 ± 0.004	1.653MetAsp: 1.653 ± 0.011	2.192MetGlu: 2.192 ± 0.008	0.779MetPhe: 0.779 ± 0.005	1.659MetGly: 1.659 ± 0.008	0.515MetHis: 0.515 ± 0.003	0.814MetIle: 0.814 ± 0.005	1.462MetLys: 1.462 ± 0.007	1.996MetLeu: 1.996 ± 0.01	0.756MetMet: 0.756 ± 0.005	0.899MetAsn: 0.899 ± 0.005	1.249MetPro: 1.249 ± 0.007	1.053MetGln: 1.053 ± 0.006	1.265MetArg: 1.265 ± 0.007	1.989MetSer: 1.989 ± 0.008	1.339MetThr: 1.339 ± 0.007	1.675MetVal: 1.675 ± 0.007	0.236MetTrp: 0.236 ± 0.002	0.609MetTyr: 0.609 ± 0.004	0.0MetXaa: 0.0 ± 0.0
Asn	2.095AsnAla: 2.095 ± 0.008	0.765AsnCys: 0.765 ± 0.005	1.649AsnAsp: 1.649 ± 0.008	1.967AsnGlu: 1.967 ± 0.007	1.195AsnPhe: 1.195 ± 0.006	2.874AsnGly: 2.874 ± 0.013	1.05AsnHis: 1.05 ± 0.006	1.959AsnIle: 1.959 ± 0.008	2.101AsnLys: 2.101 ± 0.007	3.397AsnLeu: 3.397 ± 0.011	1.1AsnMet: 1.1 ± 0.006	1.763AsnAsn: 1.763 ± 0.008	2.289AsnPro: 2.289 ± 0.01	1.782AsnGln: 1.782 ± 0.008	1.968AsnArg: 1.968 ± 0.007	3.231AsnSer: 3.231 ± 0.011	2.379AsnThr: 2.379 ± 0.009	2.21AsnVal: 2.21 ± 0.01	0.394AsnTrp: 0.394 ± 0.003	1.054AsnTyr: 1.054 ± 0.006	0.0AsnXaa: 0.0 ± 0.0
Pro	4.389ProAla: 4.389 ± 0.016	1.056ProCys: 1.056 ± 0.006	2.998ProAsp: 2.998 ± 0.013	4.0ProGlu: 4.0 ± 0.019	1.718ProPhe: 1.718 ± 0.008	4.843ProGly: 4.843 ± 0.03	1.708ProHis: 1.708 ± 0.01	2.06ProIle: 2.06 ± 0.011	2.764ProLys: 2.764 ± 0.015	5.078ProLeu: 5.078 ± 0.016	1.282ProMet: 1.282 ± 0.006	2.042ProAsn: 2.042 ± 0.009	6.276ProPro: 6.276 ± 0.03	3.151ProGln: 3.151 ± 0.015	2.986ProArg: 2.986 ± 0.012	6.35ProSer: 6.35 ± 0.023	3.682ProThr: 3.682 ± 0.017	3.98ProVal: 3.98 ± 0.014	0.503ProTrp: 0.503 ± 0.004	1.54ProTyr: 1.54 ± 0.009	0.0ProXaa: 0.0 ± 0.0
Gln	3.534GlnAla: 3.534 ± 0.016	1.019GlnCys: 1.019 ± 0.007	2.447GlnAsp: 2.447 ± 0.011	3.733GlnGlu: 3.733 ± 0.015	1.272GlnPhe: 1.272 ± 0.006	3.274GlnGly: 3.274 ± 0.014	1.517GlnHis: 1.517 ± 0.007	1.819GlnIle: 1.819 ± 0.007	2.486GlnLys: 2.486 ± 0.011	4.55GlnLeu: 4.55 ± 0.02	1.198GlnMet: 1.198 ± 0.007	1.75GlnAsn: 1.75 ± 0.007	3.056GlnPro: 3.056 ± 0.017	3.871GlnGln: 3.871 ± 0.03	3.306GlnArg: 3.306 ± 0.015	3.81GlnSer: 3.81 ± 0.014	2.774GlnThr: 2.774 ± 0.014	2.871GlnVal: 2.871 ± 0.01	0.539GlnTrp: 0.539 ± 0.004	1.26GlnTyr: 1.26 ± 0.006	0.0GlnXaa: 0.0 ± 0.0
Arg	3.427ArgAla: 3.427 ± 0.01	1.154ArgCys: 1.154 ± 0.008	3.072ArgAsp: 3.072 ± 0.011	4.303ArgGlu: 4.303 ± 0.016	1.79ArgPhe: 1.79 ± 0.007	3.82ArgGly: 3.82 ± 0.019	1.641ArgHis: 1.641 ± 0.009	2.309ArgIle: 2.309 ± 0.014	3.478ArgLys: 3.478 ± 0.011	5.196ArgLeu: 5.196 ± 0.014	1.353ArgMet: 1.353 ± 0.006	2.058ArgAsn: 2.058 ± 0.007	3.192ArgPro: 3.192 ± 0.012	2.864ArgGln: 2.864 ± 0.012	4.427ArgArg: 4.427 ± 0.018	4.653ArgSer: 4.653 ± 0.018	3.019ArgThr: 3.019 ± 0.011	3.357ArgVal: 3.357 ± 0.015	0.624ArgTrp: 0.624 ± 0.004	1.483ArgTyr: 1.483 ± 0.006	0.001ArgXaa: 0.001 ± 0.0
Ser	5.395SerAla: 5.395 ± 0.013	1.824SerCys: 1.824 ± 0.009	4.402SerAsp: 4.402 ± 0.012	5.059SerGlu: 5.059 ± 0.013	2.799SerPhe: 2.799 ± 0.009	5.883SerGly: 5.883 ± 0.015	2.41SerHis: 2.41 ± 0.01	3.255SerIle: 3.255 ± 0.01	3.971SerLys: 3.971 ± 0.012	8.351SerLeu: 8.351 ± 0.023	2.012SerMet: 2.012 ± 0.007	3.012SerAsn: 3.012 ± 0.009	6.925SerPro: 6.925 ± 0.029	4.3SerGln: 4.3 ± 0.016	4.564SerArg: 4.564 ± 0.016	10.608SerSer: 10.608 ± 0.04	5.307SerThr: 5.307 ± 0.017	5.384SerVal: 5.384 ± 0.013	0.93SerTrp: 0.93 ± 0.005	2.08SerTyr: 2.08 ± 0.008	0.001SerXaa: 0.001 ± 0.0
Thr	4.144ThrAla: 4.144 ± 0.016	1.242ThrCys: 1.242 ± 0.009	2.972ThrAsp: 2.972 ± 0.01	3.991ThrGlu: 3.991 ± 0.017	1.875ThrPhe: 1.875 ± 0.007	4.123ThrGly: 4.123 ± 0.014	1.602ThrHis: 1.602 ± 0.008	2.431ThrIle: 2.431 ± 0.012	2.772ThrLys: 2.772 ± 0.014	5.48ThrLeu: 5.48 ± 0.014	1.396ThrMet: 1.396 ± 0.007	1.94ThrAsn: 1.94 ± 0.007	4.334ThrPro: 4.334 ± 0.018	2.674ThrGln: 2.674 ± 0.011	2.684ThrArg: 2.684 ± 0.014	5.145ThrSer: 5.145 ± 0.017	4.202ThrThr: 4.202 ± 0.031	4.227ThrVal: 4.227 ± 0.019	0.682ThrTrp: 0.682 ± 0.007	1.36ThrTyr: 1.36 ± 0.007	0.001ThrXaa: 0.001 ± 0.0
Val	3.986ValAla: 3.986 ± 0.01	1.514ValCys: 1.514 ± 0.008	3.167ValAsp: 3.167 ± 0.009	4.41ValGlu: 4.41 ± 0.02	2.253ValPhe: 2.253 ± 0.009	3.524ValGly: 3.524 ± 0.011	1.532ValHis: 1.532 ± 0.006	2.732ValIle: 2.732 ± 0.012	3.695ValLys: 3.695 ± 0.022	5.666ValLeu: 5.666 ± 0.018	1.51ValMet: 1.51 ± 0.005	2.461ValAsn: 2.461 ± 0.01	3.512ValPro: 3.512 ± 0.014	2.838ValGln: 2.838 ± 0.011	3.208ValArg: 3.208 ± 0.011	5.277ValSer: 5.277 ± 0.016	4.141ValThr: 4.141 ± 0.024	4.359ValVal: 4.359 ± 0.018	0.705ValTrp: 0.705 ± 0.004	1.659ValTyr: 1.659 ± 0.008	0.001ValXaa: 0.001 ± 0.0
Trp	0.61TrpAla: 0.61 ± 0.003	0.216TrpCys: 0.216 ± 0.002	0.592TrpAsp: 0.592 ± 0.004	0.72TrpGlu: 0.72 ± 0.004	0.391TrpPhe: 0.391 ± 0.003	0.61TrpGly: 0.61 ± 0.005	0.267TrpHis: 0.267 ± 0.003	0.455TrpIle: 0.455 ± 0.004	0.629TrpLys: 0.629 ± 0.004	1.047TrpLeu: 1.047 ± 0.006	0.327TrpMet: 0.327 ± 0.003	0.467TrpAsn: 0.467 ± 0.003	0.413TrpPro: 0.413 ± 0.004	0.468TrpGln: 0.468 ± 0.004	0.719TrpArg: 0.719 ± 0.005	0.866TrpSer: 0.866 ± 0.005	0.648TrpThr: 0.648 ± 0.006	0.629TrpVal: 0.629 ± 0.004	0.182TrpTrp: 0.182 ± 0.003	0.316TrpTyr: 0.316 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.295TyrAla: 1.295 ± 0.005	0.654TyrCys: 0.654 ± 0.004	1.287TyrAsp: 1.287 ± 0.006	1.5TyrGlu: 1.5 ± 0.007	0.966TyrPhe: 0.966 ± 0.006	1.695TyrGly: 1.695 ± 0.011	0.818TyrHis: 0.818 ± 0.006	1.299TyrIle: 1.299 ± 0.008	1.347TyrLys: 1.347 ± 0.008	2.371TyrLeu: 2.371 ± 0.009	0.644TyrMet: 0.644 ± 0.005	1.114TyrAsn: 1.114 ± 0.007	1.342TyrPro: 1.342 ± 0.008	1.274TyrGln: 1.274 ± 0.006	1.647TyrArg: 1.647 ± 0.009	2.362TyrSer: 2.362 ± 0.01	1.62TyrThr: 1.62 ± 0.01	1.444TyrVal: 1.444 ± 0.007	0.352TyrTrp: 0.352 ± 0.003	0.877TyrTyr: 0.877 ± 0.005	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 82392 proteins (58348648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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